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Search Results: 1 - 10 of 295470 matches for " ]李凤杰 "
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卡培他滨单药或联合方案治疗转移性乳腺癌临床疗效观察
Clinical Curative Effect Observation of the Treatment of Metastatic Breast Cancer (MBC) with Capecitabine Medicine or Combination Chemotherapy
 [PDF]

, , 常建英, , 袁佳, 刘诗苑, 冉立
Advances in Clinical Medicine (ACM) , 2014, DOI: 10.12677/ACM.2014.44016
Abstract:
目的:观察卡培他滨单药或联合方案治疗蒽环及紫衫类化疗后转移的乳腺癌的临床疗效及毒副反应。方法:2007年7月~2014年6月贵州省肿瘤医院乳腺、妇科肿瘤科收治转移性乳腺癌20例,其中:锁骨上淋巴结转移4例,肺转移5例,骨转移4例,肝转移1例,脑转移1例,皮肤转移1例,对侧乳腺转移1例,多脏器转移3例。全组病例均行蒽环类或/和紫杉类药物辅助化疗。全组病例给予含卡培他滨单药或联合方案化疗。治疗前中位KPS评分90分。其中单药治疗2例;卡培他滨连用曲妥珠单抗2例;联合贝伐单抗1例;联合吉西他滨9例;联合顺铂1例;联合紫杉醇2例;联合多西紫杉醇3例;化疗周期数2~6周期,中位周期数:4周期。所有病例治疗后均根据RECIST实体瘤客观评价标准(1.0版)进行疗效评价,毒副反应按WHO抗癌药物毒副反应评价标准进行评价。结果:其中有1例因失访后未能进行疗效评价。可评价例数共19例,其中1例达CR;6例达PR;6例达SD;6例达PD,有效率为36.8% (7/19)。治疗后出现转移的时间为2~33月,中位无疾病进展时间(PFS)为13月。20例患者出现1例4度骨髓抑制,1例3级吐消化道反应,经对症治疗后好转,其余1~2级消化道反应患者均能承受。出现4例1~2级手足综合症。结论:以卡培他滨单药或联合方案对既往紫衫、蒽环类化疗失败的转移性乳腺癌患者有一定疗效,且不良反应可以耐受,可作为转移性乳腺期有效治疗方案。
Objective: To observe the clinical curative effect, toxic and side effect after the treatment of anth-racene ring and Paclitaxel chemotherapy with capecitabine for the recurrence metastasis of breast cancer. Method: From July 2007 to June 2014, Guizhou tumor hospital’s breast and gynecological oncology section received and treated 20 patients with metastatic breast cancer, among which, there were 4 cases with neck and supraclavicular lymph node metastasis, 5 cases with pulmonary metastasis, 4 cases with bone metastases, 1 case with liver metastasis, 1 case with brain metastases, 1 case with skin metastasis, 1 case with contralateral breast transfer and 3 cases with systemic multiple transfer. All patients underwent anthracycline or/and taxane adjuvant chemotherapy. They were given capecitabine medicine or combination chemotherapy. The median KPS score before the treatment in full cases was 90. there were 2 cases with capecitabine medicine; 2 cases with Capecitabine combined with Trastuzumab; 1 case with Capecitabine combined with bevacizumab; 9 cases with Capecitabine combined with gemcitabine; 1 case with Capecitabine combined with cis-platinum; 2 cases with Capecitabine combined with TAX (taxol); 3 cases with Capecitabine combined with docetaxel; 2 - 6 cycles of chemotherapy, the median cycles: 4. For all patients, the objective evaluation criteria in solid tumors (RECIST version 1.0) was used to evaluate the curative effect, and adverse reaction was evaluated by the toxicity of anticancer drug WHO standard evaluation. Result: There was 1 case lost to evaluate because of failure to follow-up. There were 19 cases evaluable, among which, 1 case reached CR; 6 cases reached PR; 6 cases reached SD; 6 cases reached PD, the effective rate of 36.8% (7/19). Transfer time is 2 - 33 months after treatment. The progression-free survival is 13 months. In 20 cases, 1 case had 4 degrees of bone marrow inhibition, 1 case
翼吊式双发民机机体/动力装置一体化数值分析
,鄂秦,
力学学报 , 2000, DOI: 10.6052/0459-1879-2000-2-1998-181
Abstract:
坳陷湖盆三角洲前缘沉积微相构成及其分带性――以鄂尔多斯盆地上三叠统延长组为例
[],王多云[]
天然气地球科学 , 2006,
Abstract: 以鄂尔多斯盆地上三叠统延长组为例,研究了坳陷湖盆三角洲前缘沉积微相构成和微相组合,共识别出截削式和完整式水下分流河道、河口坝、远砂坝、席状砂、分流问湾等5种沉积微相和水下分流河道叠加组合、河口坝叠加组合、水下分流河道与河口坝叠加组合、河口坝与远砂坝、席状砂的叠加组合等4类微相组合,在此基础上,重点论述了三角洲前缘沉积微相组合的时空分布规律,并以三角洲前缘坡折带为界,将三角洲前缘分为“台型前缘”、“坡型前缘”和“盆型前缘”3部分,各部分有独特的沉积微相组合形式。
全三维解释方法探讨与实践
,王小善,
石油地球物理勘探 , 1996,
Abstract: ?随着野外三维勘测技术、室内资料处理技术的进步以及解释方法和交互解释工作站功能的不断完善,现在已有可能实现全三维解释。本文以yh工区三维地震资料为例,通过对区域自动追踪、面块切片解释、三维立体数据解释、三维解释可视化等技术的应用,不仅探索了全三维解释方法的实现过程,而且使三维解释的精度与效率大大提高。
一种大规模地形可视化的平滑调度算法
,霞?,黄天羽?
软件学报 , 2007,
Abstract: 提出一种适于大规模地形绘制的光滑调度算法.采用四叉树分块结构和z型填充曲线组织地形数据,利用地形数据的局部连续性提高调度效率;设计一种内存空间分配算法调度地形数据,实现对恒定帧速率绘制算法的支持;通过可控调度区实现调度优先级计算,在内存空间需求和调度时间需求之间取得平衡;采取预估调度的策略实现平滑调度并有效减少绘制中的缺块现象.算法实现了地形场景漫游中的数据平滑调度,有效地避免了因内外存大数据量交换而引起的显示延迟和跳跃现象.实验结果表明,利用平滑调度算法,数据调度的准确性和稳定性有了较大提高,在地形漫
FLUORESCENCE EMISSION AND ENERGY TRANSFER OF PHYCOBILISOMES FROM THERMOPHILIC CYANOBACTERIUM MASTIGOCLADUS LAMINOSUS DURING DISSOCIATION
嗜热蓝藻层理鞭枝藻(Mastigocladus laminosus)藻胆体在解离过程中荧光发射光谱和光能传递的研究

