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Search Results: 1 - 10 of 33215 matches for " ?kuli? Milan Z. "
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One view on the position of crime victim in criminal procedure for organized crime
kuliMilan Z.
Temida , 2004, DOI: 10.2298/tem0401017s
Abstract: In this paper the position of victim in criminal procedure for organized crime is analyzed. Through recent changes of our criminal procedure law, the special type of procedure is created in relation to organized crime, with inclusion of large number of specific criminal procedure norms. These new solutions contribute to the protection of victims/witnesses, although there are still more space for the improvement. Legislative body still needs to overcome deeply embedded attitude that the witnesses and victims are the exclusive source of evidence, or, in other words, that the witness testimony is only way to find out evidence information. The victim has to be treated at the first place as a person to whom specific position in criminal procedure, with special regard on the protection of her basic rights, should be guaranteed.
Possibilities for improvement of the position of victims of trafficking in people within criminal procedure
kuliMilan Z.
Temida , 2002, DOI: 10.2298/tem0202005s
Abstract: In this paper main possibilities for improvement of the position of victims of trafficking in people within criminal procedure are discussed. The special focus of the analysis is on the issues regarding theoretical base for improvement of the position of victim in criminal procedure. Also, the analysis of international documents related to the protection of victims within criminal procedure, review of laws which allow for organized crime to be proved easier and of legal possibilities (within Yugoslav and comparative law) for prevention of secondary victimization, i.e. for protection of victims, is done.
Examination of genotoxic effects of fumagillin in vivo
KuliMilan,Aleksi? Nevenka,Stanimirovi? Zoran,Risti? Sini?a
Genetika , 2009, DOI: 10.2298/gensr0903329k
Abstract: Fumagillin is an antibiotic derived from the fungus Aspergillus fumigatus. It has been used successfully for the treatment of intestinal microsporidiosis in HIV-positive humans, as well as in those suffering from intestinal amebiasis and microsporidial keratoconjunctivitis. In veterinary medicine it is approved for the treatment of microsporidiosis in bees and fish. In this research fumagillin was tested for the ability to provoke chromosomal aberrations in mouse bone marrow cells. BALB/c mice were administered fumagillin by gastric probe in doses of 5, 10 and 20 mg/kg b.w. Water-sugary syrup was the negative and cyclophosphamide (15 mg/kg b.w.) the positive control. Significantly increased frequencies (p<0.01 or p<0.001) of numerical chromosomal aberrations (aneuploidies and poliploidies) was observed both in the medium (10 mg/kg b.w.) and the highest (20 mg/kg b.w.) dose of fumagillin. Structural chromosomal aberrations (gaps, breaks and insertions) were noticeably more frequent in comparison to negative control only in the highest experimental dose of dycikloheksilamine. These results clearly showed that fumagillin in concetrations 10 and 20 mg/kg b.w. had a genotoxic potential in vivo.
In vivo investigations of clastogenic effect of levamisole hydrochloride on bone marrow cells of BALB/c mice
KuliMilan,Stanimirovi? Zoran,Risti? Sini?a,Markovi? Biljana
Veterinarski Glasnik , 2005, DOI: 10.2298/vetgl0506549k
Abstract: Cytotoxic and genotoxic examinations were performed of the effect of levamisole hydrochloride (2.2 mg/kg bm, 4.4 mg/kg bm, LD50-25% mg/kg bm and LD50-75% mg/kg bm) on bone marrow cells of mice of the BALB/c strain. The effect of levamisole hydrochloride on kinetics of the cellular cycle and the appearance of structural and numerical changes in chromosomes of bone marrow cells were followed. The therapeutic dose of levamisole of 2.2 mg/kg bm showed the ability to increase the mitotic activity of the observed cells, thus confirming knowledge of the immunostimulative effect of this dose of the medicine under in vivo conditions. The other tested doses of levamisole in this experiment, observed in comparison with the control group, had an opposite effect, i.e. they caused a reduction in the mitotic activity of bone marrow cells. All the examined doses in vivo showed the ability of inducing numeric (aneuloid and polyploid) and structural (lesions, breaks and insertions) chromosomal aberrations. On this basis, it can be concluded that the examined doses have a genotoxic effect.
