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Search Results: 1 - 10 of 387543 matches for " 王建丽 "
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雌激素通过非基因效应激活钙离子流调控子宫内膜癌细胞外信号调节激酶通路
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北京大学学报(医学版) , 2015,
Abstract: ?目的:研究子宫内膜癌ishikawa细胞中,雌激素通过钙离子通道及雌激素受体引发钙离子流继而影响细胞外信号调节激酶(extracellularsignal-regulatedkinases,erk)活化通路的机制。方法:激光共聚焦实验检测雌激素作用下及加入雌激素受体的抑制剂ici182780和钙通道阻滞剂nifedipine后胞浆内游离钙离子浓度的变化,western-blotting方法检测同样条件下erk通路的激活。结果:17β-雌二醇(17β-estrodiol,e2)和偶联牛血清白蛋白(bovineserumalbumin,bsa)的17β-雌二醇(e2-bsa)在作用1min后均可以引发瞬时的钙离子流,钙离子的浓度增高可以被雌激素受体的抑制剂ici182780和钙通道阻滞剂nifedipine抑制。在ishikawa细胞,e2可以快速激活erk通路,加入雌激素受体抑制剂ici182780后,e2作用5min和30min,erk通路未被阻抑。加入钙离子通道阻滞剂nifedipine后,5min时雌激素对erk通路的激活未被阻抑,但30min时nifedipine阻抑了erk通路的激活。e2-bsa对erk通路的活化也在作用30min后被nifedipine阻抑。结论:雌激素可以通过钙离子通道快速激发钙离子流,进而影响erk通路的活化。
雌激素通过非基因效应激活钙离子流调控子宫内膜癌细胞外信号调节激酶通路
Nongenomic effects of estrogen on extracellular signal-regulated kinases through?initiating transient calcium flux in endometrial cancer

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- , 2015, DOI: 10.3969/j.issn.1671-167X.2015.03.022
Abstract: 关键词: 子宫内膜肿瘤, 钙, 细胞外信号调节MAP激酶类, 雌激素类
Key words: Endometrial neoplasms, Calcium, Extracellular signal-regulated MAP kinases, Estrogens
百合科六属十五种植物的细胞学研究
,顾志
植物分类学报 , 1993,
Abstract: 本文对云南西北部百合科6属15种的染色体和核型进行了报道。 (1)Clintonia udensis Trautv.et Mey间期核属于浓密分散型,前期染色体属于渐变型,分裂中期体细胞染色体2n=14=8m+4sm+2st(2SAT),核型不对称性属于2A型;(2)鹿药属四个种间期核属于复杂中央微粒型,前期染色体属于中间型,分裂中期体细胞染色体分别为Smilacina henryi(Baker)Wang et Tang,2n=36=12m+16sm+6st+2t(2SAT), 核型不对称性属于2C型;Smilacina fusca Wall., 2n=36=14m(2SAT)+12sm+10st(2SAT), 核型不对称性属于2B型; Smilacina tatsienensis(Franch.)Wang et Tang, 2n=36=22m+2sm+2st(2SAT), 核型不对称性属于2C型;Smilacina atropurpurea(Franch.)Wang et Tang,2n=36=18m+6sm(2SAT)+12st,核型不对称性属于2C型;(3)黄精属四个种的间期核属于复杂中央微粒型,前期染色体属于中间型,分裂中期体细胞染色体分别为Polygonatum kingianum Coll.et Hesml.,2n=30=12m(2SAT) +6sm+lst+2t, 核型不对称性属于2C型; Polygonatum cirrhifolium(Wall.) Royal,2n=30=10m+4sm+12st+4t, 3C型; Polygonatum curvistylum Hua, 2n=78=24m(2SAT)+14sm(6SAT)+40st, 核型不对称性属于3C 型; Polygonatum cathcartii Baker,2n=32=12m+6sm+10st+2t+2bs,核型不对称性属于2C型;(4)百合属,假百合属,豹子花属三个属的间期核和前期染色体形态相似,都属于复杂中央微粒型,前期染色体属于中间型,分裂中期体 细胞染色体分别为Lilium henricii Franch,2n=24=2m(2SAT)+2sm+10st+10t,核型不对称性属于3A型;Lilium bakerianum Coll.et Hesml.var. rubrum St
四元胶乳互穿聚合物网络的组成对其性能的影响
