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Search Results: 1 - 10 of 17156 matches for " vitamin E "
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The Role of Vitamin E in Cerebral Hypoxia: An Ultrastructural Study  [PDF]
Essam Eldin A. Salama, Ali Hassan A. Ali, Abdullah M. Aldahmash, Saeed M. Abou El Makarem, Tarek A. El Ghamrawy, Gamal M. Aboulhassan, Hisham Alkhalidi, Mohammed Mubarak
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.41018
Abstract:

Hypoxia, due to impaired cerebral blood flow, has hazardous effects on brain structure and function. To minimize as much as possible the neurological consequences from hypoxic-ischemic (HI) brain injury, neuro-protective strategies are urgently required. Vitamin E has been shown to have protective effects against cerebral ischemia, possibly due to its anti-oxidant effects. Thirty albino rats, of both sexes, were obtained from the animal house at King Khalid University Hospital, King Saud University. They were divided into three groups; each included 10 animals: Group A was considered as a control one, animals of Group B were subjected to a permanent link to the carotid arteries on both sides and animals of Group C underwent permanent link to carotid arteries on both sides and concomitantly were given Vitamin E as an anti-oxidant. Animals of Group C were injected by Vitamin E (equivalent to 15 mg/day), into the peritoneal cavity as a single dose for a week and after the prescribed period the mice were sacrificed under deep anesthesia and their brains were extracted and prepared for an electron microscopic study of brain tissue. Specimens from animals of Group B showed a large number of neurons that had been deteriorated. Mitochondria were the most affected organelles. There were a large number of dark cells which probably resulted from shrunken nerve cells and exhibited opaque nuclei. The number of affected nerve cells was much lower in brain tissues from animals of the Group C which revealed absence of dark cells. The study did not disclose any similar changes in brain tissues of the control group animals. Our results suggested that treatment with Vitamin E after hypoxia-ischemia

Vitamin E in ataxia and neurodegenerative diseases: A review  [PDF]
Fatima. Imounan, Naima. Bouslam, Jehanne. Aasfara, Kaoutar. El alaoui, Wafa. Regragui, El Hachmia. Ait Benhaddou, Ahmed. Bouhouche, Ali. Benomar, Mohamed. Yahyaoui
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.24033
Abstract: Vitamin E is one of the most important lipid-soluble antioxidants. It is essential for the neurological function but its role in the central nervous system has not fully been elucidated. It is known that tocopherol acts in protecting cell membranes from oxidative damage and it can act as an anti-in?ammatory agent, which may also be neuroprotective, as well as regulating speci?c enzymes. There is growing evidence that oxidative stress plays a key role in the pathophysiology of several neurodegenerative disorders. These diseases are defined by the progressive loss of speci?c neuronal cell populations and are associated with protein aggregates. We reviewed some aspects related to the role of antioxidant properties of Vitamin E in preventing and/or curing neurodegenerative disorders such as the Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, ataxia, tardive dyskinesia and Huntington’s disease.
Effects of Inclusion of Polyunsaturated Fatty Acids and Antioxidants on Spermatozoa Morphology of Potchefstroom Koekoek Cockerels  [PDF]
Caiphus Hlungwani, Francois K. Siebrits, Tshimangadzo L. Nedambale
Open Journal of Animal Sciences (OJAS) , 2015, DOI: 10.4236/ojas.2015.52018
Abstract: This study was conducted to determine the effects of increasing dietary polyunsaturated fatty acids (PUFA) and antioxidants (Se and vitamin E) on spermatozoa morphology. At 24 weeks of age, Potchefstroom Koekoek cockerels (n = 60) were selected from the base population. Cockerels were randomly allocated into five dietary treatments with 12 cockerels per dietary treatment. The diets consisted of commercial layer diet (CL), commercial cockerel diet (CC), modified layer diet (ML), modified layer diet +PUFA (MLP), and modified layer +PUFA+ antioxidants (MLPA) diet. At 36 weeks of age, six cockerels with ≥ 75% sperm motility rate following analysis by Computer Aided Sperm Analysis (CASA) were selected from the base population in each dietary treatment group. Semen volume, sperm cells concentration and dead cells did not differ significantly among any of the groups. However, live and normal spermatozoa were significantly higher in the MLPA group. The bent mid-piece, bent mid-piece plus droplets, proximal droplets and distal droplets were significantly lower in the MLPA group. From this study it can be concluded that supplementation of polyunsaturated fatty acids and antioxidants may be of vital importance for normal morphology characteristics of spermatozoa in Potchefstroom Koekoek cockerels.
