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Search Results: 1 - 10 of 110830 matches for " 徐学欣 "
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口腔微生物组在口腔精准医疗中的运用
Oral microbiome in the precision medicine

,何金枝,
- , 2017, DOI: 10.7518/gjkq.2017.06.001
Abstract: 摘要: 现代医学已从“以疾病为导向”转至“以患者为导向”,开启了以个体化医疗为目标的精准医疗时代。人体的生理功能不但由自身基因组决定,还受共生菌群即人类微生物组的塑造与影响。目前,人类微生物组的研究已经超越了简单解析组成成员与疾病之间的相关性,开始深入分析其对复杂疾病发病、诊断及治疗的贡献,这些突破性研究成果有望成为推动个性化精准医疗的重要助力。本文着重介绍口腔微生物组的最新研究进展、口腔微生物组在疾病早期风险预警、早期诊断、治疗及疗效评估等方面的探索性运用,讨论了口腔微生物组在精准医疗发展中的潜力,以及整合口腔微生物组信息,实现精准医疗所面临的重大挑战。
Abstract: Modern medicine has shifted from “disease oriented” to “patient oriented” and has consequently created a new era of personalized medicine or precision medicine. The physiological functions of the human body are determined not only by the human genome but also by symbiotic microflora. Currently, studies on the human microbiome have extended from a simple analysis of the association of bacteria and diseases to a complex analysis of the role of microbiome in the pathogenesis, diagnosis, and treatment of diseases. These breakthroughs possibly promote the practice of personalized/precision medicine. This review summarizes the advances in oral microbiome-related research. In particular, the potential role of oral microbiome in the risk prediction, diagnosis, treatment evaluation, and prognosis of diseases is extensively discussed. Current challenges in the development of oral microbiome-based precision medicine are also described.
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菌斑生物膜产碱代谢与龋病
Relationship of alkali production by plaque biofilm and dental caries

周双双,,,
- , 2016, DOI: 10.7518/gjkq.2016.05.018
Abstract: 摘要: 口腔微生态内酸碱代谢是调控口腔微生态平衡的重要因素,影响着微生物群落组成和菌斑生物膜形成。菌斑生物膜的产碱代谢可能阻碍产酸耐酸菌在低pH值环境中获得优势地位,恢复并维持微生态平衡;同时也直接升高微生态内pH值,遏制牙表面脱矿。菌斑生物膜主要的产碱活动包括精氨酸脱亚胺酶系统介导的精氨酸代谢和尿素酶介导的尿素水解反应。精氨酸代谢可抑制生物膜中产酸菌生长,促进产碱共生菌生长,促进龋状态下的口腔微生态恢复平衡。尿素代谢可抑制龋病发生,含产碱底物的口腔卫生护理产品具有良好的龋病防治效果。本文就近年来菌斑生物膜的产碱代谢及其与龋病关系等研究进展作一综述。
Abstract: Alkali production within oral microecology is necessary to modulate the balance of the microenvironment, which influences the configuration and characteristics of the oral microflora. Alkali production impedes the predominance of acidogenic and aciduric bacteria in a low-pH microenvironment and restores micro-ecological balance. Alkali production directly increases environmental pH, attenuates demineralization, and promotes tooth surface remineralization. Alkali production is mainly attributed to microbial arginine metabolism mediated by the arginine deiminase system and urea hydrolysis. Arginine metabolism prevents the growth of acid-generating bacteria but stimulates the growth of alkali producing bacteria; thus, the restoration of microbial disequilibrium in a cariogenic biofilm can be facilitated. Similar caries resistance has been observed in a population with increased urea metabolism. In vivo and in vitro data have indicated that the regulation of microbial alkali production represents a promising ecological approach to caries management. This paper aims to review current studies on the alkali production within oral biofilm, to elucidate the effects of alkali production on microbial ecology, and to describe the onset/progression of dental caries.
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聚四氟乙烯膜管内植入自体许旺氏细胞桥接面神经的实验研究
,广,马跃,孙善珍
华西口腔医学杂志 , 2005,
Abstract: 目的 观察聚四氟乙烯膜管内植入自体许旺氏细胞桥接修复面神经缺损的效果。方法 采用聚四氟乙烯膜管桥接家兔面神经1.0cm的缺损,将快速提取获得的自体许旺氏细胞植入膜管内作为实验组,选择单纯聚四氟乙烯膜管桥接面神经缺损为对照组,用电生理测试和组织学观察等方法对修复后不同时期神经再生情况进行评价。结果 实验组各时期神经再生情况均优于对照组,其中实验组术后16周时面神经传导速度为29·70m/s,而对照组为23·00m/s,统计学处理两者有显著性差异(P<0·05)。结论 一定数量有活力的自体许旺氏细胞植入聚四氟乙烯膜管制成的面神经再生室内,可以获得较好的面神经修复效果。
微喷带补灌对冬小麦耗水特性和产量的影响
,,,谷淑波
- , 2016, DOI: 10.7606/j.issn.1009-1041.2016.04.13
Abstract: 为给适于麦田精量灌溉的新型灌溉设施和方法的研发提供理论依据,于2011-2013年冬小麦生长季,选用高产冬小麦品种济麦22为材料,以全生育期不灌水处理和传统畦灌处理为对照,设置6个不同带宽(60、80、100 mm)和孔径(1.0和0.8 mm)配置的微喷带补灌处理,研究了微喷补灌对冬小麦耗水特性和产量的影响。结果表明,在60~100 mm带宽范围内适当增大微喷带带宽,或在80 mm带宽下增加内喷孔孔径均可显著提高灌溉水分布均匀系数。带宽80 mm、内喷孔孔径1.0 mm配置的微喷带灌溉处理(T80/1.0)下小麦拔节期至开花期对80~200 cm土层贮水的消耗量低于其他处理,对0~40 cm土层贮水的消耗量亦较低,其开花期补灌水量、全生育期总灌水量和总耗水量均低于其他微喷带灌溉处理。T80/1.0处理籽粒产量、水分利用效率及灌溉效益均显著高于带宽为60 mm的处理及内喷孔孔径为0.8 mm、带宽为80 mm和100 mm的处理;T80/1.0处理与传统畦灌处理相比,灌水均匀度和籽粒产量均显著差异,但全生育期总灌水量减少33.2~70.8 mm,总耗水量减少47.6~52.2 mm,水分利用效率提高2.1~2.9 g·hm-2·mm-1。说明小麦生育中后期采用带宽80 mm、内喷孔孔径1.0 mm配置的微喷带进行按需补灌,有明显的节水高产效果。
口腔精准医学:现状与挑战
,,郑黎薇,程磊,
华西口腔医学杂志 , 2015, DOI: 10.7518/hxkq.2015.03.021
Abstract: 精准医学是人类基因组计划的延续,是医学发展的必然产物,是一种考虑人群基因、环境及生活方式个体差异的促进健康和治疗疾病的新兴医学模式。本文首次提出口腔精准医学的概念,以口腔典型疾病为例,结合近期的研究成果与学者观点,阐述口腔精准医学对口腔学科发展的指导意义及实现口腔精准医学将面对的机遇与挑战。
STUDIES ON THE TOXITY OF SILICA CRYSTALS TO CULTURED MACROPHAGES IN ABDOMINAL CAVITY OF MICE BY ELECTRON DIFFRACTION AND ELECTRON MICROPROBE
二氧化硅对体外培养巨噬细胞的毒性研究

