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Search Results: 1 - 10 of 12855 matches for " 翁齐铖 "
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血清乙型肝炎核心相关抗原阴性正常参考值的探讨
张占卿,陆伟,王雁冰,,张智勇,周新兰
- , 2016, DOI: 10.16118/j.1008-0392.2016.02.006
Abstract: 目的 探讨血清HBcrAg合理的阴性正常参考值。方法 初治的乙型肝炎患者230例和非乙型肝炎患者52例入选本研究。血清HBcrAg采用化学发光酶免疫法和Fujirebio Lumipulse G1200全自动化学发光免疫系统检测。数据处理和统计分析采用SPSS 16.0软件。结果血清HBcrAg呈非正态分布(P<0.01)。HBsAg阳性患者血清HBcrAg与HBV DNA呈显著正相关(P<0.01)。血清HBcrAg诊断HBsAg阳性患者的ROC曲线下面积(0.953)显著大于对角参考线下面积(P<0.01)。当血清HBcrAg≥1500U/ml、≥1250U/ml、≥1000U/ml、≥750U/ml、≥500U/ml时,其诊断HBsAg阳性患者的灵敏度和特异度分别为0.865和0.981、0.865和0.962、0.870和0.923、0.896和0.904、0.909和0.885。结论 血清HBcrAg<1000U/ml可能是合理的阴性正常参考值。
Objective To explore the rational negative normal reference value of serum hepatitis B core-related antigen(HBcrAg). Methods Two hundred and thirty patients with Nave hepatitis B and 52 non- hepatitis B patients were enrolled in the study. Serum HBcrAg levels were measured by Fujirebio Lumipulse G1200 automatic chemiluminescence immunoassay system. SPSS 16.0 software was used for data processes and statistical analyses. Results Serum HBcrAg values were non-normal distribution(P<0.01). Serum HBcrAg values were positively correlated with HBV DNA in HBsAg-positive patents(P<0.01). The area under ROC curve of serum HBcrAg in the diagnosis of HBsAg-positive patients was 0.953. When the cut-off values of serum HBcrAg were taken as 1500U/ml, 1250U/ml, 1000U/ml, 750U/ml, 500U/ml, the sensitivity and specificity in diagnosis of HBsAg-positive patients were 0.865 and 0.981,0.865 and 0.962,0.870 and 0.923,0.896 and 0.904,0.909 and 0.885. Conclusion Serum HBcrAg<1000U/ml may be the reasonable negative normal reference value
血清病毒学标记物预测慢性乙型肝炎肝组织病理状态的评价
张占卿,陆伟,,张智勇,王雁冰,冯艳玲
- , 2015, DOI: 10.16118/j.1008-0392.2015.04.012
Abstract: 目的评价血清病毒学标记物预测慢性乙型肝炎(CHB)肝组织病理状态的有效性。方法 CHB患者211例,其中HBeAg阳性和阴性患者分别为125例和86例。血清HBsAg、HBeAg、抗-HBc和HBcrAg分别采用化学发光微粒子免疫法和化学发光酶免疫法检测,血清HBV DNA采用实时荧光定量PCR检测。结果 HBeAg阳性患者,血清HBsAg、HBeAg、HBcrAg、HBV DNA与病理学分级和分期均呈显著负相关(P<0.05);血清抗-HBc与病理学分级和分期均呈显著正相关(P<0.05);HBeAg阴性患者,血清HBsAg、抗-HBc与病理学分级和分期无显著相关性(P>0.05);血清HBcrAg、HBV DNA与病理学分级和分期均呈显著正相关(P<0.01)。有序logistic回归分析显示,HBeAg阳性患者,血清HBsAg预测病理学分级和HBsAg、HBeAg预测病理学分期的偏回归系数有统计学意义(P<0.05);HBeAg阴性患者,血清HBcrAg和HBV DNA预测病理学分级和分期的偏回归系数均有统计学意义(P<0.05)。结论 血清HBsAg和血清HBsAg、HBeAg分别有预测HBeAg阳性患者肝组织病理学分级和分期的价值,血清HBcrAg和HBV DNA均有预测HBeAg阴性患者肝组织病理学分级和分期的意义。
