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Search Results: 1 - 10 of 462086 matches for " ?olovi? Nata?a "
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Primary Burkitt’s lymphoma of the stomach
oloviNataa,Radovanovi? Neboj?a,Vidovi? Ana,olovi? Milica
Srpski Arhiv za Celokupno Lekarstvo , 2011, DOI: 10.2298/sarh1108523c
Abstract: Introduction. Burkitt’s lymphoma belongs to the group of non-Hodgkin’s lymphomas with B immunophenotypic features of lymphoma cells. It has tendency for extranodal localization primarily in the gastrointestinal tract and retroperitoneum. Primary Burkitt’s lymphoma of the stomach is very rare. Stomach is most frequently involved secondarily, growing from intrabdominal tumorous mass into the stomach. Case Outline. The authors present a 30-year-old male in whom after 6 months duration of temporarily melaenas the diagnosis of Burkitt’s lymphoma was established by endoscopic examination and biopsy of ulceroinfiltrative lesion on the antral part of the stomach. The patient was in clinical stage IIE. After one cycle of chemotherapy according to protocol R-HyperCVAD, a subtotal distal gastrectomy and additional three cycles of the same chemotherapeutic protocol a complete remission was achieved. Conclusion. Burkitt’s lymphoma is a highly aggressive non-Hodgkin’s lymphoma often present in extranodal sites. It should be treated with systemic intensive chemotherapy and surgical removal of tumorous mass when possible. Long-term survival using the combination therapy is possible to achieve in 40-80% of patients.
Abscess of the spleen
Grubor Nikica,olovi? Radoje,oloviNataa,Radak Vladimir
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0502046g
Abstract: Splenic abscess is a rare disease but with increasing frequency. The authors present 9 patients with splenic abscess treated at the Institute of Digestive System Diseases, Clinical Centre of Serbia, in a period from January 1, 1986 to May 15, 2004. Splenic abscess was the complication of septic endocarditis in 4, trauma in 2, dental infection in 1, while in 2 cases it was the complication of chemotherapy in myeloproliferative disorders. All 9 patients had fever, 7 - abdominal pain, 4 - left shoulder pain, and 1 patient had nausea and vomiting. Higher white blood count was found in 6 patients, pleural effusion in 4, elevated left hemidiaphragm in 1 and basal pneumonia in 1 patient as well. Ultrasonography and CT were the most reliable diagnostic procedures. CT was superior in diagnosis of multiple small abscesses. Culture of the pus recovered the Enterococcus in 3 cases, Streptococcus a hemolyticus in 1, Staphylococcus epidermidis and Candida albicans in 1, Staphylococcus aureus, E. Coli and Candida albicans in 1, Staphylococcus aureus and Salmonella enteritidis in 1 case. Eight patients underwent splenectomy and 1 was cured by combined antibiotics in high doses. One patient died postoperatively due to septic endocarditis that had been present before surgery. The authors believe that splenectomy and antibiotics administered according to drug susceptibility test as well as management of underlying disease are the method of choice for splenic abscess treatment. Conservative antibiotic treatment is indicated in selected cases only.
Symptomatic calcified splenic artery aneurysm: Case report
olovi? Radoje,oloviNataa,Grubor Nikica,Kaitovi? Marko
Srpski Arhiv za Celokupno Lekarstvo , 2010, DOI: 10.2298/sarh1012760c
Abstract: Introduction. Although the third most common aneurysm within the abdomen, after aneurysms of the aorta and iliac arteries, splenic artery aneurysms are rare, but not exceptionally. Owing to new imaging techniques, they have been discovered with increasing frequency. Case Outline. Authors present a 47-year-old woman, multipara, who presented with left upper abdominal pain in whom X-ray showed a calcified ring in the area of distal pancreas. Selective angiography confirmed a splenic artery aneurysm of its proximal part. During an open surgery the aneurysm was excised (aneurismectomy) without immediate, early or late complications. The patient became symptom-free. Conclusion. In patients, particularly women, the multiparas who present with epigastric or left upper abdominal pain of unknown aetiology, splenic artery aneurysm has to be taken into account. Further diagnostic procedures such as plain X-ray and selective angiography in suspected cases should be performed. Surgery or other treatment modalities are to be seriously considered in all patients, particularly in those with increased risk of rupture.
