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In this paper, by using a 2D anatomical model of the intact sinoatrial node (SA) node and surrounding atrial muscle of the rabbit heart proposed by Zhang et al., the effect of the distribution of death cells on the pacemaking and conductibility of SA node is investigated by computer simulation. The results show, on the one hand, using this model, we can obtain the phenomenon of abnormal rhythm in heart with physiological defect, such as, once the number of the myocardial death cell to reach a certain level in the aging heart due to SA-atrium conduction block, etc., and these will induce the cardiac sudden death. On the other hand, more importantly, the effect of the cardiac pacemaker can be understood by analyzing the spacial distribution of dead cells in the myocardium: Under the regulation of acetylcholine with certain concentration excreted by nervous system, and as well as the number of dead cells reaches in a certain proportion, such conduction block of pacemaker activity is closely relate to the spatial distribution of dead cells. It is not only proportional to the number of death cells, and the ratio of dead cells to normal cells in the organization, but also inverse proportion to the distance of dead cells location. Finally, we discussed the effect of thus distribution for dif-ferent concentrations of acetylcholine. Our simulation results may contribute to the understanding about the internal mechanism of the abnormal rhythm in complex cardiac system, and provide a theoretical guidance on the clinical diagnosis of sick sinus syndrome and prevention.