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Search Results: 1 - 10 of 44 matches for " áRNYASI MARIANN "
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METODELE GENETICII MOLECULARE CA INSTRUMENTE PENTRU AMELIORAREA OVINELOR
JáVOR A.,HUSZENICZA G.,CZEGLéDI L.,áRNYASI MARIANN
Lucrari Stiintifice : Zootehnie si Biotehnologii , 2007,
Abstract: Autorii au prezentat pe scurt proiectele lor de cercetare din ultimii 10 ani ndomeniul geneticii moleculare la oaie. S-au realizat investiga ii asupra receptoruluide melatonin 1a (Mel1A) ca gen candidat care influen eaz sezonalitateareproduc iei la oaie. Cercet rile s-au efectuat pe trei rase, i anume Awassi,Merinos prolific maghiar i igaie. La aceste rase s-au determinat pozi iilemuta iilor genelor n func ie de secven a d referin a GeneBank nr. U14109. ntotal, la cele trei rase s-au identificat un num r de 16 polimorfisme nucleotidicesingulare (SNP). Exonul II a genei Mel1A este puternic polimorfic. ase din SNPidentifica i produc modific ri ale aminoacizilor din proteina care poate fi cauzamodific rilor func iei i/sau construc iei receptorului de melatonin . Studiul se vacontinua pentru a investiga cele trei rase pentru muta iile func ionale, construireade haplotipuri i asocierile dintre haplotipuri i activitatea ovarian extrasezon. Oalt abordare o reprezint studiul de caz a programului maghiar de ameliorarefolosind berbeci importan i din rasa Booroola. n Europa, Ungaria a fost prima ar care a importat berbeci i oi din rasa Merinos Booroola, pe baza c rora s-a formato nou ras Merinos Prolific Maghiar, recunoscut n 1992. n concluzia studiilor depan acum, rezultatele au ar tat c rata ridicat de ovula ie la cast ras esteprodus de muta ia receptorului genei BMPR-1B. Eficien a programului deameliorare dea cre te frecven a alelei FecB n aceast popula ie de ovine a fost ntarziat de aplicarea anterioar a metodelor improprii de clasificare genotipic .Un proiect mai amplu al echipei de cercet tori este acela de a estima diferen elegenetice dintre variatele tipuri de oi igaie i urcan din Estul, Centrul i SudulEuropei. n prezent, n cadrul institutului se deruleaz urm toarele proiecte decercetare: cartografierea locilor nsu irilor cantitative pentru produc ia de lapte dincromozomul 6 la rasa Awassi; polimorfismul genelor proteinei din lapte la rasa igaie; determinarea genotipurilor Callipyge la popula ia SuffolkMaghiar; ncruci area raselor de ovine de lan pentru a produce ovine pentru p r.
Educating the Citizen of Academia Online?
Mariann Solberg
International Review of Research in Open and Distance Learning , 2011,
Abstract: The Arctic is a vast, sparsely populated area. The demographic situation points to online distance education as a solution to support lifelong learning and to build competence in the region. An overall aim of all university education is what Hans Georg Gadamer calls Bildung, what we in Norwegian call dannelse and what Richard Rorty has called edification. A first problem to be addressed here is that in online distance learning some teachers find that is harder to support the development of the student’s voice. Being able to express oneself and to position oneself in a scientific community is vital for a well-educated graduate. Another problem in online education has been the extensive use of writing as a means in the student’s learning process. Writing is vital to academic education, but in online courses there is in general a danger of overuse. At the University of Troms we have tested the web conference tool Elluminate Live. This is a real-time application, integrated in the University’s learning management system (LMS), Fronter. The application enables synchronous oral dialogue, simultaneous sharing of texts, and so forth. I present our main experience with the use of Elluminate Live and discuss the extent to which this application has turned out to be helpful in developing the quality of online courses.
Efficacy of progression testing in predicting nursing student academic success
Mariann M. Harding
Journal of Nursing Education and Practice , 2012, DOI: 10.5430/jnep.v2n2p137
Abstract: Objective: The aim of this review is to study the accuracy of commercially available progression examinations inpredicting student success to determine if there are significant differences in scores for those who are academicallysuccessful and to discuss the implications of the findings in relation to the use of progression policies. Methods: Research papers published between January 2001 and November 2011 were identified in CINAHL, MEDLINEand Health Source: Academic databases. The search was performed using standardized systematic search methods withthe following terms: student success, progression testing, standardized testing, midcurricular, ATI and HESI . Results: Two studies met the inclusion criteria of reporting quantitative relationships between computerized assessmentmeasures and academic success. Both reported that MC-HESI scores positively correlated with academic success andscores attained in capstone nursing courses and that there were significant differences in scores between those who wereand were not successful academically.Conclusions: The MC-HESI may be a useful instrument for identifying students who are at risk for not successfullycompleting the nursing program. The use of information obtained from this test, and other progression testing, can enablefaculty to identify at-risk students at an earlier point within the curriculum and assist them by developing a remediationplan for student success through the remainder of their nursing education.
