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Neoadjuvant Chemotherapy of Epirobicin, Oxaliplatin, Capecitabine Regimen in Patients with Advanced Gastric Cancer: A Two Year Study
F Samiei,A Maddah Safai,E Esmati,A Alibakhshi
Tehran University Medical Journal , 2012,
Abstract: Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is the standard treatment for locally advanced gastroesophageal junction (EGJ) cancers. The purpose of this study was to evaluate response and tolerability to neoadjuvant regimen combining epirobicin, oxaliplatin and capecitabin (EOX) in locoregionally advanced gastric cancer.Methods: We recruited 28 patients with histologically confirmed advanced gastric or EGJ adenocarcinoma in this study performed in the Cancer Institute of Imam Khomeini Hospital in Tehran, Iran in 2010-2011. Staging workup included chest and abdominal computed tomography (CT) scans, upper gastrointestinal endoscopy, endoscopic ultrasonography (EUS), measurement of carcinoembryonic antigen (CEA), complete blood cell count (CBC), and liver and renal function tests. After three treatment cycles with EOX regimen, we evaluated response to the neoadjuvant chemotherapy by performing endoscopic ultrasonography (EUS) and chest and abdominal CT scans.Results: The mean age of the patients was 56.64±11.08 years (ranging from 37 to 78 years). Most patients were classified as having stage III (98.8%) cancer before chemotherapy while most were classified as stage II (57.14%) after the treatment. Only 28.5% of tumors were resectable before chemotherapy, but 82.1% of them were resectable upon the treatment. 75% of tumors were downstaged after chemotherapy.Conclusion: Regarding the acceptable response and downstaging of tumors and low toxicity of EOX regimen in locoregionally advanced gastric cancer, evaluation of this regimen as a neoadjuvant chemotherapy in larger phase III clinical trials in Iranian patients would be both necessary and logical.
Application of Finite Fourier Transform and Similarity Approach in a Binary System of the Diffusion of Water in a Polymer  [PDF]
Hisham A. Maddah
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.44003
Abstract: This paper describes the method of two important mathematical techniques used in chemical engineering applications. Solving a mass transfer problem, weather in finite or semi-infinite domain, may seem difficult without the practice of Finite Fourier Transform (FFT) and Similarity Transformation. Finite systems refer to any closed system that has a specific boundary that can be determined. For example, polymer sheets, membranes, storage tanks, oil reservoirs and a human stomach are determined to be finite systems where FFT is applicable to derive expressions for concentration profiles of the materials in the system. However, Similarity Transformation method is used to identify the concentration profile in semi-infinite systems that have no limits. It has been approved that we may also use the similarity procedure for finite systems since our results are almost the same. Methodologies of both techniques have been discussed thoroughly in order to apply them to a water-polymer diffusion system for the determination of the concentration of water in a polymer sheet of PET. Discussion and comparison between FFT and similarity is included to illustrate the power of each mathematical procedure in predicting and modeling mass concentrations.
Efficacy of Microwave and Infrared Radiation in the Treatment of the Skin Lesions Caused by Leishmania major in an Animal Model
SE Eskandari,A Azimzadeh,M Bahar,Z Safai Naraghi
Iranian Journal of Public Health , 2012,
Abstract: Background: Cutaneous leishmaniasis caused by L. major is an important public health problem in endemic areas. The aim of this study was to explore the therapeutic effect of microwave and or infrared radiation in the treatment of lesion induced in BALB/c mice by L. major inoculation.Methods: The footpad lesion was induced in BALB/c mice by inoculation of L. major promastigotes subcutaneously. The lesion was treated with 600 watts power, 2.450 GHz frequency and/or infrared device with 150 watts and a wave length of 890 nanometres. The size of the lesion was recorded by footpad swelling measurement every 10 days. Results: The lesion growth was significantly hampered in treated mice compared with the untreated control group (P<0.05). Infrared radiation was more effective than microwave in inhibiting ulcer enlargement.Conclusion: Infrared radiation and microwave significantly hampered L. major lesion growth in BALB/c mice. This therapeutic effect was more in infrared radiation treated mice than microwave treated mice.
Comparison of the Effectiveness of the Transactional Analysis, Existential, Cognitive, and Integrated Group Therapies on Improving Problem-Solving Skills  [PDF]
Bahramali A. Ghanbari-e-Hashem-Abadi, Mustafa Bolghan-Abadi, Zahra Vafaei-e-Jahan, Raheleh Maddah-Shoorcheh, Elaheh Maddah-Shoorcheh
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24048
Abstract: Problem-solving is one of the necessities of life in twenty first century. Therefore, Psychologists consider it as a skill that everyone must learn it. The purpose of the present study is to compare the effectiveness of the transactional analysis, existential, cognitive, and integrated group therapies on improving problem–solving skills. For this purpose, 65 subjects of the clients who were referring to the Ferdowsi University of Mashhad's Mental Health Centre were selected randomly and subjects placed in 5 groups in random assignment method (13 participants in each group). The research method is Pre-test/Post-test control group design. To gather the data, Long & Cassidy’s problem solving styles questionnaire (1996) was used. In the descriptive level, the data were analyzed using mean and standard deviation, and in the inferential level Analysis of Covariance test (ANCOVA) was used. The results of data analysis were indicative of the fact that after modifying pretest scores, there was a significant difference between group’s subjects. The results showed that group therapies were effective on improving problem-solving skills and that cognitive and integrated group therapies were more effective on improving problem-solving skills comparing to other groups. Regarding the results of the present study, it can be concluded that transactional analysis, existential, cognitive and integrated group therapies were effective on improving problem-solving skills of the clients who were referring to the Ferdowsi University of Mashhad's Mental Health Centre.
