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Comparing measurements of mitral valve area by two-dimensional planimetry and continuity equation in patients with mitral stenosis
R Sattarzadeh Badkoobeh,L Derakhshan,A Farhang Zand Parsa,A Pasha Meysamie
Tehran University Medical Journal , 2012,
Abstract: Background: Measurements of mitral valve area (MVA) are essential to determine the severity of mitral stenosis (MS) and adopt the best management strategies. The aim of the present study was to compare MVA determined by two-dimensional (2D) planimetry to MVA measured by continuity equation (CE) in patients with moderate to severe MS. Methods: We evaluated 73 consecutive patients with the diagnosis of MS scheduled for balloon mitral valvuloplasty or with moderate to severe rheumatic MS admitted at the echocardiography clinic of Imam Khomeini Hospital in 2010. Using 2D images of mitral valve obtained from paraesternal short axis view, 2D planimetry of the mitral orifice area was performed by an experienced cardiologist. MVA by CE was calculated from aortic forward stroke volume divided by transmitral time-velocity integral.Results: The mean value of MVA by 2-D planimetry was 1.0±0.3 cm2. The average values of MVA measured by PHT and CE were 1.0±0.3 cm2 and 0.9±0.4 cm2, respectively. The MVA determined by planimetry correlated well with CE (r=0.832, standard error of estimation [SEE]= 0.166, P<0.001). The mean values of MVA calculated by CE highly correlated with those calculated by 2-D planimetry in patients presenting with both non-significant (r=0.701) and significant (r=0.761) AIs. Conclusion: When planimetry is not feasible, such as in severe calcification of mitral valve or after percutaneous balloon valvuloplasty, CE could be an alternative method for MVA measurement in comparison with PHT.
How addicts think about addiction and community problems?
A. Meysamie,B. Faramarzi,K. Holakouie Naieni
Tehran University Medical Journal , 2006,
Abstract: Background: addiction and drug abuse have many risk factors in community and individual attitude; also causes much diversity in community perception and attitude toward addiction. Methods: in this study we assessed attitude toward an addict in 42 addict men and asked about problems in their community and recreational behaviors. They were residents of a rural area in Babol city. In the control group we assessed the same parameters in 268 non addicts in the same area. All of the addicts have been using opium more than many times a week at least for recent 6 months. Data collected via a semi structured questionnaire through conversation. Results: There was a significant difference between addicts’ attitude toward toward addiction compare to non-addicts’. Both addicts and non-addicts indicated that the first three community problems in their area were unemployment, lack of recreational facilities and addiction, in respective order. Answering questions about recreational activities, both groups indicated that there were no recreational facilities in the community. Conclusion: In planning a preventive approach, there is a major role for attitude toward addiction in any community. The conflict seen in this study between addicts’ attitudes toward an addicted person and addiction as a community problem has it’s interesting feature. Recreation and physical and cultural facilities need to pay more attention as indicated by our study participants. This seems to have an important impact in prevention of many community problems as well as addiction.
Assessment of Attitude and Knowledge about Intentional Abortion in Pre-married Females
Jarahi L.,Meysamie A.P.,Fayaz Bakhsh A.
Qom University of Medical Sciences Journal , 2012,
Abstract: Background and Objectives: Assessment of intentional abortion and women's knowledge about its causes and complications is an important priority for women's health, but because of the sensitivity, the investigations in this topic are rare. This study was performed for the first time in order to determine women's knowledge and attitude toward intentional abortion.Methods: Women referring to pre-marriage counseling centers in Mashhad, Iran, were selected with easy sampling method and accessed with knowledge and attitude questionnaire. Data were analyzed by Q-Square, T-Test and Pearson correlation. Results: Of 480 participants, 71% (CI95%=66.8-75.0) had opposed attitudes about the intentional abortion and 26.5% (CI95%=22.6-30.5) had appropriate knowledge. Between lower age and lower education, lack of interest to contraceptive use with low women's knowledge-attitude scores, there was a significant relationship (p<0.05). Conclusion: Most of the participants opposed attitudes to intentional abortion, but more than 70% of them had low knowledge about this topic. Inappropriate knowledge about causes and its adverse consequences, especially the beginning of marital life can lead to unwanted pregnancy, intentional and unsafe abortion that need attention.
