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维医沙疗对兔膝骨关节炎血液流变学和血液动力学影响
卫荣,·,杨少玲,·吾甫
科技导报 , 2009,
Abstract: 探讨维医沙疗对兔膝骨关节炎动物模型血液流变及血液动力学的影响,为维医沙疗的研究提供科学依据。选用20只模型新西兰兔,用右后肢固定的方法建立兔膝骨性关节炎动物模型,随机分为2组A组为自由活动组,10只,解除石膏固定后,让其自由活动;B组为沙疗组,10只,解除石膏固定后让其自由活动,同时进行沙疗。待沙疗结束,检测血液流变学及血液动力学指标。结果表明,①与自由活动组比较,沙疗组在干预后全血黏度低切、中切、高切,红细胞电泳指数,红细胞压积均降低(P<0.05);血浆黏度,全血还原黏度低切降低明显(P<0.01),均具有统计学意义;沙疗组沙疗前后比较,全血黏度低切、中切、高切,血浆黏度,全血还原黏度低切均明显有降低(P<0.01);全血还原黏度高切,红细胞压积也有降低(P<0.05),均具有统计学意义。②与自由活动组比较,沙疗组在干预后右下肢的PS、ED数值均升高,差异均具有统计学意义(P<0.01);沙疗组沙疗前后,右下肢股动脉收缩期血流峰值(PS)、舒张期血流峰值(ED)数值明显增加并具有统计学意义(P<0.01)、阻力指数(RI)的数值降低具有统计学意义(P<0.05)。由此得出结论维医沙疗可改善模型动物的全血黏度指标;同时使其埋沙部位下肢股动脉血流速度加快,并减轻血管阻力。这可能是其抗炎作用的机制之一。
维医沙疗对股动脉分支的血流动力学影响
布热比.依明,富荣昌,阿达依.谢亚孜旦,.
- , 2016, DOI: 10.3871/j.1004-7220.2016.05.431
Abstract: 目的 研究维医沙疗对人体股动脉分叉血管血流动力学及受力的影响,进而揭示维医沙疗对人体股动脉血栓成因的作用机制。方法 在室内维医沙疗系统中对受试者进行维医沙疗,用飞利浦便携式彩色多普勒超声诊断仪分别测试受试者维医沙疗前后的股动脉血流速度峰值、内径和阻力指数(resistant index,RI),并进行统计学分析;重构股动脉分支的三维流-固耦合有限元模型,采用ANSYS workbench模拟计算维医沙疗前后流场的血流速度、压力、壁面切应力和股动脉壁的应力、应变、总位移。结果 维医沙疗后股动脉血流速度峰值的平均值和内径分别增大了32.43%和2.63%,RI降低了4.88%,股动脉血流速度峰值和RI维医沙疗前后差异均具有统计学意义(P<0.05),股动脉内径维医沙疗前后差异没有统计学意义(P>0.05)。维医沙疗后股动脉血流速度、压力和壁面切应力最大值分别增大29.91%、68.52%和46.55%;维医沙疗后股动脉壁的总位移、应力和应变最大值分别增大65.85%、45.45%和44%。结论 维医沙疗对加快血流速度、降低RI有显著影响,能增大股动脉血管内径,从而改善股动脉内血液的循环;并且维医沙疗后股动脉壁面切应力、血流速度、压力以及股动脉壁所受应力、应变和总位移有所增大,分叉处的高压力区域有所减少,维医沙疗对降低股动脉粥样硬化及血栓形成有一定的积极作用。
Objective To study effects from sand therapy of Uyghur medicine on hemodynamics in femoral artery branch and stress, so as to further discuss the functions and mechanisms of Uyghur sand therapy for treatment of femoral artery thrombosis formation. Methods Uyghur sand therapy was conducted on the subjects by indoor Uyghur sand therapy system. The peak values of blood flow velocity, inner diameter and resistance index (RI) of femoral artery before and after receiving Uyghur sand therapy were measured by the ultra-portable Doppler Diagnostic Ultrasound System for statistic analysis. Three-dimensional fluid-solid coupling model of femoral artery branch was reconstructed, and blood flow velocity, pressure, wall shear stress in the flow field as well as the equivalent stress, strain, total displacement on femoral artery wall were simulated and analyzed by the ANSYS Workbench. Results After receiving Uyghur sand therapy, the mean peak values of blood flow velocity and inner diameter of femoral artery increased by 32.43% and 2.68%, while the mean values of RI decreased by 4.88%, which showed it had the statistical difference(P<0.05).But no statistical difference was found in the inner diameter with or without Uyghur sand therapy (P>0.05).Besides, the maximum values of blood flow velocity, pressure and wall shear stress increased by 29.91%,68.51%,46.54%,respectively, while the maximum values of equivalent stress, equivalent strain, total displacement on femoral artery wall increased by 65.85%,45.45%,44%, respectively, after receiving Uyghur sand therapy. Conclusions Uyghur sand therapy can increase blood flow velocity and decrease RI obviously,and help to expand the inner diameter of femoral artery to make blood circulation inside improved. With Uyghur sand therapy, the shear stress, blood flow velocity, pressure as well as the stress, strain, total displacement on femoral artery walls also increase, meanwhile,high pressure area on femoral artery branch reduces to