Objective To assess the application of serum viral markers in prediction of pathological status of liver tissue in patients with chronic hepatitis B. Methods Two hundred and eleven patients with chronic hepatitis B, including 125 HBeAg-positive and 86 HBeAg-negative patients, were enrolled in present study. Serum HBsAg, HBeAg, anti-HBc and HBcrAg were measured by chemilu-minescence microparticle immunoassay and chemiluminescence enzyme immunoassay, respectively; HBV DNA was assayed by Real Time fluorescent quantitative PCR. ResultsIn HBeAg-positive patients, serum HBsAg, HBeAg, HBcrAg and HBV DNA were significantly correlated negatively with the pathological grading and staging of liver tissue(P<0.05), and serum anti-HBc was significantly correlated positively with the pathological grading and staging of liver tissue(P<0.05). in HBeAg-negative patients, serum HBsAg and anti-HBc were not correlated with the pathological grading and staging of liver tissue(P>0.05), however, serum HBcrAg and HBV DNA were significantly correlated positively with the pathological grading and staging of liver tissue(P<0.01). Ordinal logistic regression analyses showed that in HBeAg-positive patients the partial regression coefficients of serum HBsAg in predicting the pathological grading and serum HBsAg, HBeAg in predicting the pathological staging of liver tissue had statistical significance(P<0.05); in HBeAg-negative patients, the partial regression coefficients of serum HBcrAg and HBV DNA in predicting both the pathological grading and staging of liver tissue had statistical significance(P<0.05). Conclusion Serum HBsAg and HBsAg, HBeAg in HBeAg-positive patients have predictive value to the pathological grading and staging, and serum HBcrAg and HBV DNA in HBeAg-negative patients have predictive significance to the pathological grading and staging of liver tissue
委陵菜黄酮在大鼠体内的药动学研究
,,段宏泉
药物评价研究 , 2010,
Abstract: 目的:建立测定血浆中委陵菜黄酮的分析方法,初步对该化合物在大鼠体内的经时过程进行考察。方法:建立委陵菜黄酮的HPLC测定方法,考察大鼠iv委陵菜黄酮(10、20、40 mg/kg)后血药浓度-时间曲线。结果:大鼠尾iv 3 个剂量委陵菜黄酮后,血浆药时曲线符合三室模型,药时曲线下面积AUC0-180分别为346.05、455.74和1 655.14 μg/(mL?min),分布相半衰期t1/2α分别为103.90、15.59和9.49 min,消除相半衰期t1/2β分别为30 580.98、2 045.70和894.84 min。结论:iv给药后,委陵菜黄酮血浆药时曲线符合三室模型,在大鼠体内迅速分布,但消除速率较慢。
珠江三角洲全新世环境变化与文化起源及传播的关系

地理科学 , 1994,
Abstract: 珠江三角洲全新世环境变化直接导致不同文化类型的演替、园圃业与稻作业的兴起,特别是海陆变迁、水系河网演变促进了珠江三角洲晚期原始文化和稻作文化的传播,并最终促使文化区的形成.