Focal nodular hyperplasia
olovi? Radoje,Grubor Nikica,Radak Vladimir,oloviNataa
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0508363c
Abstract: Thanks to ultrasonography, computed tomography, and nuclear magnetic resonance, not only symptomatic but also asymptomatic liver tumors are discovered more frequently than before. Focal nodular hyperplasia (FNH) is one such tumor, most frequently an asymptomatic tumor of the liver, which predominantly appears in women during the generative period, who have taken oral contraceptives for several years. We present a 27-year-old woman, who has never taken either oral contraceptives or other hormones, in whom a left lobe liver tumor was unexpectedly discovered during a routine investigation performed for psychiatric complaints. The tumor, removed by left lateral bisegmentectomy (segments II and 111), was composed of two tumoral nodes: 70x58x47 mm and 20x20x20 mm, the bigger one of which had a light grey central stellate scar. Histology revealed a focal nodular hyperplasia. The postoperative recovery was uneventful and the patient stayed symptom free for more than three years after surgery.
Inflammatory pseudotumours of spleen
olovi? Radoje,Micev Marjan,Grubor Nikica,oloviNataa
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0904189c
Abstract: Introduction. Inflammatory pseudotumours are benign lesions of unknown aetiology that can appear almost in any organ, sometimes along with infectious agents like Epstein-Barr virus. They are very rare in the spleen, with about 80 cases described in the world literature. The tumour is a single, very rarely multinodal, lesion. Middle-aged patients are mostly affected. Symptoms are either absent or uncharacteristic so that the tumours are discovered by chance or during the investigations for other diseases. Although the tumour may be suspected before surgery, the exact diagnosis is established by the histological and immunohistochemical examination of the spleen removed as lymphoma or some other lymphoproliferative disorder because they cannot be ruled out. Outline of Cases. The authors present 3 female patients 36, 48 and 56 years of age (average age 46.6 years) with the inflammatory pseudotumour of the spleen. Two patients complained of a mild pain in the epigastrium and below the left costal margin, while in the third patient the tumour of the spleen was discovered by chance during the examination after the traffic accident trauma. On examination, only slight epigastric tenderness was found in two patients. Except for the elevated white blood cells in one patient, laboratory data were within normal limits. All 3 patients were submitted to splenectomy as lymphoma of the spleen could not have been ruled out. Two patients developed transient postsplenectomy thrombocytosis which was treated with aspirin. The exact diagnosis of the tumours was established by the histological and immunohistochemical investigation. Conclusion. Inflammatory pseudotumours of the spleen may not be so rare as it is believed. Thanks to the new diagnostic modalities (US, CT, MRI), an increasing number of reports of these tumours may be expected. They have to be taken into consideration in the differential diagnosis of solitary or multi-modal lesions of the spleen. Splenectomy is a treatment of choice.
Malignant carcinoid tumor of the pancreas
olovi? Radoje B.,Micev Marjan,oloviNataa,Zogovi? Sergej
Srpski Arhiv za Celokupno Lekarstvo , 2002, DOI: 10.2298/sarh0206204c
Abstract: Carcinoid tumors arise from argentaffine cells or from a primitive stem cells which may differentiate into anyone of a variety of adult endocrine-secreting cells. Carcinoid tumor of the pancreas is a very rare tumor with less than 50 cases reported in world literature. In literature it is denoted "pancreatic serotoninoma" or "serotonin-producing pancreatic tumor". Due to its rarity the tumor is an unusual cause of carcinoid syndrome. As the carcinoid tumor of the pancreas does not always causes carcinoid syndrome its absence does not necessarily exclude the existence of the tumor. The tumor is frequently malignant. Over 50% of patients have metastases at the time of surgery. This is the reason why radical surgery is not possible in a number of patients. Excisional surgery offers the best chance for recovery or long term survival. We report on a 57-year-old woman with carcinoid syndrome caused by malignant carcinoid tumor of the head of the pancreas without liver or other distant metastases; it was successfully excised with pylorus preserving cephalic duo-denopancreatectomy (after Longmire-Traverso) and radical lymphadenectomy. The diagnosis was established on the basis of histologic and immunohistochemical findings. The patient is symptom free for more than eight months.
