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Search Results: 1 - 10 of 9786 matches for " ?ivanovi? Sandra "
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Arthrosonography and biomarkers in the evaluation of destructive knee cartilage osteoarthrosis
ivanoviSandra,Petrovi?-Rackov Ljiljana,ivanovi? Aleksandar
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0912653z
Abstract: Introduction. Knee osteoarthrosis (OA) is a degenerative disease with progressive loss of cartilage of joints and bone destruction. During this process, the release of fragments of connective tissue matrix is detected in the biological fluids such as human cartilage glycoprotein (YKL-40), cartilage oligomeric matrix protein (COMP) and collagen type I C terminal telopeptid (CTX-I). Objective. The aim of the study was to determine the degree of connection cartilage thickness measured by ultrasound with serum concentrations of biomarkers YKL-40, COMP and CTX-I in patients with primary knee OA. Methods. The analysis included 88 patients with the diagnosis of knee OA. Ultrasound examination of knees were done by two rheumatologists. The analysis of serum samples determined the concentration of COMP, YKL-40 and CTX-I by the ELISA method. Results. The average age of patients was 69.97±9.37 years and the duration of knee OA 6.46±6.73 years. The average cartilage thickness of the femoral condyle was 1.33±0.20 mm; of the medial condyle (MC) (front access) 1.30±0.23 mm, (rear access) 1.30±0.29 mm and lateral condyli (LC) (front access) 1.39±0.27 mm. The average cartilage thickness of MC (front access) was 1.27 mm (0.98-1.42 mm), (rear access) 1.27 mm (0.84-1.46 mm) and LC (front access) 1.36 mm (1.01-1.57 mm) (p=0.002). There was a significant connection in the negative direction between the patients' age and the cartilage thickness of MC (front and rear access) and LC (front access) (r=-0.253; p=0.017). There was a significant negative direction of interrelationship between the cartilage thickness of MC (front access) (r=-0.259; p=0.015) and LC (front access) and the disease duration (r=-0.259; p=0.015). In patients with knee OA lasting for 5 years the measured cartilage thickness was 1.27 mm (1.16-1.49 mm), and 0.99 mm (0.94-1.23 mm) (p=0.007) in those lasting for 20 years. There was a significant relationship in a negative direction between the concentration of YKL-40 and cartilage thickness of MC (front access) (r=-0.249; p=0.019). Conclusion. The progressive loss of cartilage during the long-term evolution of osteoarthrosis is most extensive in the femoral MC. The increased serum levels of YKL-40 can be a good indicator of joint cartilage destruction.
Effects of Tibolone on Markers of Bone Metabolic Activity in Postmenopausal Women
Sne ana Mari Krejovi , Aleksandar ivanovi , Sandra ivanovi , Rade Markovi
Journal of Medical Biochemistry , 2012, DOI: 10.2478/v10011-011-0050-2
Abstract: Osteoporosis, a systemic disease of the bones, is a serious health and socio-economic problem because of its consequences, i.e. broken bones. It is believed that 10% of the world's population suffers from osteoporosis and it affects mostly postmenopausal women (postmenopausal osteoporosis). Tibolone is a synthetic steroid that has estrogenic, androgenic, and progestagenic properties. It has been used primarily for the prevention of postmenopausal osteoporosis and treatment of climacteric symptoms. The research included a group of 40 postmenopausal women with osteopenia treated with tibolone. The control group included 40 postmenopausal women who were not taking any medication. Control group patients were older (54.5 ± 9.84) than the patients treated with tibolone (51.6 ± 6.22). Bone metabolic activity was evaluated using osteocalcin (N-MID osteocalcin) for bone formation and CTX I for bone resorption. Blood samples were taken before therapy was introduced and 3 months after its introduction. The average value of osteocalcin after three months of tibolone therapy was 26.32 ± 3.312 ng/mL compared to the average osteocalcin value prior to therapy of 29.6 ± 3.343 ng/mL. The average value of CTX I three months after tibolone therapy of 0.2870 ± 0.0783 ng/mL was lower compared to the average CTX I value before the therapy of 0.4539 ± 0.1144 ng/mL. Our results show the efficacy of tibolone in preventing bone loss, which was highly statistically significant. They also reveal its suppressive effects on bone formation and resorption, but these effects are statistically less significant. Tibolone significantly reduces the level of bone resorption in postmenopausal women with osteopenia. Its effects on bone formation are less expressed. The parameters of bone metabolic activity are a very useful diagnostic means in the evaluation of tibolone effects on bone metabolic activity and in the prognosis of bone mass loss.
