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Search Results: 1 - 10 of 335339 matches for " 王琳玲 "
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Hg2+胁迫对小麦幼苗中蔗糖酶和苯丙氨酸解氨酶活性的影响、
段璋,
河南农业科学 , 2011,
Abstract: 为了研究汞对小麦幼苗叶片、根和萌发种胚的蔗糖酶(Inv)和苯丙氨酸解氨酶(PAL)活性的影响,采用水培法,用不同浓度的Hg2+对小麦进行浸种处理,测定小麦在不同时间和不同器官的Inv和PAL活性,结果表明,随着Hg2+浓度的递增,小麦幼苗叶片、根和萌发种胚中,酸性和中/碱性Inv的活性都呈先上升而后下降的趋势,小麦幼苗叶片、根和萌发种胚的PAL的活性也呈先上升而后下降的趋势。不同器官的两种酶活性相比,快速生长的叶片和根部的酶活性都比萌发种胚的高。低浓度Hg2+(≤0.100mmol/L)对小麦幼苗的Inv和PAL活性有短暂的促进作用,高浓度Hg2+(≥0.200mmol/L)对Inv和PAL活性有显著的抑制作用。当Hg2+浓度为0.100mmol/L时,各种Inv和PAL活性达到最大,由此推断,此浓度是影响小麦幼苗生长的阈值浓度。
糜米发酵液中优势乳酸菌分离鉴定
,刘爱国,李娜,
食品科学 , 2007,
Abstract: ?本实验对生产发酵剂扩培后的糜米发酵液进行乳酸菌的分离鉴定。从样品中分离到12株乳酸菌,9株属于乳杆菌属的6个种,3株属于乳球菌属的乳酸乳球亚种。它们赋予产品良好的风味,适于作食品发酵剂。
维生素D改善孤独症谱系障碍患儿行为
Vitamin D Supplementation Improves Autistic Symptoms in a Child with Autism Spectrum Disorder
 [PDF]

贾飞勇, ,, 徐志达, 冯俊燕,
Asian Case Reports in Pediatrics (ACRP) , 2014, DOI: 10.12677/ACRP.2014.23005
Abstract:
目的:近年来,研究发现维生素D不足和缺乏是引起孤独症谱系障碍的环境因素之一,本研究目的在于探讨补充维生素D治疗儿童孤独症谱系障碍的可能性。方法:对我科应用维生素D治疗的1例孤独症谱系障碍的临床资料进行了回顾性分析。结果:患儿因言语发育落后和不听指令来我科就诊,结合患儿的临床症状,根据DSM-IV标准,该患儿确诊为孤独症谱系障碍。ABC,CARS和M-CHAT-R量表用来评估患儿症状的严重程度。血清25(OH)D水平为14.3 ng/ml。给予患儿维生素D肌肉注射和口服共两个月,患儿临床症状好转,疾病严重程度减轻,血清25(OH)D水平升至51.8 ng/ml。结论:补充维生素D有可能改善孤独症谱系障碍患儿的临床症状。
Objective: Vitamin D insufficiency and deficiency is recently regarded as one of the environmental factors related with autism spectrum disorders. The aim of this paper is to investigate the possible effect of vitamin D supplementation on autistic behavioral manifestations of a child with autism spectrum disorders. Methods: The clinical data of one case with autism spectrum disorders with vitamin D supplementation in our department was retrospectively analyzed. Result: The child was referred to our department for language delay and unresponsivity to instruction. In view of his clinical manifestation, diagnosis of autism spectrum disorders was made according to DSM-IV. ABC, CARS and M-CHAT-R were used to assess the autistic severity in the clinic. Serum 25(OH) level was 14.3 ng/ml. Vitamin D3 intramuscular injection and oral administration were carried out according to protocol of our clinical trial registration. With a two-month following-up, the autistic symptoms were gradually improved according to clinical manifestation and assessment batteries. Meanwhile, Serum 25(OH) level was 51.8 ng/ml. Conclusion: Vitamin D supplementation may be effective in ameliorating the autistic behavioral problems in children with autism spectrum disorders.
BTBR T~(+)tf/J小鼠:孤独症谱系障碍理想的动物模型
BTBR T~(+)tf/J Mouse: An Ideal Animal Model for Autism Spectrum Disorders
 [PDF]

