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Search Results: 1 - 10 of 2729 matches for " yellow fever. "
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Aspectos críticos do controle da febre amarela no Brasil
Tauil,Pedro Luiz;
Revista de Saúde Pública , 2010, DOI: 10.1590/S0034-89102010005000014
Abstract: this paper presents epidemiological and control characteristics of yellow fever in brazil, taking its wild and urban transmission cycles into consideration. no urban cases have been reported in brazil since 1942, but urban yellow fever cases were reported in paraguay in 2008, after more than 50 years without registered cases in the americas. the two main objectives of yellow fever control programs in brazil are to reduce the number of wild cases and to maintain zero incidence of urban cases. although there is a consensus regarding control measures that should be applied in areas endemic for the wild form, this is not so in relation to areas infested by aedes aegypti. the arguments for and against expansion of the vaccination area are discussed. environmental and entomological studies are needed so that areas receptive to wild-type transmission can be recognized, even if they have been silent for many years.
The thermal stability of yellow fever vaccines
Ishak, Ricardo;Howard, Colin R.;
Memórias do Instituto Oswaldo Cruz , 1990, DOI: 10.1590/S0074-02761990000300011
Abstract: the assessment of yellow fever vaccine thermostability both in lyophilized form and after reconstitution were analyzed. two commercial yellow fever vaccines were assayed for their thermal stability. vaccines were exposed to test temperatures in the range of 8 (graus) c to 45 (graus) c. residual infectivity was measured by a plaque assay using vero cells. the titre values were used in an accelerated degradation test that follows the arrhenius equation and the minimum immunizing dose was assumed to be 10 (ao cubo) particles forming unit (pfu)/dose. some of the most relevant results include that (i) regular culture medium show the same degradation pattern of a reconstituted 17d-204 vaccine; (ii) reconstituted yf-17d-204 showed a predictable half life of more than six days if kept at 0 (graus) c; (iii) there are differences in thermostability between different products that are probably due to both presence of stabilizers in the preparation and the modernization in the vaccine production; (iv) it is important to establish a proper correlation between the mouse infectivity test and the plaque assay since the last appears to be more simple, economical, and practical for small laboratories to assess the potency of the vaccine, and (v) the accelerated degradation test appears to be the best procedure to quantify the thermostability of biological products.
Superdosagem da vacina 17DD contra febre amarela, em uma regi?o do sul do Brasil
Carneiro, Marcelo;Lara, Beanir da Silva;Schimidt, Betina;Gais, Lediana;
Revista da Sociedade Brasileira de Medicina Tropical , 2011, DOI: 10.1590/S0037-86822011000200025
Abstract: introduction: yellow fever is a preventable disease when using a safe, effective vaccine. methods: a prospective clinical follow-up of 49 people who received an overdose of the wrong vaccine against yellow fever during the 2009 outbreak in a rural area of the vale do rio pardo, state of rio grande do sul. results: during 45 days of clinical follow-up, only 1 (2.1%) case presented manifestations of a possible acute viscerotropism as an adverse postvaccination event. conclusions: in the group of people monitored following an overdose of anti-yellow fever vaccine, observation confirmed almost total absence of adverse events.
A cien a?os de la puesta en práctica del gran descubrimiento de Finlay*
López Espinosa,José Antonio;
Revista Cubana de Medicina General Integral , 2001,
Abstract: one of the most relevant events in the latin american and cuban medicine history in all times was the confirmation and implementation at the end of 1900 and beginning of 1901 of the theory advocated by dr. carlos j. finlay barrés since 1881 about the role of aedes aegypti mosquito as the yellow fever-transmitting agent. this article is aimed at providing some details about this event so as to change somehow the faded and dusty aspect of this event given by the course of time, as well as to pay homage in a modest way to this cuban wise man and remember the place where 100 years ago it was proved to the scientific world by conclusive tests that his works were the highest real scientific achievements up to that moment
A mortality study of the last outbreak of yellow fever in Barcelona City (Spain) in 1870
Canela Soler,Jaume; Pallarés Fusté,Maria Rosa; Abós Herràndiz,Rafael; Nebot Adell,Carme; Lawrence,Robert S.;
Gaceta Sanitaria , 2009, DOI: 10.1590/S0213-91112009000400007
Abstract: background: the last outbreak of yellow fever in the city of barcelona, spain, was caused by a ship arriving from cuba. the objective of this study was to describe and analyze the epidemic of 1870 by using the available mortality data. methods: the information on 1,235 deaths identified in the parochial registries was analyzed, using statistical and epidemiological procedures for epidemic outbreaks. results: mortality due to yellow fever was 549.7 per 100,000 inhabitants. the temporal distribution of the deaths showed two peaks at the end of september and october with the last fatalities occurring in december 1870. the distribution of the fatalities in the city's neighborhoods was unequal. in la barceloneta, in particular, more fatalities were found in the streets adjacent to the port than in the most remote streets (r=0.83; p<0.0001). conclusions: this study reveals a temporal bimodal mortality distribution for yellow fever during the outbreak, with a high impact in adult men and in the la barceloneta neighborhood.