Supplementation of Vitamin E and C Reduces Oxidative Stress in Broiler Breeder Hens during Summer  [PDF]
B. P. Jena, N. Panda, R. C. Patra, P. K. Mishra, N. C. Behura, B. Panigrahi
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.48A004
Abstract: The present experiment was carried out to evaluate the effects of vitamin E and C supplementation on the antioxidant status of broiler breeder hens during summer. Two hundred seventy broiler breeder birds (coloured) were divided into nine groups with three replicates having 10 birds in each, and were supplemented two levels of antioxidant vitamins E (250 mg or 500 mg/kg) or C (200 mg or 400 mg/kg) alone or in combinations for a period of 8 weeks. All the vitamin supplemented groups showed significantly lowered malondialdehyde (MDA) level, higher activities of superoxide dismutase (SOD), catalase (CAT) enzymes and higher Ferric Reducing Antioxidant Power (FRAP) activities in erythrocytes than control. However, supplementation with combination of vitamins proved to be better than individual supplementation. It could be concluded that the combination of vitamins C and E at lower level (@ 200 mg/kg and 250 mg/kg, respectively) had higher erythrocytic antioxidant status in coloured broiler breeder hens as compared to individual vitamin supplementation during hot and humid stress.
Vitamin A, Vitamin E, Lutein and β-Carotene in Lung Tissues from Subjects with Chronic Obstructive Pulmonary Disease and Emphysema  [PDF]
Michael W. Sch?ffer, Somdutta Sinha Roy, Shyamali Mukherjee, Salil K. Das
Open Journal of Respiratory Diseases (OJRD) , 2013, DOI: 10.4236/ojrd.2013.32008
Abstract: Vitamin A (VA) and its active metabolites play an essential role in lung airway function. Patients with moderate to severe chronic obstructive pulmonary disease (COPD) have a lower serum retinol concentration, and improvement of their 1-second Forced Expiratory Volume (FEV1) is achieved with VA supplementation. In order to test our hypothesis that the VA signaling pathway is compromised in COPD, we obtained 20 lung samples from COPD patients differing in the degree of emphysema as judged by their FEV% values. All were smokers or were exposed to secondhand smoke. Levels of VA (retinol/retinyl ester), tocopherols and carotenoids (lutein, beta-carotene) in these samples were determined using HPLC. Additional analytes beside VA were included for their known roles as antioxidants and modulators of VA-action. VA levels (retinol/retinyl ester) decreased significantly with the increase in severity of emphysema. Among other analytes, α-tocopherol levels fell by 25.8% in the severe emphysema group in comparison to the mild emphysema group, and lutein levels similarly decreased in severe compared to moderate emphysema groups. However, beta-carotene levels remained unchanged. Thus there is a significant linear correlation between lung VA-levels and the severity of emphysema. There was also a significant reduction in the levels of α-, δ-tocopherol and lutein in the severe emphysema group of COPD patients who either smoked or were exposed to smoke.
The Bioavailability of Vitamin E in Fortified Processed Foods  [PDF]
Inga Schneider, Ute Bindrich, Andreas Hahn
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.33048
Abstract: Objectives: Vitamin E is an important human lipophilic antioxidant and is required for many metabolic functions. A high vitamin E intake appears to favorably impact a variety of disease processes. The vitamin E intake, excluding sup-plemental intake, of the vast majority of adults is below the current recommended level. By consuming vitamin E-enriched food, it is possible to take in adequate amounts of vitamin E. Vitamin E intake from enriched foods might prevent certain diseases without the need to ingest specific vitamin E supplements. The vitamin E that is present in enriched foods has to exhibit maximal bioavailability to ensure a sufficient intake of vitamin E from one portion of fortified food. The aim of the present study was to develop an enriched food that has highly bioavailable vitamin E. Furthermore, we wanted to examine whether vitamin E bioavailability can be affected by the technological properties of fortified food. Methods: Volunteers were given test foods (cream cheese and mayonnaise) that had been fortified with 60 mg of RRR-α-tocopherol. The test foods were technologically modified and the bioavailability of RRR-α-tocopherol was determined via a short-term kinetic measurement, which was 24 h long, and a long-term kinetic measurement, which was 28 d long. The test foods were characterized with respect to matrix properties. Results: In comparison to the mayonnaise group the serum α-tocopherol area under the curve (AUC) was significantly higher in the cream cheese group, as shown in the short-term kinetic (p = 0.010) and long-term kinetic (p = 0.017) studies. Conclusions: In conclusion, RRR-α-tocopherol was more bioavailable in cream cheese than in mayonnaise in both short-term and long-term periods. Hence, food matrices affect bioavailability of RRR-α-tocopherol. Fortified foods with proven high α-tocopherol bioavailabilities could be merchandised as functional foods with diseases prevention properties.