,,, 李洪华, 冯俊燕, 贾飞勇
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.33003
Abstract:
孤独症谱系障碍(autism spectrum disorders, ASD)是一组起源于儿童早期的以社会交往交流障碍和重复刻板的行为和兴趣为主要症状的神经发育性障碍。目前研究表明,ASD存在遗传基础,并在一定的环境诱导下发病,包括母体免疫因素、自身免疫紊乱及自然环境因素等,且存在脑发育的异常。但ASD的病因及发病机制尚不完全明确,尚需我们进一步研究。动物模型是评价实验结果的重要依据,确立合适的ASD模型是实验的基础。由于ASD是多因素引起的、可能涉及多种病理机制的疾病,能否选择精准复制ASD病理特征和临床症状的动物模型对ASD的深入研究具有重大意义。BTBR T~(+)tf/J (简称BTBR)小鼠是一种近交系小鼠,它不仅具有ASD的核心症状:社交减少、社交场合中发出的超声波少、重度的重复理毛行为;同时还具备与ASD类似的脑发育异常以及免疫生化指标异常。因此,BTBR小鼠是目前研究自闭症的理想模型,本文就BTBR小鼠与ASD的关系进行总结。
Autism spectrum disorder (ASD) is a complex heterogeneous of neuro developmental disorders which originate from the early childhood with the core symptoms of impaired communication, social impairments, and restricted and repetitive behaviors and interests. Research has so far indicated that ASD exists genetic basis and may be induced bursting out under certain conditions which include the factors such as maternal immunity, autoimmune disorder, natural environment etc., and children with ASD exist cerebral dysplasia. However, the pathogenesis of ASD is still inadequately understood which needs us to make further study on it. Animal model can be used as an important basis for evaluating the experimental results. Therefore, to establish an appropriate ASD model is the foundation of experiment. Since ASD is a kind of disease caused by many factors and may include many kinds of pathogenetic mechanisms, whe- ther we can choose an animal model which can accurately replicate the pathological and clinical features of ASD is of great significance for the further research of ASD. BTBR T~(+)tf/J (BTBR for short) mice is a kind of inbred strain mice which not only possesses the core symptoms such as reduction of social intercourse, lack of ultrasonic on social occasions and severe repeated grooming behavior, but also possesses cerebral dysplasia and immune biochemical index abnormalities similar to ASD. Based on this, BTBR mice is currently the ideal model for the study of autism. The aim of this article is to summarize the relationship between BTBR mice and ASD.
维生素D在自闭症中作用的研究进展
Role of Vitamin D in Autism
 [PDF]

贾飞勇,, 冯俊燕, , 李洪华,
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.34004
Abstract:
自闭症临床表现为行为障碍,存在着免疫异常、氧化应激改变甚至基因异常。自闭症患儿普遍存在着维生素D缺乏。维生素D除了传统的钙磷代谢调节作用外,尚具有免疫调节、增加谷胱甘肽的合成及基因稳定等功能。我们最新的研究表明维生素D能够改善自闭症患儿的行为,提示维生素D参与了自闭症的致病过程。本文就维生素D在自闭症中的可能作用的研究进展作一综述。
Autism is characterized by abnormal immunology, altered oxidative stress and even genetic ab-normality in addition to behavioral problems. Vitamin D deficiency is ubiquity in children with autism. Vitamin D plays a role in regulating immune, up-regulating glutathione, and controlling genome in addition to traditional action on calcium and phosphate regulation. We recently reported that vitamin D supplementation could improve the behavioral manifestations in autistic child, which illustrated that vitamin D was involved in the pathogenesis of autism. Herein we summarize the research progress of the role of vitamin D in autism.
左乙拉西坦和奥卡西平治疗伴中央颞区棘波儿童良性癫痫的对比研究
Comparative Study in Treatment of Benign Childhood Epilepsy with Centrotemporal Spikes by Levetiracetam and Oxcarbazepine
 [PDF]