Investigations of genotoxic potential of levamisole hydrochloride in bone marrow cells of Wistar rats
KuliMilan,Stanimirovi? Zoran,Markovi? Biljana,Risti? Sini?a
Veterinarski Glasnik , 2006, DOI: 10.2298/vetgl0602003k
Abstract: An experiment was performed under in vivo conditions on bone marrow cells of Wistar rats. The following doses of levamisole hydrochloride were tested: a therapeutic dose of 2.2 mg/kg bm, a dose of 4.4 mg/kg bm, LD50 -25% mg/kg bm, and LD50 -75% mg/kg bm. We followed the effect of levamisole hydrochloride on kinetics of the cell cycle and the appearance of structural and numeric changes in chromosomes in bone marrow cells. The therapeutic dose of levamisole of 2.2 mg/kg bm exhibited a capability to increase mitotic activity in the observed cells, thus confirming knowledge of the immunostimulative effect of this dose of the medicine under in vivo conditions. The other tested doses of levamisole in this experiment, observed in comparison with the control group, had an opposite effect, namely, they caused a reduction in the mitotic activity of bone marrow cells. All the examined doses in vivo exhibited the ability to induce numeric (aneuploid and polyploid) and structural (lesions, breaks and insertions) chromosomal aberrations. It can be concluded on the grounds of these findings that the examined doses have a genotoxic effect.
Evaluation of genotoxic effects of fumagillin by sister chromatide exchange and chromosomal aberration tests in human cell cultures
Stanimirovi? Z.,Pejin Ivana I.,Kuli?i? Z.,?iporovi? Milanka
Acta Veterinaria , 2007, DOI: 10.2298/avb0703257s
Abstract: Fumagillin is a naturally secreted antibiotic of the fungus Aspergillus fumigatus. In veterinary medicine fumagillin is used against nosemosis in bees and microsporidiosis in fish. Since fumagillin is stable in honey in a honey bee hive there is a possible genotoxic risk to beekeepers and consumers of honey contaminated with this substance. The genotoxic effect of fumagillin was evaluated in sisterchromatid exchange (SCE) and chromosome aberration tests in cultured human peripheral blood lymphocytes at three concentrations (1.02, 3.07 and 9.20 _g/mL), with 1:1 water-sugar syrup as the negative control and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) as the positive control. The mitotic and proliferative indices were calculated to detect the cytostatic effect of fumagillin. The results revealed that all tested concentrations of fumagillin (1.02, 3.07 and 9.20 _g/mL) significantly (p<0.001) increased the SCE frequency per cell and decreased the proliferative activity of human cultured lymphocytes which was manifested in the decrease in mitotic and proliferative indices. Significant increase (p<0.001) in aneuploidy and polyploidy was induced by medium and maximum concentrations of fumagillin. Besides, maximum concentrations of fumagillin significantly (p<0.001) increased the frequency of monitored structural aberrations of gap, break and insertion type. The results of this study demonstrate the genotoxic potential of fumagillin in vitro.
Prevalence of gastrointestinal helminths in calves in Western Serbia
Kuli?i? Z.,Aleksi? Nevenka,?or?evi? M.,Gaji? B.
Acta Veterinaria , 2012, DOI: 10.2298/avb1206665k
Abstract: This study was undertaken to estimate the prevalence of gastrointestinal helminths in calves in western Serbia. Throughout 2011 faecal samples were collected from 600 calves aged up to 180 days, samples were examined with the flotation method and a modified McMaster technique. The parasitizing helminth species were identified and the level of infection compared between different age groups. As many as 64.17% animals were found to be infected. The following parasite species were diagnosed: Moniezia spp. (3.17%), Toxocara vitulorum (35.00%), Strongyloides papillosus (34.50%), gastrointestinal strongyles (4.50%) and Trichuris discolor (2.17%). The majority of calves were infected with two, fewer with three or one helminth species, and the smollest number of calves harboured four parasite species. The prevalence of established helminth infections varied depending on the calves' age.