路荣昭,,顾天青,高士
生物物理学报 , 1996,
Abstract: Changes in fluorescence emission spcetra of phycobilisomes from Mastigocladus laminosus durihg dissociation in phosphate buffer of various molarity were studied. The 77k fluorescence emission spectrum of intact phycobolisomes showed one peak: F685, characterstic of termnal emitters. That of partial dissociated phycobilisomes indicated three bands: F652, F660 and F685, characteristic of C-phycocyanin (C-PC), allophycocyainn (APC) and torminal emitters respectively. Of the three bands, F652 was a main peak, F685 was a second peak and F660was a weak shoulder. When phycobilisomes were severely dissociated, the main peak shifted to 644nm; while F683, which originated from terminal emitters, became a weak peak instead of F685, F660 disappeared. We suggest that in these phycobilisomes some C-PC contact with APC and other contact with terminal terminal, an energy transfer chain shown as follows:
Investigation and Thoughts on the Development of China''s Meteorological Journals
我国大气科学类期刊近年进展调研与思考

侯翠香,,耀先
中国科技期刊研究 , 2010,
Abstract: 在新的历史发展时期,为探讨我国大气科学类期刊健康、协调、可持续发展之路,调研分析了近年来国内大气科学类期刊的突出进展,3种新刊相继诞生,8种期刊创新更名;期刊定位以及稿源不断改善;国际化程度显著提高,3种期刊先后被SCI或SCIE收录;优秀期刊竞相涌现等等;多角度统计分析了部分优秀期刊成功办刊的经验、特色与优势,思考并提出了创办一流大气科学期刊的相关建议与对策,为大气科学类期刊特别是地方性期刊的管理部门及出版部门提供决策参考和依据,共同推动我国大气科学类期刊事业的创新发展.
糠酸加氢负载型催化剂的制备及催化性能
浙齐,丁云,姜文
分子催化 , 2005,
Abstract: 选用不同的贵金属钌、铑、钯、铂,不同的金属担载量,不同的催化剂载体氧化硅、活性炭(AC)、γ-三氧化二铝等,制备了多种负载型催化剂,采用连续操作的固定床微型反应器评价了它们的糠酸加氢催化性能.研究表明,金属钯的性价比最好,钯的最佳担载量为0.8%,最适宜的催化剂载体是γ-三氧化二铝.催化剂0.8%Pd/γ-Al2O3,具有良好的催化活性和选择性.优化了该催化剂上糠酸加氢的反应条件,结果表明,在1.0MPa、150oC、氢气空速2000h^-1、糠酸的乙酸乙酯溶液的空速4.0h^-1的条件下,糠酸转化率达100%,四氢糠酸选择性为99.0%.
Pd-Ni/Al2O3催化剂上α-呋喃甲酸加氢反应研究
浙齐,丁云,姜文
分子催化 , 2005,
Abstract: 采用连续流动固定床微型反应器考察了Pd―Ni/Al2O3催化剂上α-呋喃甲酸加氢生成α-四氢呋喃甲酸的反应.研究了反应的温度,压力,气、液体流速,以及氢油比对催化反应性能的影响.结果表明;在2.5MPa,200℃.氢气空速6600h^-1,液体空速3.0h,氢油比为200时,α-呋喃甲酸转化率为94%,α-四氢呋喃甲酸选择性100%,产率94%,催化剂连续运转300h后未见活性下降.应用程序升温还原(TPR)和程序升温脱附(TPD)技术考察了催化剂表面吸附状态与催化加氢活性的关系.结果表明Pd―Ni/Al2O3催化剂表面存在两种活性中心,催化加氢反应主要在较弱的活性中心上进行.该催化剂体系反应活性高,选择性和稳定性好,反应条件温和,操作简单,产物易分离,具有良好的应用前景.
具有分段常数变元的Logistic型积分微分方程的振动性
黄利航,,
福州大学学报(自然科学版) , 2010,
Abstract: 研究了一类具有分段常数变元的Logistic型积分微分方程, 并利用已知方法将其线性化. 通过研究此线性方程所对应的特征方程, 得到了线性化方程解振动的充要条件, 从而也就获得了原方程解振动的充要条件, 最终说明所得到的线性化方程具有一般性, 通过对其简化可以得到已知文献研究的方程的线性化方程和方程解振动的充分条件.
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