沙疗下不同月龄兔膝骨关节炎股骨的骨质骨量及生物力学性能变化
Change of Volume and Mechanical Properties of Femoral Bone in Rabbits at Different Ages with Knee Osteoarthritis under Sand-therapy

胡小鑫,居来·买肉孜,黄少君,·克力,·,张春广,阿布力米·买买,张锐,西丁·阿不来提
- , 2015, DOI: 10.7507/1001-5515.20150184
Abstract: 研究维医沙疗对不同月龄兔骨性关节炎(OA)股骨的骨质骨量变化及生物力学性能的影响。实验选用新西兰大白兔成熟期组16只,生长期组16只,对其右后股骨膝关节腔注射木瓜蛋白酶建OA模型,成熟期组随机分2组:对照组(不沙疗)8只,沙疗组8只;生长期组随机分2组:对照组(不沙疗)8只,沙疗组8只;采用CT扫描4次(建模前1 d、建模第13、27、41 d),MIMICS软件获取股骨模型、各骨质的骨体积和骨体积比的变化;最后进行股骨三点弯曲试验,获得弹性载荷和弹性挠度并计算截面惯性矩、最大弯曲正应力、弯曲弹性模量和结构刚度。实验结果表明:①成熟期兔股骨OA建模前1d与第13d相比较,松质骨量增多而皮质骨量减少(P<0.05);而各自相比对照组,沙疗组在沙疗作用下OA兔股骨松质骨量减少和皮质骨量增多(P<0.05)。②各自相比对照组,沙疗组OA兔股骨挠度和横截面惯性矩无统计学差异(P>0.05),而截面面积、最大弯曲正应力、最大载荷、弹性模量和结构刚度变大(P<0.05)。本研究显示:①维医沙疗对不同月龄兔OA股骨的各骨质骨量变化都有良性影响。②维医沙疗能改善不同月龄兔OA股骨的力学性能。
The present paper is aimed to study the effect of sand-therapy with Uyghur medicine on biomechanical properties and femoral bone volume of the femur of osteoarthritis (OA) rabbits at two different ages. In the experiments, we injected Papain through the joint space of right knees into the bodies of New Zealand rabbits (16 in the growing group, and 16 in the mature group), and established an OA model. The 16 rabbits in the mature group were divided randomly into 2 sub-groups: 8 in control group (no sand therapy), and 8 sand-therapy group. The 16 rabbits in the growing group were divided randomly into 2 groups as well: 8 in the control group (no sand therapy), and 8 in the sand-therapy group. We carried out CT scanning four times (1 day before, 13th, 27th and 41st days after the establishment of the model, respectively). After importing the CT data to MIMICS, the different volumes of each sclerotin were recorded and change of the percentage of each sclerotins in total femur bone volume were analyzed. Finally the rabbit femurs were given three-point bending test, the elastic load and the elastic deflection were obtained and the inertia of the section, the maximum bending stresses, the bending modulus of elasticity and the structural rigidity were calculated. The experimental results showed that ① Compared with 1 day before and 13th day after establishment of model at maturity, the cancellous bone volume increased and cortical bone volume decreased (P<0.05), but compared with those in the control group, the cancellous bone volume of femurs decrease and cortical bone volume increased under sand-therapy (P<0.05). Compared with those in the control group, there were no significant changes in the deflection and cross-sectional moment of inertia in the sand-therapy group (P>0.05), but the maximum bending normal stress, maximum load, elastic modulus, and structural stiffness (P<0.05) in the sand therapy group were larger than those in the control group. The study showed that sand-therapy in Uyghur medicine has benign effect on bone volume of the OA rabbit
骨性关节炎模型兔股骨各骨质层体积与力学性能的关联性分析
李伟,居来?买肉孜,?,张锐,西丁?阿不来提,富荣昌,张春广,阿布力米?买买,买买吐逊?