The prevalence of abdominal aortic aneurysm in Iranian male population over 65 years old
Mirsharifi R,Zhand N,Shahriyarian Sh,Meysamie A
Tehran University Medical Journal , 2011,
Abstract: "nBackground: Prevalence of Abdominal Aortic Aneurysm (AAA), estimated by various studies, ranged from 4.1% to 14.2% in men older than 60 years. Most cases of AAA are asymptomatic and often discovered incidentally. Approximately the initial presentation in 12% of cases of AAA is sudden rupture with subsequent high mortality. This study was performed to evaluate the prevalence and screening necessity of AAA among Iranian men older than 65 years old."n "nMethods: In this cross-sectional study, men older than 65 years, who referred for ultrasound examination to three different centers in Tehran, Iran at the year 2008 were included for evaluation of size of the abdominal aorta and presence of AAA."n "nResults: A total of 240 men older than 65 years enrolled in this study. AAA was found in 24 of the participants with prevalence rate of 10% in the studied population. Mean diameter of detected aneurysms was 3.93 1.435 cm. In 4 (1.7%) subjects, aneurysms greater than 5.5 cm in diameter were detected. One of these four subjects had the history of coronary artery disease and one was cigarette smoker. Three out of four had history of hypertension."n "nConclusion: Considering the estimated prevalence rate of AAA by the current study and the population of Iranian men older than 65, implementing of mass screening for AAA in this group would detect 986 asymptomatic cases each year. Therefore, the authors recommend further studies about the cost-effectiveness of mass screening for AAA among Iranian men above 65 years.
Association of Socio-demographic characteristics and cigarette smoking: Savodjbolaq city Inhabitants
Farshi S.,Sedaghat M.,Meysamie A.,Abdollahi E.
Tehran University Medical Journal , 2007,
Abstract: Background: a number of factors such as socio-demographic and socioeconomic status have emerged as being associated with smoking. The main goal of the present study was to identify the relationship of socio-demographic factors and cigarette smoking, and to determine the indicators of smoking status in a community based case-control study.Methods: Using the random multistage cluster sampling method on the basis of family list kept in the health center, a head cluster was selected, and 25 clusters of 10 members each were chosen. One member was selected from each family to fill the questionnaire. The neighborhood method was used for selection of controls. The socio-demographic characteristics was assessed by a self administered questionnaire. Data analysis was performed using SPSS V-11.5 software. Logistic regression was used to assess the association of age, sex, marital status, family size, number of close friends, number of smoking friends, and presence of smokers in the family with smoking status. Results: The mean smoking consumption of smokers in this study was 14.6 per day. The mean age of smoking initiation was 18.6 years. Fifty percent of people initiated smoking at ages less than 18. The mean years of education were significantly higher in nonsmokers. A significant inverse relationship exists between the number of cigarettes smoked per day and educational levels. The positive association between number of cigarette smoked per day and age was found (OR=1.2, CI 95% 1.07-1.4). Number of smoking friends in smokers were significantly more than in nonsmokers. Multivariate analysis revealed that age, and number of smoking friends, could be predictors of smoking status. The association between sex, marital status, family size, and education with smoking status were not significant. Conclusions: This study revealed the association between several socio-demographic factors with smoking status. Antismoking strategies for adults tend to emphasize smoking cessation, preventing smoking initiation is also important during young adulthood. Anyway, educational interventions are highly suggested.
