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Search Results: 1 - 10 of 206143 matches for " 刘志向 "
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计及网损成本的发电权交易模式
黄大为,志向,杨春雨,孙文胜,蔡国伟,王建元
电力系统自动化 , 2010,
Abstract: 如何在发电权交易中计及网损成本是保证交易合理、高效的重要问题之一。针对这一问题,分析比较了现有发电权交易模型的优缺点,提出了适合中长期交易的改进集中撮合交易模式。首先,运用最小二乘B系数法确定网损成本与交易电量之间的量化关系;然后,构建计及网损成本的社会效益最大化模型,通过求解该模型,确定发电权交易双方买入和卖出的总电量;最后,以此交易电量为约束,建立撮合交易的数学模型。以IEEE30节点系统为例,对所提出的交易模式的特点进行了分析,分析结果验证了该模型的合理性和有效性。
30岁及以下肾肿瘤患者临床特征分析
时佳子△,志向,,王杰,,杨庆,叶华茂,王林辉
- , 2016, DOI: 10.16781/j.0258-879x.2016.07.0920
Abstract: 目的 探讨30岁以下肾肿瘤患者的发病情况、临床病理特征及治疗预后特点。 方法 回顾性分析2001年1月至2014年12月长海医院收治的所有30岁以下肾肿瘤患者的临床资料,对患者的基本信息、临床症状、手术情况、病理结果和预后情况进行总结分析。 结果 本组患者共有137例,占同期所有肾肿瘤患者的3.84%(137/3570)。男性67例(48.9%),女性70例(51.1%),平均年龄为(24.47±4.80)岁。因体检发现79例(57.66%),腹部或腰部疼痛起病39例(28.47%),单纯肉眼血尿10例,因包块发现者7例,另有2例因尿频尿急就诊。137例患者中,手术治疗133例(占97.1%),其余4例为内科保守治疗。获术后病理125例,其中肾细胞癌75例(占60%),血管平滑肌脂肪瘤42例(33.6%),肾母细胞瘤6例,神经内分泌肿瘤、肾小球旁细胞瘤各1例。121例获访病例中,肾细胞癌64例,3年生存率为82.86%,5年生存率为61.53%;所有血管平滑肌脂肪瘤患者预后均良好,无一例死亡。6例肾母细胞瘤患者中,2例死于肿瘤转移。1例神经内分泌瘤及1例肾小球旁细胞瘤患者预后良好。结论 30岁以下肾肿瘤患者中仍然以恶性为主,但良性血管平滑肌脂肪瘤占相当比例。定期体检利于肿瘤的早期发现、改善预后。
Objective To evaluate the incidence, clinicopathologic features, treatments and prognosis of renal tumor patients under the age of 30 years old. Methods The clinical data of renal tumor patients under 30, who were treated between January 2001 and December 2014, were retrospectively analyzed. The general information, incidence, clinical manifestations, pathological outcomes, treatment strategies, and prognosis were analyzed. Results A total of 137 patients were included in this study, which accounted for 3.84% (137/3570) of all renal tumor cases in our hospital at the same period. The mean age of 137 patients was (24.47±4.80) years old, including 67 males and 70 females. 79 patients (57.66%) were diagnosed during health check-up, 39 patients were diagnosed for abdomen or flank pain, gross hematuria and mass as the main clinical symptoms were separately found in 10 and 7 patients, the other 2 patients saw a doctor for urinary frequency and urgency. 133 patients received operations, the rest received conservative medical management. 125 cases of postoperative pathology were got: 75 renal cell carcinomas, 42 angiomyolipomas, 6 nephroblastomas, one neuroendocrine tumor, and one juxtaglomerular cell tumor. 121 patients had been followed-up. The 3 and 5 years survival rates of renal cell carcinoma were 82.86%(29/35)and 61.53%(8/13). 2 cases of nephroblastoma died of tumor metastasis. All the angiomyolipoma, neuroendocrine tumor, juxtaglomerular cell tumor patients had good prognosis. Conclusion Most of renal tumors in patients under the age of 30 years old are malignant. But it is noteworthy that benign angiomyolipoma also accounts for a considerable proportion. Regular health check-up is benefit for early diagnosis and better prognosis
