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Search Results: 1 - 10 of 68620 matches for " 寇俊萍 "
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动脉血栓相关治疗靶点及新药研究进展
李龙,
- , 2017,
Abstract: 动脉血栓(arterial thrombosis,AT)为一种临床常见病及多发病,并可诱发急性心肌梗死、缺血性脑卒中等缺血性心脑血管疾病,具有高致残率和高致死率的特点,严重危害人类健康。AT形成过程中涉及到内皮细胞、白细胞、血小板等多种因素的参与。积极寻找AT形成过程中可干预进程的治疗靶点,并根据靶点开发相关治疗药物具有重大的意义。本文就近5年来防治AT形成和抗栓治疗涉及到的相关靶点研究现状,及针对上述靶点研发的抗栓药物进展研究作一综述,以期为研制治疗AT的创新药物提供可能线索和依据。
Arterial thrombosis(AT)is a common disease which usually causes acute myocardial infarction, ischemic stroke and other ischemic cardiovascular and cerebrovascular diseases, which shows high rates of morbidity and mortality, and has become a serious problem to human health. It is increasingly clear that the interactions among platelets, the endothelium and leukocytes are important throughout all stages of the atherothrombotic process. It is of great significance to search for therapeutic targets in the process of AT and developing the therapeutic drugs based on those newly discovered targets. This article reviews the research advances in the discovery of antithrombotic targets and the current situation of drug development based on those antithrombotic targets found in the recent 5 years, in order to provide some references or clues for the development of innovative drugs to prevent and treat AT
正交设计-重复试验法优选当归芍药散的提取工艺
汤明辉,,朱丹妮,严永清
中国中药杂志 , 2000,
Abstract: 目的:筛选抗老年性痴呆药-当归芍药散的提取工艺参数。方法:以蒎烷单萜苷-芍药苷为指标成分,以HPLC法为含量测定方法,以芍药苷提取率为评价标准,采用正交设计-重复试验法,优化选择提取工艺。结果:提取次数与提取时间对方中芍药苷的提取率有显著性影响。结论:当归芍药散最佳提取工艺条件为加水8倍,浸泡40min,提取2次,每次1h。
天然产物防治急性肺损伤的作用机制研究进展
俞苏岚,余秀,
- , 2016,
Abstract: 急性肺损伤(acute lung injury,ALI)是临床上常见的危重病症,发病率和致死率逐年增高,其本质为炎症反应失衡,引发弥漫性肺泡及肺血管内皮细胞损伤、肺组织水肿及肺不张等病理特征。其调控途径涉及NF-κB、MAPK等信号通路和TLRs、PPARγ、腺苷A2A等主要相关受体。天然产物在防治ALI方面日益受到关注,其作用机制研究也不断深入。本文综述近3年来天然产物对ALI病理特征的改善作用及其所涉及的信号通路和相关受体,以期为研制防治ALI的创新药物提供一定线索和依据。
Acute lung injury(ALI)is a common critical disease with increasing morbidity and mortality rate in clinic. Its major pathological cause is the inflammation imbalance, which can cause diffuse alveolar and pulmonary vascular endothelial cell injury, lung edema and atelectasis. Many pathways and receptors, such as NF-κB and MAPK signaling pathways, and the adenosine A2A receptors, Toll-like receptors(TLRs), peroxisome proliferator-activated receptor gamma(PPARγ), etc. are involved in ALI. Nowadays, prevention and treatment of ALI with natural products attract more and more attention. This article reviews the advances in the mechanisms research of natural products in recent three years against ALI so as to provide some references and clues for the development of innovative drugs to prevent and treat ALI