吉林大学学报(医学版) , 2013, DOI: DOI:10.7694/jldxyxb20130408
Abstract: 目的:探讨骨性关节炎(OA)模型兔股骨各骨质层体积和力学性能的变化,阐明各骨质层体积与力学性能的关联性。方法:10只新西兰大白兔右后股骨关节腔分别在第1、5和12天注射0.3mL?kg-13%木瓜蛋白酶,建立OA模型,左后腿为正常对照组。分别在建模3d前及建模后第7、27和37天进行4次CT扫描,将CT数据导入MIMICS软件,在MIMICS软件中提取股骨模型并获得各股骨骨质层的总体积。第4次CT扫描后,取兔左右股骨作为试件,进行三点弯曲试验,获得负载-挠度曲线。对比弹性载荷和弹性挠度,计算最大弯曲正应力。结果:与正常对照组比较,在兔股骨生长过程中,模型组兔右腿横截面惯性矩和挠度无明显变化(P>0.05),但股骨生长速度、最大抗弯强度、最大抗弯正应力、股骨硬质骨增加速度和密质骨增加速度显著降低(P<0.05),软质骨减少速度基本一致(P<0.05)。结论:OA可导致兔股骨各骨质层增加的速度和力学性能显著降低,其力学性能与各骨质层存在关联。
运用传统维吾尔医药物疗法治疗抑郁症体会
力努?阿不都热依,?吾买,古哈?麦
中国中医药信息杂志 , 2007,
Abstract:
异常黑胆质性哮喘血栓前状态的变化特点
·吐,热古力·司马义,·乌甫,·艾则孜,·吾甫
科技导报 , 2014, DOI: 10.3981/j.issn.1000-7857.2014.17.010
Abstract: 为探讨新疆维吾尔族异常黑胆质型哮喘患者血栓前状态的变化特点,对76例哮喘患者按维医体液论进行辨证分型(其中异常黑胆质型哮喘组30例,非异常黑胆质型哮喘组46例),并与健康对照组89名进行对照,检测血小板膜表面糖蛋白CD41和CD62P、内皮素(ET-1)、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制剂-1(PAI-1)和凝血4项指标,即血浆纤维蛋白原(FIB)水平、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)。研究发现,与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组CD62P、ET-1、PAI-1水平均升高,差异有统计学意义(P<0.05),且异常黑胆质性哮喘组CD62P、ET-1、PAI-1水平高于非异常黑胆质性哮喘组,差异有统计学意义(P<0.05)。与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组t-PA含量均降低,差异有统计学意义(P<0.05),且以异常黑胆质性哮喘组下降较明显,差异有统计学意义(P<0.05)。与正常对照组相比,异常黑胆质性哮喘组和非异常黑胆质性哮喘组FIB含量明显升高,差异有统计学意义(P<0.01),且异常黑胆质性哮喘组FIB含量高于非异常黑胆质性哮喘组,差异有统计学意义(P<0.05)。APTT、PT时间较正常对照组偏短,差异有统计学意义(P<0.05),APTT、PT时间在异常黑胆质性哮喘组最短,其次为非异常黑胆质性哮喘组。研究表明,异常黑胆质性哮喘患者的血管内皮细胞、血小板、凝血和纤溶功能都发生紊乱,提示异常黑蛋质性哮喘处于血栓前状态,且这种状态较非异常黑胆质性哮喘更为突出。
异常黑胆质性哮喘与白细胞介素-13基因多态性的关系
·吐,热古力·司马义,·艾则孜,·乌甫,·吾甫
科技导报 , 2013, DOI: 10.3981/j.issn.1000-7857.2013.h1.017
Abstract: 本文通过对76例哮喘患者按维医体液论进行辨证分型,其中异常黑胆质性哮喘组30例、非异常黑胆质性哮喘组46例、正常对照组89例,采用聚合酶联反应——限制性片段长度多态性(PCR-RFLP)技术检测各组IL-13基因intron3+1923位点及IL-13基因+2044位点的多态性,来探讨新疆维吾尔族异常黑胆质性哮喘与白细胞介素-13(IL-13)基因多态性间的关系.结果发现IL-13基因intron3+1923位点多态性,在三组间有显著性差异(P<0.01),基因型频率异常黑胆质性哮喘组TT、TC基因型分布频率明显高于非异常黑胆质性哮喘组和正常对照组(P<0.01),非异常黑胆质性哮喘组TT、TC基因型分布频率高于正常对照组(P<0.05),而正常对照组CC基因型分布频率明显高于异常黑胆质性哮喘组(P<0.01)和非异常黑胆质性哮喘组(P<0.05),非异常黑胆质性哮喘组CC基因型分布频率高于异常黑胆质性哮喘组(P<0.05),等位基因T、C的频率分布在三组人群中有差异(P<0.01).T等位基因频率分布异常黑胆质性哮喘组高于正常对照组(P<0.01).C等位基因分布频率异常黑胆质性哮喘组低于正常对照组(P<0.05).IL-13基因+2044位点基因型频率及等位基因频率分布在各组间比较无差异(P>0.05).结果表明,新疆维吾尔族异常黑胆质性哮喘可能与IL-13基因intron3+1923位点多态性有关,而与IL-13基因+2044位点无关.