Detection of bone erosions in knee osteoarthrosis by serum biomarkers
ivanoviSandra,Petrovi?-Rackov Ljiljana,Jevti? Milorad
Srpski Arhiv za Celokupno Lekarstvo , 2010, DOI: 10.2298/sarh1002062z
Abstract: Introduction. Osteoarthrosis (OA) is a degenerative chronic disease characterized by destruction of joint articular cartilage and subchondral bone with formation of osteophytes and usuries on joint surface. Quantitative and dynamic changes in remodeling of joint tissue reflect matrix molecules that dismiss as fragments in joint liquid, blood and urine where they can be detected. Human cartilage glycoprotein (YKL-40) is synthesised by chondrocytes and synovial cells and plays a significant role in remodel tissue. Objective. The aim of the paper was the parallel analysis and determination of the degree of correlation between ultrasound indicators destruction of joints, bone erosion (usuries), and serum YKL-40 concentrations in patients with primary osteoarthrosis of the knee. Methods. The analysis included 88 patients with the diagnosis of knee OA. Ultrasound review of knees was done by two rheumatologists. The analysis of serum samples determined the concentration of YKL40 by ELISA method. Results. The average age of patients was 69.97±9.37 years, duration of knee OA 6.46±6.73 years. The mean value of age in 59 patients with usuries was 72.05±7.74, at 29 without usuries 65.75±11.00 (p=0.003). The average value (median) thickness cartilage in medial condyl femur (front access) in patients with usuries was 1.25 mm (1.12-1.36 mm), without usuries 1.35 mm (1.20-1.51 mm) (p=0.016). The central YKL40 value of biomarkers in the patients without usuries was 81 ng/ml (46.5-120.5 ng/ml), with usuries the medial condyil 138 ng/ml (89.5-175.0 ng/ml), the lateral 106 ng/ml (63.0-201.5 ng/ml) and both condyl 86 ng/ ml (69.75-140.5 ng/ml) (p=0.004). The central value YKL40 after 5 year-duration of disease was 83.68±33.65 ng/ml, after 10 years 138.22±48.88 ng/ml, after 15 years 209.30±79.36 ng/ml, and after 20 years 218.50±106.51 ng/ml (p=0.000). The biomarker YKL 40 may be a marker for usuries (area 0.691, p=0.004; confidence interval 0.574-0.808). If you took the optimal cut-off of 84.5 ng/ml, then YKL40 sensitivity to the usuries was 69.5%, and specificity 51.7%. Conclusion. Increased concentrations of biomarkers YKL40 may be an indicator of the degree of destructive changes in the knee osteoarthrosis.
