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Search Results: 1 - 10 of 66729 matches for " 贾燕飞 "
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家庭微系统对学业情绪的影响——一项来自访谈的结果
The Effect of Family Microsystem on Academic Emotions—A Study from the Interview
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, 朱琳, 王芳, 董妍
Advances in Psychology (AP) , 2015, DOI: 10.12677/AP.2015.51003
Abstract:
本研究采用半结构式访谈考察了家庭微系统对子女学业情绪的影响。初一至高二共135名学生参加了访谈。结果表明,在家庭物理环境中,大多数青少年认为家庭收入对自己的学业情绪没有影响,有独立学习空间、家庭书籍量多会对青少年的学业情绪有影响;在家庭及父母特征中,更高比例的青少年认为父母的受教育程度、职业、父母表达情绪的特点以及父母调节情绪的方式均不会影响自己学业情绪,然而父母关系不融洽的被试多数认为该因素影响了自己的学业情绪;在家庭心理环境中,更高比例的被试认为父母陪伴学习、父母对青少年的教育期望以及对待青少年成绩的态度等家庭因素对自己的学业情绪有影响,大约有一半的被试认为与父母的关系会影响自己的学业情绪。
This research adopts semi-structured interviews to investigate the family microsystem’s effect on children’s academic emotions. 135 students took part in the interviews. The results showed that, in the family physical environment, a majority of teenagers considered that family income had no effect on their academic emotions, while independent learning space and family book quantity would affect adolescent’s academic emotions; In family and parents characteristics, a higher pro-portion of teenagers thought that parental education, occupation, the characteristics of parents express emotions and the way they regulate emotions would not influence their academic emotion, while most teenagers whose parental relationship not harmonious thought that the factor affected their academic emotions; In the family mental environment, a higher proportion of subjects con-sidered that parents accompany learning, parental educational expectation and the attitude toward scores affected their academic emotions, and approximately half of the subjects thought that their relationship with parents could influence their academic emotion.
维生素D改善孤独症谱系障碍患儿行为
Vitamin D Supplementation Improves Autistic Symptoms in a Child with Autism Spectrum Disorder
 [PDF]

, 王冰, 单玲, 徐志达, 冯俊, 杜琳
Asian Case Reports in Pediatrics (ACRP) , 2014, DOI: 10.12677/ACRP.2014.23005
Abstract:
目的:近年来,研究发现维生素D不足和缺乏是引起孤独症谱系障碍的环境因素之一,本研究目的在于探讨补充维生素D治疗儿童孤独症谱系障碍的可能性。方法:对我科应用维生素D治疗的1例孤独症谱系障碍的临床资料进行了回顾性分析。结果:患儿因言语发育落后和不听指令来我科就诊,结合患儿的临床症状,根据DSM-IV标准,该患儿确诊为孤独症谱系障碍。ABC,CARS和M-CHAT-R量表用来评估患儿症状的严重程度。血清25(OH)D水平为14.3 ng/ml。给予患儿维生素D肌肉注射和口服共两个月,患儿临床症状好转,疾病严重程度减轻,血清25(OH)D水平升至51.8 ng/ml。结论:补充维生素D有可能改善孤独症谱系障碍患儿的临床症状。
Objective: Vitamin D insufficiency and deficiency is recently regarded as one of the environmental factors related with autism spectrum disorders. The aim of this paper is to investigate the possible effect of vitamin D supplementation on autistic behavioral manifestations of a child with autism spectrum disorders. Methods: The clinical data of one case with autism spectrum disorders with vitamin D supplementation in our department was retrospectively analyzed. Result: The child was referred to our department for language delay and unresponsivity to instruction. In view of his clinical manifestation, diagnosis of autism spectrum disorders was made according to DSM-IV. ABC, CARS and M-CHAT-R were used to assess the autistic severity in the clinic. Serum 25(OH) level was 14.3 ng/ml. Vitamin D3 intramuscular injection and oral administration were carried out according to protocol of our clinical trial registration. With a two-month following-up, the autistic symptoms were gradually improved according to clinical manifestation and assessment batteries. Meanwhile, Serum 25(OH) level was 51.8 ng/ml. Conclusion: Vitamin D supplementation may be effective in ameliorating the autistic behavioral problems in children with autism spectrum disorders.