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功能高分子学报 , 1995,
Abstract: 用分步乳液聚合法合成了具有核壳结构的胶乳互穿聚合物网络LIPN(PMMA-PS)/(Pn-BA-PAA);讨论了LIPN组成对乳液与膜性能的影响,提出了四元LIPN核壳结构的基本轮廓,探讨了软硬单体最佳配比及丙烯酸单体用量。
艾比湖保护区荒漠植被时空过程变化及其植被指数影响因素分析
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草业学报 , 2015, DOI: 10.11686/cyxb20150502
Abstract: 利用1990-2011年Landsat数据,结合了4个气象站点的年降水量、年均温数据,基于垂直地带性特征和荒漠植被指数对艾比湖保护区的遥感图像进行了专家知识决策树分类。研究了典型绿洲-荒漠交错带的荒漠草地等地物近20年的面积变化、NDVI及其与气候因子的关系。结果表明,1)近20年间植被类型的NDVI值大致呈山前荒漠>荒漠草原>盐生草甸>草本沼泽>荒漠的规律。2)近20年降水量与温度都呈上升趋势,植被NDVI和气温主体呈不显著负相关,与降水主体呈显著正相关。3)研究区在保护区建立前,荒漠植被退化十分严重,荒漠植被面积大量减小,大多向不可用地类转化,保护区建立后的生态环境有了很大改善。可见政府的政策导向对荒漠生态环境具有重要作用。
gm(1,1)模型在外饰面涂层耐久性预测中的应用
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涂料工业 , 2010,
Abstract: ?应用gm(1,1)模型对外饰面涂层厚度变化情况进行了预测,用外饰面涂层的厚度变化来反映不同种类涂料耐久性的好坏,在初始模型的基础上引入了二阶弱化算子d2,使预测结果更加精确,并通过matlab简化了模型计算,对所建模型进行了残差检验、关联度检验、均方差检验和小误差概率检验,精度均满足要求。结果表明:模型对于单调数列的预测精度高,可以用于外饰面涂层耐久性的预测。
纳米tio2对外饰面涂层改性的试验研究
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涂料工业 , 2010,
Abstract: ?用纳米tio2对3种常用的外墙涂料进行改性,在人工加速老化环境中对改性前后涂层的性能进行对比实验研究,对涂层光泽、厚度变化进行了测试,并采用红外光谱技术对涂层的老化程度进行定量分析。结果表明:经过60d的加速老化后,未改性涂层的光泽损失率、涂层厚度损失率分别是改性涂层的2.1倍和3.1倍;ft-ir测试结果表明未改性涂层的老化程度是改性涂层的2.45倍。
益气类中药对博来霉素致肺纤维化大鼠模型气道重塑的影响
Effects of Qi Invigorating Herbs on the Airway Remodeling of Bleomycin Induced Pulmonary Fibrosis in Rats Model
 [PDF]

, 张伟, 朱雪, , 杨景青, 李莹莹, 郭俊美
Traditional Chinese Medicine (TCM) , 2014, DOI: 10.12677/TCM.2014.31004
Abstract: 目的:观察博莱霉素(BLM)所致肺纤维化模型大鼠肺组织病理形态和肺组织中转化生长因子(TGF-β1)的表达水平,探讨益气类中药对肺纤维化的作用及其机制。方法:32只健康雄性SD大鼠随机分为空白组、模型组、益气组、泼尼松组,采用气管内滴加博莱霉素的方法制作肺纤维化模型,并应用相应的药物灌胃干预,各组大鼠分别于第28 d处死,肺组织切片经HE染色后观察病理形态,ELISA法测定大鼠肺组织中TGF-β1的表达水平。结果:与空白组比较,其余各组大鼠肺组织中TGF-β1表达明显增强(P < 0.01);两治疗组肺纤维化程度较模型组明显减轻(P < 0.01)TGF-β1表达也明显低于模型组(P < 0.01);益气组肺纤维化程度较泼尼松组轻(P < 0.05)TGF-β1表达也明显低于泼尼松组(P < 0.01)结论:益气类中药能够抑制
环境磷形态分析中的磷-31核磁共振技术
31-P Nuclear Magnetic Resonance (31P-NMR) in Environmental Phosphorus Analysis
 [PDF]

陆瑾, 海文, 郝红, 高博,
Hans Journal of Soil Science (HJSS) , 2013, DOI: 10.12677/HJSS.2013.13004
Abstract: 磷-31核磁共振(31P-NMR)技术因可以增强研究者对环境中磷素组分信息的认识而广受关注。本文综述了该技术在环境磷素形态表征方面的研究成果,对31P-NMR技术的原理、样品制备方法及分析流程进行了系统阐述。环境样品的制备过程(包括样品前处理方法、提取时间、提取剂比例、样品浓缩方法等)对检测结果的精密度和准确度具有显著影响。论文同时综述了该技术在土壤、湖泊、海洋及湿地磷循环等研究领域的研究成果,并对该技术未来的研究及应用重点进行了展望,旨在为环境磷形态分析中的核磁共振技术的发展应用以及标准化研究提供借鉴。