, 李洪华,, , 冯俊燕, 贾飞勇
International Journal of Psychiatry and Neurology (IJPN) , 2014, DOI: 10.12677/IJPN.2014.34005
Abstract:
目的:为明确左乙拉西坦(Levetiracetam, LEV)单药治疗首发伴中央颞区儿童良性癫痫(benign child-hood epilepsy with centro-temporal spikes, BECT)患儿的疗效及对认知的影响,采用奥卡西平(Oxcar- bazepine, OXC)作为对照进行开放性、平行性研究。方法:在来我院门诊就诊符合BECT诊断标准的患儿中选取104例,随机分为2组。OXC组51例,LEV组53例。以实验前3个月的每月平均发作次数为基线发作水平,每2~4周电话或门诊回访,记录临床发作次数。服药前、服药后3个月、6个月、12个月进行认知功能评定(4~6岁采用韦氏学龄前及小学智力量表,6~16岁采用韦氏儿童智力量表)。结果:1) 疗效比较:3次回访二组有效率、各组组内不同回访时间有效率比较无差异。2) 认知功能比较:基线时及12个月治疗后两组儿童比较无统计学差异。两组患儿用药后自身对照比较均显示多项分测验得分有增高趋势,OXC组治疗前后得分改变无统计学意义,LEV组的词汇及数字广度分测验得分的提高幅度与治疗前相比有统计学意义。结论:首选LEV治疗儿童BECT疗效与OXC相似,对BECT患儿的认知无不良影响。
Objective: To clarify the therapeutic effect and the cognitive improvement of Levetiracetam (LEV) monotherapy on the first BECT (benign childhood epilepsy with centro-temporal spikes, BECT) compared with Oxcarbazepine (OXC) in an open and parallel study. Methods: 104 patients who were admitted in our hospital and conformed to the BECT diagnostic criteria were divided into two groups randomly: OXC therapy group (51 cases) and LEV therapy group (53 cases). The monthly average seizure times of the 3 months before the beginning of the study were taken as the baseline seizure level, while the seizures times were recorded after telephone follow-up or clinical return visits per 2 - 4 weeks. Evaluations on cognitive functions were conducted before the treatment and 3 months, 6 months and 12 months after the treatment (Wechslet preschool and primary scale of intelligence were applied to the patients at the age of 4 - 6, and Wechsler intelligence scale for children were applied to those at the age of 6 - 16). Results: 1) Comparison of curative effects: The curative effect difference between the LEV group and OXC group and the difference during the different period of each group were both not significant. 2) Comparison of cognitive function: There is no statistical difference between the two groups before and after treatment. Both the two groups showed an increasing trend of intelligence test scores after treatment. There was no statistical significance between scores before and after OXC treatment, while the scores difference of words and digit span before and after the treatment of LEV had statistical significance. Conclusions: The curative effect of LEV on the first BECT patients is similar to OXC without adverse influence on cognition.
5-羟色胺在孤独症谱系障碍中的研究进展
Research Progress of Serotonin in Autism Spectrum Disorders
 [PDF]

丽丽,,, 冯俊燕, 贾飞勇
International Journal of Psychiatry and Neurology (IJPN) , 2015, DOI: 10.12677/IJPN.2015.43003
Abstract:
孤独症谱系障碍(ASD)是一组以不同程度的社会交流、交往障碍和限制性、重复性行为、兴趣及活动异常为主要特征的发育行为障碍性疾病。ASD的发病率逐渐增加,但其病因不明。5-羟色胺(5-HT)是一种在人体中广泛存在的单胺类神经递质,对神经精神活动等具有一定的调节作用。研究发现,ASD患者的5-HT水平在外周血中升高,脑内降低,这种反常现象在ASD患者中较为常见。且5-HT转运体(5-HTT)基因异于常人。因此,5-HT系统的异常可能是影响ASD的一项危险因素。
Autism spectrum disorder (ASD) is a group of developmental behavioral disorders which have the main features like different levels of social interaction and communication barriers, restrictive and repetitive behaviors and abnormal interests and activities. The onset of ASD shows a trend of increase year by year, but its etiology is unknown. Serotonin is a monoamine neurotransmitter which is widely present in the human body and has a regulatory role in other neuropsychiatric events. The study found that the 5-HT of patients with ASD level increased in peripheral blood and decreased in the brain. This anomaly was common in ASD patients. 5-HT transporter gene was different from ordinary people. Therefore, the abnormality of 5-HT system may be a risk factor for ASD.

高速铁路用HRBF500钢筋混凝土梁疲劳性能试验研究
,陈青萍,
工业建筑 , 2010, DOI: 10.13204/j.gyjz201011006
Abstract: 对配置500MPa细晶粒(HRBF500)钢筋混凝土梁的疲劳性能的研究鲜见报道,设计、制作2根矩形和2根T形截面的HRBF500钢筋混凝土(C50)简支梁,并进行静力加载和疲劳试验。基于试验结果,分析了静载作用下不同截面形式和不同配筋率的梁受拉钢筋应变、跨中挠度以及梁裂缝发展规律,研究了钢筋应力幅值大于150MPa时,各钢筋混凝土梁在疲劳荷载作用下的受力性能。结果表明,最大疲劳荷载和振幅是影响试验梁是否发生疲劳破坏的主要因素。
外阴皮肤转移性腺癌一例
,王婷婷,
华西医学 , 2012, DOI: CNKI:51-1356/R.20120115.1604.044
Abstract:
减肥保健食品中非法添加盐酸西布曲明的检测
,张妤,宝珠
食品科学 , 2008,
Abstract: ?建立减肥保健食品中非法添加化学成分盐酸西布曲明的定性、定量检测方法。采用薄层色谱法、高效液相色谱-二极管阵列检测法、lc/ms/ms联用技术进行定性鉴别,并采用高效液相色谱法测定其中盐酸西布曲明的含量。结果在抽取的43种市售产品中,有9种检出了盐酸西布曲明。该方法快速、简便、准确、可靠,可用于有效监测保健食品中非法添加的盐酸西布曲明。
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