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Search Results: 1 - 10 of 94850 matches for " 程伟渊 "
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肿瘤蛋白MDMX与抑制剂PMI作用机制的分子动力学研究
Molecular Dynamics Insight into the Interaction Mechanism of Inhibitor PMI with MDMX
 [PDF]

, 梁志强,, 伊长虹, 王克彦, 李洪云, 陈建中
Hans Journal of Computational Biology (HJCB) , 2012, DOI: 10.12677/hjcb.2012.23003
Abstract: 恢复抑癌蛋白p53的功能已经成为一种治疗癌症的新途径。本文采用分子动力学模拟和MM-PBSA方法计算了抑制剂PMI与肿瘤蛋白MDMX的结合自由能。结果表明范德华相互作用驱动了PMIMDMX的结合。同时也使用基于残基对的自由能分解方法计算了残基残基相互作用,结果不仅表明PMI5个残基能与MDMX产生强烈的相互作用,而且也表明CH-CHCH-ππ-π相互作用主导了PMIMDMX疏水性裂缝中的结合。我们期望这个研究能为抑制p53-MDMX相互作用药物的研发提供理论上的启示。
Restoration of p53 function is considered to be a new therapeutic strategy for anti-cancers. Molecular Dynamics (MD) simulations coupled with Molecular
试论自我意识理论在教育中的应用
桑标,
心里发展与教育 , 1994,
Abstract: 本文分两部分.第一部分对自我意识的有关理论探讨作了回顾,指出研究者对其在概念界定、表现形式、发展研究上的种种看法;第二部分着重阐述了自我意识理论在教育中的应用问题,认为自我意识不仅仅为教学活动、师生关系、班级组织等教育实践提供理论依据,而且更重要的是实现教育内化的关键.
基于Beowulf集群的大电力系统可靠性评估蒙特卡罗并行仿真
刘洋,周家启,谢开贵,胡小正,建翼,,,陈炜骏,胡博
中国电机工程学报 , 2006,
Abstract: 研究了大电力系统可靠性评估并行仿真问题:分别采用状态采样法和系统状态转移采样法进行Monte-Carlo并行仿真。建立了与收敛判据相结合的任务分配拓扑结构,并根据2种采样方法的不同需要采用了不同的伪随机数生成方式,详细地分析了配合收敛控制的异步模拟过程,最后基于构建的Beowulf集群环境进行测试系统的可靠性评估计算。2种Monte-Carlo并行仿真方法均得到较高的加速比和并行效率,其可靠性指标的计算结果亦与串行环境下得到的结果基本保持一致。该文所做工作是对国外若干电力系统可靠性评估并行仿真研究的深入和发展。
恶性胶质瘤患者外周血淋巴细胞基因表达谱的研究
迎新,唐文
第三军医大学学报 , 2006,
Abstract:
1989年本校科研简况
董安芬,
南京林业大学学报(自然科学版) , 1989, DOI: 10.3969/j.jssn.1000-2006.1989.04.019
Abstract: <正>1989年我校科研工作取得了较好的成绩。全年在研项目总数为107项。其中国家攻关、部(省)重点课题29项;国家自然科学基金等基金项目16项;国家及部标准制订项目11项;校自选课题为51项。国家自然科学基金获准了6项,资助金额达15.30万元。基础理论研究项目的不断增加,促进了我校科研工作的后劲。
柔性结构振动主动控制的气浮机动台实验系统
,
重庆大学学报 , 1998,
Abstract: 针对目前存在的对具有刚性运动基的刚体-柔性体耦合结构的振动主动控制缺乏深入研究的状况,阐述了建立该实验系统的意义,详细介绍了气浮机动台实验系统的各组成部分及作用,整个系统已基本建成,使运动基在气浮状态下以不同的角速度实现不同的角位移。
基于原-对偶内点算法的WLAV状态估计

电力系统自动化 , 1999,
Abstract: 针对现有WLAV状态估计算法存在的问题,将原—对偶内点算法引入WLAV状态估计问题的求解过程。结合WLAV状态估计问题的特点,提出了罚参数修正及迭代限制方法,并利用稀疏矩阵技术进行计算。算例分析表明,该算法的数值稳定性好、迭代次数少、计算速度较快,性能优于传统方法。
机车编组方式对列车再充气特性的影响
Influence of locomotive marshalling mode on air-recharging characteristic of train