乳头状肾细胞癌临床特征及预后相关因素分析(附113例报告)
刘佳毅,志向,,汪洋,杨庆,陈星晔,叶华茂,王林辉
- , 2016, DOI: 10.16781/j.0258-879x.2016.08.1049
Abstract: 目的:分析单中心乳头状肾细胞癌(papillary renal cell carcinoma,PRCC)的临床特征,探讨与肾乳头状细胞癌预后相关的临床指标。 方法:通过回顾性分析2005年1月至2015年5月在长海医院住院手术,且经术后病理证实为PRCC的113例患者的临床、病理及随访资料。研究终点为总生存期,生存分析数据采用Kaplan-Meier法进行计算,并用Log-rank法对生存率进行分析比较。采用Cox回归模型进行多因素分析。 结果: 乳头状肾细胞癌占同期收治肾癌患者的4.80%,男女比4.4:1。年龄17-80岁,平均54.5岁。肿瘤平均直径为5.26cm。乳头状肾细胞癌患者1、3、5年生存率分别为100%、98.5%,81.3%。本组中I型乳头状肾细胞癌39例,II型乳头状肾细胞癌55例,未知分型18例。Log-rank检验结果显示,分型(p=0.035)、是否有初始症状(p=0.008)与患者的生存时间有关。Cox多因素回归分析结果显示,是否有区域淋巴结转移(p=0.035)、是否有癌栓(p=0.035)是PRCC患者生存时间的独立影响因素。 结论: PRCC是一种低度恶性的肾细胞癌,分期较早,预后较好。其中,Ⅱ型预后差于I型,有初始症状提示预后不良。
Objective To analyze the characteristics and the prognostic significance of papillary renal cell carcinomas (PRCC). Methods Data about 113 patients with papillary renal cell carcinomas at the time of surgery were retrospectively collected from Changhai Hospital between 2005 and 2015. The prognostic factors were evaluated by Log-rank test.Kaplan-Meier survival curve was used to estimate the survival rate. Results The incidence rate of PRCC was 4.80% in RCC.And the median age was 54.5 years; M/F ratio was 4.4:1. 55 cases were type I, and 18 were type II, the rest remained unknown.The one-year, 3-year and 5- year survival rates were 100%, 98.5%, 81.3%. The Log rank test showed that type (P=0.035), symptoms at presentation (P=0.008) were associated with survival time. The muhivariable Cox regression model revealed that regional lymph node involvemen(p=0.035)、cancer embolus(p=0.035)were independent predictors of aggressive PRCC. Conlusion PRCC is a distinct type of renal cell carcinoma exhibiting a low degree of malignancy, type II, with initial symptoms indicate worse prognosis
3D单孔腹腔镜在泌尿外科手术中应用的单中心研究
志向,,汪洋,吴登爽,时佳子,王林辉
- , 2016, DOI: 10.16118/j.1008-0392.2016.03.011
Abstract: 目的 报道单中心开展的20例3D单孔腹腔镜手术,探讨该手术的可行性和安全性,总结操作经验,并评价其临床应用特点和价值。方法 收集2013年8月至2014年11月长海医院泌尿外科完成的20例3D单孔腹腔镜手术患者的临床资料和围手术期数据。20例患者中男性9例,女性11例。年龄31岁至69岁,平均55.8岁,平均体质指数24.64kg/m2。其中经腹腔入路14例,经腹膜后入路6例。9例肾上腺切除术,5例肾癌根治术,4例无功能肾切除术,1例肾部分切除术,1例腹膜后囊肿切除术。分析患者围手术期情况,手术时间、出血量、手术并发症和手术中转情况。结果 20例患者均在不增加任何额外切口的情况下顺利完成手术,无中转开放。在3D单孔腹腔镜下共完成5种类型手术,其中有肾上腺切除术、肾癌根治术和无功能肾切除术分别进行经腹腔镜入路和经腹膜后入路进行。本组20例3D单孔腹腔镜手术均未出现外科并发症。20例手术平均时间为156.3±56.1min,患者术后(4.5±1.6)d出院。术后第3天,15例患者疼痛评分为0分,3例为1分,2例为2分。结论 初步经验表明: 3D单孔腹腔镜下手术安全、可行、有效。3D腹腔镜由于手术图像立体感强,手术操作精确度高,手眼协调难度明显降低,能降低单孔腹腔镜手术操作的难度,具有良好的临床应用前景。目前3D单孔腹腔镜完成的手术例数较少,其长期临床疗效尚需前瞻性大样本多中心临床随机对照研究进一步证实。
