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Search Results: 1 - 10 of 54618 matches for " 范芳芳? "
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边缘性人格障碍的病因机制
Pathogenetic Mechanisms of the Borderline Personality Disorder
 [PDF]

, 王振宏
Advances in Psychology (AP) , 2013, DOI: 10.12677/AP.2013.36043
Abstract: 边缘性人格障碍是以持久而普遍的认知、情绪和行为失调为特征的一种严重而复杂的行为障碍。从发展心理病理学的视角来看,边缘性人格障碍与童年期不良家庭环境、混乱的依恋关系、家庭史因素等心理社会风险因素有关,也与5-羟色胺、多巴胺等神经递质的功能缺损,前额边缘环路失调,自主神经功能失调有关,尤其重要的是边缘性人格障碍的形成可能是环境风险因素与脆弱的神经生物因素交互作用共同影响的结果。对边缘性人格病因机制考察的未来研究应该更加注重追踪研究,从多层次、多领域考察心理社会因素与生物学因素的交互在BPD病中的作用。
Borderline personality disorder (BPD), which is characterized by persistent and pervasive cognitive, emotional, and behavioral dysregulation, is among the most severe and perplexing behavioral disorders. From the developmental psychopathology approach, Borderline personality disorder is associated with psychological and social risk factors including poor family environments during childhood, disrupted attachment relationships and family history factors, and it is related to dysfunctional neurotransmitter systems, including serotonin, dopamine and so on. It is also related to dysfunction of frontolimbic circuitry and the peripheral nervous system. Most importantly, the emergence of BPD was the results of the interaction between environmental risk factors and vulnerable neurobiological factors across development. Future researches about pathogenetic mechanisms of the borderline personality disorder should focus on longitudinal or developmental studies and examine the role of the interaction between environmental risk factors and neurobiological factors in BPD from other fields and more comprehensive assessments of more methods.
晶体LaAlO3:Eu中Eu3+的光谱分析

科学通报 , 1996,
Abstract: 本文针对LaAlO_3:Eu的晶体结构特征,利用DSCPCF模型和不可约张量方法,首次推导出D_3场中的配位场微扰矩阵元,设计了配位场理论算法和计算机程序,可用于三角对称稀土配合物的光谱解析,我们具体计算分析了LaAlO_3:Eu的低温荧光光谱的归属,结果与实测值相当一致.D_3点群的状态按照子群链关系SO(3)的不可约表示进行划分,相应的基向量标记为|(γSL)JιгPρ>,其中J,Г,P分别表示SO(3),O和D_3群的不可约表示符号,ρ是P的行标,且为三维旋转群基向量|JM>的线性组合,其中变换系数S_(M,P_ρ)~(J,ιг)=sum fromγS_(M,ιгγ)~JS_(γ,P_ρ)~(ιг)由文献1]查得.若定义T_m~k为:则由张量算符方法和Wigner-Eckart定理,得到所有稀土4f~N(N=l,…,13)组态各支谱项在D_3场中的配位场微扰矩阵元表达式,仅为6个T_m~k参数的线性组合:线性组合系数f_m~k可按照J值分类列出.三个系数a,b,c与具体组态的支谱项有关.由理论分析可知,LaAlO_3:Eu具有D_3对称性,中心Eu~(3+)离子周围有12个氧原子配位,选择坐标系的OZ沿三重对称轴C_3,OX在垂直于c晶轴的平面、偏离a晶轴-30°角,则得到配位多面体EuO_(12)]中配位氧
虚拟团队的人员激励研究

科技进步与对策 , 2004,
Abstract: 在波特―劳勒激励模型的基础上分析了虚拟团队的人员激励体系,研究如何在努力―绩效―报酬―满意的体系下,激励虚拟团队员工的积极性和创造欲,以实现组织目标的最优化。虚拟团队员工激励模型
借鉴美国经验加快我国技术创新步伐

科技进步与对策 , 2003,
Abstract: 技术创新是促进美国经济发展的根本动力,美国技术创新主要是靠企业来实现的,政府只在创新系统制度的安排方面起主要作用,通过对美国技术创新的分析,提出了我国进行技术创新的一些建议。美国技术创新中国建议
中外两大数据库中“cjd”与“asp”的比较研究

图书情报工作 , 2004,
Abstract: ?对中外两大数据库“cnki”与“ebscohost”中的cjd与asp所收期刊情况、检索方法、检索功能、检索效率等进行比较研究与探讨。
高校区域教学联合体文献资源共享运行模式研究