Biliary mucinous cystadenoma of the liver with focal malignant alteration
olovi? Radoje,Grubor Nikica,Micev Marjan,oloviNataa
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0502065c
Abstract: Biliary mucinous cystadenoma of the liver is a rare tumor that develops almost exclusively in women. Its typical localization is near the hepatic hilus. It may become malignant, and therefore careful histological examination of the entire resected specimen is mandatory. Incomplete excision results in recurrence and occasionally in malignant alteration. The authors present a 66-year old woman who presented with the right upper abdominal pain and occasional vomiting, and who was diagnosed with cystic lesion of the right lobe of the liver. The lesion was totally excised by an open operation. It was filled with mucinous viscous fluid and there was proliferation in one part of the internal surface. The cystic lesion communicated with the common hepatic duct through a tiny duct (above the cystic duct), but in spite of that, it did not contain bile. Histological examination showed mucinous cystadenoma with focal malignant alteration. After the uneventful recovery, the pain and vomiting were eliminated and she has remained symptom free so far.
Necrosis of the duodenum resulting from acute necrotising pancreatitis and treated with complete duodenopancreatectomy
olovi? Radoje,Grubor Nikica,Radak Vladimir,oloviNataa
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0512510c
Abstract: Necrosis of the duodenum resulting from acute necrotising pancreatitis is a rare but potentially lethal complication. A small number of cases has been reported so far, the majority of which having, unfortunately, had a lethal outcome. We present the cases of two patients, a 21-year-old woman and a 54- year-old man, both suffering from extensive duodenal necrosis stemming from acute necrotising pancreatitis, and both cases involving the second and third sections of the duodenum, one of which was probably caused by the thrombosis of nutritive blood vessels, the other by an abscess of the head of the pancreas. Due to the extent of the necrosis of the duodenum, there was no option to close so large a hole or to employ any less drastic procedure, so that a complete duodenopancreatectomy had to be performed. One patient survived and has remained in good health for a period of almost ten years, to date. The other patient died six days after surgery due to infection, in spite of an absence of any sort of anastomic complications.
Primary pancreatic non-Hodgkin's lymphoma
oloviNataa,?emeriki? Vesna,olovi? Radoje,Grubor Nikica
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0506276c
Abstract: Diffuse large-cell B lymphoma of the pancreas is a rare disease, representing less than 1% of all non-Hodgkin's lymphomas and less than 0.9% of all malignant tumors of the pancreas. About 150 cases of the disease have been observed so far. The tumors are more frequent in the head of the pancreas then in other parts of the organ. They are usually larger (average size of 8 cm) and are non-resectionable. As a rule, exact diagnosis is based on the histology and the immunohistology of the specimen taken during open surgery performed for general diagnosis of the pancreatic tumor. Very rarely can a very reliable and experienced cytopathologist establish a proper diagnosis based on material obtained from a fine needle biopsy. The disease usually responds positively to immunochemotherapy according to protocol R-CHOP. Occasionally, additional radiotherapy may be required. We present two women, 66 and 49 years old, in whom a diagnosis of large-cell B lymphoma of the pancreas was established, based on the histology and the immunohistochemistry of a specimen taken during open surgery performed in order to remove pancreatic tumors, which turned out to be non-resectionable. After immunochemotherapy, the symptoms disappeared and the tumors shrank, in one patient after additional radiotherapy. The authors would like to point out the importance of a proper histological diagnosis, which permitted the application of immunochemotherapy alone or together with additional radiotherapy with at least temporarily favorable results.
Isolated metastasis of the granulosa cell tumor of the ovary in the small intestine mesentery 19 years after salpingo-oophorectomy
olovi? Radoje,Grubor Nikica,Micev Marjan,oloviNataa
Srpski Arhiv za Celokupno Lekarstvo , 2006, DOI: 10.2298/sarh0612546c
Abstract: Introduction: Granulosa cell tumor is uncommon malignant tumor which belongs to the sexual cord-stromal tumors of the ovary. It arises from the specialized stromal cells of the ovary. These tumors are unilateral in 95%. Over 90% of patients survive more than 10 years after surgery, but the recurrence may appear even 25 years after surgery. CASE REPORT The authors present a 54-year old woman who was admitted for abdominal pain and ultrasonography revealed tumor in the abdomen. During the surgery, a spheric, well circumscribed tumor of the mesentery, close to the forth portion of duodenum, was excised. Histological and immunohistochemical examinations verified that it was the metastasis of the granulosa cell tumor of the ovary that had been removed 19 years ago when salpingo-oophorectomy had been performed. Postoperative recovery was uneventful. Twenty six months later, the tumor 4 cm in diameter recurred, and was localized to the left of duodenum, close to the inferior mesenteric artery, which was perfectly ideally, together with fat tissue and surrounding lymph nodes. She has remained symptom free so far. Conclusion: To the best of our knowledge, this is the first case of the isolated metastasis of the granulosa cell tumor in the mesentery, that appeared 19 years after original surgery.
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