Objective To assess the safety and feasibility of 3D laparoendoscopic single-site (3D-LESS) technique in urological operations. Methods Twenty patients received 3D-LESS urological operations in Changhai Hospital from August 2013 to November 2014, including 9 males and 11 females with an average age of 52.8years (31-69 years) and a BMI of 24.64kg/m2. Among 20 operations, 14 were completed via intraperitoneal approach and 6 via retroperitoneal approach; and there were 9 cases of adrenalectomy, 5 of radical nephrectomy, 4 of nephrectomy, 1 of partial nephrectomy and 1 of resection of retroperitoneal cyst. The perioperative parameters, operation time, blood loss, complications and transform to open surgery were analyzed. Results All twenty 3D-LESS operations were smoothly completed and no one was transformed to open surgery. In this study, there were 5 kinds of operations performed with 3D-LESS technique and 3 kinds (adrenalectomy, radical nephrectomy and nephrectomy) of operations performed via both intraperitoneal and retroperitoneal approach. During all the 20 operations, there were no surgical complications. The total operative time was 156.3±56.1min,the hospital stay after operation was 4.5±1.6 days. Donor Visual Analog Pain Scores at postoperative day 3 were 2/10 (2 cases), 1/10 (3 cases) and 0/10(15 cases), respectively. Conclusion Our initial experience shows that the 3D-LESS operation is safe, feasible and effective. The 3D imaging system provides anatomical layering similar to open surgery, and the 3D video techniques would make the LESS operation easier. However, more clinical experiences are needed to be accumulated in the future
单孔与标准腹腔镜肾部分切除术的临床疗效对比
鲍一,,志向,吴登爽,吴震杰,陈俊明,李鹏,王林辉
- , 2016, DOI: 10.16781/j.0258-879x.2016.07.0899
Abstract: 目的 通过对比单孔腹腔镜和标准腹腔镜下肾部分切除术的临床疗效,探讨单孔腹腔镜肾部分切除术的手术特点及其安全性、可行性和优缺点。方法 2009年8月至2015年2月同一手术组完成的12例单孔腹腔镜肾部分切除术,选择手术日期相近、肿瘤大小和DAP评分类似、进行标准腹腔镜肾部分切除术的患者22例作为对照组,回顾性分析两组患者的临床资料,比较临床疗效。结果 两组共34例患者均顺利完成手术,无中转开放手术。两组患者的体质量指数、肿瘤大小、DAP评分差异均无统计学意义(P>0.05)。单孔组和标准腹腔镜组术后肠道恢复时间分别为(1.50±0.71)d和(2.45±0.96)d,疼痛评分分别为3.5±1.2和4.3±0.9,切口满意度评分分别为8.1±1.8和7.2±2.1,差异均有统计学意义(P<0.05);手术时间分别为(213.1±33.9)min和(208.5±65.7)min,术中出血量分别为(92.7±66.8)mL和(162.3±168.1)mL、热缺血时间分别为(20.5±12.8)min和(19.5±7.5)min,差异均无统计学意义(P>0.05)。术前和术后1个月分别采用99mTc-DTPA测定双肾肾小球滤过率(GFR),单孔组和标准腹腔镜组患肾术后GFR较术前分别下降(3.7±8.6)mL/min和(8.9±10.1)mL/min,差异无统计学意义(P>0.05)。结论 单孔多通道腹腔镜肾切除术安全、有效,对于肿瘤直径较小、位置较好的肾肿瘤的治疗效果与标准腹腔镜相似。
Objective To compare the clinical outcomes of laparoendoscopic single-site (LESS) and traditional standard laparoscopy partial nephrectomy surgery, so as to investigate the characteristics, safety, feasibility, advantages and disadvantages of LESS nephrectomy surgery. Methods The same surgical group completed 12 cases of LESS partial nephrectomy from August 2009 to February 2015; 22 cases who received standard laparoendoscopic partial nephrectomy in the same period served as controls; two groups had similar tumor size and DAP scores. The clinical