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Objectives: This article aims to construct information dissemination network in the Weibo on the safety of genetically modified foods, analyze network characteristics, and further explore influential factors of the network. Methods: The sample and data were collected in Sina Weibo, while Excel, SPSS, and NetDraw were employed to build networks and analyze statistically. Results: Centrality indicators in information dissemination network in the Weibo on the safety of genetically modified foods are significantly influenced by professional areas, attitudes, and regions of Weibo users at the statistical level.