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QUANTIFICATION OF PHARMACOLOGICALLY ACTIVE MARKERS GALLIC ACID, QUERCETIN AND LUPEOL FROM ACACIA LEUCOPHLOEA WILLD FLOWERS BY HPTLC METHOD
V Leela,A Saraswathy
International Research Journal of Pharmacy , 2013,
Abstract: TLC densitometric method for quantification of gallic acid, quercetin and lupeol using HPTLC is developed. This is the first report of quantification of these three bioactive compounds viz Gallic acid, quercetin and lupeol using HPTLC from this plant. Quantification of gallic acid and quercetin was carried out from the methanolic extract using the solvent system of Toluene: Ethyl acetate: Formic acid (6:4:0.8 v/v/v). Lupeol was quantified from chloroform extract using the solvent system of Toluene: Ethyl acetate (7:3 v/v). The Rf values of gallic acid, quercetin and lupeol are 0.22, 0.37 and 0.70 respectively. The linearity ranges for gallic acid (100 to 600ng), quercetin (2000 to 7000ng) and lupeol (100 to 1200ng) with correlation coefficients (r-values) of 0.99968, 0.99708, 0.99971 respectively. The amount of gallic acid, quercetin and lupeol was 124.31, 580.4, 24.89 μg/ml respectively. Quantification of gallic acid, quercetin and lupeol showed good resolution and separation from other constituents of extract. Its main advantages are its simplicity, accuracy, and selectivity. This method can also be used for the estimation of these compounds in other herbal preparations and may be useful for standardization purposes.
Phytochemical Investigation Of The Tender Shoot Of Bambusa Bamboos (Linn.) Voss
Saraswathy A,Vidhya B
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: Phytochemical investigation of the ethyl alcohol extract of the tender shoot of Bambusa bamboos (Linn.) Voss yielded p- hydroxybenzaldehyde, p- hydroxybenzoic acid, p- hydroxyphenylacetic acid, β-sitosterol and β-sitosterol-β-D-glucopyranoside. All the compounds are reported for the first time from the tender shoot of Bambusa bamboos.
Frequencies of X-ray induced chromosome aberrations in lymphocytes of xeroderma pigmentosum and Fanconi anemia patients estimated by Giemsa and fluorescence in situ hybridization staining techniques
Saraswathy, Radha;Natarajan, A.T.;
Genetics and Molecular Biology , 2000, DOI: 10.1590/S1415-47572000000400031
Abstract: blood lymphocytes from xeroderma pigmentosum (xp) and fanconi anemia (fa) patients were assessed for their sensitivity to ionizing radiation by estimating the frequency of x-ray (1 and 2 gy)-induced chromosome aberrations (ca). the frequencies of aberrations in the whole genome were estimated in giemsa-stained preparations of lymphocytes irradiated at g0 or g2 stages. the frequencies of translocations and dicentrics involving chromosomes 1 and 3 as well as the x-chromosome were determined in slides stained by fluorescence in situ hybridization (fish) technique. an increase in all types of ca was observed in xp and fa lymphocytes irradiated at g0 when compared to controls. the frequency of dicentrics and rings was 6 to 27% higher (at 1 and 2 gy) in xp lymphocytes and 37% higher (at 2 gy) in fa lymphocytes than in controls, while chromosome deletions were higher in irradiated (30% in 1 gy and 72% in 2 gy) than in control xp lymphocytes and 28 to 102% higher in fa lymphocytes. in g2-irradiated lymphocytes the frequency of ca was 24 to 55% higher in xp lymphocytes than in controls. in most cases the translocation frequencies were higher than the frequencies of dicentrics (21/19).
Frequencies of X-ray induced chromosome aberrations in lymphocytes of xeroderma pigmentosum and Fanconi anemia patients estimated by Giemsa and fluorescence in situ hybridization staining techniques
Saraswathy Radha,Natarajan A.T.
Genetics and Molecular Biology , 2000,
Abstract: Blood lymphocytes from xeroderma pigmentosum (XP) and Fanconi anemia (FA) patients were assessed for their sensitivity to ionizing radiation by estimating the frequency of X-ray (1 and 2 Gy)-induced chromosome aberrations (CA). The frequencies of aberrations in the whole genome were estimated in Giemsa-stained preparations of lymphocytes irradiated at G0 or G2 stages. The frequencies of translocations and dicentrics involving chromosomes 1 and 3 as well as the X-chromosome were determined in slides stained by fluorescence in situ hybridization (FISH) technique. An increase in all types of CA was observed in XP and FA lymphocytes irradiated at G0 when compared to controls. The frequency of dicentrics and rings was 6 to 27% higher (at 1 and 2 Gy) in XP lymphocytes and 37% higher (at 2 Gy) in FA lymphocytes than in controls, while chromosome deletions were higher in irradiated (30% in 1 Gy and 72% in 2 Gy) than in control XP lymphocytes and 28 to 102% higher in FA lymphocytes. In G2-irradiated lymphocytes the frequency of CA was 24 to 55% higher in XP lymphocytes than in controls. In most cases the translocation frequencies were higher than the frequencies of dicentrics (21/19).
