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Brilliant cresyl blue staining for screening hemoglobin H disease: Reticulocyte smear
?brahim Kula?,ule ünal,Fatma Gümrük
Turkish Journal of Hematology , 2009,
The frequency of A91V in the perforin gene and the effect of tumor necrosis factor-α promoter polymorphism on acquired hemophagocytic lymphohistiocytosis
Hamza Okur,ule ünal,Günay Balta,Didem Efendio?lu
Turkish Journal of Hematology , 2011,
Abstract: Objective: Numerous acquired etiological factors, such as infections, malignancies, and collagen tissue disorders, are involved in the development of acquired hemophagocytic lymphohistiocytosis (AHLH). Not everyone with the same etiological factors developments AHLH, which suggests the role of additional genetic or environmental predisposing factors that remain to be identified. Materials and Methods: Perforin gene A91V missense transition (C>T change at position 272 in exon 2 of the perforin gene) and TNF-α gene promoter-1031 T>C nucleotide substitution are 2 candidate genetic predisposing factors due to their potential to alter inflammatory responses. In the present study these changes were investigated in healthy controls and AHLH patients.Results: A91V transition was observed in 7 of the 159 (4.4%) controls. Among the 44 AHLH patients, 5 (11.3%) were heterozygous and the difference in the frequency of A91V transition, although striking (odds ratio: 2.8), was not statistically significant (p=0.09). All A91V-positive patients had infection. TNF-α-1031 T>C polymorphism was examined in 164 healthy controls and 40 AHLH patients, and the CC risk-elevating genotype was noted in 7 (4.3%) of the controls and 1 (2.5%) of the AHLH patients. The frequency of C and T alleles was 22.5% (n=18) and 77.5% (n=62) among the AHLH patients, and 22% (n=72) and 78% (n=259) among the controls, respectively. There wasn’t a statistically significant difference between the groups in terms of allele frequencies (p>0.05).Conclusion: The present results indicate that compared to controls, A91V mutation was 2.8-fold more prevalent (according to the odds ratio) in the AHLH patients. A91V mutation is not uncommon in the general population and increases the risk of AHLH in patients with an underlying condition, especially those with an underlying infection.
Transient depletion of innate immunity in varicella infections in otherwise healthy children
Nursat Erdemli,ule ünal,Hamza Okur,Gülten Se?meer
Turkish Journal of Hematology , 2009,
Abstract: Objective: Varicella is a common childhood infection and has a number of complications in the unvaccinated population. Perforin, found in natural killer cells, is important for the killing of virally infected cells. For this reason, the aim of this study was to determine natural killer cell count and activity, perforin expression, and Fas and soluble Fas ligand (sFas-L) levels in immunocompetent children with varicella infection and define any possible relations between the levels and varicella complications. Material and Methods: Forty children were analyzed at diagnosis and on the 15th day of varicella infection. There was a significant difference in hemoglobin levels and leukocyte and platelet counts between days 0 and 15.Results: Thirteen (32%) patients were found to be lymphopenic. Natural killer cell count and activity were significantly higher on day 15 when compared to values at diagnosis. The Fas-mediated apoptotic pathway was found to be active in acute varicella infection because Fas and sFas-L levels at diagnosis were higher than values on day 15. Conclusion: These findings suggest that the Fas and Fas-L apoptotic pathway is active during the acute phase of the viral infection and that it becomes inactive by day 15, paralleling the hematologic recovery.
Early detection of pulmonary fungal infection by CT scan in pediatric ALL patients under chemotherapy or in post-transplantation period with primary complaint of chest pain
ule ünal,Bar?? Ku?konmaz,Betul Tavil,Selin Ayta? Elmas
Turkish Journal of Hematology , 2010,
Abstract: We describe herein four children with acute lymphoblastic leukemia who were diagnosed as pulmonary fungal infection after presenting with chest pain. The plain radiologic evaluations failed to reveal any positive findings, whereas computerized tomography (CT) scanning showed nodular opacification with or without cavitation. This experience suggests that chest pain may be an initial symptom of an invasive fungal infection in patients with leukemia, and CT scan of the lungs should be performed urgently for the early diagnosis and treatment, despite normal plain X-rays.
Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants
ule ünal,Bar?? Ku?konmaz,Necati Balamtekin,G?khan Baysoy
Turkish Journal of Hematology , 2010,
Abstract: Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.