中药有效成分抑制氧化应激诱导的神经细胞凋亡机制研究进展
申凯,,余伯阳
- , 2015,
Abstract: 氧化应激诱导的神经细胞凋亡,在神经退行性疾病的发生及发展过程中发挥重要作用,其调控途径主要包括NF-κB通路、p53通路、MAPK通路、PI3K/Akt通路、Nrf2通路等信号通路。大量文献报道,中药有效成分具有显著抑制氧化应激诱导的神经细胞凋亡的生物活性。本文综述近5年来中药有效成分抑制氧化应激诱导的神经细胞凋亡的相关机制研究进展,以期为阐释中药有效成分防治神经退行性疾病的作用机制,更有效地防治神经退行性疾病提供参考依据和线索。
Oxidative stress-induced neuronal apoptosis plays a vital role in the development of neurodegenerative disorders, while at present its regulation pathways mainly include the NF-κB pathway, p53 pathway, MAPK pathway, PI3K/Akt pathway, Nrf2 pathway, as well as other signaling pathways. Research findings suggest that the active components in Chinese materia medica exert significant biological activities in the treatment of oxidative stress-induced neuronal apoptosis. In the present paper, we review the recent research advances on the relative mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis, so as to provide some references or clues for the clarification of possible mechanisms of active components in Chinese materia medica and the treatment of related neurodegenerative diseases
一测多评法测定8个银翘解毒系列制剂中的7种酚酸类成分的含量
,张俐,郭青,,余伯阳,谷丹华
药学学报 , 2015,
Abstract: 建立8个银翘解毒系列制剂中君药金银花所含的7种酚酸类成分(新绿原酸、绿原酸、隐绿原酸、咖啡酸、异绿原酸b、异绿原酸a、异绿原酸c)的一测多评统一方法.首先,采用hplc以绿原酸为内参物,建立绿原酸与其他6种酚酸类成分的相对校正因子(rcf),并用不同浓度、不同色谱柱、不同hplc验证其耐用性,利用金银花提取物作随行对照定位各待测色谱峰.然后利用rcf计算8个不同银翘解毒系列制剂样品中其他6种酚酸类成分的含量,并与外标法的测定结果进行比较,对该方法进行可行性验证.结果表明,所建立的平均相对校正因子的耐用性良好(rsd在0.80%~2.56%),一测多评法测定样品中的酚酸类成分的含量与外标法的含量测定结果一致(相对平均偏差<0.93%).因此,一测多评法可以成功应用于8个银翘解毒系列制剂中金银花的酚酸类成分的定量控制.
益智丸对小鼠记忆、脑内SOD、MDA及免疫功能的影响
,禹志领,田景萱,马世平,严永清
中国中药杂志 , 1997,
Abstract: 采用跳台和避暗法实验对益智丸进行研究,结果表明益智丸100mg/kg连续ig给药15天,能明显促进正常小鼠的记忆功能;100,200,500mg/kg连续ig给药5天,能明显对抗东莨菪碱、亚硝酸钠及乙醇引起的记忆障碍;200,500mg/kg连续ig给药41天,明显改善D半乳糖所致的亚急性衰老小鼠的记忆损害,并升高其脑内SOD活力,降低MDA含量,抑制其胸腺指数的下降;另外,益智丸还能升高环磷酰胺诱导的免疫低下小鼠炭粒廓清指数及溶血素抗体生成量,增强氢化泼尼松抑制的细胞免疫反应。
关于病证结合动物模型研究现状的思考
柴程芝,,朱丹妮,严永清,余伯阳
中国中药杂志 , 2009,
Abstract: 构建病证结合动物模型要符合中医临床诊疗模式,应该遵循“方-证-病-效”相结合的研究思路。所谓“方”,是指临床疗效确切的经典复方。“证”是指方证,即复方的临床应用指征。“病”,是指现代医学疾病。“效”是指疗效。构建病证结合动物模型要选择临床疗效确切的经典复方并规范其临床应用指征,挖掘与复方主治证候相关现代医学疾病的关键病理环节选择恰当的造模方法,通过动物再现较直观、较明显的主要症状和体征,再以复方干预进行疗效验证。这种以临床疗效确切的经典复方为切入点,采用能够体现证候与疾病关联性的造模手段构建动物模型的思路不仅符合中医临床诊疗模式,还可以为病证结合动物模型的构建提供思路与方法学借鉴。
中药调节内质网应激的研究进展
周华娜,姜楠,韩雨薇,
- , 2015,
Abstract: 内质网是真核细胞中蛋白质合成、折叠与分泌的重要细胞器,内质网内稳态失衡时,即发生内质网应激(endoplasmic reticulum stress,ERS)。调节细胞内质网应激是防治多种疾病的重要途径和策略之一。本文综述了近3年中药调节肿瘤、心血管疾病、神经系统疾病、糖尿病等相关细胞的内质网应激的研究进展,为阐释中药防治相关重大疾病的作用特点和可能机制提供线索和参考。
