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Search Results: 1 - 10 of 760 matches for " 林东海 "
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蛋白质多肽主链上原子之间距离的计算
林东海
科学通报 , 1992,
Abstract: 蛋白质溶液构象是分子生物学极其重要的研究课题,为此设计的计算程序DISGEO,DISMAN,DISNMA(待发表)是根据距离几何原理设计的,以核磁共振技术的NOESY和COPY谱获取多肽链中原子对(主要是H—H对)距离约束计算蛋白质分子的三维空间结构.目前这些程序设计细节尚未报道.而多肽链中原子之间距离的计算是设计这些程序的关
高自旋CD_n体系重聚INEPT实验谱的计算
林东海
科学通报 , 1993,
Abstract: 1引言对自旋为1/2的弱耦合体系,人们已作了详细的研究;但对自旋大于1/2的高自旋弱耦合体系,由于表示上的困难,还没有很好的理论处理方法。虽然曾出现几种方法来描述高自旋体系的演化,如密度矩阵法,多极算符理论,投影算符法,但这些方法计算繁复,常常要用计算机才能完成,物理意义也不直观。高汉宾提出用广义积算符方法描述高自旋体系,是一种比较方便直观的方法。但此方法需引入一组正交算符{z},而{z}算符在脉冲作用
代谢组学研究现状与展望
徐旻,林东海,刘昌孝
药学学报 , 2005,
Abstract: 中科院“百人计划”研究基金国家973计划资助项目(2004cb518902);国家高技术研究发展计划(863计划)资助项目(2003aa2z347d).
人参皂苷的体内分布与代谢研究概况
张蓓,林东海,刘珂
中国中医药信息杂志 , 2007,
Abstract:
Interaction of Proteins with Metal Ions Studied by NMR Techniques: A Review
用核磁共振方法研究金属离子与蛋白质的相互作用

ZHANG Fang,LIN Dong-hai,
张芳
,林东海

波谱学杂志 , 2009,
Abstract: Metal ions interact with protein using a great variety of mechanisms to regulate protein functions. Some metal ions bind tightly and specifically to proteins and markedly regulate protein function, while others interact loosely and nonspecifically with proteins and only act as cofactors for protein functioning. In this review, we describe nuclear magnetic resonance (NMR) techniques which are widely used to investigate inter-molecular interactions between proteins and diamagnetic/paramagnetic metal ions. Special emphasis is put on the NMR techniques the can be used to elucidate the structure and function of metalloproteins, including chemical shift mapping, paramagnetic NMR and backbone dynamics detection. Examples are given to illustrate how the NMR techniques can be used to map inter-molecular interaction between proteins (calmodulin, zinc fingers and prion proteins) and metal ions.
时基校正投影电视墙数字处理系统
林东
福州大学学报(自然科学版) , 1998,
Abstract: 提出一种基于时基校正原理的组合投影电视墙数字处理系统,该系统免去了通常必需的时基校正器,讨论了采用不同存储器方案系统的时基可校正性,设计了一种时基校正电视墙系统,并说明对时基误差的消除方法.
基于FIFO帧存储的任意视频图象信号发生器
林东
福州大学学报(自然科学版) , 2003,
Abstract: 提出一种基于先入先出 (FIFO)帧存储的任意视频图象信号发生器的设计方法 ,介绍了系统的软件和硬件构成 ,特别是帧存储器的设计、软硬件接口方法以及视频图象信号的生成过程 ,并介绍在电视墙调试中的应用实例 .
A NEW FORMALISM FOR DESCRIBING THE EVOLUTION OF DENSITY OPERATORS
描述自旋体系密度算符演化的新方法

LIN DONG-HAI,WU QIN-YI,
林东海
,吴钦义

物理学报 , 1993,
Abstract: A new formalism for describing the evolution of density operators was proposed. It can evaluate the evolution of density operators of strongly and weakly coupled spin systems in a u-nified way, and describe the experiments involving weak RF pluse. Some problems were explicitly treated including spin tickling, isotropic mixing in systems of two coupled nuclei (I= 1/2), dipolar evolution and strongly coupled AB and ABX spin systems.
Residual Dipolar Couplings and Their Applications in Determination of Protein Structures
残留偶极耦合及其在蛋白质结构研究中的应用

LIN Dong-hai,LIU Xue-hui,
林东海
,刘雪辉

波谱学杂志 , 2005,
Abstract: In recent years residual dipolar couplings have been employed to obtain the long-range conformational constraints such as the relative orientations between the chemical bonds in biomolecules for calculation or refinement of three-dimensional structures of proteins and protein complexes in solution This review describes the measurement of residual dipolar couplings using multi-dimensional NMR techniques and their applications in determination of protein structures: refining protein structures, evaluating protein structures, determining the relative orientation between protein domains, obtaining information about ligand conformation and orientation, etc
Mapping Protein-Ligand Interaction by NMR Techniques: A Review
用NMR技术研究蛋白质-配体相互作用

LIN Dong-hai,HONG Jing,
林东海
,洪晶

波谱学杂志 , 2005,
Abstract: 蛋白质-配体相互作用的研究对理解生命过程、药物设计和药物筛选具有相当重要的科学意义和巨大的经济价值.NMR是研究蛋白质-配体相互作用的最有用的技术之一,有着显著的优势.本文综述了近年来国际上用NMR技术研究蛋白质-配体相互作用的发展状况和趋势,先介绍表征蛋白质-配体相互作用的重要参数,然后介绍如何判断蛋白质或配体与复合物的化学交换类型以及所能获得的有关蛋白质-配体相互作用的信息,最后介绍具体用于研究蛋白质-配体相互作用的若干NMR技术以及基于NMR的药物筛选技术.
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