Inflammation in knee osteoarthrosis: Cause of aggravation
ivanoviSandra,Nikoli? Sandra,Jevti? Milorad,Koci? Sanja
Medicinski Pregled , 2010, DOI: 10.2298/mpns1010668z
Abstract: Introduction. Knee osteoarthrosis is a degenerative disease which induces intense trouble. Material and methods. The aim of the study was the parallel analysis of clinical and ultrasound examination in patients diagnosed with knee osteoarthrosis. A group of 88 patients underwent the clinical examination and the outflow and size of flexion were determined, the intensity of pain was assessed by the patient's mark on VAS, the functional ability by HAQ index, and the size of effusion and synovitis by arthrosonography. Results. The minimal outflow was diagnosed in 34.1% of patients, medium in 22.7%, and significant in 4.5%. Synovitis was evident in 67% of patients, 17.0% had nodular, 30.7% diffuse and 19.3% nodular-diffuse type. Effusion was observed in 75% of patients. The average size of synovitis in suprapatellar recess (SR) in the patients with significant, medium and lateral outflow was 6.68 (2.93-10.04) mm (p=0.000), 1.57 (0-5.53) mm (p=0.006) and 6.18 (3.44-7.10) mm (p=0.000), respectively. The grade of pain on VAS was the highest in patients with significant outflow 70(60-95) (p=0.014), effusion 60 (50-80) (p=0.024) and nodular type of synovitis 70 (50-90) (p=0.029). There was a significant correlation on VAS in the positive direction with the size of effusion (r=0.238, p=0.025) and synovitis in LR (r=0.215, p=0.044), HAQ index (r=0.502, p=0.000), and in the negative direction with the size of flexion (r=-0.346, p=0.001). The average size of flexion in the patients with significant outflow was 90 (82.5-90)°(p=0.000), HAQ index 1.99 (1.49-2.30) (p=0.078). HAQ index depended on effusion in LR in the positive direction (p=0.014). Discussion and Conclusion. Clinically significant outflow is shown by arthrosonography as the biggest in SR, moderate and minimal only in LR. Moderate or significant outflow, effusion and nodular type of synovitis lead to intensive pain. Patients with bigger functional disability had intense pain, significant outflow in LR and significantly limited motions.
Potential risk factors for developing diabetes mellitus type 2
ivanovi? Du?ica,?ipeti? Sandra,Stamenkovi?-Radak Marina,Mila?in Jelena
Medicinski Pregled , 2010, DOI: 10.2298/mpns1004231z
Abstract: Introduction Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing diabetes type 2 among diabetic individuals and to compare the presence of risk factors among diabetic individuals with and without positive family history for type 2 diabetes. Material and methods This study was conducted in Cuprija during the period from February to June 2002. The case group included 137 individuals having diagnosis type 2 diabetes. The control group included 129 subjects having the following diagnoses: hypertension, angina pectoris, chronic obstructive lung disease, gastric ulcer or duodenal ulcer. All participants were interviewed at the Medical Center Cuprija using structural questionnaire. The data were collected regarding demographic characteristics, exposure to various chemical and physical agents, stress, smoking, obesity, physical inactivity and family history of diabetes. In the statistical analysis chi square test was used. Results The diabetic individuals were statistically significantly older (40 and more years old) (p=0,000), and they came from rural areas more frequently (p=0,006) than the individuals without diabetes. Significantly more diabetics had lower educational level (p=0,000) and they were agriculture workers and housewives significantly more frequently (p=0,000) than nondiabetic individuals. Furthermore, obesity (p=0,000) and physical inactivity (p=0,003) were significantly more frequent among the diabetic individuals than the nondiabetics. The diabetic individuals had significanly (p=0,000) more numbers of relatives with diabetes mellitus type 2 than the nondiabetics. The diabetic individuals with positive family history of diabetes were significantly older (p=0,021) and more frequently from urban areas (p=0,018) than the diabetic individuals without the positive family history of diabetes. Also they were significantly less exposed to physical agents (p=0,004). Discussion In our study, like in many others, age, place of residence, education, occupation, obesity, physical inactivity, positive family history of diabetes type 2 and exposure to physical agents were identified as potential risk factors for diabetes type 2. Conclusion Different risk factors are probably responsible for developing type 2 diabetes among individuals with and without positive family history of type 2 diabetes.