Cigarette Smoking in Iran
A Meysamie,R Ghaletaki,N Zhand,M Abbasi
Iranian Journal of Public Health , 2012,
Abstract: Background: Cigarette smoking is the largest preventable cause of death worldwide. No systematic review is available on the situation of the smoking in Iran, so we decided to provide an overview of the studies in the field of smoking in Iranian populations.Methods: Published Persian-language papers of all types until 2009 indexed in the IranMedex (http://www.iranmedex.com) and Magiran (http://www.magiran.com). Reports of World Health Organization were also searched and optionally employed. The studies concerning passive smoking or presenting the statistically insignificant side effects were excluded. Databases were searched using various combinations of the following terms: cigarette, smoking, smoking cessation, prevalence, history, side effects, and lung cancer by independent reviewers. All the 83 articles concerning the prevalence or side effects of the smoking habit in any Iranian population were selected. The prevalence rate of daily cigarette smoking and the 95% confidence interval as well as smoking health risk associated odds ratio (OR) were retrieved from the articles or calculated.Results: The reported prevalence rates of the included studies, the summary of smoking-related side effects and the ORs (95%CI) of smoking associated risks and the available data on smoking cessation in Iran have been shown in the article.Conclusion: Because of lack of certain data, special studies on local pattern of tobacco use in different districts, about the relationship between tobacco use and other diseases, especially non communicable diseases, and besides extension of smoking cessation strategies, studies on efficacy of these methods seems to be essential in this field.
fms Like Tyrosine kinase3- Internal Tandem Duplication (FLT3-ITD) in Acute Myeloid Leukemia, Mutation Frequency and its Relation with Complete Remission, 2007- 2008
Amir Hossein Emami,Ramin Shekarriz,A Meysamie,Ramazanali Sharifian
International Journal of Hematology-Oncology and Stem Cell Research , 2009,
Abstract: "nIntroduction: About half of acute myeloid leukemia (AML) adult patients have no cytogenetic abnormalities as a main determinant of complete remission after treatment, so other markers are needed such as FLT3-ITD (Fms-like Tyrosine kinase3-internal tandem duplication) mutations in patients with normal karyotype. The objective of this study was assessing the frequency of FLT3-ITD mutations and its relation with complete remission in different FAB (French- American- British) and cytogenetic subgroups of AML patients who had been hospitalized at Tehran Imam Khomeini Hospital, hematology ward. "nMethods: The current study, was a cross sectional descriptive study which was performed during the years 2007-2008. Population frame were consecutive patients whose diseases were confirmed and who had been hospitalized in Tehran Imam Khomeini Hospital, hematology ward. Contemporary, flowcytometry, cytogenetic and chromosomal studies were performed for the cytogenetic subgroup assessment and to investigate the presence of FLT3-ITD mutation. Finally, complete remission achievement after induction chemotherapy were assessed. The obtained data was entered onto the information forms and analyzed by statistical tests. "nResults: Out of 40 patients who participated in this study, 18 (45%) were female and 22 (55%) were male. The median age of the patients with mutation was 33 years of age, and the ones without mutation were 39.5. M1, M2 and M4 FAB subgroups, with respectively 60, 37.5 and 35.7%, had the most occurrence of mutation. There was no significant relationship between mutation and the FAB subgroups (P=0.45). Favorable, intermediate and adverse cytogenetic risk groups had respectively 10, 37 and 66.7% mutations and 69.2% of the patients were in the normal karyotype group. Seventeen (42.5%) of the 40 patients achieved complete remission. 17.6% of them had mutations. There was no relationship between mutation and complete remission (P=0.085). "nConclusion: There was no relationship between the presence of FLT3-ITD mutation and complete remission achievement following chemotherapy.