,张锡元,曹连,Perry Jean-Pierre,Galle Pierre,ZhangLili
生物物理学报 , 1991,
Abstract: Workers who inhale silica powder through respiratory system over a long per-iod of time will suffer silicosis. The first thing happening after silica crystals enter the lungs they will be engulfed by macrophages. We studied this process in the cultured cells by TEM, Electron Diffraction, and Electron Microprobe. This paper reported that, macrophages were sampled in abdominal cavity of the mice, purified and cultured. We have demonstrated that the phage-function of the cells resume after three days culturing by Trypan Blue vital staining test. Then, the samples for TEM in the presence of SiO2 were prepared by Gomori reaction for visualizing ACPase activities in the cells were performed. The electron diffraction and electron microprobe were used to localized the silica crystals and the distribution of lead- and sulphur. We defined two ways of silica toxity to the macrophages. One way is that, silica crystals destroyed the membrance of lysosomes, then the macrophages destroyed by the hydrolytic enzymes released from lysosomes. The other way is that, the metabolism was influenced after silica crystals engulfed and there may be something wrong with the lysosomes but not broken, then inno-rmal autophagies happened, so the macrophages dead gradually.
甘肃盐渍土及土壤水分改良三环节探讨
,张立新,刘永智,王家澄,顾同
冰川冻土 , 1998,
Abstract: 甘肃省气候干旱、寒冷,水资源缺乏,盐渍土分布面积大,表聚性强,采取治理措施后具有反复性.因为“盐随水迁”是基本规律,盐渍土的治理应遵循因地制宜的综合治理原则,重点抓好土壤水分改良三环节抑制地面蒸发、控制地下水位和改进灌溉方式.
添加稀土元素对AZ91D镁合金腐蚀性能的影响
,张娅,卫中领,,陈秋荣
腐蚀科学与防护技术 , 2009,
Abstract: 通过全浸腐蚀试验、极化曲线、电子探针(EPMA)以及场发射扫描电镜(FESEM)研究了在AZ91D镁合金中添加稀土元素MM、Di、Y、Nd、Gd和Ho后的耐蚀性规律.添加稀土元素后,AZ91D镁合金的耐蚀性得到不同程度提高,合金中的β相减少,出现含有稀土元素的第三相.添加稀土元素的合金的阴极极化行为减弱,腐蚀电流减小.
钴钯同时测定的新方法
张光,李成,国华,刘彬,金育
化学学报 , 1985,
Abstract:
大白菜品种间杂交一代遗传规律的初步探讨
廉志宏,昭晞,刘志荣,陆长苹,
华北农学报 , 1964, DOI: 10.7668/hbnxb.1964.03.009
Abstract: 建国后,各地有很多农业科学研究单位利用大白菜品种间杂交培育新品种,或利用杂交一代的优势,提高大白菜产量。据报导,通过品种间杂交已培育出不少优良品种,如中国农业科学院果树研究所,用兴城大矬菜一号与大麻叶、小包头等品种杂交培育出跃进一号大白菜;浙江农业大学用北京白口与天津绿杂交培育出浙江白口及浙江绿两个新品种,河北省石家庄地区农业科学研究所用正定大桩与兴城大矬菜杂交培育出抗病二号大白菜等。
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