Frequency of chromosomal aberrations in the evaluation of genotoxic potential of dicyclohexylamine (fumagillin) in vivo
Stanimirovi? Z.,Stevanovi? Jevrosima,Kuli? M.,Stoji? V.
Acta Veterinaria , 2006, DOI: 10.2298/avb0604353s
Abstract: Dicyclohexylamine (fumagillin), as an antibiotic produced by fermentation of Aspergillus fumigatus, is used in human medicine for the treatment of intestinal microsporidiosis in patients with HIV infection, intestinal amebiasis and microsporidial keratoconjunctivitis. In veterinary medicine fumagillin is effective in suppressing microsporidiosis of bees and fish. In this study, the genotoxicity of fumagillin was evaluated in mouse bone marrow cells using chromosome aberrations (CA) assay. Dicyclohexylamine was administered to mice by gavage in a dose of 25, 50, 75 mg/kg b.w., with water-sugar syrup as the negative control and cyclophosphamide as the positive control (40 mg/kg b.w) Significantly increased frequency (p<0.01 or p<0.001) of numerical chromosomal aberrations (aneupliodies and polyploidies) and structural chromosomal aberrations of gaps, breaks and centric rings were observed only at the highest experimental dose of dicyclohexylamine, compared with the negative control. However, in point of induction of Rb translocations, both the median (50 mg/kg b.w) and highest (75 mg/kg b.w) experimental dose showed a significant (p<00.001) increase (7.12 ± 0.26 and 9.00 ± 0.10, respectively) in comparison with the negative control (0.00 ± 0.00). Chromosomes 4 and 19 participated in these Rb translocations. These results suggest that dicyclohexilamine (fumagillin) has genotoxic potential in mammal in vivo chromosomal aberration (CA) test system.
Ecology of Anopheles mosquitoes in Belgrade area: Estimating vector potential for malaria retransmission
Daki? Zorica,Kuli?i? Z.,Stajkovi? N.,Pelemi? M.
Acta Veterinaria , 2008, DOI: 10.2298/avb0806603d
Abstract: Belgrade is situated in the area that is potentially at risk from malaria outbrakes. Until eradication, the main vector of malaria in this area was Anopheles maculipennis s. s. (previous name An. typicus) and secondary vectors were An. messeae and An. atroparvus. In this study we examined the distribution and ecology of Anopheles mosquitoes (Diptera, Culicidae) in Belgrade. Females of Anopheles mosquitoes were collected from animal shelters in Belgrade at eight locations during 2003. Egg morphology was used to identify the specimens. A total of 3704 females deposited eggs ready for identification. Three species of An. maculipennis complex were identified: An. messeae, An. atroparvus and An. maculipennis s. s.. The most abundant species were An. messeae (64%). The relative frequency of three species varied depending on the site of collection. Seasonal fluctuations of mosquitoes' species varied. Each develops in a distinct type of water, too. The three species of the An. maculipennis complex, particularly An. messeae and An. atroparvus, are considered as potential vectors of malaria in Belgrade. With the possible reintroduction of Plasmodium species due to climatic changes and increased travel to and from the countries where malaria is endemic, a more efficient vector control is necessary.
Assessing the yield point of concrete steels based upon known chemical composition
M. ?i?ko Kuli,Z. Mrdulj?a,B. Klarin
Metalurgija , 2010,
Abstract: This research is based on both, theoretical and experimental work and aims to assessment the yield point of concrete steels, based on the known alloy chemical composition. The experimental portion of the work was performed at the Split steelmaking factory, which produces concrete steels from the waste iron. The theoretical portion of this study involves mathematical modelling carried out using the software package MATLAB. The work presented here provides both a scientific and practical contribution to the field. By using mathematical modelling, the accuracy of the estimation of the yield point is improved by 8,5%. Using this correlation enables the reduction of the concrete steel production costs because it is possible to reduce the use of expensive tests for the characterization of strength and mechanical properties.
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