data were retrospectively analyzed to compare the clinical efficacies of the two groups. Results All procedures were completed successfully without conversion to open cases in the two groups. The body mass index, tumor size or DAP scores were not statistically different between the both groups (P>0.05). The bowel recovery time, pain score, and cutouts satisfaction scores of LESS group were significantly different between the two groups ([1.50±0.71] d vs[2.45±0.96] d, 3.5 ±1.2 vs 4.3±0.9, and 8.1±1.8 vs 7.2±2.1, P<0.05). The operation time, blood loss, and warm ischemia time of LESS group were not significantly different from those of the standard group ([213.1 ±33.9] min vs[208.5 ±65.7] min,[92.7 ±66.8] mL vs[162.3±168.1] mL, and[20.5±12.8] min vs[19.5±7.5] min, P>0.05). The renal glomerular filtration rate (GFR) was measured with 99mTc-DTPA before and 1 month after the operation, and the GFR of LESS and standard laparoendoscopic groups had a decrease of (3.7±8.6) mL/min and (8.9±10.1) mL/min, respectively, showing no significant difference (P>0.05). Conclusion The LESS nephrectomy is safe and effective, which has a similar outcome with standard laparoendoscopic partial nephrectomy when the tumor is small and in a good position
3D打印技术在泌尿外科的应用进展
志向,王林辉
- , 2018, DOI: 10.16781/j.0258-879x.2018.02.0199
Abstract: 近些年,3D打印技术因其低成本和个体化设计的优势在医疗领域的应用取得了重要进展。在临床,3D打印模型可用于术前评估决策、手术培训和医疗设备研发等。目前已有许多关于3D打印技术或者3D打印材料等在泌尿外科领域应用的报道。在未来,3D打印技术将在泌尿外科领域中发挥越来越重要的作用。本文综述了国内外3D打印技术在泌尿外科的应用进展,并展望了3D打印技术在泌尿外科领域的应用前景。
Recently, three-dimensional (3D) printing gains a lot of attention in the medical field for its potential benefits in manufacturing low-cost and personalized surgical devices. 3D printing models can be applied in pre-operative planning, surgical training and medical equipment development. Many researches have reported that 3D printing technology and 3D printing materials had been used in the field of urology. 3D printing may be a useful and cost-effective tool in the field of urology in the future. Herein, we reviewed the current applications of 3D printing and outlooked the application prospect of 3D printing technology in the field of urology
RNA干扰p38基因对肾癌786-O细胞生物学特性的影响及对舒尼替尼的增敏作用
陈俊明,,吴登爽△,志向,吴震杰,,鲍一,叶华茂,杨庆,曲乐,王林辉
- , 2016, DOI: 10.16781/j.0258-879x.2016.07.0799
Abstract: 目的 探讨RNA干扰p38基因对人肾癌细胞株786-O增殖、侵袭、细胞周期和细胞对舒尼替尼敏感性的影响。方法 构建针对p38的siRNA531和siRNA659两条siRNA,分别将其转染至肾癌786-O细胞株,即为siRNA531组和siRNA659组,同时设置转染无义siRNA的阴性对照组和仅加转染试剂的空白对照组。应用RT-PCR技术检测786-O细胞p38 mRNA的表达,蛋白质印迹法检测p38蛋白的表达。CCK-8法检测细胞的增殖情况和对舒尼替尼的敏感性,流式细胞术检测细胞的周期改变情况,Transwell实验检测细胞的侵袭能力。结果 RT-PCR及蛋白质印迹法检测发现siRNA转染后786-O细胞p38 mRNA及蛋白的表达均降低。与空白对照组和阴性对照组相比,siRNA531组和siRNA659组786-O细胞在转染后3~5 d时的增殖率均降低(P<0.05,P<0.01),细胞对舒尼替尼的敏感性增加,两组对舒尼替尼的IC50值均低于阴性对照组[(3.2±0.3)、(1.4±0.1) μmol/mL vs (5.4±0.2) μmol/mL,P<0.05]。siRNA531组、siRNA659组G1期细胞数量明显多于对照组,且两组786-O细胞出现G0/G1阻滞。转染24 h后,两组的穿膜细胞数分别为56.43±6.02、34.00±8.12,与阴性对照组(76.27±5.08)相比,两组细胞的侵袭能力均下降(P<0. 01)。结论 通过转染p38特异性siRNA可以成功沉默肾癌细胞株786-O的p38基因的表达,抑制肾癌细胞株786-O的增殖、侵袭能力,增加其对舒尼替尼的敏感性,为后续研究肾癌治疗及靶向耐药奠定基础。
