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Search Results: 1 - 10 of 12491 matches for " 5 Stephen Smyth "
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Cryptosporidiosis in developing countries
William J. Snelling,1 Lihua Xiao,2 Guadalupe Ortega-Pierres,3 Colm J. Lowery,1 John E. Moore,4 Juluri R. Rao,5 Stephen Smyth,6 B. Cherie Millar,4 Paul J. Rooney,4 Motoo Matsuda,7Fiona Kenny,8 Jiru Xu,9 James S.G. Dooley.1
Journal of Infection in Developing Countries , 2007,
Abstract: Globally, Cryptosporidium infection continues to be a significant health problem where it is recognized as an important cause of diarrhoea in both immunocompromised and immunocompetent people. In developing countries persistent diarrhoea is the leading cause of death in children younger than five years of age, where it accounts for 30 to 50 percent of those deaths. Encouragingly an increasing number of investigations in developing countries employ molecular tools, significantly improving the quality of epidemiological information. This improved Cryptosporidium monitoring, with appropriate molecular methods, in surface water, livestock, wildlife and humans, will increase current knowledge of infection and transmission patterns, and ultimately help to control Cryptosporidium via improved risk assessments in the future.
Vol. 5 No. 5 2009
Canadian Social Science , 2009,
Abstract: A Multinational Corporation Microeconomic Model for Exchange Rate and FDI TAN You-sheng ( 1 ) Harmonious Development in West China Based on Constructive Postmodernism YU Yong-yue ( 11 ) Application of Analytic Hierarchy Process (AHP) in shipyard project investment Risk Recognition YAO Hui-li, LIAN Chun-guang, LIN Shi-zhong, BAI Jing-xian & SUN Hong-xia ( 17 ) Malay Women’s Responses to a Changing World:
Vol. 5 No. 5 2009
Canadian Social Science , 2009,
Abstract: Un modèle microéconomique d’une société multinationale pour le taux de change et l'IDE TAN You-sheng ( 1 ) Développement harmonieux de l'Ouest de la Chine, fondé sur un post-modernisme constructif YU Yong-yue ( 11 ) Application du Procèssus hiérarchique analytique (PHA) dans l’identification des risques de l'investissement dans un projet de chantier naval YAO Hui-li, LIAN Chun-guang, LIN Shi-zhong, BAI Jing-xian & SUN Hong-xia ( 17 ) Les réponses des femmes malaisiennes à un monde en mutation:
GT 5
Revista Brasileira de Ecoturismo , 2012,
Abstract: O ecoturismo é uma atividade relativamente nova, sendo a sua normatiza o também recente, tanto no Brasil quanto no exterior. Muitos ambientalistas o consideram como uma atividade de baixo impacto, mas se for desenvolvido sem levar em conta seus princípios básicos, uma série de danos ambientais poder o ser desencadeados. Esse eixo pretende discutir sobre as políticas e práticas relacionadas o turismo na natureza e sobre a dinamiza o da economia de regi es que apresentem recursos naturais com elevado potencial procurando, paralelamente, promover a conserva o do meio ambiente e a inser o das comunidades locais. Coordena o: Profa. Dra. Camila Gon alves de Oliveira Rodrigues (UFFRJ), Prof. Dr. Davis Gruber Sansolo (UNESP) e Prof. Dr. Sidnei Raimundo (USP)
Nonfamilial, MPL S505N-Mutated Essential Thrombocythaemia
Ruth Morrell,Stephen E. Langabeer,Liam Smyth,Meegahage Perera,Gerard Crotty
Case Reports in Hematology , 2013, DOI: 10.1155/2013/729327
Abstract: Mutations of MPL are present in a significant proportion of patients with the myeloproliferative neoplasms (MPN), primary myelofibrosis (PMF), and essential thrombocythaemia (ET). The most frequent of these mutations, W515L and W515K, occur in exon 10 of MPL, which encodes the receptor for thrombopoietin. Another exon 10 mutation, MPL S505N, has been shown to be a founder mutation in several pedigrees with familial thrombocythaemia where it is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis. Rare cases of sporadic, nonfamilial, MPL S505N MPN have been documented, but the presenting laboratory and clinical features have not been described in detail. The diagnosis and clinical course of a case of MPL S505N-positive MPN are presented with diagnostic features and treatment response resembling typical ET but with evidence of increasing bone marrow fibrosis. Further MPN cases possessing this genotype require reporting in order to ascertain whether any particular morphological or clinical features, if present, determine clinical course and aid the refinement of therapeutic options. 1. Introduction Essential thrombocythaemia (ET) is a chronic myeloproliferative neoplasm (MPN) characterised by a sustained peripheral blood thrombocytosis, increased large megakaryocytes in the bone marrow and clinically by episodes of thrombosis or haemorrhage. While approximately half of all ET and primary myelofibrosis (PMF) patients harbour the JAK2 V617F mutation, a further subset has evidence of somatic, activating, MPL (myeloproliferative leukemia virus oncogene) exon 10 mutations that are more frequently found in PMF than ET. MPL encodes the thrombopoietin receptor which is a major regulator of megakaryocytopoiesis and platelet formation. The most commonly observed mutations of MPL are the W515L and W515K [1, 2] although several others have been described within this codon and elsewhere within MPL exon 10, albeit at a much lower frequency [3–5]. ET patients harbouring MPL W515L/W515K mutations tend to have lower haemoglobin and higher platelet levels than those ET patients with the JAK2 V617F, but the presence of a MPL W515L/K mutation does not appear to affect survival, fibrotic or leukaemic transformation [6]. Another MPL exon 10 activating mutation, S505N, has been described in familial thrombocythaemia [7, 8] where conversely, its presence is associated with splenomegaly, higher thrombotic risk, and progression to myelofibrosis [9]. Very few cases of nonfamilial ET with the MPL S505N mutation have been reported to date with