Graves-Basedow disease and potential risk factors
ivanovi? Du?ica,?ipeti? Sandra,Stamenkovi?-Radak Marina,Mila?in Jelena
Vojnosanitetski Pregled , 2008, DOI: 10.2298/vsp0808633z
Abstract: Background/Aim. Graves-Basedow disease is a common multifactorial genetic syndrome, which is determined by several genes and environmental factors. The aim of the present study was to investigate the presence of risk factors for developing Graves-Basedow disease between the groups of individuals with and without Graves-Basedow disease, and to compare the presence of risk factors between the affected individuals with or without positive family history for Graves- Basedow disease. Methods. This cross-sectional study was conducted in uprija (central Serbia) during a period from December 2001 to April 2002. The case group comprised 132 individuals diagnosed with Graves-Basedow disease. The control group comprised 130 subjects without any of endocrine diseases. All participants were interviewed at the Medical Center uprija using structural questionnaire. Data were collected on basic demographic characteristics, exposure to various chemical and physical agents, stress, smoking and family history of Graves-Basedow disease. In statistical analysis chi-square test was used. Results. The individuals with Graves-Basedow disease were statistically significantly older (above 50) (p = 0.020), exposed to stress (p = 0.024) and to physical agents (p = 0.031), and had significantly (p = 0.000) more relatives with Graves-Basedow disease than those without the disease. Among the affected individuals with positive family history of Graves-Basedow disease the number of women was significantly higher (p = 0.000), than the affected individuals without positive family history of Graves- Basedow disease. Conclusion. In our study, as in many other, gender, age, positive family history of Graves-Basedow disease and exposure to physical agents were identified as potential risk factors for the increased incidence of Graves- Basedow disease. Different risk factors are probably responsible for developing Graves-Basedow disease among the affected individuals with or without positive family history of Graves-Basedow disease. .
Immune Complexes and Complement in Serum and Synovial Fluid of Rheumatoid Arthritis Patients
Zoran Miju kovi , Ljiljana Rackov, Janko Pejovi , Sandra ivanovi , Jelica Stojanovi , Zoran Kova evi
Journal of Medical Biochemistry , 2009, DOI: 10.2478/v10011-009-0016-9
Abstract: Rheumatoid arthritis (RA) is predominantly an intraarticular inflammatory and autoimmune disease that involves different autoantibodies and effector mechanisms. The aim of the study was to determine the utility of Circulating Immune Complexes (CIC) and complement components (C3c, C4) as possible markers for the disease activity in laboratory diagnostics. In a cross-section study 59 patients, according to the clinical criteria, were categorized into two groups: group with moderate (MA, n=24), and group with severe activity (SA, n=35) of RA. The concentration of CIC, C3c and C4 in sera (S) and synovial fluids (SF) was examined by an immunonephelometric method in both groups and compared with values in the control group (n=15) of patients with lesions of the menisci. Obtained results showed that there was no statistical significance in the values of C3c and C4, in both biological fluids, among all tested groups. Significant differences were found in the levels of CIC in both fluids, while testing the parameters (× ± SD, IU/mL) in the sera of groups with SA and MA of RA: 7.43 ± 13.40; 3.01 ± 2.92 (p<0.05) and SF: 13.47 ± 21.1, 5.33 ± 7.53 (p<0.001), respectively. These differences were higher between the group with SA and CG. Results for the concentrations of CIC were significantly higher in SF compared to sera: in the RA group with SA by 77% and group with MA by about 82%. These data could provide a confirmation of the hypothesis about local, intraarticular autoantibodies and subsequent CIC production. It can be concluded that the examination of CIC concentration in serum, and where it is possible in SF, is a useful marker of disease activity in RA patients, in contrast to the tested components of the complement. This statement does not exclude their consumption within immune effector mechanisms, but elicits the possibility that lower molecular fragments (C3d, C4d), as well as the novel activation products, could be better disease activity markers in RA patients.
