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Search Results: 1 - 10 of 23620 matches for " 6-diamino-5-[4-benzylidene]pyrimidin-2(5H)-one "
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A Facile Synthesis of 9,10-Dimethoxybenzo[6,7]- ox-epino[3,4-b]quinolin-13(6H)-one and Its Derivatives  [PDF]
Dingqiao Yang, Xiuli Liang, Xiongjun Zuo, Yuhua Long
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.32013

A concise and efficient method for the synthesis of novel 9,10-imethoxybenzo[6,7]oxepino[3,4-b]quinolin13(6H)-one and its derivatives 7a-p has been developed via the intramolecular Friedel-Crafts acylation reactions of 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic acids 6a-p with polyphosphoric acid (PPA) as catalyst and solvent under mild conditions. The key intermediates 6a-p were prepared through the in situ formation of ethyl 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylates 5a-p followed by hydrolysis with aqueous ethanolic sodium hydroxide solution. The novel synthetic method has the advantages of good yields, easy work-up, and environmentally friendly character, which may provide a novel highly efficient process for making quinoline and related azaheterocycle libraries.

DABCO catalyzed synthesis of new 2-amino-8-arylidene-4-aryl-5,6,7,8-tetrahydrobenzo- 4H-pyran-3-carbonitriles from α, -bis(substituted benzylidene)cycloalkanones
Gholam Hossein Mahdavinia,Mohammad Ali Bigdeli,Fatemeh Kooti
Bulletin of the Chemical Society of Ethiopia , 2012,
Abstract: The synthesis of new series of 2-amino-8-arylidene-4-aryl-5,6,7,8-tetrahydrobenzo-4H-pyran-3-carbonitriles from the reaction of α, -bis(substituted benzylidene)cycloalkanones with malononitrile under reflux conditions in the presence DABCO in good to excellent yields has been described.DOI: http://dx.doi.org/10.4314/bcse.v26i2.8
New Quinazoline Related Derivatives with Antimicrobial Activity: Part II
S.M. Mosaad,K.I. Mohammed,M.A. Ahmed,S.G. Abdel-Hamide
Journal of Biological Sciences , 2004,
Abstract: A series of 2-(4-chlorophenyl)-6-iodoquinazoline carrying different acyclic or heterocyclic moieties were prepared and tested for their activity against certain strains of Gram negative bacteria, Gram positive bacteria and pathogenic Fungi. The results revealed that some of synthesized compounds displayed marked activity against some of the tested microorganisms
New Quinazoline Related Derivatives with Antimicrobial Activity: Part I
S.M. Mosaad,K.I. Mohammed,M.A. Ahmed,S.G. Abdel-Hamide
Pakistan Journal of Biological Sciences , 2004,
Abstract: A new series of anthranilic acid derivatives were prepared through reaction of 2-(4-chlorophenyl)-6-iodo-4(H)-3,1-benzoxazine 3 with some amines. Reaction of {2-(4-chlorophenyl)-3-amino-6-iodo-3,4-dihydro-quinazolin-4-one} 6 and {2-(4-chlorobenzoyl-amino)-5-iodobenzoic acid hydrazide} 7 with some aldehydes and acid anhydrides was also reported. The structures of the new compounds were confirmed by microanalyses and spectral data. Some compounds showed promising antibacterial activities against Staphylococcus aureus and Bacillus Subtillis. Compounds 5h and 5K showed the highest activity (MIC = 12.5 g ml 1), compound 12 a (MIC = 20.0 g ml 1), compounds 5 a-g, 5 I, 5 j, 6 r, 9 a-h, (MIC = 50 g ml 1) and compounds 8 g, 12 b, 12 c, (MIC = 100 g ml 1).
Synthesis of Some Aldoxime Derivatives of 4H-Pyran-4-ones
Fateme Abrishami,Reza Teimuri-Mofrad,Yadollah Bayat,Aziz Shahrisa
Molecules , 2002, DOI: 10.3390/70200239
Abstract: Aldoxime derivatives of 4H-pyran-4-ones 4-7a,b have been synthesized by the reaction of di(aminoxymethyl) pyranones 3a,b with aromatic aldehydes.
A Novel Approach to the Synthesis of 6-Amino-7-hydroxy-flavone
Lijun Tang,Shufen Zhang,Jinzong Yang,Wentao Gao,Jian Cui,Tianyu Zhuang
Molecules , 2004, DOI: 10.3390/91000842
Abstract: A novel approach to the synthesis of 6-amino-7-hydroxyflavone (1) is described. Reaction in acetone of 2′,4′-dihydroxy-5′-nitroacetophenone and benzoyl chloride in the presence of potassium carbonate affords 3-benzoyl-7-hydroxy-6-nitroflavone, which is cleaved in 5% ethanolic potassium hydroxide to give 1-(2,4-dihydroxy-5-nitrophenyl)-3- phenyl-1,3-propanedione. The 1,3-diketone thus formed is then transformed into 7-hydroxy- 6-nitroflavone, followed by reduction to afford the title compound.
Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-4H-oxazol-5-one Derivatives as Antitumor Agents
Franciele Cristina Savariz,Mary Ann Foglio,Jo?o Ernesto de Carvalho,Ana Lúcia T. G. Ruiz,Marta C. T. Duarte,Mauricio Ferreira da Rosa,Emerson Meyer,Maria Helena Sarragiotto
Molecules , 2012, DOI: 10.3390/molecules17056100
Abstract: In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β-carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4-methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H-oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC50 values of 0.48, 1.50 and 1.07 μM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed.
Microwave Assisted Synthesis of 2,2'-Arylene-substituted Bis(4H-3,1-Benzoxazin-4-one) Derivatives Using the Complex Cyanuric Chloride/N,N-Dimethylformamide
Mehdi Shariat,Mohd Wahid Samsudin,Zuriati Zakaria
Molecules , 2012, DOI: 10.3390/molecules171011607
Abstract: A new and efficient method has been designed to prepare 2,2'-arylene-substituted bis(4H-3,1-benzoxazin-4-one) derivatives by using the mixture of cyanuric chloride and N,N-dimethylformamide in a microwave-assisted reaction. The method used and presented here has good rate enhancement and excellent yields.
Microwave-assisted one-pot synthesis of symmetrical 4H-pyran-4-ones
Moghaddam, Firouz Matloubi;Bardajee, Ghasem Rezanejade;Ismaili, Hossein;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000500022
Abstract: we report a simple, fast, efficient and benign procedure for solvent-free microwave-assisted one-pot synthesis of symmetrical 4h-pyran-4-ones in the presence of polyphosphoric acid or diphosphorous pentoxide. various 4h-pyran-4-ones were prepared using this very simple and fast green protocol.
催化学报 , 2012, DOI: 10.1016/S1872-2067(11)60355-0
Abstract: ?Aone-potthreecomponentBiginellicondensationofdifferentsubstitutedaromaticandaliphaticaldehydeswithethylacetoacetateandureatotherespective3,4-dihydropyrimidin-2-(1H)-onesundersolvent-freeconditionsthatissimple,effective,andenvironmentallyfriendlywasshown.Ammoniumdihydrogenphosphate(NH4H2PO4)wasusedasanon-toxic,inexpensive,andeasilyavailablecatalyst.Thefacilereactionconditionandsimpleisolationandpurificationproceduresofthismethodmakeitagoodoptionforthesynthesisofdihydropyrimidinones.
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