Wireless Technologies Bridging the Digital Divide in Education
Gerard Smyth
International Journal of Emerging Technologies in Learning (iJET) , 2006,
Abstract: The objective of this paper is to demonstrate how the latest wireless standards and technologies may overcome the digital divide in education in the developed and developing worlds. The concept of the digital divide is discussed in the traditional socio-economic sense and expanded in terms of the learner's location, age, culture and background. It is important that we understand the full extent and complexities of this division if we are to effectively bridge it. Why and how the digital divide may be bridged is examined. Apart from the inherent inequalities that need to be addressed from an ethical perspective, it is very much in the interests of governments and citizens globally that Information and Communications Technology (ICT) is made available to all as quickly and cost-effectively as possible. New forms of wireless protocols are overcoming challenges of terrain, infrastructure and finance. It is proposed that, by leveraging open broadband wireless standards, like Wireless Fidelity (Wi-Fi*) and Worldwide Interoperability for Microwave Access (WiMAX*), and implementing Mobile Computing architecture, it is now possible to make dramatic strides in this direction. The paper continues with a general overview of these wireless standards and technologies followed by an in-depth look at Wi-Fi and WiMAX. The paper goes on to give examples of the Innovation Centre's involvement in delivering solutions and new usage models for eLearning that utilize the latest wireless standards and technologies. The challenges and successes of these projects are outlined and metrics are presented where available.
To Love the Orientalist: Masculinity in Leila Aboulela's The Translator
Brendan Smyth
Journal of Men, Masculinities and Spirituality , 2007,
Abstract: This paper examines representations of Orientalist and Islamic masculinity in Leila Aboulela’s The Translator. In her representation of the character of Rae Isles, Aboulela writes back to repressive Western traditions of Orientalist masculinity, fashions a narrative which negotiates a way out of stagnant binaries of West and East, and offers a model of progressive, socially engaged masculinity rooted in Islamic tradition.
The Mahler measure of algebraic numbers: a survey
Chris Smyth
Mathematics , 2007,
Abstract: A survey of results for Mahler measure of algebraic numbers, and one-variable polynomials with integer coefficients is presented. Related results on the maximum modulus of the conjugates (`house') of an algebraic integer are also discussed. Some generalisations are given too, though not to Mahler measure of polynomials in more than one variable.
Survey article: Seventy years of Salem numbers
Chris Smyth
Mathematics , 2014, DOI: 10.1112/blms/bdv027
Abstract: I survey results about, and recent applications of, Salem numbers.
A Probabilistic Characterization of the Dominance Order on Partitions
Clifford Smyth
Mathematics , 2015,
Abstract: A probabilistic characterization of the dominance partial order on the set of partitions is presented. This extends work in "Symmetric polynomials and symmetric mean inequalities". Electron. J. Combin., 20(3): Paper 34, 2013. Let $n$ be a positive integer and let $\nu$ be a partition of $n$. Let $F$ be the Ferrers diagram of $\nu$. Let $m$ be a positive integer and let $p \in (0,1)$. Fill each cell of $F$ with balls, the number of which is independently drawn from the random variable $X = Bin(m,p)$. Given non-negative integers $j$ and $t$, let $P(\nu,j,t)$ be the probability that the total number of balls in $F$ is $j$ and that no row of $F$ contains more that $t$ balls. We show that if $\nu$ and $\mu$ are partitions of $n$, then $\nu$ dominates $\mu$, i.e. $\sum_{i=1}^k \nu(i) \geq \sum_{i=1}^k \mu(i)$ for all positive integers $k$, if and only if $P(\nu,j,t) \leq P(\mu,j,t)$ for all non-negative integers $j$ and $t$. It is also shown that this same result holds when $X$ is replaced by any one member of a large class of random variables. Let $p = \{p_n\}_{n=0}^\infty$ be a sequence of real numbers. Let ${\cal T}_p$ be the $\mathbb{N}$ by $\mathbb{N}$ matrix with $({\cal T}_p)_{i,j} = p_{j-i}$ for all $i, j \in \mathbb{N}$ where we take $p_n = 0$ for $n < 0$. Let $(p^i)_j$ be the coefficient of $x^j$ in $(p(x))^i$ where $p(x) = \sum_{n=0}^\infty p_n x^n$ and $p^0(x) =1$. Let ${\cal S}_p$ be the $\mathbb{N}$ by $\mathbb{N}$ matrix with $({\cal S}_p)_{i,j} = (p^i)_j$ for all $i, j \in \mathbb{N}$. We show that if ${\cal T}_p$ is totally non-negative of order $k$ then so is ${\cal S}_p$. The case $k=2$ of this result is a key step in the proof of the result on domination. We also show that the case $k=2$ would follow from a combinatorial conjecture that might be of independent interest.
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