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Search Results: 1 - 10 of 193348 matches for " ?uri? Jelena D. "
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Potential application of surfactant systems in formulation of dosage forms with slightly soluble substances
Milovi? Mladen R.,uriJelena D.,Vasiljevi? Dragana D.,uri? Zorica R.
Hemijska Industrija , 2012, DOI: 10.2298/hemind120130036m
Abstract: In order to achieve fast release of ibuprofen, slightly soluble model substance (0.52104 mol/l), surfactant systems for oral use with different PEG-40 hydrogenated castor oil (C)/diethylene glycol monoethyl ether (T) ratios were investigated. Comparison between dissolution profiles for ibuprofen from formulated systems and from two commercial products, film tablets and soft capsules, is presented in this paper. Photon correlation spectroscopy has shown that after high dilution with water, surfactant systems were able to form micellar solutions. The size of micelles varies from 14.8 ± 0,075 nm to 16.2 ± 0,021 nm with increasing C/T ratio from 1:2 to 2:1. Although with increasing content of PEG-40 hydrogenated castor oil larger micelles have formed, lower values of polydispersity index indicated that more homogeneous distribution of micelles size was gained. Conductometric analysis has demonstrated that system composing of C/T ratio 2:1, has shown most pronounced interaction between droplets, which can be seen as high rise of electrical conductivity with increasing water content (% (wwater/wtotal)) in the sample. No significant difference in percolation threshold between formulations with different C/T ratios was observed. Different surfactant systems were adsorbed on magnesium aluminometasilicate, as adsorbent with high specific active surface (≈300 m2/g), in order to investigate potential influence of adsorbent on ibuprofen dissolution rate. Formulated systems, with or without adsorbent were filled in hard gelatin capsules. The dissolution profiles of ibuprofen from different formulations were obtained in 30 minutes by dissolution apparatus with rotating baskets and compared with dissolution profiles of ibuprofen from commercial products. For formulations without adsorbent faster release of ibuprofen in first minutes of dissolution test, showed formulations with C/T ratio 2:1 and 1:1. Magnesium aluminometasilicate, as adsorbent with high specific surface area, significantly improved release rate of ibuprofen from formulation with C/T ratio 2:1, but, for formulation with C/T ratio 1:1, significantly lower release of ibuprofen was observed. Formulations with other C/T ratios in terms of fast ibuprofen release did not give satisfying results. Obtained results show that in comparison to dissolution profile of ibuprofen from commercial products proper C/T ratio as well as magnesium aluminometasilicate, as adsorbent with high specific surface area, can significantly increase release of ibuprofen.
Identity and interculturality: Serbia as a place of interweaving of Balkans and (Central) Europe
Filozofija i Dru?tvo , 2008, DOI: 10.2298/fid0803217d
Abstract: This article is an attempt to find a suitable concept for possible reconstruction and integration of various cultural identities, which are diverse and internally layered. The view on issues of identity taken from Serbia - the country in 'transition' faring through different temptations in search for an appropriate identity which could mean a chance for integrity in processes of identity changes - is specific in as much as it could consider itself as a subject of history and not only as 'otherness' designated by other parties.
Anthropo(bio)centrism and relations with the environment
Filozofija i Dru?tvo , 2011, DOI: 10.2298/fid1103175d
Abstract: The text deals with some problems that facing research of the environment. Beside conceptual issues adherent to Serbian language, solving of real environmental problems in general, should resolve the dichotomy anthropocentrism vs. biocentrism which stems from the conflicting human nature and appears just unsustainable in ecology. Among other topics, the meaning of the argument of “ecology as a new great narrative” which enables continued progress and mutual legitimization of science and democracy is being examined from the point of view of their universal relevance. It also deals with effectiveness of theories that implicate the irrelevance of human kind for its own liberation from anthropocentric worldview which narrows the prospects of survival.