正交优化载药超高分子量聚乙烯药物分散及性能
,屈树新,廖跃,段可,
复合材料学报 , 2011, DOI: CNKI:11-1801/TB.20110720.1424.035
Abstract: 应用正交设计法选取阿仑膦酸钠(ALN)加入超高分子量聚乙烯(UHMWPE)后均匀分散的最佳工艺参数,运用社会科学统计软件包(SPSS)对正交实验结果进行极差与方差分析,在最佳工艺参数下制备ALN/UHMWPE,通过拉伸力学性能实验、XRD、DSC、SEM及EDS表征样品性能。由正交实验得出ALN加入后均匀分散最佳工艺条件:表面活性剂F68,分散方式为超声分散,ALN质量分数1%,分散温度37℃;方差分析表明,实验具有统计学意义;拉伸力学实验结果表明,表面活性剂F68的加入可以有效提高(ALN-F68)/UHMWPE拉伸强度与断裂伸长率;加入表面活性剂样品的结晶度较未加表面活性剂对照样有所提高,但均低于空白UHMWPE,ALN没有改变UHMWPE晶型及其热熔性质;加入表面活性剂有助于ALN在UHMWPE中的均匀分散。
台湾发展有机农业的主要成效及其借鉴作用
伯奇,林娇健,王子
科技导报 , 2002,
Abstract: 20世纪以来,石油农业的发展在取得重大成就的同时,也带来了严重的负面影响,尤其是过量使用化学合成物对人体健康造成了相当程度的损害。顺应世界环保的潮流,大力发展有机农业已刻不容缓。进入90年代后,面对生态环境遭受破坏的严酷现实,台湾加强对农业新产业的开发力度,相继建立了一批生态、精致、休闲、有机等新型农业,为推进农业产业化升级起到了积极的导向作用[1]有许多技术措施与管理经验值得借鉴。
台湾发展有机农业的主要成效及其借鉴作用
伯奇,林娇健,王子
科技导报 , 2002,
Abstract: 20世纪以来,石油农业的发展在取得重大成就的同时,也带来了严重的负面影响,尤其是过量使用化学合成物对人体健康造成了相当程度的损害。顺应世界环保的潮流,大力发展有机农业已刻不容缓。进入90年代后,面对生态环境遭受破坏的严酷现实,台湾加强对农业新产业的开发力度,相继建立了一批生态、精致、休闲、有机等新型农业,为推进农业产业化升级起到了积极的导向作用[1]有许多技术措施与管理经验值得借鉴。
催化精馏过程模拟稳态模型的研究进展
永君,惠新
化工进展 , 2010,
Abstract: 对催化精馏过程模拟的平衡级模型、非平衡级模型和非平衡池模型3个常用的稳态模型及其求解方法进行了综述,并简要分析了各模型和求解方法的优缺点,讨论了催化精馏过程模拟的稳态模型及其求解方法未来的发展方向。
高血压患者酒精依赖影响因素病例对照研究
杨丽全,王惠珍,,郑玉仁,魏碧蓉,郑建盛
中国公共卫生 , 2011, DOI: 10.11847/zgggws2011-27-11-53
Abstract: ?酒精依赖行为是长期过量饮酒引起的中枢神经系统中毒,表现为对酒精的渴求和经常需要饮酒的强迫性体验.近年来,酒精滥用和依赖性障碍的发生率呈明显上升趋势.高血压患者确诊后仍长期酗酒,将对心、脑和肝等脏器造成严重损害.目前研究多侧重于饮酒是高血压发病危险因素的探索,较少对高血压患者患病后酒精依赖行为的影响因素进行调查.本研究于2009年3月-2010年5月对福建省103例高血压患者患病后酒精依赖行为进行病例对照研究,探索改善高血压患者患病后酗酒行为的干预措施,为制定干预措施、进行健康教育和家庭护理提供依据.
火灾后混凝土预应力桥梁检测试验与评估
Test and Assessment of Prestressed Concrete Bridge after Fire
 [PDF]

冯兆祥,, 缪长青
Hans Journal of Civil Engineering (HJCE) , 2015, DOI: 10.12677/HJCE.2015.45029
Abstract: 以常熟浒浦大桥为背景,对于火灾后预应力钢筋混凝土桥梁进行评估分析研究。从火灾裂缝、混凝土脱落、受力钢筋露筋等方面对于桥梁进行了火灾病害观测分析,通过混凝土强度测定、静力荷载试验和有限元分析,对于火灾后桥梁的承载能力进行了分析评估。结果表明受火区作用较严重的简支空心板力学性能下降明显。
Changshu Hupu Bridge was taken as an example to test and evaluate the prestressed concrete bridge after fire. On the fire crack, the concrete loss, and the reinforced exposure, the bridge fire disease was observed and analyzed. Taking the determination of concrete strength, static loading testing, and finite element analysis, the carrying capacity of the bridge after fire was analyzed and evaluated. The results showed that the simply-supported hollow slab mechanics performance in seriously fired area declines obviously.
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