School Bullying in the Primary School. Report of a Research in Hajdú-Bihar County (Hungary)
Mariann Buda,Erika Szirmai
Journal of Social Research & Policy , 2010,
Abstract: Bullying has long been researched in different communities and cultures and has proven to be a phenomenon that seriously endangers individuals and communities as well. Among its consequences are different psychosomatic symptoms, deteriorating study or work performance, depression, suicidal ideation, unhealthy social climate or acts of crime. The present study presents some of the findings of a research carried out in 24 schools of Hajdú-Bihar County in 2008. The 1006 large sample of 5th and 7th grade students (age 11 and 13) answered questions on their bullying-related experiences and attitudes. Data were collected in a questionnaire on types of bullying, prevalence, students’ mood, feeling of well-being and their social environment. Findings show that similarly to results of earlier research a large number of students are involved in bullying. In the sample the most common types are name-calling and ostracism, whereas beating and threatening are less frequent. Correlations with age, gender and academic performance show that the younger age-group is more involved in beating and spreading gossip, girls in relational bullying, and academically weaker students are most often involved in bullying events. Variables of mood, feelings of well-being, social and study climate are analyzed with a focus on studying correlations between feelings and relations within the smaller communities. Victims appear to be in the worst position on all measures, including number of friends, stress, emotions towards school or social climate. However, they show a more positive attitude for studying than bullies or bully-victims.
Medication of Production Animals – Cure of Malfunctioning Animals or Production Systems?
Chrièl Mariann,Dietz Hans
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-s6
Abstract: Medication is used in all intensive animal productions. However, the increasing problems with resistant bacteria in all animal productions and in humans are supported by a number of reports. Special attention is given to the risk for transmitting food-borne (multi) resistant zoonotic agents to humans due to failure in antibiotic treatment resulting in lower cure rates or higher case fatality rates. The use of medication in humans per se is capable of selecting for resistance in human pathogens. Nevertheless, the amount of used medication/antimicrobials in treatment of Danish production animals goes far beyond the amount used for human consumption. The increase in consumption has not been followed by a similarly increased mortality, e.g. illustrated by the number of rendered animals, increased use of injection medicine for veterinary treatments of diseased animals, or increased number of remarks on the carcasses from the slaughterhouses. Medication in animal production is facing its limits and relevant economic alternatives have to be developed. The strategy for the future must concentrate on using medication only for clinically diseased animals and not as a strategic treatment of the whole herd in order to maximise growth and camouflage of suboptimal production systems and insufficient management.
Medication of Production Animals – Cure of Malfunctioning Animals or Production Systems?
Chrièl Mariann,Dietz Hans
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-s65
Abstract: Medication is used in all intensive animal productions. However, the increasing problems with resistant bacteria in all animal productions and in humans are supported by a number of reports. Special attention is given to the risk for transmitting food-borne (multi) resistant zoonotic agents to humans due to failure in antibiotic treatment resulting in lower cure rates or higher case fatality rates. The use of medication in humans per se is capable of selecting for resistance in human pathogens. Nevertheless, the amount of used medication/antimicrobials in treatment of Danish production animals goes far beyond the amount used for human consumption. The increase in consumption has not been followed by a similarly increased mortality, e.g. illustrated by the number of rendered animals, increased use of injection medicine for veterinary treatments of diseased animals, or increased number of remarks on the carcasses from the slaughterhouses. Medication in animal production is facing its limits and relevant economic alternatives have to be developed. The strategy for the future must concentrate on using medication only for clinically diseased animals and not as a strategic treatment of the whole herd in order to maximise growth and camouflage of suboptimal production systems and insufficient management.
Medication of Production Animals – Cure of Malfunctioning Animals or Production Systems?
