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Search Results: 1 - 10 of 41941 matches for " 韩天佼 "
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DPP-Ⅳ抑制剂三维药效团模型构建
3D Pharmacophore Model Construction of DPP-Ⅳ Inhibitors
 [PDF]

, 李悦青, 谷俊峰, 曹志, 赵伟杰, 王希诚
Hans Journal of Chemical Engineering and Technology (HJCET) , 2012, DOI: 10.12677/hjcet.2012.22010
Abstract: 以20个文献报道的二肽基肽酶Ⅳ(DPP-Ⅳ)抑制剂作为训练集,利用Discovery Studio构建了DPP-Ⅳ抑制剂的三维药效团模型。所得最优药效团模型Hypo1具有一个氢键受体,一个疏水基团,一个可离子化正电中心,一个芳香环和5个排除体积,Fischer交叉验证结果表明该模型具有较高的置信度。Hypo 1对测试集中20个DPP-Ⅳ抑制剂活性进行了预测,结果显示有较好的预测能力。利用该模型进行ZINC数据库搜索,得到预测活性小于10 nmol?L–1的化合物1369个。将这些化合物对接到DPP-Ⅳ的活性位点并根据PLP2评分函数筛选出21个评分较高的化合物,为设计和合成新型的DPP-Ⅳ抑制剂提供了理论参考。
The 3D pharmacophore model of DPP-Ⅳ inhibitors was established using the Discovery Studio software with the training set of 20 DPP-Ⅳ inhibitors. The best pharmacophore hypothesis (Hypo 1) consists of one hydro- gen-bond acceptor, one hydrophobic point, one positive ionizable group, one aromatic ring as well as five excluded volumes. Fischer’s validation clearly shows that proposed Hypo 1 has highly predictive ability and can be efficiently used as a 3D query for virtual screening to retrieve potential inhibitors from ZINC databases. The hit compounds sub- sequently were docked into the DPP-Ⅳ active site and 21 compounds were obtained based on PLP2 scoring function. Therefore, this study could provide scientific basis for denovo design of DPP-Ⅳ inhibitors.
基于聚类分析的城市交通TOD优化控制方法
,徐洁琼,
交通运输工程学报 , 2014,
Abstract: 为了降低环形线圈车辆检测器故障率,基于指数平滑异同移动平均线法对缺失历史数据进行修补,运用Ward最小方差法对历史交通流量数据进行聚类分析,以改进立方群准则作为聚类终止条件,确定TOD多方案控制的最优方案数和最佳切换时刻,利用交通信号配时优化软件Synchro对TOD优化控制方法进行仿真验证。验证结果表明优化控制方法能够提供更精细的TOD控制方案,更能体现对实际交通需求波动的响应,优化后控制方案的车均延误减少率平均为11.90%,其中早高峰前时段的车均延误减少率为20.27%,晚低峰、晚高峰和早高峰的车均延误减少率分别为12.99%、8.07%、6.25%。
浅析高校辅导员应具备的法律素养
Analysis on the Legal Accomplishment of University Counselors
 [PDF]


Advances in Social Sciences (ASS) , 2015, DOI: 10.12677/ASS.2015.42011
Abstract:
高校辅导员的法律素养包括法律意识、法律知识和法律思维三方面内容。高校辅导员要提升自己的法律素养,应当具备尊法、守法、用法的法律意识,具备规范辅导员主体自身和规范辅导员工作职责的法律法规知识,具备工作中评估法律风险用法、开展工作依法、遇到问题找法的法律思维。
The legal accomplishment of university counselors includes three aspects: legal awareness, legal knowledge and legal thinking. If the university counselors want to improve their legal accom-plishment, they should possess the legal awareness of respecting the law, obeying the law and ap-plying the law; the legal knowledge about regulating counselors themselves and their duties; and the legal thinking, in their work, of assessing the legal risk of the work with laws, carrying out the work according laws, and solving problems through laws.
PLC液压控制系统在长钢轨引导车上的应用
Application of PLC in Control System of the Long Rail Guide Car
 [PDF]

,
Open Journal of Circuits and Systems (OJCS) , 2013, DOI: 10.12677/OJCS.2013.21001
Abstract:
本文提出了长钢轨引导车的液压控制系统,实现了长钢轨引导车各功能的准确控制在该车的连接梁相对水平度的检测中,采用三模冗余容错技术,提高数据采集的可靠性。在PLC对开关量进行控制的基础上,运用PID调节,实现了对模拟量闭环控制。
In this paper, hydraulic control of the long rail guide car is proposed, achieving the precise control of the long rail guide car’s each function. The detection of connection beam relative levelness has been improved reliability based on the three die redundant fault-tolerant technology. On the basis of the PLC’s controlling, the amount of the switch and the use of PID regulation, the analog closed-loop control is realized.