Cultural identity and democracy standards: Integration processes in Serbia
Filozofija i Dru?tvo , 2007, DOI: 10.2298/fid0703149d
Abstract: This text is aimed at showing that particularity of different cultural identities is compatible with the generality of standards - the differences can be organically included in the whole which gives them the meaning. Global meaning of the identity transformation is in the need for freedom and real democracy, that means overcoming mechanisms of instrumental reasoning and power usurpation. The process of cultural transformations requires deliberate choices which provide us identity and value to our humane standards.
On sustainability of the identity
Filozofija i Dru?tvo , 2009, DOI: 10.2298/fid0903199d
Abstract: The article deals with different philosophical interpretations or views on identity. The dynamics of these interpretations represents the axis of the identity transformation concept in the global processes related to the changes of paradigms which are developed in correspondence with the issues of the (de)construction of identity throughout the history.
A social-eco-democrat between ideals and reality
Filozofija i Dru?tvo , 2010, DOI: 10.2298/fid1003093d
Abstract: The challenge of discovering what is generally important vis-à-vis human being, through dealing with seemingly local topics, was the ideal of a late Serbian philosopher, ethicist and social theorist Prof. Dr. Svetozar Stojanovi , the ideal that he, by his own self-understanding, was persistently explored. The rediscovery of his world-view initiated by his recent passing, has a potential to arouse momentous thinking on the principles of identity transformation.
Identity paradoxes
Filozofija i Dru?tvo , 2010, DOI: 10.2298/fid1002275d
Abstract: The article considers paradoxical nature of identity that emerges from: 1) the very concept of identity whose abstract generality unites various and even opposite features; 2) the processual nature of reality that is easier to express in the poetical metaphors or abstract principles than in unambiguous conceptual networks; 3) the oppose relationship between being and knowledge, mind and matter, subject and object, self and personality. Entangled in the labyrinth which evade efforts to be conceptually defined, the modern thinking of identity moves towards abandoning the idea of “self” on behalf of the “ego” and towards the misapprehension of identity as being identical. This corresponds to the “time of the lost spirit” stretched between the simultaneous need to find an identity and to give it up.
Serbia in European integration: Identity transformation
Filozofija i Dru?tvo , 2006, DOI: 10.2298/fid0630163d
Abstract: Serbia’s current identity transformation should make it possible to establish internal integrity which coexists with an external integration of European society. Which obstacles are on the way and how they could be surmounted? These are some of questions posed in this article with the aim to conceive more fundamental research of actual problems of the society in Serbia.
The processes of identity integration
Filozofija i Dru?tvo , 2009, DOI: 10.2298/fid0902153d
Abstract: Despite inevitable elusiveness of its meanings, explication of the persisting issues of identity remains the challenge for contemporary humans. Inability to achieve full insight into its complexity points to the need to corelate basic ideas as the essential way of self-cognition and self-awareness, which represent the meaning, value and the purpose of humanity. The development of global processes can, in the same spirit, be viewed as a contribution to the conscious transformation and integration of identities.
In silico methods in stability testing of hydrocortisone, powder for injections: Multiple regression analysis versus dynamic neural network
Solomun Ljiljana N.,Ibri? Svetlana R.,Pejanovi? Vjera M.,uriJelena D.
Hemijska Industrija , 2012, DOI: 10.2298/hemind120207023s
Abstract: This article presents the possibility of using of multiple regression analysis (MRA) and dynamic neural network (DNN) for prediction of stability of Hydrocortisone 100 mg (in a form of hydrocortisone sodium succinate) freeze-dried powder for injection packed into a dual chamber container. Degradation products of hydrocortisone sodium succinate: free hydrocortisone and related substances (impurities A, B, C, D and E; unspecified impurities and total impurities) were followed during stress and formal stability studies. All data obtained during stability studies were used for in silico modeling; multiple regression models and dynamic neural networks as well, in order to compare predicted and observed results. High values of coefficient of determination (0.950.99) were gained using MRA and DNN, so both methods are powerful tools for in silico stability studies, but superiority of DNN over mathematical modeling of degradation was also confirmed.
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