Chriél Mariann,Dietz Hans
Acta Veterinaria Scandinavica , 2003, DOI: 10.1186/1751-0147-44-s1-p6
Abstract:
Changing the Chevreul Illusion by a Background Luminance Ramp: Lateral Inhibition Fails at Its Traditional Stronghold - A Psychophysical Refutation
János Geier, Mariann Hudák
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026062
Abstract: The Chevreul illusion is a well-known 19th century brightness illusion, comprising adjacent homogeneous grey bands of different luminance, which are perceived as inhomogeneous. It is generally explained by lateral inhibition, according to which brighter areas projected to the retina inhibit the sensitivity of neighbouring retinal areas. Lateral inhibition has been considered the foundation-stone of early vision for a century, upon which several computational models of brightness perception are built. One of the last strongholds of lateral inhibition is the Chevreul illusion, which is often illustrated even in current textbooks. Here we prove that lateral inhibition is insufficient to explain the Chevreul illusion. For this aim, we placed the Chevreul staircase in a luminance ramp background, which noticeably changed the illusion. In our psychophysical experiments, all 23 observers reported a strong illusion, when the direction of the ramp was identical to that of the staircase, and all reported homogeneous steps (no illusion) when its direction was the opposite. When the background of the staircase was uniform, 14 saw the illusion, and 9 saw no illusion. To see whether the change of the entire background area or that of the staircase boundary edges were more important, we placed another ramp around the staircase, whose direction was opposite to that of the original, larger ramp. The result is that though the inner ramp is rather narrow (mean = 0.51 deg, SD = 0.48 deg, N = 23), it still dominates perception. Since all conditions of the lateral inhibition account were untouched within the staircase, lateral inhibition fails to model these perceptual changes. Area ratios seem insignificant; the role of boundary edges seems crucial. We suggest that long range interactions between boundary edges and areas enclosed by them, such that diffusion-based models describe, provide a much more plausible account for these brightness phenomena, and local models are insufficient.
Mental disorder and caregiver burden in spouses: the Nord-Tr?ndelag health study
Mariann Idstad, Helga Ask, Kristian Tambs
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-516
Abstract: Data were obtained from questionnaires administered to the adult population of Nord-Tr?ndelag County, Norway during the period 1995-1997. The present study is based on a subsample where 9,740 couples were identified. Subjective burden in spouses of persons with mental disorder was compared with subjective burden in spouses of persons without mental disorder, using analysis of variance (ANOVA). All analyses were stratified by sex.Adjusting for several covariates, spouses of persons with mental disorder scored significantly lower on subjective well-being and significantly higher on symptoms of anxiety and depression compared to spouses of index persons without mental disorder. Although highly significant, the effect sizes were moderate, corresponding to a difference in standard deviations ranging from .34 - .51.Our study supports the notion that there is an association between mental disorder in one partner and subjective burden in the spouse, but not to the same extent that have been reported in earlier studies, as our results do not indicate that a large proportion of the spouses reach a symptom level of anxiety and depression that reflects clinical mental disorder.The global burden of mental disorder is increasing [1]. Depression alone is reported to be one of the leading causes of disability worldwide, accounting for 4.4% of lost years of healthy life due to premature death or disability (DALYs) on a global basis [2] and 6.2% of all DALYs in the European Region [1]. Prevalences for mood- and anxiety disorders within a 12-month period have been estimated to 9.5% and 18.1%, respectively, in the United States [3]. Similarly, in Norway almost 10% of the adult general population has been suffering from a depression disorder and almost 20% from anxiety disorders during a 12 month period [4]. Prevalence for anxiety and depression in the European Region at any point in time has been estimated to 100 million people, corresponding to 11.5% of the population [1]. The economi
Intracellular shuttling of a Drosophila APC tumour suppressor homolog
Adam Cliffe, Julius Mieszczanek, Mariann Bienz
BMC Cell Biology , 2004, DOI: 10.1186/1471-2121-5-37
Abstract: We generated a Drosophila strain that expresses E-APC (dAPC2) tagged with green fluorescent protein (GFP-E-APC) and we analysed its junctional association with fluorescence recovery after photobleaching (FRAP) experiments in live embryos. This revealed that the junctional association of GFP-E-APC in epithelial cells is highly dynamic, and is far less stable than that of the structural components of the adherens junctions, E-cadherin, α-catenin and Armadillo. The shuttling of GFP-E-APC to and from the plasma membrane is unaltered in mutants of Drosophila glycogen synthase kinase 3 (GSK3), which mimic constitutive Wingless signalling. However, the stability of E-APC is greatly reduced in these mutants, explaining their apparent delocalisation from the plasma membrane as previously observed. Finally, we show that GFP-E-APC forms dynamic patches at the apical plasma membrane of late embryonic epidermal cells that form denticles, and that it shuttles up and down the axons of the optic lobe.We conclude that E-APC is a highly mobile protein that shuttles constitutively between distinct subcellular locations.The Adenomatous polyposis coli (APC) protein is an important tumour suppressor in the colonic epithelium [1]. A key function of this highly conserved protein is to antagonize Wnt signalling, by constitutively downregulating the transcriptional activity of β-catenin/Armadillo, a key effector of the Wnt signalling pathway [2]. Loss of this function is thought to be critical in the initiation of colorectal tumorigenesis as it causes a transcriptional switch in the intestinal epithelium towards actively dividing crypt progenitor cells [3-5]. APC proteins are highly conserved among vertebrates and flies, and flies encode two APC proteins with overlapping roles in Wnt signalling during development [6,7].However, APC proteins have additional functions in connection with the actin and microtubule cytoskeletons that appear to be separate from their function in controlling Wnt si
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