BTBR T~(+)tf/J小鼠:孤独症谱系障碍理想的动物模型
BTBR T~(+)tf/J Mouse: An Ideal Animal Model for Autism Spectrum Disorders
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王冰, 杜琳, 单玲, 李洪华, 冯俊,
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.33003
Abstract:
孤独症谱系障碍(autism spectrum disorders, ASD)是一组起源于儿童早期的以社会交往交流障碍和重复刻板的行为和兴趣为主要症状的神经发育性障碍。目前研究表明,ASD存在遗传基础,并在一定的环境诱导下发病,包括母体免疫因素、自身免疫紊乱及自然环境因素等,且存在脑发育的异常。但ASD的病因及发病机制尚不完全明确,尚需我们进一步研究。动物模型是评价实验结果的重要依据,确立合适的ASD模型是实验的基础。由于ASD是多因素引起的、可能涉及多种病理机制的疾病,能否选择精准复制ASD病理特征和临床症状的动物模型对ASD的深入研究具有重大意义。BTBR T~(+)tf/J (简称BTBR)小鼠是一种近交系小鼠,它不仅具有ASD的核心症状:社交减少、社交场合中发出的超声波少、重度的重复理毛行为;同时还具备与ASD类似的脑发育异常以及免疫生化指标异常。因此,BTBR小鼠是目前研究自闭症的理想模型,本文就BTBR小鼠与ASD的关系进行总结。
Autism spectrum disorder (ASD) is a complex heterogeneous of neuro developmental disorders which originate from the early childhood with the core symptoms of impaired communication, social impairments, and restricted and repetitive behaviors and interests. Research has so far indicated that ASD exists genetic basis and may be induced bursting out under certain conditions which include the factors such as maternal immunity, autoimmune disorder, natural environment etc., and children with ASD exist cerebral dysplasia. However, the pathogenesis of ASD is still inadequately understood which needs us to make further study on it. Animal model can be used as an important basis for evaluating the experimental results. Therefore, to establish an appropriate ASD model is the foundation of experiment. Since ASD is a kind of disease caused by many factors and may include many kinds of pathogenetic mechanisms, whe- ther we can choose an animal model which can accurately replicate the pathological and clinical features of ASD is of great significance for the further research of ASD. BTBR T~(+)tf/J (BTBR for short) mice is a kind of inbred strain mice which not only possesses the core symptoms such as reduction of social intercourse, lack of ultrasonic on social occasions and severe repeated grooming behavior, but also possesses cerebral dysplasia and immune biochemical index abnormalities similar to ASD. Based on this, BTBR mice is currently the ideal model for the study of autism. The aim of this article is to summarize the relationship between BTBR mice and ASD.
维生素D在自闭症中作用的研究进展
Role of Vitamin D in Autism
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, 单玲, 冯俊, 王冰, 李洪华, 杜琳
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.34004
Abstract:
自闭症临床表现为行为障碍,存在着免疫异常、氧化应激改变甚至基因异常。自闭症患儿普遍存在着维生素D缺乏。维生素D除了传统的钙磷代谢调节作用外,尚具有免疫调节、增加谷胱甘肽的合成及基因稳定等功能。我们最新的研究表明维生素D能够改善自闭症患儿的行为,提示维生素D参与了自闭症的致病过程。本文就维生素D在自闭症中的可能作用的研究进展作一综述。
Autism is characterized by abnormal immunology, altered oxidative stress and even genetic ab-normality in addition to behavioral problems. Vitamin D deficiency is ubiquity in children with autism. Vitamin D plays a role in regulating immune, up-regulating glutathione, and controlling genome in addition to traditional action on calcium and phosphate regulation. We recently reported that vitamin D supplementation could improve the behavioral manifestations in autistic child, which illustrated that vitamin D was involved in the pathogenesis of autism. Herein we summarize the research progress of the role of vitamin D in autism.
左乙拉西坦和奥卡西平治疗伴中央颞区棘波儿童良性癫痫的对比研究
Comparative Study in Treatment of Benign Childhood Epilepsy with Centrotemporal Spikes by Levetiracetam and Oxcarbazepine
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单玲, 李洪华, 杜琳, 王冰, 冯俊,
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.34005
Abstract:
目的:为明确左乙拉西坦(Levetiracetam, LEV)单药治疗首发伴中央颞区儿童良性癫痫(benign child-hood epilepsy with centro-temporal spikes, BECT)患儿的疗效及对认知的影响,采用奥卡西平(Oxcar- bazepine, OXC)作为对照进行开放性、平行性研究。方法:在来我院门诊就诊符合BECT诊断标准的患儿中选取104例,随机分为2组。OXC组51例,LEV组53例。以实验前3个月的每月平均发作次数为基线发作水平,每2~4周电话或门诊回访,记录临床发作次数。服药前、服药后3个月、6个月、12个月进行认知功能评定(4~6岁采用韦氏学龄前及小学智力量表,6~16岁采用韦氏儿童智力量表)。结果:1) 疗效比较:3次回访二组有效率、各组组内不同回访时间有效率比较无差异。2) 认知功能比较:基线时及12个月治疗后两组儿童比较无统计学差异。两组患儿用药后自身对照比较均显示多项分测验得分有增高趋势,OXC组治疗前后得分改变无统计学意义,LEV组的词汇及数字广度分测验得分的提高幅度与治疗前相比有统计学意义。结论:首选LEV治疗儿童BECT疗效与OXC相似,对BECT患儿的认知无不良影响。
