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Search Results: 1 - 10 of 219596 matches for " . Guarner C. "
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Effective treatment of common variable immunodeficiency associated diarrhea
Córdova Guevara,H.; Guarner Aguilar,L.;
Revista Espa?ola de Enfermedades Digestivas , 2009, DOI: 10.4321/S1130-01082009000300009
Abstract: common variable immunodeficiency disorder (cvid), the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders. cvid has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. up to 60% of the patients with non-treated cvid develop diarrhea and 10% associated idiopathic malabsorption with weight loss. the case of a 50-year-old woman with cvid-associated diarrhea, abdominal pain and bloating of one year's duration is reported. an exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. she later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved. in conclusion, we report the case of a patient with cvid-related chronic diarrhea who responded well to oral budesonide treatment. this outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients.
Effective treatment of common variable immunodeficiency associated diarrhea Diarrea asociada a inmunodeficiencia común variable tratada con budesonida
H. Córdova Guevara,L. Guarner Aguilar
Revista Espa?ola de Enfermedades Digestivas , 2009,
Abstract: Common variable immunodeficiency disorder (CVID), the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders. CVID has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. Up to 60% of the patients with non-treated CVID develop diarrhea and 10% associated idiopathic malabsorption with weight loss. The case of a 50-year-old woman with CVID-associated diarrhea, abdominal pain and bloating of one year's duration is reported. An exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. She later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved. In conclusion, we report the case of a patient with CVID-related chronic diarrhea who responded well to oral budesonide treatment. This outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients. La inmunodeficiencia común variable (IDCV) es la deficiencia primaria de anticuerpos sintomática más frecuente y está caracterizada por infecciones bacterianas recurrentes, especialmente de las vías aéreas superiores e inferiores, y también asociada a incremento de enfermedades autoinmunes y neoplasias. Presenta alta prevalencia de enfermedades gastrointestinales infecciosas, inflamatorias y neoplásicas. Hasta el 60% de los pacientes con IDCV no tratados desarrollan diarrea y el 10% desarrollan malabsorción idiopática asociado a pérdida de peso. Presentamos el caso de una mujer de 50 a os con IDCV que presenta diarrea crónica, con dolor y distensión abdominal desde hace 1 a o. Realizándose múltiples exploraciones y descartando causas secundarias de diarrea crónica, se inicia tratamiento con dieta y loperamida sin mejoría. Posteriormente se realiza tratamiento con budesonida vía oral durante 3 meses con desaparición de la clínica y mejoría de la calidad de vida de la paciente. En conclusión presentamos el caso de una paciente con IDCV y diarrea crónica que presenta muy buena respuesta al tratamiento con budesonida vía oral. Esta observación provee al digestólogo de una nueva opción terapéutica para este difícil grupo de pacientes.
Study on the electrical resistance of the sleeper-fastening elements system in railway tracks
Barroso, F. J.,Guarner, P.,López, C.
Materiales de Construccion , 2012,
Abstract: The electrical resistance of the sleeper-fastening elements system in a wet railway track is a very important parameter. This is because the rails are electric conductors in the circuit of signaling and traction systems. This electrical resistance, defined as a characteristic value of the sleeper-fastening elements-water system is a measurand obtained with reference measurement procedures as described in international standards. But it is subject to many kinds of undefinitions that result in a very high dispersion. In this work the dependence of this parameter on variables such as the water conductivity, the temperature and the relative humidity is shown, and several ways to reduce it to minimum values are also established. En vías de ferrocarril sometidas a condiciones medioambientales desfavorables la resistencia eléctrica del conjunto formado por una traviesa y el sistema de sujeción del raíl es un parámetro muy importante. Esto se debe a que los raíles actúan como conductores eléctricos en los sistemas de se alización y tracción. Esta resistencia eléctrica, definida como un valor característico del sistema traviesa-elementos de sujeción-agua se mide con procedimientos normalizados. Sin embargo estos procedimientos están sujetos a ciertas indefiniciones que provocan una elevada dispersión. En este trabajo se estudia la dependencia de este parámetro en variables tales como la conductividad del agua, la temperatura y la humedad relativa, y se establecen estrategias para reducir dicha dispersión a valores mínimos.
Pancreatic pseudocyst located in the liver Pseudoquiste pancreático de localización hepática
I. Les,J. Córdoba,V. Vargas,L. Guarner
Revista Espa?ola de Enfermedades Digestivas , 2006,
Abstract: Pancreatic pseudocyst is a common complication of acute and chronic pancreatitis. Extrapancreatic locations of pancreatic pseudocyst in the liver, pleura, mediastinum, or pelvis have been described. However, a pancreatic pseudocyst located in the liver is an infrequent condition. We present the case of a 46-year-old man with pancreatic pseudocyst located in the liver secondary to chronic alcoholic pancreatitis. During admission, the patient underwent an abdominal CT scan that showed a mass located in the head and body of the pancreas, as well as a thrombosis of the splenic vein. A percutaneous needle aspiration biopsy of the pancreas was obtained under CT guidance, which showed no tumoral involvement. Fourty-eight hours after the procedure the patient developed abdominal pain and elevated serum amylase levels. A pancreatic MRI exam showed two pancreatic pseudocysts, one of them located in the left hepatic lobe, the other in the pancreatic tail. Chronic pancreatitis signs also were found. Enteral nutrition via a nasojejunal tube was administered for two weeks. The disappearance of the pancreatic pseudocyst located in the pancreatic tail, and a subtotal resolution of the pancreatic pseudocyst located in the liver were observed. To date twenty-seven cases of pancreatic pseudocyst located in the liver have been published, most of them managed with percutaneous or surgical drainage.