白癜风患者维医证候学特征及其临床流行病学调查与免疫功能变化的相关性
买买·艾买提,苏木·艾克,·艾则孜,阿西江·斯,哈力旦·铁力木,·托乎,布合力其·巴克,乃比江·吐,·吾甫
科技导报 , 2013, DOI: 10.3981/j.issn.1000-7857.2013.23.011
Abstract: 通过观察新疆白癜风患者的维医证候特征及其临床流行病学特征,探讨白癜风患者各体液证型与免疫功能变化的关系。采用流式细胞技术、酶联免疫吸附试验(ELISA法)检测全血中CD3+、CD4+、CD8+、CD25+、白介素-2(IL-2)、白介素-4(IL-4)、白介素-6(IL-6)、白介素-8(IL-8)、细胞间附分子(ICAM-1)、γ干扰素(IFN-γ)、肿瘤坏死因子(TNF-а)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)和干细胞因子(SCF)等指标,并进行分析。结果显示,183例白癜风患者中女性106例(57.92%),男性77例(42.08%),3~15岁之间的患者比例较高(36.61%),白癜风患者在不同异常体液中的构成比不同,黏液质型白癜风组107例(占58.47%)和非黏液质型白癜风组76例(占41.53%),其构成比大小顺序为异常黏液质型白癜风>异常黑胆质型白癜风>异常胆液质型白癜风>异常血液质型白癜风。与正常对照组相比,CD8+、IL-2、IL-6、IL-8、IFN-γ、TNF-а、ICAM-1在异常黏液质型白癜风组和非异常黏液质型白癜风组均升高(P0.05)。由此推断,异常黏液质型白癜风是白癜风维医主要证型,且白癜风患者存在自身免疫调节的异常,异常黏液质型白癜风患者的免疫功能紊乱程度较非异常黏液质型白癜风患者更为明显。
天山花楸果实多糖的提取工艺优化
阿米·阿布都肉苏,严雯,白洁,·
食品科学 , 2011,
Abstract: ?为确定以花楸果实多糖的提取工艺,先用分光光度法测定超声提取的天山花楸不同部位多糖的含量,再设计正交试验筛选超声提取天山花楸果实多糖的最佳工艺条件。结果表明:天山花楸各部位中果实含糖量最高,为4.63%。最佳工艺条件为以95%乙醇溶液醇沉、料液比1:45(g/ml)、超声时间45min、超声功率240w,天山花楸果实中多糖含量可达到5.92%。其中,料液比是影响天山花楸多糖得率的显著性因素。
180例冠心病维医异常体液分型的量化诊断入选项专家咨询研究
阿衣努·买,肯·阿西,,·吾甫
科技导报 , 2010,
Abstract: 为了建立冠心病异常体液分型诊断标准,以非诊断疾病临床相关信息为依据,对诊断明确的180例冠心病患者进行了量化诊断入选项专家咨询研究。入选的证候要素进行多分类Logistic回归分析,共线性诊断及主成分分析;使用主成分改进的多分类Logistic回归分析方法确立各证候要素对证候的贡献度,据OR值分冠心病各异常体液主症、次症。研究结果显示,异常黑胆质型冠心病的主症为心神不宁,口唇青紫,舌体中等大小、舌苔灰黑色,皮肤较凉,尿色发青;次症为舌质青紫,尿每次量少,多梦、噩梦。异常血液质型冠心病的主症为面色发红,结膜稍红,口不干,口味微苦,脉象粗、有力,大便干结;次症为睡眠尚少,出汗不多,尿色黄赤。异常粘液质型冠心病的主症为少气懒言,口唇淡白,口黏,口淡无味,出汗较多,肢体麻木;次症为面色苍白,舌苔白腻、边缘齿痕,脉象弱、沉,睡眠较多,尿量较多。异常胆液质型冠心病的主症为面色暗淡,目光无神、结膜偏黄,舌苔黄腻,皮肤较热,脉象细、硬;次症为心急易怒,面色发黄,口味甘苦,皮肤粗糙,尿色偏黄。经过对量化诊断入选项专家咨询所得到的临床信息的统计分析,认为研究结果与临床实际比较符合,可靠性高。由此得出结论将量化诊断入选项专家咨询研究应用于维医病证异常体液分型诊断的标准化、量化、科学化研究中,可以获得具有代表性和普适性的临床病证信息,故可为临床冠心病异常体液分型诊断提供客观依据。
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