Objective: To clarify the therapeutic effect and the cognitive improvement of Levetiracetam (LEV) monotherapy on the first BECT (benign childhood epilepsy with centro-temporal spikes, BECT) compared with Oxcarbazepine (OXC) in an open and parallel study. Methods: 104 patients who were admitted in our hospital and conformed to the BECT diagnostic criteria were divided into two groups randomly: OXC therapy group (51 cases) and LEV therapy group (53 cases). The monthly average seizure times of the 3 months before the beginning of the study were taken as the baseline seizure level, while the seizures times were recorded after telephone follow-up or clinical return visits per 2 - 4 weeks. Evaluations on cognitive functions were conducted before the treatment and 3 months, 6 months and 12 months after the treatment (Wechslet preschool and primary scale of intelligence were applied to the patients at the age of 4 - 6, and Wechsler intelligence scale for children were applied to those at the age of 6 - 16). Results: 1) Comparison of curative effects: The curative effect difference between the LEV group and OXC group and the difference during the different period of each group were both not significant. 2) Comparison of cognitive function: There is no statistical difference between the two groups before and after treatment. Both the two groups showed an increasing trend of intelligence test scores after treatment. There was no statistical significance between scores before and after OXC treatment, while the scores difference of words and digit span before and after the treatment of LEV had statistical significance. Conclusions: The curative effect of LEV on the first BECT patients is similar to OXC without adverse influence on cognition.
5-羟色胺在孤独症谱系障碍中的研究进展
Research Progress of Serotonin in Autism Spectrum Disorders
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王丽丽, 杜琳, 单玲, 冯俊,
International Journal of Psychiatry and Neurology (IJPN) , 2015, DOI: 10.12677/IJPN.2015.43003
Abstract:
孤独症谱系障碍(ASD)是一组以不同程度的社会交流、交往障碍和限制性、重复性行为、兴趣及活动异常为主要特征的发育行为障碍性疾病。ASD的发病率逐渐增加,但其病因不明。5-羟色胺(5-HT)是一种在人体中广泛存在的单胺类神经递质,对神经精神活动等具有一定的调节作用。研究发现,ASD患者的5-HT水平在外周血中升高,脑内降低,这种反常现象在ASD患者中较为常见。且5-HT转运体(5-HTT)基因异于常人。因此,5-HT系统的异常可能是影响ASD的一项危险因素。
Autism spectrum disorder (ASD) is a group of developmental behavioral disorders which have the main features like different levels of social interaction and communication barriers, restrictive and repetitive behaviors and abnormal interests and activities. The onset of ASD shows a trend of increase year by year, but its etiology is unknown. Serotonin is a monoamine neurotransmitter which is widely present in the human body and has a regulatory role in other neuropsychiatric events. The study found that the 5-HT of patients with ASD level increased in peripheral blood and decreased in the brain. This anomaly was common in ASD patients. 5-HT transporter gene was different from ordinary people. Therefore, the abnormality of 5-HT system may be a risk factor for ASD.

基于TCGA数据库的肝癌发生关键基因筛选
Identification Key Genes of Hepatocellular Carcinoma Base on TCGA Database
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俊君, 何宁, 张静, 姜骊,, 周琳, 郑树森
Hans Journal of Surgery (HJS) , 2015, DOI: 10.12677/HJS.2015.41001
Abstract:
目的:肝癌是消化系统常见恶性肿瘤,是全世界第三位死亡原因和中国第二位死亡原因。肿瘤基因组图谱(TCGA)计划利用大规模测序为主的基因组分析技术,通过广泛的合作,理解癌症的分子机制,本研究利用TCGA数据库深入挖掘肝癌发生关键基因。材料方法:根据标准流程对TCGA数据进行处理、整合,对数据类型及水平进行评估,用R语言(3.1.1版本)中自带的DESeq和edgeR程序包进行分析,结果以热图(pheatmap)、韦恩图(VennDiagram)、hist、PlotMA等表示。差异基因的判断标准:1,表达量在2倍以上或者0.5倍以下,2,P < 0.05,3,基因排名在前10%。结果:TCGA数据库现有癌组织mRNA芯片信息17张,匹配正常组织mRNA芯片信息9张,共26张。Hist图反映的是每个经统计后P值得分布规律,图中可刊出P值接近0处频率很高,反映差异基因的数量很大。PLotMA图反应基因表达量的分布规律,提示表达上升基因数量较多。用DESeq方法一共找到719个差异基因,而用edgeR方法找到4413个差异基因,两种方法都鉴别出的共同差异基因713个。结论:TCGA法相较于传统的芯片筛选具有样本数量大、费用小、分析简单等优势,为更多的人进行大规模的肝癌基因组学研究以及基于基因组学的后续功能研究提供了可能性。
Objective: Hepatocellular carcinoma (HCC) is a common cancer of the digestive system, is the third cause of death worldwide and the second cause of death in China. The Cancer Genome Atlas (TCGA) aims to better understand the molecular mechanisms of cancer by using a large-scale genome se-quencing-based analysis techniques and extensive cooperation. This study introduces TCGA data-base to find key genes of HCC events. Materials and Methods: The data from TCGA were processed, integrated according to the standard procedure of TCGA, data types and levels were carefully as-sessed. Bioinformatics analysis was done using the DESeq and edgeR package of R language (3.1.1 version). Results were showed as pheatmap, VennDiagram, hist, PlotMA etc. Differences were de-fined as follows: expression increased more than two folds; P <0.05; gene ranked in the top 10%. Results: 17 mRNA chips of HCC and 9 mRNA chips of normal tissue were collected from TCGA data- base. Hist figure reflected the number of different gene was large. PLotMA map showed the distribu-tion of gene expression, suggesting most genes of different expression were increased. 719 diffe-rentially expressed genes were found by DESeq, while 4413 by edger, among which 713 were com-mon different genes. Conclusion: Compared to conventional microarray, TCGA method has its own advantages such as larger number of samples, less cost and easier for analyzing, offering opportuni-ty for large-scale genomic studies of HCC and subsequent functional genomics-based research.