Quality control standards for the roots of Three Plumbago species
Ariyanathan S,Saraswathy A,Rajamanickam G
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: Physicochemical parameters of roots of three Plumbago species, Plumbago capensis, P. rosea and P. zeylanica belonging to Plumbaginaceae were analyzed. Microbial contamination, aflatoxins, pesticide residue and heavy metal content were also determined. Attempt has also been made to estimate the biologically active chemical plumbagin present in them and the data compared. The study ensures that the quality control parameters do help in the proper standardization of the crude drugs in drug development process for global acceptance.
Antioxidant, heavy metals and elemental analysis of Holoptelea integrifolia planch
Saraswathy A,Devi S,Ramasamy D
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: The ethanol crude extract of stem bark of Holoptelea integrifolia Planch. traditionally used in Indian system of medicine was screened for its antioxidant activity using a-tocopherol as standard antioxidant. The free radical scavenging potential of the extract was evaluated by two different antioxidant methods; ferric thiocyanate and thiobarbituric acid method. The ethanol extract was found to exhibit good antioxidant property. Further physico-chemical constants, elemental and heavy metal analysis of stem bark have been described.
Analgesic and antiinflammatory activity of Amukkarac curanam
Saraswathy A,Devi S,Pradeep Chandran R
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: Amukkarac curanam a polyherbal Siddha formulation was examined for its analgesic and antiinflammatory activity at a dose of 500 mg/kg, p.o. The experimental methods used were tail immersion and acetic acid induced writhing method for analgesic and cotton pellet induced granuloma formation for antiinflammatory activity. Pentazocine (10 mg/kg, intraperitoneally) and aspirin (150 mg/kg, orally) clinically used analgesics were used as standard analgesics. Indomethacin (10 mg/kg, orally) was used as standard for antiinflammatory study. Amukkarac curanam showed significant analgesic and antiinflammatory activity in the above study.
Comparative HPTLC fingerprint profile of Illicium verum Hook.f. and Illicium griffithii Hook.f. & Thoms fruits
Saraswathy A,Vidhya B,Amala K
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: Objective: To establish the fingerprint profile of two Illicium species namely Illicium verum Hook.f. and Illicium griffithii Hook.f. & Thoms using high performace thin layer chromatography (HPTLC) technique. Methods: CAMAG HPTLC system equipped with TLC autosampler 4 applicator, TLC scanner 3 and win CATS 1.4.4. software was used. n-hexane, chloroform and ethyl acetate extracts of the fruits were developed in suitable mobile phase using standard procedures and scanned under UV at 254nm, 366 nm and under visible light. Results: The HPTLC fingerprinting of the n-hexane, chloroform and ethyl acetate extracts showed several peaks with different Rf values. Conclusion: HPTLC fingerprint profile of two Illicium species may be useful in differentiating the species and also helpful in the identification and authentication of these species
GC-MS Analysis of N-Hexane Extract of Epaltes divaricata (L.) Cass
Amala K,Saraswathy A,Amerjothy S
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: The investigation was carried out to determine the possible chemical components of Eplates divaricata (L.) Cass. whole plant using GC-MS analysis of N-hexane extract which led to identification of 11 compounds. Not much information available on phytochemcial components of Epaltes divaricata (L.) Cass. This is the first attempt to investigate the GC-MS analysis of n-hexane extract of this plant. The analysis revealed that this plant contains mainly n-hexadecanoic acid (Rt 22.48); 9,12-octadecadienoic acid (Z,Z) (Rt 24.67); hexacosane (Rt 31.06) observed found to be 5.06, 6.03 and 6.60% respectively. The content of hexatriacontane (Rt 32.30) was found to be 14.36%.
Essential oil constituents of Illicium griffithii and its antimicrobial activity
Saraswathy A,Shakila R,Lavanya S,Arunmozhidevi A
Pharmacognosy Magazine , 2010,
Abstract: The essential oil of the fruit of Illicium griffithii Hook f. et Thoms. was extracted using Clevenger′s apparatus. Forty-one compounds were characterized by gas chromatography-mass spectroscopy (GC-MS). 4-Methyl-6-(2-propenyl)-1,3-benzodioxole was characterized as the major constituent, followed by linalool amongst the volatile constituents. The essential oil was found to be effective against Aspergillus niger, Penicillium spp. and Saccharomyces cerevisiae and possessed considerable activity against Staphylococcus aureus and was inactive against Klebsiella pnemoniae, Pseudomonas aureginosae, Proteus vulgaris and Escherichia coli.
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