The Reconstruction of Sociology in Eastern Europe—Expectations and Dilemmas  [PDF]
Mirjana Ule
Sociology Mind (SM) , 2014, DOI: 10.4236/sm.2014.44027
Abstract: The article raises two questions: why do sociologists in Western Europe hold expectations of theoretical innovations in sociology in (post-)transitional Eastern European countries, and why is it that sociologists from Eastern Europe do not meet these expectations. The assumption is that these expectations are primarily a response to the theoretical crisis of modern sociology itself, rather than the effect of its knowledge of changes in transitional countries or its willingness to really listen to sociologists from those countries and accept them as equal partners. The attempt to answer the second question involves an analysis of the multilayered reality of sociology in post-socialism, including the loss of the socialist and civil-society utopias which have been replaced by pragmatic endeavors to re-establish a market society and its institutions. Despite the differences between the social situations in the East and West, today’s “Eastern” and “Western” social scientists are confronted by similar global problems and challenges. While the present crisis of the capitalist economy and neo-liberalism certainly has its structural causes, what needs to be questioned here are the very assumptions underlying the world order and the key mechanisms of its functioning.
An unusual presentation of pediatric acute lymphoblastic leukemia with parotid gland involvement and dactylitis
ule ünal,Bar?? Ku?konmaz,Yasemin I??k Balc?,Bülent Cengiz
Turkish Journal of Hematology , 2010,
Abstract: Mumps infection during the course of childhood acute lymphoblastic leukemia (ALL) treatment has been reported to have a mild course and this was related to the intrinsic low cytopathological effect of the virus, contrasting with the severe course of measles and Varicella zoster virus infections in immunocompromised patients. Herein, we present a three-year-old girl, who was previously vaccinated against mumps infection, admitted with bilateral parotid swelling, dactylitis and serum immunoglobulin M positivity for mumps infection and diagnosed to have ALL with bilateral persistent parotid involvement, inconsistent with mumps infection. Acute leukemia should be suspected during the atypical course of any disease during childhood. Besides, mumps infection at presentation of ALL, as similar to infection emerging during the period of the leukemia treatment, has a mild course.
Serum Erythropoietin Levels in Pediatric Hematologic Disorders and Impact of Recombinant Human Erythropoietin Use
Mualla ?etin,ule ünal,Fatma Gümrük,Aytemiz Gürgey
Turkish Journal of Hematology , 2009,
Abstract: Objective: In anemic patients, the correlation between serum erythropoietin (sEpo) level and the severity of anemia has been reported previously. However, in different anemia groups, different sEpo levels are measured in patients with similar hemoglobin levels and the etiology of this situation could not be explained. Methods: We evaluated hemoglobin and sEpo levels in 31 iron deficiency anemia, 26 Fanconi anemia (FA), 21 thallasemia intermedia (TI), 15 acute lymphoblastic leukemia (ALL) patients at presentation and 12 healthy controls. Results: In all disease groups, an inverse linear correlation was shown between hemoglobin and logarhytmic sEpo level. The covariance analyses according to corrected hemoglobin levels exhibited the highest sEpo level in FA, followed by ALL, TI and iron deficiency anemia, sequentialy. Conclusion: There was no statisticaly significant difference of sEpo levels in FA patients in terms of androgen treatment and this finding supports that androgen affects erythropoisis directly, and has no effect on erythropoietin. The results indicate that there is no erythropoietin deficiency in the anemia of these patients and the admnistration of exogenous erythropoietin offers no clinical benefit.
Hypertrichosis: the possible side effect of cyclosporin in an infant with hemophagocyticlymphohistiocytosis receiving HLH-2004 chemotherapy protocol
Sinem Akgül,Yasemin I??l Balc?,ule ünal,Ayfer Alika?ifo?lu
Turkish Journal of Hematology , 2009,
Abstract: Hemophagocyticlymphohistiocytosis is a life-threatening condition of severe hyperinflammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. The immediate treatment strategies include immune suppressive therapy such as corticosteroid, etoposide and cyclosporin A. Herein, we present a 13-month-old infant who developed severe hypertrichosis after the administration of HLH-2004 treatment protocol. We discuss the various hypotheses regarding the causal relationship between cyclosporin A and hypertrichosis, emphasizing the importance of patient follow up.
China and Sub-Saharan Africa’s Economic Development: A Multipolar Specification  [PDF]
Abdelrasaq Nal
Technology and Investment (TI) , 2015, DOI: 10.4236/ti.2015.63015
Abstract: Within the purview of contemporary international development discourse, China, alongside other regional powers are perceived as growth poles or drivers of global development. In the context of Africa’s development around which some of the emergent issues have been framed, analyses often proceed along a bilateral framework where the influence of China is isolated and assumed to be neither connected with nor shaped by the influences of other growth poles. Inspired by recent development in policy circles, this paper develops a multipolar framework to explain ways by which dimensions of possible interactions amongst activities of growth poles can affect development outcomes in other regions. It is then used to demonstrate how a nexus of Sino-EU activities has had limited impact on the development of Africa’s manufactured exports in comparison with similar nexus involving China and US.
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