图书情报工作 , 2007,
Abstract: ?对徐州高校教学联合体资源共建共享状况、共享建设的可行性因素进行了分析,探讨了联合体资源共享运行的整体框架设计、共享原则、建设内容、保障体系,研究了运行过程中的几种共享服务模式,对联合体资源共享建设中的问题做了几点思考总结。
拉唑类药物中间体硫醚化合物的合成
Synthesis of the Sulfoether Intermediates of Prazole Compounds
 [PDF]

刘善和, , 方红新, 张千峰
Journal of Organic Chemistry Research (JOCR) , 2014, DOI: 10.12677/JOCR.2014.22004
Abstract:
通过质子泵抑制剂作用机理设计了四种具有潜在治疗消化性疾病疗效的质子泵抑制剂衍生物,该类化合物可作为新药筛选的候选药物,为新药研发提供参考。采用的2-氯甲基-4-烷氧基-甲基吡啶盐酸盐、硫醇和甲醇钠的摩尔配比为1:1.1:2.5,高效地合成了该类化合物的硫醚中间体,硫醚产率基本在80%以上,反应条件温和,操作简单。
Four derivatives of proton pump inhibitors which have potential therapeutic efficacy of digestive diseases were designed based on the mechanism of action of proton pump inhibitor. These com- pounds can be used as new drug candidates and provide a reference for new drug development. Finally, these sulfoether intermediates were efficiently synthesized by using 2-chloro-4-alkoxy- methylpyridine hydrochloride, mercaptan and sodium methoxide, and the molar ratio of the three ingredients is 1:1.1:2.5. The yields of them are mostly above 80%. The reaction has the advantage of mild conditions and simple operation.
1-(4-氯-3-甲基吡啶甲基)-N-硝基咪唑烷-2-基胺的合成
Synthesis of 1-(4-Chloro-3 Methylpyridine)-N-Nitroimidazolealkanes-2-Amine
 [PDF]

陈向莹, , 夏佳美, 张千峰
Hans Journal of Chemical Engineering and Technology (HJCET) , 2016, DOI: 10.12677/HJCET.2016.66022
Abstract:
采用4-氯-3-甲基-2-氯甲基吡啶与2-硝基亚氨基咪唑烷进行缩合反应,合成出产物为1-(4-氯-3-甲基吡啶甲基)-N-硝基咪唑烷-2-基胺,其产率为92.3%。通过对蚜虫的毒性测试和防治飞虱的田间药效试验,研究了1-(4-氯-3-甲基吡啶甲基)-N-硝基咪唑烷-2-基胺的生物活性。
1-(4-Chloro-3-methylpyridine)-N-nitroimidazolealkanes-2-amine was synthesized by condensation reaction of 4-chloro-3-methyl-2-chloromethylpyridine and 2-nitroiminoimidazolidine. The total yield is 92.3%. Through the toxicity test of aphids and field trials of preventing BPH, it studied 1-(4-chloro-3-methylpyridine)-N-nitroimidazolealkanes-2-amine biological activity.
氯甲基吡啶衍生物的工业化生产方法
Industrial Production Methods of Chloromethylpyridine Derivatives
 [PDF]

陈向莹, , 夏佳美, 张千峰
Hans Journal of Chemical Engineering and Technology (HJCET) , 2016, DOI: 10.12677/HJCET.2016.66021
Abstract:
针对现有技术存在的问题,本文提供一种生产成本相对较低、对环境友好、对废物进行最大限度的循环利用的氯甲基吡啶衍生物的工业化生产方法。该生产工艺主要分为N-氧化、硝化、亲核取代、重排水解和氯甲基化五个工段。
In view of the problems existing in the prior technology, this paper provides an industrial produc-tion method of chloromethylpyridine derivatives. The synthetic product of this method is relatively low in cost, friendly to environment, and can make the best use of waste. The production process is divided into five sections: N-oxidation, nitration, nucleophilic substitution, rearrangement hydrolysis and chloromethylation.
2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析
Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine
 [PDF]

陈向莹, , 夏佳美, 张千峰
Journal of Organic Chemistry Research (JOCR) , 2016, DOI: 10.12677/JOCR.2016.44014
Abstract:
以2,3,5-三甲基吡啶为起始原料,经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。
2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.
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