Objective To investigate the effects of p38 gene sliencing on the proliferation, invasion, cell cycle and sensitivity to sunitinib of human renal carcinoma cell line 786-O. Methods We designed two sequence-specific small interfering RNA(siRNA531 and siRNA659) targeting p38 gene and transfected them into renal carcinoma cell line 786-O. 786-O cells transfected with nonsense siRNA served as negative control and those cultured with transfection medium served as blank control. The change of p38 gene expression was observed by RT-PCR and the expression of p38 protein was detected by Western blotting analysis.The proliferation, sensitivities to sunitinib, invasion capabilities, and the cell cycle of 786-O cells were examined by CCK-8 assay, transwell chamber test and flow cytometry, respectively. Results RT-PCR and Western blotting analysis revealed that p38 expression in p38 siRNA group was significantly decreased compared with the controls. The cell proliferation rates were also significantly decreased 3-5 days after siRNA531 or siRNA659 transfection compared with the controls (P<0. 05, P<0. 01), and cells in the siRNA531 and siRNA659 groups become more sensitive to sunitinib compared with negative control group, with two IC50 values being significantly lower than that of the negative control group ([3.2±0.3],[1.4±0.1] μmol/mL vs[5.4±0.2] μmol/mL; P<0.05). In addition, analysis of cell cycle demonstrated a marked G0/G1 arrest of the 786-O cells transfected with siRNA531 or siRNA659. We also noticed that 24 h after transfection, the cell invasion capabilities was significantly decreased in siRNA531 and siRNA659 compared with negative control (numbers of cells permeating septum:56.43±6.02, 34.00±8.12 vs 76.27±5.08; P<0. 01). Conclusion We have successfully suppressed p38 gene expression by specific siRNA, which
冲击波处理的结晶MgO的化学分析正电子谱研究
张菊,郑小明,志向
催化学报 , 1996,
Abstract: ?
316L-20G双金属复合管焊缝组织元素扩散分析
范兆廷,张胜涛,殷林亮,刘佳,志向
重庆大学学报 , 2012, DOI: 10.11835/j.issn.1000-582X.2012.11.016
Abstract: 通过对20G钢内衬316L金属复合管的焊缝区、316L基体以及20G钢进行EDS元素扫描,再采用扫描电镜对316L焊缝区、20G钢焊缝区进行线扫描分析,对焊缝组织主要合金元素的扩散进行了研究。结果表明:焊缝过渡层中合金元素被碳钢稀释,碳原子向316L和焊缝扩散,同时316L和焊丝中的合金元素Cr、Ni也向碳钢中渗透,但过渡层起到了良好的隔离作用,致使316L不锈钢金属中合金元素含量没有明显降低,保持了316L母材耐腐蚀性能。
植纤复合材料新进展首条生产线已通过省级签定

复合材料学报 , 1987,
Abstract: 创新性的一年生植物纤维复合材料—麻屑/树脂板的生产线,已于1987年4月30日,在安徽省舒城县新型材料厂通过了省级鉴定。鉴定会由省科委主持,省的教委、经委、计委和县委以及国内一些院校的领导参加了会议。鉴定委员会由国内和省内13个单位的专家、学者组成。省电视台对会议进行了录象并播放。与会者对我国(也是世界上)的第一条植纤复合材料生产线投入正常的工业化生产,给予了很高的评价。
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