Due to its advantages in improving our knowledge about the P fractions in environmental samples, the 31-P nuclear magnetic resonance (31P-NMR) technology has received extensive attention. This paper summarized the current studies on the characterization of P fractions in sediments by using this technology, and described the technical principles, sample preparation method and analytical procedures of this technol- ogy. The preparation procedures of environmental samples have a significant influence on the accuracy and precision of testing results, including determination of sample pretreatment, extraction time, sample to ex- traction ratio and concentration method. The specific application fields of this technology were also summa- rized in this paper. 31P-NMR technology has been applied in the field of Soil, Lake, Ocean, Wetland, and has made a number of achievements. Some future research focuses were expected in this paper in order to pro- vide theoretic support for the development and application as well as standardization of 31P-NMR technology in the future.
GC-MS法测定苯胺法合成2-巯基苯并噻唑的废树脂
Determination of Composition in Spent Resins from the Aniline Process Adopted to the Synthesis 2-Mercaptobenzothiazole by Gas Chromatography-Mass Spectrometry
 [PDF]

张家, 张梅梅, 张圣光,, 程相林, 留成
Advances in Analytical Chemistry (AAC) , 2015, DOI: 10.12677/AAC.2015.51001
Abstract:
采用气相色谱–质谱法(GC-MS)对工业苯胺法合成2-巯基苯并噻唑(促进剂M)的副产废树脂进行了定性、定量测定。废树脂经四氢呋喃溶解后,采用GC-MS法测定,样品中分离的各种成分用NIST08谱库进行对照检索,采用面积归一法,计算出各化合物成分的相对含量。共鉴定了废树脂中的7种有机化合物,其中2-巯基苯并噻唑(M)和苯并噻唑(BT)的相对含量最高,分别为29.2%、31.1%。苯胺含量为6.2%,2,6-二叔丁基-4-甲基苯酚含量为17.4%,苯并噻唑衍生物含量共为14.2%,所鉴定的7种有机化合物峰面积之和占到总峰面积的98.1%。
The relative content and constituents of spent resins from the aniline process adopted to the syn-thesis 2-mercaptobenzothiazole (the Accelerator M) were analyzed by gas chromatography-mass spectrometry (GC-MS). After being dissolved in tetrahydrofuran, spent resins were measured by GC-MS and identified by NIST08. The relative content of each component was determined by area normalization. Total 7 constituents were identified in spent resins, wherein the relative contents of 2-mercaptobenzothiazole (M) and benzothiazole (BT) were the highest, accounting for 29.2% and 31.1% respectively. The contents of aniline, 2,6-Di-tert-butyl-4-methylphenol and benzothiazole derivative were 6.2%, 17.4% and 14.2%, taking 98.1% of the total peak area.
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