中美生物医学合作研究计划及其前景
吕群, 王世颖, 朱小, 筱琴, 董尔丹
中国科学 生命科学 , 2015, DOI: 10.1360/N052014-00236
Abstract: 中美生物医学合作研究计划实施3年来,收到了来自中美双方科学家共657项申请.这些申请在研究内容上涉及肿瘤、感染性疾病(包括HIV感染和艾滋病相关研究)、过敏性疾病、医学免疫学、精神健康及神经性疾病(中风和帕金森病).经过国家自然科学基金委员会和美国国立卫生研究院的联合评审程序,有109项申请项目获得了资助.联合评审的机制和获资助的109个研究项目的合作研究为今后中美双方的进一步合作奠定了基础.
男性高脂血症患者氧化应激水平叶酸干预评价
慧影,罗廷光,沈天行,,马静
中国公共卫生 , 2012, DOI: 10.11847/zgggws2012-28-05-14
Abstract: ?目的了解叶酸对高脂血症人群体内氧化应激水平的影响,为高脂血症患者预防心脑血管疾病的发生提供参考依据.方法于2010年6-7月在云南省云县人民医院体检人群中招募80例高脂血症男性患者,随机分为干预组和对照组,每组各40例;干预组患者每人口服叶酸片2.5mg/d,对照组患者不服用任何药物,干预时间为3个月;分别在干预前、后对2组患者进行体格检查、问卷调查和实验室检测.结果干预前、后比较,2组患者能量、蛋白质、脂肪、碳水化合物、膳食纤维、视黄醇当量、硫胺素、核黄素、叶酸、维生素C和维生素E等膳食营养素日平均摄入量差异均无统计学意义(P>0.05);2组患者总胆固醇(TC)、总甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、血糖(GLU)、总蛋白(TP)、白蛋白/球蛋白比值(A/G)、尿酸(UA)等生化指标水平差异均无统计学意义(P>0.05);干预前,2组患者血清8-异前列腺素(8-iso-PG)、丙二醛(MDA)、总抗氧化能力(T-AOC)、谷胱甘肽过氧化物酶(GSH-Px)、叶酸等指标水平差异均无统计学意义(P>0.05);干预后,干预组患者血清T-AOC和叶酸水平均高于对照组患者(P<0.05),血清MDA水平低于对照组患者(t=-5.995,P<0.001),血清8-iso-PG和GSH-Px水平2组间差异无统计学意义(P>0.05);相关分析结果表明,血清叶酸水平与MDA水平呈负相关关系(r=-0.536,P<0.001),与T-AOC水平呈正相关关系(r=0.239,P=0.033).结论补充叶酸可改善男性高脂血症患者体内的氧化应激水平.
道路交通违法行为研究:基于计划行为理论的视角
王良秋,孙婷婷,董妍,,安然
心理科学进展 , 2015,
Abstract: ?依据计划行为理论(thetheoryofplannedbehavior,tpb)开展道路交通违法行为研究,是多学科交叉研究的一个新视角。目前,研究者扩展了tpb的认知成分,在道路交通违法行为研究中增加了描述性规范、道德规范、预期后悔、过去行为以及风险感知等变量。结果发现,tpb扩展模型可以有效预测多种道路交通违法行为的意图和行为;依据tpb理论开展的干预研究也取得了良好的效果。未来的研究应进一步完善tpb理论及其扩展模型,并将其应用到更多的道路交通违法行为干预中。
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