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The inversion of injection profile was easily induced in single slug injection in heterogeneous reservoirs; it was unfavorable for enhancing oil recovery. In allusion to the problems of high cost, long duration and heavy workload of laboratory simulation, which were hard to be described by conventional reservoir simulation, based on percolation theory and physical-chemical property in polymer flooding, an uncross flow linear percolation model of two parallel layers was established. Compared with the characteristics of simulation software, a simulation method for profile inversion was proposed based on the sorting of reservoir physical property. The studied method is used for systematically studying the factors influencing the profile inversion; the result shows that the permeability contrast, its injection time and its concentration are the major factors affecting the inversion; it provides a technical support for studying the regulation and the reduction of profile inversion in polymer flooding.