基于锥形流量延误函数的公交行程时间模型
姜璐璐,,,徐辉
公路交通科技 , 2014,
Abstract: 针对交通规划软件常用的BPR公交流量延误函数在饱和度接近或大于1时,计算值与实际值相差急剧增大的不足,提出一种锥形流量延误函数,并分析了其对公交行程时间的影响,进而通过等式关系实现模型在交通仿真软件EMME/3中的实用化。相关的案例分析显示,在公交行程时间拟合方面,锥形流量延误模型较传统的BPR曲线模型误差均值降低5.57%,误差的波动降低50.60%,效果显著。
电解海水防污技术研究现状
马长江,,刘刚,冰
腐蚀科学与防护技术 , 2005,
Abstract: 综述了电解防污技术的原理和特点,介绍了电解海水防污技术的原理和装置以及国内外的研究现状、影响有效氯产量的几个因素.同时,对比了电解海水防污技术、电解铜-铝防污技术、电解氯-铜防污技术的特点.
对电解海水防污中电流效率影响因素的初探
,杜敏,,刘刚
腐蚀科学与防护技术 , 2005,
Abstract: 简单介绍了电解海水防污中对电流效率有影响的因素.在青岛近海海域建立了实验室模拟电解海水防污系统,并以此作为研究对象.对电解海水防污中影响电流效率的因素流速、海水温度和输出电流大小进行了研究,结果表明电流效率与海水流速不呈简单的正(反)比关系;该模拟电解海水防污系统的最佳输出电流为15A;电流效率随海水温度降低而降低.
混合交通流条件下区域交通信号控制优化模型
,邢冰,,刘婧
交通运输工程学报 , 2015,
Abstract: 针对传统区域交通控制技术无法应对机非冲突干扰的问题,结合中国城市道路混合交通流的特点,研究了交叉口与路段非机动车对机动车的干扰。分析了区域路网机动车交通特征,确定了混合交通特性相似的区域。基于路段非机动车的阻滞作用,分析了交叉口通行能力的折减与相邻交叉口相位差的优化。以区域路网机动车总延误为优化目标,建立了非机动车影响条件下的区域交通信号控制优化模型,优化了信号周期时长、绿信比和相位差等参数,并利用遗传算法求解模型。利用VISSIM仿真软件,以上海市杨浦区五角场环形区域路网为例对优化模型进行验证。验证结果表明现状信号控制方案下区域路网7个交叉口机动车的车均延误为24.5~42.9s,平均为35.99s,路网总延误为256.39h,优化后交叉口的车均延误为21.8~36.4s,平均为30.12s,路网总延误为214.57h,7个交叉口车均延误减少了10%~24%,平均为16.31%。可见,优化模型能够显著降低区域路网车均延误与总延误,提高区域路网通行效率。
混合交通流条件下区域交通信号控制优化模型
Optimal model of regional traffic signal control under mixed traffic flow condition

,邢冰,,刘婧
- , 2015,
Abstract: 针对传统区域交通控制技术无法应对机非冲突干扰的问题,结合中国城市道路混合交通流的特点,研究了交叉口与路段非机动车对机动车的干扰。分析了区域路网机动车交通特征,确定了混合交通特性相似的区域。基于路段非机动车的阻滞作用,分析了交叉口通行能力的折减与相邻交叉口相位差的优化。以区域路网机动车总延误为优化目标,建立了非机动车影响条件下的区域交通信号控制优化模型,优化了信号周期时长、绿信比和相位差等参数,并利用遗传算法求解模型。利用VISSIM仿真软件,以上海市杨浦区五角场环形区域路网为例对优化模型进行验证。验证结果表明:现状信号控制方案下区域路网7个交叉口机动车的车均延误为24.5~42.9 s,平均为35.99 s,路网总延误为256.39 h,优化后交叉口的车均延误为21.8~36.4 s,平均为30.12 s,路网总延误为214.57 h,7个交叉口车均延误减少了10%~24%,平均为16.31%。可见,优化模型能够显著降低区域路网车均延误与总延误,提高区域路网通行效率。
Considering that traditional regional traffic control technology could not cope with the interference problems of motor vehicles and non-motorized vehicles conflict, the characteristics of mixed traffic flow in China’s urban road were combined, and the interferences of non-motorized vehicles on motor vehicles at intersections and links were researched. The traffic characteristics of motor vehicles in regional road network were obtained, and the regions with similar mixed traffic characteristics were defined. Based on the blockade effect of non-motorized vehicle, the capacity reduction of intersections and phase difference optimization of adjacent intersections were analyzed. The total delay of motor vehicles in regional road network was used as optimization objective, the optimal model of regional traffic signal control influenced by non-motorized vehicles was built, and signal cycle length, split ratio and phase difference were optimized. Genetic algorithm was introduced to solve the optimal model. Taking the Wujiaochang annular regional road network in Yangpu District of Shanghai as an example, the optimal model was verified by using VISSIM software. Verification result indicates that for signal control scheme before optimization, the average delays of each motor vehicles are 24.5-42.9 s at 7 intersections, the average value is 35.99 s, and total vehicle delay is 256.39 h in regional road network. For signal control scheme after optimization, the values are 21.8-36.4 s, 30.12 s and 214.57 h respectively. The decrement rate of average each vehicle delay is 10%-24% at 7 intersections, the average value is 16.31%. So the optimal model can effectively reduce each vehicle delay andtotal vehicle delay in regional road network, and the operational efficiency increases in the regional road network significantly. 4 tabs, 4 figs, 26 refs
一种基于功角计算的振荡闭锁方案
黄少锋,赵远,申洪明,
电力系统自动化 , 2015, DOI: 10.7500/AEPS20131010009
Abstract: 针对现有振荡闭锁措施在应用中存在的不足,研究了一种基于功角计算的振荡闭锁方案。新方案将再故障时刻的系统运行功角作为识别振荡程度的依据,与根据失稳条件所确定的边界判据相结合,在功角小于整定值时允许距离保护在振荡闭锁期间快速开放,功角较大时闭锁距离元件。研究结果表明,新判据原理直观,实现简单,能够定量地反映系统振荡进程,并与振荡周期自适应,改善了距离保护在振荡闭锁期间开放的性能;对系统两侧电势幅值不等的讨论提高了本方法应用的可靠性和适用性。基于PSCAD/EMTDC仿真结果验证了新方案的正确性。
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