Depression developed into a result of the interaction of stress and individual stress susceptibility, the possible risk factors were the early life pressure and gene-environment interaction, which played an important role in the development of individual stress susceptibility. The glucocorticoid receptor gene promoter apparent adjustment was considered to be the molecular basis of the susceptibility of stress. Brain-deried neurotrophic factor promoters of the protein modification may be antidepressants and electric shock treatment of adjustment mechanism. Clinical genetics research indicated that genomic imprinting involved in the biplor disorder come on, but had no direct evidence of the molecules of the report. Through the research resistance to manic function of group of protein deacelation base enzyme inhibitors-valproic acid salt and DNA methylation donor-S-adenosine armour sulfur acid, showed that DNA methylation involved in emotional adjustment. Two-way barrier patient autopsy discovered that the brain membrane combined with catecholamine-O-phenol-o-methyl shift enzyme promoter of the DNA methylation change there. A single egg with two-way obstacles of twins shared the PPIEL was found DNA methylation state. The conclusion was that epigenetic may act in emotional disorders. It was necessary for further study of epigenetic mechanisms of affective disorder.