surgical treatment for chronic pancreatitis: report of three cases
Abdollahi A,Maddah GH,Tavassoli A
Tehran University Medical Journal , 2009,
Abstract: "nBackground: Chronic pancreatitis is a progressive fibrosis of the pancreas that leads to loss of endocrine and exocrine function of pancreas. The most common symptom is intractable pain. Which adversely effects quality of life, remains the most common indication for surgery in patients with chronic pancreatitis. Case report: Three patients underwent operations for chronic pancreatitis at the Ghaem hospital, Mashhad University of Medical Sciences Mashhad, Iran. Indication for operation in all cases were intractable abdominal pain. In all of the three patients complete relief of symptoms was obtained. There was no morbidity and mortality. In one patient exocrine function of pancreas and malabsorpation resolved after surgery. Conclusions: Although chronic pancreatitis is uncommon, but in persistent abdominal pain surgery should be considered. Surgery for patients with chronic pancreatitis can be performed safely with minimal morbidity and effective in control of pain and malabsorption.
L Arteriosclerose et le Diabete ( A Propos de 24 Operations)
M. SAFAI
Acta Medica Iranica , 1977,
Abstract:
Esophagogastric mesenchymal tumors: analysis of 24 patients
Bagheri R,Maddah Gh,Tavasoli A
Tehran University Medical Journal , 2011,
Abstract: "nBackground: Gastrointestinal mesenchymal tumors are classified as tumors that originate from smooth muscles. Gastrointestinal stromal tumors (GIST) are the most common types of the proposed tumors and can be seen in the GI tract from the esophagus to the anus, but they are mostly seen in the stomach. Mostly from the stomach and asymptomatic, the majority of patients would benefit from surgery as the best method of treatment."n "nMethods: In this retrospective study we evaluated the data of patients with the diagnosis of esophageal or gastric mesenchymal tumors admitted in Ghaem and Omid Hospitals affiliated to Mashhad University of Medical Sciences in Iran, from 1992 to 2010. We analyzed factors such as age, sex, presenting symptoms and signs, diagnostic methods, types of pathology, types of treatment, morbidity, mortality and 3-year survival rates."n "nResults: Twenty four patients (16 male, 8 female) with a mean age of 50 were included in the study. The common site of tumor was gastric fundus. The most common symptom at the time of diagnosis was epigastric fullness which was observed in almost 50% of the patients. The most common type of surgery in the patients was subtotal gastrectomy and no hospital mortality was recorded. Paralytic ileus was the commonest complication seen in five patients (20.5%). Adjuvant therapy had been performed in eight patients (33.1%). Following the patients three years postoperatively, there were only three deaths (12.45%)."n "nConclusion: Regarding to the low mortality and morbidity of the surgeries, surgical treatment, if tolerated, is recommended for all Esophagogastric mesenchymal tumors patients.
Massive upper gastrointestinal bleeding due to esophago- thyroidal artery fistula following foreign body aspiration: a case report
Bagheri R.,Maddah Gh.,Abdollahi A.
Tehran University Medical Journal , 2007,
Abstract: Background: Immediate treatment when an esophageal foreign body is suspected is critical because of the possibility of serious complications. The presence of foreign bodies in the esophagus usually occurs accidentally in children and mentally retarded adults. A greater risk of perforation of the esophagus, development of a mediastinal, as well as airway compromise is present when a foreign body is lodged longer than 24 hours. Furthermore, this condition results in complications, such as hemorrhage or esophageal fistula, when treatment is delayed. We herein report a case of esophageo-thyroidal artery fistula, a rare complication resulting from the delayed removal of an esophageal foreign body. Patient presentation: A 34 year-old female who had swallowed her dental prosthesis one week previously was referred for severe gastrointestinal bleeding. Surgery to remove the foreign body was performed. To determine the cause of continued bleeding after the endoscopy and angiography, we performed a neck exploration, which revealed hemorrhage from a fistula between thyroid vessels and the esophagus. After surgical resection of the fistula, the patient was discharged from the hospital in good condition and has had no related problems for six months.Conclusions: Considering the complications resulting from the delay of the removal of foreign bodies from the esophagus, these objects should be removed as soon as possible.
Study of optical properties of thin copper films on glass substrate using Kramers-Kronig method
A Morteza Ali,R Maddah,M Heidari
Iranian Journal of Physics Research , 2010,
Abstract: Different thicknesses of 99.97% Cu are deposited on glass substrate by thermal evaporation method at the rate of 2A /sec. Kramers-Kronig method is used for the analysis of the reflectivity constant in the range of 200nm
Quality Monitoring of Various Local and Imported Brands of Bottled Drinking Water in Saudi Arabia  [PDF]
Hisham A. Maddah, Abdulazez S. Alzhrani
World Journal of Engineering and Technology (WJET) , 2017, DOI: 10.4236/wjet.2017.54047
Abstract: Minerals and constitutes in drinking water are vital for the nutrition of human bodies. Certain limits of water quality parameters must be met to ensure the safety of bottled drinking water for the human consumption. Thirty two local and twelve imported brands of bottled water in Saudi Arabia have been collected to verify their compliance with international and local standards which are EPA (2016), WHO (2013) and SASO (2009). A proposed scoring system is used to evaluate the water quality. Fayha and Hilwa brands have been selected as the best local brands whereas Volvic brand as the optimal imported brand in the western region of Saudi Arabia. The local water brands are more reliable to the standards than the imported brands. Licensed water brands in Saudi Arabia are found to have a good water quality which satisfied the quality requirements.
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