Arthrosonography and the Biomarker Cartilage Oligomeric Matrix Protein in the Detection of Knee Osteoarthrosis Effusion
Sandra ivanovi , Ljiljana Petrovi Rackov, Du an Vu eti , Zoran Miju kovi
Journal of Medical Biochemistry , 2009, DOI: 10.2478/v10011-009-0005-z
Abstract: Osteoarthrosis of the knee is a degenerative disease with inflammatory episodes objectively shown by arthrosonography. Cartilage Oligomeric Matrix Protein - COMP is a useful biomarker for early cartilage destruction. The aim of this paper is a comparative analysis of the clinical, arthrosonographic findings and the COMP concentration in the sera of patients for the detection of joint inflammation. The analysis included 88 patients with knee OA. Clinical examination determined the outflow, arthrosonography the size of synovitis and effusion, and serum analysis the COMP concentration (ng/ml). Minimum outflow had 34.1% of patients, moderate 22.7%, and significant 4.5%. Sensitivity of the clinical diagnosis of outflow is 73%, and specificity 73% (p=0.000). Seventy five percent of patients had effusion; 28.4% of patients in the suprapatellar recessus (SR), 27.3% in the medial (MR), and 62.5% in the lateral (LR). In SR, effusion was 10.13±4.35 mm, MR 8.53±2.27 mm, LR 11.38±4.44 mm. Synovitis was found in 67% of patients, in SR the size of 4.84±3.57 mm, in MR 3.15±1.86 mm, in LR 6.09±2.80 mm. The average value of the size of effusion in patients with significant outflow in SR was 13.85 (10.36-17.43) mm (p=0.000), MR 4.9 (0-10.22) mm (p=0.008), LR 12.0 (11.34-14.50) mm (p=0.000), in LR with moderate outflow 6.94 (1.16-8.13) mm and minimum outflow 4.9 (0-7.25) mm. There is a significant correlation between the size of synovitis and effusion in the SR, MR and LR (p=0.000). The average value of the concentration of COMP in patients without effusion was 54 (44.5-58) ng/ml, with effusion 57 (48.75-64.25) ng/ml (p=0.030). Arthrosonography and the determination of the COMP concentration are sensitive methods for diagnosing joint effusion.
On injection-ejection fluid influence through different accelerating porous surfaces on unsteady 2d incompressible boundary layer characteristics
Ivanovi? De?an,Ivanovi? Vladan
Theoretical and Applied Mechanics , 2005, DOI: 10.2298/tam0502131i
Abstract: Through the porous contour in perpendicular direction, the fluid of the same properties as incompressible fluid in basic flow, has been injected or ejected with velocity who is a function of the contour longitudinal coordinate and time. The corresponding equations of unsteady boundary layer, by introducing the appropriate variable transformations, momentum and energy equations and two similarity parameters sets, are transformed into generalized form. These parameters are expressing the influence of the outer flow velocity, the injection or ejection velocity and the flow history in boundary layer, on the boundary layer characteristics. Obtained generalized solutions are used to calculate the distributions of velocity, and shear stress in laminar-turbulent transition of unsteady incompressible boundary layer on different porous contours: circular cylinder, thin elliptical cylinder and aerofoil, whose centers velocities changes in time as a degree functions. The ejection of fluid postpones the boundary layer separation, i.e. laminar-turbulent transition, and vice versa the injection of fluid favors the separation. Boundary layer characteristics are found directly, no further numerical integration of momentum equation.
Macroregional centers in function of regional development of Serbia
ivanovi? Zora
Glasnik Srpskog Geografskog Dru?tva , 2009, DOI: 10.2298/gsgd0903023z
Abstract: Beside the dominance of Belgrade in regional development of Serbia and marginal role of medium sized cities, macroregional centers were for a long time important carriers of economic development and a driving force of the overall prosperity. The objective of this work is to indicate the role of macroregional centers in the regional development of Serbia through their analysis and comparison of the results with the average values on the state level. Their existence represents a precondition for decentralization of Serbia. .
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