胡杨,,
- , 2017,
Abstract: 为量化机车编组方式对重载列车再充气特性的影响,结合神华铁路万吨重载列车纵向动力学试验结果,对万吨重载列车再充气 特性进行分析,并利用基于气体流动理论的空气制动系统仿真方法,建立列车空气制动系统模型,通过试验对比验证仿真系统的准确 性,对不同机车编组、多机车不同滞后时间和不同减压量的再充气过程进行仿真。计算结果表明:列车头部机车数目增加对首车再充 气特性影响较小,2种编组列车的副风缸压强差值小于15 kPa; 单编列车充风时间是3辆机车编组充风时间的2.4倍; 当机车集中于列 车前部时,充风时间缩短量与机车数目增加量非正比关系,即3辆机车集中编组的充风时间不是单编列车充风时间的3/10; 机车数目 对于充风时间的影响完全取决于编组方式,分散编组减压50 kPa的充风时间较集中编组节省37%~75%,机车集中编组减压110 kPa的 充风时间是分散编组的1.5~3.5倍,分散编组常用全制动的充风时间为机车集中编组的30%~63%; 从控机车滞后时间对充风时间影 响较小,充风时间增长量与滞后时间相近; 得到4种机车编组方式不同减压量的充风时间的二次拟合函数,随着减压量的增加,4种机 车编组的充风时间增长缓慢。
In order to quantify the influence of locomotive marshalling mode on the air-recharging characteristic of heavy-haul train, combining with longitudinal dynamics test results of Shenhua ten-thousand-tons heavy-haul trains, the air-recharging characteristics of train were analyzed, and the train air brake system model was established by using the air brake system simulation method based on airflow theory. The accuracy of the simulation system was verified by test result comparison, and the air-recharging processes on different locomotive marshalling modes, different lag times of multi-locomotives and different pressure reductions were simulated. Calculation result shows that the locomotive's quantity in the front of train has little influence on the air- recharging characteristic of first vehicle, and the difference of auxiliary reservoir pressures for two marshalling modes is less than 15 kPa. The air-charging time of single locomotive marshalling mode is 2.4 times of air-charging time of three locomotives marshalling mode. When the locomotive has centralized on the forepart of the train, the charging time reduction is non-proportional to the increase number of locomotives, which means that the air-charging time of three locomotives concentrated marshalling mode is not three tenth of the air-charging time for single locomotive marshalling train. The influence of locomotive number on air-charging time depends entirely on the marshalling mode. The air-charging time of distributed power marshalling mode with 50 kPa reduction compared to concentrated locomotive marshalling mode decreases by 37%-75%. The air-charging time of locomotive concentrated marshalling mode with 110 kPa reduction is 1.5-3.5 times of distributed power marshalling mode. The air-charging time of distributed power marshalling mode for full service braking is 30%-63% of locomotive concentrated marshalling mode. The lag time of slave control locomotive has little influence on the air-charging time. The increment of air-charging time is similar to the lag time. The quadratic fitting
高校环境教育新模式浅析—以福建省为例
Analysis of New Model of Environmental Education in Universities—Take Fujian Province as an Example
 [PDF]

冯杰,
Sustainable Development (SD) , 2016, DOI: 10.12677/SD.2016.61007
Abstract:
面对日益恶化的自然环境,人们意识到进行环境教育,提升大众的环境意识是解决环境问题的根本途径。党的十八届五中全会将“绿色”作为“十三五”规划的重要理念,具有十分深远的意义。福建省植被覆盖率达61%以上,长久以来,福建省将生态文明大省作为自己的发展目标,环境建设也取得了一定的成就。但仍存在很多问题,特别是在高校环境教育方面。分析福建省环境教育现实问题,结合福建省具体情况,提出高校环境教育发展的“三元空间”模式,以期助力福建省高校环境教育发展。
In the face of the deteriorating natural environment, people get to realize that to carry on the en-vironmental education and enhance the public’s environmental consciousness is the fundamental way to solve the problem of environment. In the Fifth Plenum of the 18th Central Committee of the Communist Party of China, the government regards “green” as an important concept of the “Thir-teenth Five-Plan”, which has very far-reaching significance. The vegetation coverage of Fujian province is above 61%, and for a long time, Fujian province attaches much importance to the eco-logical civilization and regards it as its own development goals, which makes some achievements in environmental construction. But there still remain many problems, especially in the exploration of university environmental education. According to the reality and current situation of envi-ronmental education in Fujian province, the model of “three dimensions” is put forward to boost the development of environmental education in universities in Fujian Province.
发达国家环境教育模式探析及经验借鉴
Analysis of Developed Countries Environmental Education Mode and Experience for Reference
 [PDF]

冯杰,
Advances in Social Sciences (ASS) , 2016, DOI: 10.12677/ASS.2016.51005
Abstract:
20世纪60年代以来,全球环境问题特别是发达国家日益突出,发达国家最早开始着手进行多方面的治理探索,并取得了较好效果。长期的环境治理经验使发达国家逐步认识到环境教育是进行环境治理的首要任务,高等院校是环境教育专题研究的主阵地,积累了丰富的环境教育经验。总结发达国家环境教育的实践经验,为创新我国的环境教育模式,创造有利的环境教育氛围,最终推进我国环境教育事业的新发展作出努力是本文探索的落脚点和归宿。
Since the 1960s, the global environment problem is increasingly prominent, especially in devel-oped countries. At the same time, developed countries began the governance exploration early and got good effects. Long-term environmental governance experience makes developed countries gradually realize that environmental education is the priority of environmental governance. In-stitutions of universities are the main land for environmental education research, having accu-mulated rich experiences in environmental education. The aim of this paper is to summarize the practice of environmental education experience of developed countries, to create new mode and establish favorable environmental education atmosphere, and ultimately to promote the devel-opment of our country’s environmental education.
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