Evaluación retrospectiva de fiebre amarilla selvática en Venezuela, período 2003 - 2005
Finol B,Esteban; Berrueta,Eva; Levy G,Alegría; A?ez M,Florencio; Espina G,Luz Marina; Maldonado E,Mery Bell; Bermudez F,John; Valero C,Nereida;
Kasmera , 2008,
Abstract: yellow fever is a viral disease, typical of some tropical regions in south america and africa, causing numerous epidemics with high mortality rates. in order to characterize retrospectively the jungle yellow fever outbreak in venezuela in the year 2003, by determining the number of cases and deaths confirmed in the affected states according to age, sex, occupation and origin and by identifying factors that triggered the outbreak, as well as the study of cases reported in 2004 and 2005, cases officially registered in the state of zulia were studied for the period in question. zulia was the state most affected during the period evaluated, with 25 cases (p <0.001), reporting the highest attack rate during 2003; merida and monagas had the highest rates in 2004, portuguesa in 2005. the most affected age group was 25-44 years, predominantly male farm workers. results showed the high lethality of yellow fever: 46.51% in 2003, 60% in 2004 and 66.67% in 2005. the implementation of measures to establish a minimum surveillance in areas with proven activity is recommended.
Revista de Trabajos Regionales La fiebre amarilla en Zaraza por el doctor Vicente Pe?a
Rangel,Rafael;
Revista del Instituto Nacional de Higiene Rafael Rangel , 2006,
Abstract: upon revising and analysing the observations of dr. vicente pe?a on the yellow fever epidemic, at the beginning of the year, from the epidemic data, stationary character of the stegomia fasfaciata o calopus and discrimination of the signs and symptoms observed in patients or not, we concluded encouraging him to continue observing the illness.
Contribución al estudio de la fiebre amarilla en Venezuela, por Juan Manuel Iturbe, Interno de los Hospitales de Caracas
Rangel,Rafael;
Revista del Instituto Nacional de Higiene Rafael Rangel , 2006,
Abstract: reference is made to juan manuel iturbe′s doctoral thesis. also a transcription of the ietter received from dr. g. sanarelli conveying congratulations for the important and rich facts contained in the paper and requesting publications on yellow fever epidemics from any country in america.
Low frequency of side effects following an incidental 25 times concentrated dose of yellow fever vaccine
Rabello, Ana;Orsini, Marcela;Disch, Jolande;Marcial, Tania;Leal, Maria da Luz F.;Freire, Marcos da Silva;Yamamura, Anna M. Yoshida;Viana, Angelo;
Revista da Sociedade Brasileira de Medicina Tropical , 2002, DOI: 10.1590/S0037-86822002000200008
Abstract: in august/1999, a group of 14 adults from the staff of a private hospital in contagem ? minas gerais state, brazil, received unintentionally a 25 times concentrated dose of the 17-dd yellow fever vaccine (bio-manguinhos), due to a mistake at the reconstitution step. all patients were clinically and laboratorially evaluated at days 5, 13 and 35 post vaccination. frequency of side effects and clinical observations of this group of individuals were not different from the observed in recipients immunized with normal doses of the vaccine. at the second and third evaluation none of the subjects reported symptoms. none of the patients presented abnormalities at the physical examination at none of the time points and in all cases the blood examination was normal, except for a reduced number of platelets that was detected in one subject at the first and second evaluation and reverted to normal at third evaluation. at the first evaluation point, 8 subjects were serum negative and 6 serum positive for yellow fever at the plaque reduction neutralization test. in 5 subjects the observed titre was 10 times higher as the baseline of 2.36 log10 mui/ml. the samples collected at second and third evaluation (13th and 35th days) demonstrated that all subjects responded to the vaccination with the exception of one that did not present a positive result in any of the samples collected. this evaluation confirms the safety of the 17-dd yellow fever vaccine.
Low frequency of side effects following an incidental 25 times concentrated dose of yellow fever vaccine
Rabello Ana,Orsini Marcela,Disch Jolande,Marcial Tania
Revista da Sociedade Brasileira de Medicina Tropical , 2002,
Abstract: In August/1999, a group of 14 adults from the staff of a private hospital in Contagem -- Minas Gerais State, Brazil, received unintentionally a 25 times concentrated dose of the 17-DD yellow fever vaccine (Bio-Manguinhos), due to a mistake at the reconstitution step. All patients were clinically and laboratorially evaluated at days 5, 13 and 35 post vaccination. Frequency of side effects and clinical observations of this group of individuals were not different from the observed in recipients immunized with normal doses of the vaccine. At the second and third evaluation none of the subjects reported symptoms. None of the patients presented abnormalities at the physical examination at none of the time points and in all cases the blood examination was normal, except for a reduced number of platelets that was detected in one subject at the first and second evaluation and reverted to normal at third evaluation. At the first evaluation point, 8 subjects were serum negative and 6 serum positive for yellow fever at the plaque reduction neutralization test. In 5 subjects the observed titre was 10 times higher as the baseline of 2.36 Log10 mUI/ml. The samples collected at second and third evaluation (13th and 35th days) demonstrated that all subjects responded to the vaccination with the exception of one that did not present a positive result in any of the samples collected. This evaluation confirms the safety of the 17-DD yellow fever vaccine.
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