Vitamin E Bioavailability: Past and Present Insights  [PDF]
Simona Vagni, Francesca Saccone, Luciano Pinotti, Antonella Baldi
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.210146
Abstract: Over the past decades several studies have investigated the importance of an adequate vitamin E status to sustain both animal health and production in dairy cows. Cow milk is considered as a remarkable source of bioactive components promoting human health, which has renewed interest in the effects of vitamin E supplementation on its nutritional value, sensory quality and shelf life. Thus, defining relative bioavailability, utilisation and transfer into milk of different vitamin E formulations is particularly important to assess the adequate levels of supplementation for animal health and milk quality. In nature vitamin E is present under one isomeric form, RRR α-tocopherol; when α-tocopherol is synthesized chemically, a racemic mixture of 8 possible isomers of α-tocopherol in equimolar concentrations is produced (all-rac α-tocopherol). The different stereoisomers have different biopotencies in humans and livestock; the conversion factor between RRR and all-rac vitamin E was estimated by early studies on the basis of the rat foetal resorption bioassay, and then extended to other species. Recent advances on the distribution of vitamin E stereoisomers in plasma and tissues have highlighted the need to formulate new conversion factors in dairy cows as well as in humans. On account of this, the present article aims to consider past and recent data related to vitamin E in dairy cow nutrition.
Vitamin E Therapy in Non-Alcoholic Fatty Liver Disease  [PDF]
Xiangbing Shu, Li Zhang, Guang Ji
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.53016
Abstract:


Non-alcoholic fatty liver disease (NAFLD) is closely related to oxidative stress. Vitamin E (VE) is an effective antioxidant, which could relieve NAFLD symptoms by improving the balance of oxidation and anti-oxidation. However, recent researches indicate that the functional mechanisms of VE are not only limited to anti-oxidation, but also include adjusting the metabolism disorders of glucose and lipid. Furthermore, the efficacy of VE remains controversial in the treatment of NAFLD by far, and the suitable condition of patient, drug dosage, drug safety and course of treatment during clinical application still need to be discussed. Therefore, this paper reviewed the recent study progresses of clinical application of VE alone and VE and other drugs.


Effect of Vitamin E and Alpha Lipoic Acid in Nonalcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Open-Label, Prospective Clinical Trial (VAIN Trial)  [PDF]
Patrick P. Basu, Niraj J. Shah, Mark M. Aloysius, Robert S. Brown Jr.
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.45030
Abstract: Objective: Antioxidants, including alpha lipoic acid (ALA) and vitamin E, are efficacious for the treatment of nonalcoholic fatty liver disease (NAFLD). The objective was to evaluate the effects of ALA and vitamin E alone or combined as therapy for patients with NAFLD and nonalcoholic steatohepatitis (NASH). Design: Placebo-controlled, open-label, prospective study in which patients with NAFLD and NASH were randomized to treatment with ALA 300 mg (n = 40), vitamin E 700 IU (n = 40), ALA 300 mg plus vitamin E 700 IU (n = 40), or placebo (n = 35) daily for 6 months. Body mass index, homeostasis model assessment scores, fibrosis and steatosis markers, and diagnostic laboratory tests were assessed at baseline and at the end of the study. Results: Treatment with ALA and vitamin E alone or in combination, improved inflammatory cytokine levels, steatosis scores, homeostasis model assessment scores, and triglyceride levels after 6 months relative to baseline. Conclusion: Alpha lipoic acid and vitamin E, either alone or in combination, were effective treatments for patients with NAFLD and NASH.
Effects of Vitamin E and Selenium on Fertility and Lamb Performance of Yankasa Sheep  [PDF]
Suleman Ibrahim Musa, Immanuel Iordoo Bitto, John Adisa Ayoade, Olugbenga Emmanuel Oyedipe
Open Journal of Veterinary Medicine (OJVM) , 2018, DOI: 10.4236/ojvm.2018.89015
Abstract: Effects of vitamin E and Selenium administration on fertility and lamb performance of Yankasa sheep were evaluated. Thirty post pubertal ewes (1-1 1/2 years of age) and nine rams (2-2 1/2 years of age) were used for the study. The ewes were randomly assigned into 3 groups (n = 10). Animals in group 1 served as control and were administered 1 ml normal saline. Animals in group 2 were administered 90 mg Tocopherol acetate (Vitamin E), while group 3 received injection containing a combination of 100 mg tocopherol acetate and 1.97 mg sodium selenite. Two doses of the injections were administered 14 days apart (subcutaneously). Estrus was synchronized in the ewes using controlled internal drug release device (CIDR). Rams were used for estrus detection and mating starting 24 hours following withdrawal of CIDR. Ewes were allowed to carry the pregnancy to term. The results indicate higher (p < 0.05) estrus response (80.00, 100.00, 100.00), pregnancy rate (75.00, 100.00, 100.00) and lambing rate (66.6, 100.00, 100.00) in ewes following administration of vitamin E and a combination of vitamin E and selenium. Average daily weight gain of lambs was also significantly enhanced (p < 0.05) by treatment. It can be concluded that administration of Vitamin E alone and in combination with selenium resulted in improved reproductive performance on Yankasa sheep.
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