The endoplasmic reticulum is an important organelle for eukaryotic cell protein synthesis, folding and secretion. Perturbation of endoplasmic reticulum homeostasis causes endoplasmic reticulum stress. It has been considered as one of important ways and new strategies to regulate endoplasmic reticulum stress in the treatment of multiple diseases. This paper mainly reviews the advances in the research on traditional Chinese medicines for modulating endoplasmic reticulum stress related to cancer, cardiovascular diseases, neurological diseases, diabetes and other complex diseases in recent years, aiming to provide some clues and references for exploring the characteristics and possible mechanism of traditional Chinese medicines treating related diseases
中药对一氧化氮合酶/一氧化氮系统调节作用的研究进展
韩雨薇,张媛媛,赖秀英,刘晗,
- , 2017,
Abstract: 一氧化氮(nitric oxide,NO)是人体重要的信使分子,由内皮型一氧化氮合酶(nitric oxide synthase,NOS)、神经元型一氧化氮合酶和诱导型一氧化氮合酶催化而成,合成后的一氧化氮迅速跨膜扩散释放,对免疫系统、神经系统等许多生理系统具有重要调节功能。血管系统的内源性一氧化氮可增强血管系统功能、舒张血管、增强血管内皮细胞存活、抑制血小板积聚和抑制白细胞浸润。然而,病理情况下一氧化氮过量产生可能通过细胞毒性作用与细胞抑制作用导致组织损伤。本文从中药调节NOS/NO系统介导相关疾病出发,综述了近五年有关中药调节NOS/NO系统及相关通路作用的研究,以期为相关疾病治疗提供新的线索或参考,为临床合理、有效用药提供科学依据。
Nitric oxide(NO)is a vital signal messenger in human and generated by nitric oxide synthase including endothelial nitric oxide synthase(eNOS), inducible nitric oxide synthase(iNOS)and neuropathic nitric oxide synthase(nNOS). NO has important regulatory function on the immune system, nervous system and many other physiological systems. Endogenous NO can enhance the function of the vascular system and endothelial cell survival, and inhibit platelet accumulation and leukocyte infiltration. Excessive production of NO may damage tissues by cytotoxic and cytostatic effects. Thus, NO plays a dual role in physiology and pathology. This paper gives a brief review on regulatory effects of NOS-NO system by traditional Chinese medicine during the recent five years, so as to provide some clues or references for the treatment of related diseases and scientific evidene for reasonable and effective clinical application
一起酒店聚餐引起的食物中毒调查分析
Investigation of a food poisoning accident occurred in a restaurant

郁旷明,,刘战峰,吴爱,李琳
- , 2018,
Abstract: 目的 调查引起食物中毒事件的原因和可疑危险因素,为减少类似事件发生提供建议。方法 通过流行病学调查确定事件性质,查找可疑食物,通过卫生学调查发现可能的污染环节及因素,采集可疑食物和病例等标本进行实验室检测,判定可能致病因素。结果 本次事件共发生病例35例,症状主要为腹泻、腹痛等。2个病例粪便检出血清型为O3K6的副溶血性弧菌。结合病例对照研究结果和实验室检测结果推测可疑食物为蒿菜、越香蒸宝蟹2个菜肴。结论 该事件为一起副溶血性弧菌食物中毒事件,加工环节中的交叉污染为可能的危险因素。建议食品安全监管部门应进一步加强对餐饮业的管理,在食物加工环节上要督促规范操作,控制风险。
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