Effects of Two New Risk Factors on Perforated and Non-Perforated Appendicitis
B. Khorasani,A. Gholizadeh Pasha
Research Journal of Biological Sciences , 2012,
Abstract: Appendicitis has been a cause of mortality through the history and has still remained as a major problem in spite of advances and improvements of medical sciences. Acute appendicitis is the most frequent cause of acute abdomen for the patients referring to hospitals. Patients will recover after a timely diagnosis and appendectomy. However, absence of timely and proper diagnosis may result harmful complications and even death. This descriptive-analytic retrospective study was carried out with the evaluation of medical records of those went to Shahid Beheshti and Yahyanejad hospitals from 2002-2004. The data was statistically analyzed by using SPSS software and chi-square and fisher's Exact statistical tests. Out of 1190 cases of non-perforated acute appendicitis, 64.3% were in 15-34 years age group, 727 patients were male and remaining were female, 121 patients with perforated appendicitis that had the highest frequency (49.5%) were in the age group 15-34 years (60 patients), 85 patients were male (70.2%). However, the highest perforated to non-perforated appendicitis ratio (21.5%/78.4%) belongs to the age group over 65. About 16.5% patients with perforated appendicitis were urban but 83.4% patients were rural, 74.3% of the121 cases of perforated appendicitis had occurred within the first half of the year and 25.6% within the second half. This study proved that incidence of perforated appendicitis is more common between rural patients and those who had referred to hospital in the first half of the year. So living in the village and first half of the year are two important risk factors for acute appendicitis.
Perforation rate in acute appendicitis: association with different risk facotrs
B. Khorasani,A. Gholizadeyeh Pasha
Tehran University Medical Journal , 2006,
Abstract: Background: The early diagnosis of acute appendicitis before progression to gangrene or abscess formation is recognized as important to minimize morbidity from this common disease process. The aim of this study was to assess the value of different risk factors in the diagnosis of perforation. Methods: This descriptive-analytic and retrospective study was conducted to investigate epidemiological characteristics in patients with perforated and non-perforated appendicitis. A series of 1311 patients who were operated on for acute appendicitis between years 1380-1382 in Shahid Beheshti and Yahya-nejad hospitals were reviewed.. Data gathered included age at operation, gender, care sought prior to admission for appendectomy including antibiotic and analgesic therapy, time of presentation in the year, duration of symptoms, signs and symptoms at the time of admission, and the patient’s living area. Results: One hundred twenty one of 1311 patients (9%) had perforated appendicitis and 1190 patients (91%) had unperforated appendicitis. Presentation and referral in the first 6-month was associated with higher perforation rate. Patients from rural area showed a higher rate of perforations. The perforation rate was significantly higher in elderly patients (>65 year). When the duration of symptoms was more than 12 hours at presentation, the risk of perforation showed a five-fold increase. 30.7% of perforated cases had used antibiotic or sedative before referring to the hospital. Conclusion: Appendiceal perforation continues to be a complication in patients with acute appendicitis and increased in the frequency as the age of the patients increase and the duration of symptoms lengthen. We also found that the perforation rate is higher in patients from rural area and in whom present in the first 6-month of the year, a finding that was not reported so far.
Tuberculosis Surveillance Using a Hidden Markov Model
A Rafei,E Pasha,R Jamshidi Orak
Iranian Journal of Public Health , 2012,
Abstract: Background: Routinely collected data from tuberculosis surveillance system can be used to investigate and monitor the irregularities and abrupt changes of the disease incidence. We aimed at using a Hidden Markov Model in order to detect the abnormal states of pulmonary tuberculosis in Iran.Methods: Data for this study were the weekly number of newly diagnosed cases with sputum smear-positive pulmonarytuberculosis reported between April 2005 and March 2011 throughout Iran. In order to detect the unusual states of the disease, two Hidden Markov Models were applied to the data with and without seasonal trends as baselines.Consequently, the best model was selected and compared with the results of Serfling epidemic threshold which is typically used in the surveillance of infectious diseases.Results: Both adjusted R-squared and Bayesian Information Criterion (BIC) reflected better goodness-of-fit for the model with seasonal trends (0.72 and -1336.66, respectively) than the model without seasonality (0.56 and -1386.75).Moreover, according to the Serfling epidemic threshold, higher values of sensitivity and specificity suggest a higher validity for the seasonal model (0.87 and 0.94, respectively) than model without seasonality (0.73 and 0.68, respectively).Conclusion: A two-state Hidden Markov Model along with a seasonal trend as a function of the model parameters provides an effective warning system for the surveillance of tuberculosis.
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