Risk of a first communityacquired spontaneous bacterial peritonitis in cirrhotics with low ascitic fluid protein levels
. Guarner C.,Sola R.,Soriano G.,Andreu M.
Annals of Gastroenterology , 2007,
Abstract:
Papel de la flora intestinal en la salud y en la enfermedad
Guarner,F.;
Nutrición Hospitalaria , 2007,
Abstract: the terms intestinal "microflora" or "microbiota" refer to the microbial ecosystem colonizing the gastrointestinal tract. recently developed molecular biology instruments suggest that a substantial part of bacterial communities within the human gut still have to be described. the relevance and impact of resident bacteria on the host physiology and pathology are, however, well documented. the main functions of intestinal microflora include (1) metabolic activities translating into energy and nutrients uptake, and (2) host protection against invasion by foreign microorganisms. intestinal bacteria play an essential role in the development and homeostasis of the immune system. lymphoid follicles within the intestinal mucosa are the main areas for immune system induction and regulation. on the other hand, there is evidence implicating intestinal microbiota in certain pathological processes including multi-organ failure, colon cancer, and inflammatory bowel disease.
Probióticos en patología digestiva Probiotics in digestive diseases
F. Guarner
Revista Espa?ola de Enfermedades Digestivas , 2009,
Abstract:
Papel de la flora intestinal en la salud y en la enfermedad Role of intestinal flora in health and disease
F. Guarner
Nutrición Hospitalaria , 2007,
Abstract: El término "microflora" o "microbiota" intestinal hace referencia al ecosistema microbiano que coloniza el tracto gastrointestinal. Los instrumentos de biología molecular desarrollados recientemente sugieren que todavía se ha de describir una parte sustancial de las comunidades bacterianas del intestino humano. No obstante, están bien documentados la relevancia y el impacto de las bacterias residentes en la fisiología y la patología del huésped. Las principales funciones de la microflora intestinal incluyen (1) actividades metabólicas que se traducen en recuperación de energía y nutrientes, y (2) protección del huésped frente a invasión por microorganismos extra os. Las bacterias intestinales desempe an un papel esencial en el desarrollo y la homeostasis del sistema inmunitario. Los folículos linfoides de la mucosa intestinal son áreas principales para la inducción y la regulación del sistema inmune. Por otra parte, se dispone de evidencias que implican a la microbiota intestinal en ciertos procesos patológicos, incluyendo el fallo multi-orgánico, el cáncer de colon y la enfermedad inflamatoria intestinal. The terms intestinal "microflora" or "microbiota" refer to the microbial ecosystem colonizing the gastrointestinal tract. Recently developed molecular biology instruments suggest that a substantial part of bacterial communities within the human gut still have to be described. The relevance and impact of resident bacteria on the host physiology and pathology are, however, well documented. The main functions of intestinal microflora include (1) metabolic activities translating into energy and nutrients uptake, and (2) host protection against invasion by foreign microorganisms. Intestinal bacteria play an essential role in the development and homeostasis of the immune system. Lymphoid follicles within the intestinal mucosa are the main areas for immune system induction and regulation. On the other hand, there is evidence implicating intestinal microbiota in certain pathological processes including multi-organ failure, colon cancer, and inflammatory bowel disease.
Detection of Microorganisms in Granulomas That Have Been Formalin-Fixed: Review of the Literature Regarding Use of Molecular Methods
Jeannette Guarner
Scientifica , 2012, DOI: 10.6064/2012/494571
Abstract:
Detection of Microorganisms in Granulomas That Have Been Formalin-Fixed: Review of the Literature Regarding Use of Molecular Methods
Jeannette Guarner
Scientifica , 2012, DOI: 10.6064/2012/494571
Abstract: Granuloma is an organized aggregate of immune cells that under the microscope appear as epithelioid macrophages. A granuloma can only be diagnosed when a pathologist observes this type of inflammation under the microscope. If a foreign body or a parasite is not observed inside the granuloma, stains for acid-fast bacilli and fungi are ordered since mycobacteria and fungi are frequently the cause of this type of inflammation. It is calculated that 12 to 36% of granulomas do not have a specific etiology and many have wondered if with new molecular methods we could reduce this number. This paper will summarize the frequently known causes of granulomas and will present the recent literature regarding the use of molecular techniques on tissue specimens and how these have helped in defining causative agents. We will also briefly describe new research regarding formation and function of granulomas and how this impacts our ability to find an etiologic agent. 1. Introduction Granuloma is an organized aggregate of immune cells that under the microscope appear as epithelioid macrophages [1]. Epithelioid macrophages are enlarged phagocytic cells that have abundant cytoplasm and can sometimes coalesce to form multinucleated giant cells. The epithelioid macrophages and giant cells are accompanied by other inflammatory cells including lymphocytes, plasma cells, and polymorphonuclear leukocytes as well as varying degrees of necrosis. The process may be confined forming a granuloma or can infiltrate surrounding tissue thus being called granulomatous inflammation. This chronic inflammatory response has been attributed to delayed hyperimmune reaction to a persistent noxious stimulus. Traditionally, granulomatous inflammation is thought to wall of the noxious agent. However, new experimental observations in the formation of granulomas are now emerging and giving new insides as to how they form and if in reality they are encasing the agent that causes them. A granuloma or granulomatous inflammation can only be diagnosed when a pathologist observes this type of inflammation under the microscope. If a foreign body or a parasite is not observed inside the granuloma, stains for acid-fast bacilli (AFB) and fungi (GMS) are ordered as mycobacteria and fungi are frequently the cause of this type of inflammation. There are other diagnostic entities that need to be entertained depending on the tissue, but it is customary to rule out mycobacteria and fungi first before considering other diagnostic possibilities. It is calculated that 12 to 36% of granulomas do not have a specific
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