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Search Results: 1 - 10 of 7550 matches for " vascular mild cognitive impairment "
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Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment  [PDF]
James R. Hall, Leigh Johnson, April Wiechmann, Robert C. Barber, Sid O’Bryant
Open Journal of Medical Psychology (OJMP) , 2012, DOI: 10.4236/ojmp.2012.13006
Abstract: Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore differences in the presentation of depressive symptoms in various types of cognitive impairment. Method: Retrospective chart review was conducted on 254 consecutive cases of community dwelling elderly newly diagnosed with mild Alzheimer’s Dementia (AD) n = 122, mild Vascular Dementia (VaD) n = 71 or Amnestic Mild Cognitive Impairment (aMCI) n = 32 and Non-Amnestic MCI (nMCI) n = 29. Results: Analysis revealed no significant differences (p < 0.05) between the groups for total GDS score, the Dysphoria subscale or Cognitive Impairment subscale. AD endorsed significantly fewer symptoms than VaD on Apathy, Meaninglessness and Dysphoria. AD did not endorse a significantly different number of items than aMCI on any of the subscales. AD endorsed significantly fewer items than nMCI on Apathy and Meaninglessness. VaD endorsed significantly more items than the aMCI only on the Meaninglessness subscale (p > 05). No statistically significant differences were found between VaD and nMCI or between the MCI groups. Conclusions: Support is provided for the use of GDS subscales in a wide range of cognitively impaired elderly. This study suggests in mild dementia the number and type of depressive symptoms vary significantly between AD and VaD. There are indications that aMCI patients are similar in their symptom endorsement to AD and nMCI are similar to VaD which is consistent with some of the notions regarding likely trajectories of the respective MCI groups.
Evidências atuais do impacto terapêutico dos inibidores da acetilcolinesterase no transtorno cognitivo leve e na demência vascular
Gomes, Alexandre de Mattos;Koszuoski, Ricardo;
Revista de Psiquiatria do Rio Grande do Sul , 2005, DOI: 10.1590/S0101-81082005000200010
Abstract: introduction: acetylcholinesterase inhibitors constitute an effective class of drugs for the treatment of mild and moderate alzheimer's disease and are allowed by the responsible agencies for this purpose only. however, concrete evidence is still necessary in what concerns the impact of the use of such drugs to treat a large variety of cognitive disorders not classified as alzheimer's disease. the aim of this study was to review the medical literature in search for updated evidence of the impact of acetylcholinesterase inhibitors on mild cognitive impairment and vascular dementia. methods: the literature review was carried out in the lilacs, medline and ebmr databases. results and conclusions: assays using acetylcholinesterase inhibitors for the treatment of mild cognitive impairment are still small, present little power of evidence, and show only a modest improvement of symptoms. a recent study shows reduced progression of mild cognitive impairment to alzheimer's disease in the first 12 months of treatment, but this effect was not continuous. on the other hand, clinical trials involving patients with vascular dementia show encouraging results associated with the use of these drugs.
Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study
Cotroneo AM, Castagna A, Putignano S, Lacava R, Fantò F, Monteleone F, Rocca F, Malara A, Gareri P
Clinical Interventions in Aging , 2013, DOI: http://dx.doi.org/10.2147/CIA.S38420
Abstract: tiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study Original Research (3198) Total Article Views Authors: Cotroneo AM, Castagna A, Putignano S, Lacava R, Fantò F, Monteleone F, Rocca F, Malara A, Gareri P Video abstract presented by Pietro Gareri Views: 164 Published Date February 2013 Volume 2013:8 Pages 131 - 137 DOI: http://dx.doi.org/10.2147/CIA.S38420 Received: 22 September 2012 Accepted: 14 November 2012 Published: 05 February 2013 Antonino Maria Cotroneo,1 Alberto Castagna,2 Salvatore Putignano,3 Roberto Lacava,2 Fausto Fantò,4 Francesco Monteleone,5 Filomena Rocca,2 Alba Malara,6 Pietro Gareri2 1ASL 2 Turin, Piedmont, 2Elderly Health Care, Ambulatory Center for Dementia, ASP Catanzaro, Calabria, 3ASL Napoli 1, Campania, 4University Hospital Orbassano, Turin, Piedmont, 5Regina Margherita Hospital, Rome, 6Nursing Home S Domenico Lamezia Terme, ASP Catanzaro, Calabria, Italy Background: The studio di intervento nel decadimento vascolare lieve (IDEALE study) was an open multicenter Italian study, the aim of which was to assess the effectiveness and safety of oral citicoline in elderly people with mild vascular cognitive impairment. Methods: The study was performed in 349 patients. The active or citicoline group was composed of 265 patients and included 122 men and 143 women of mean age 79.9 ± 7.8 years selected from six Italian regions. Inclusion criteria were age ≥ 65 years, Mini-Mental State Examination (MMSE) score ≥ 21, subjective memory complaints but no evidence of deficits on MMSE, and evidence of vascular lesions on neuroradiology. Those with probable Alzheimer's disease were excluded. The control group consisted of 84 patients, including 36 men and 48 women of mean age 78.9 ± 7.01 (range 67–90) years. Patients included in the study underwent brain computed tomography or magnetic resonance imaging, and plasma dosage of vitamin B12, folate, and thyroid hormones. Functional dependence was investigated by scores on the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales, mood was assessed by the Geriatric Depression Scale (GDS), and behavioral disorders using the Neuropsychiatric Inventory scale. Comorbidity was assessed using the Cumulative Illness Rating Scale. An assessment was made at baseline (T0), after 3 months (T1), and after 9 months (T2, ie, 6 months after T1). The main outcomes were an improvement in MMSE, ADL, and IADL scores in the study group compared with the control group. Side effects were also investigated. The study group was administered oral citicoline 500 mg twice a day throughout the study. Results: MMSE scores remained unchanged over time (22.4 ± 4 at T0; 22.7 ± 4 at T1; 22.9 ± 4 at T2), whereas a significant difference was found between the study and control groups, both in T1 and in T2. No differences were found in ADL and IADL scores between the two groups. A slight but not statistically significant difference was found in GDS score be
The Effect of Cognitive Decline and Neuropsychiatric Symptoms on Activities of Daily Living in the Dementia Patients
N?ropsikiyatri Ar?ivi , 2008,
Abstract: Objective: Neuropsychiatric symptoms of people with dementia are frequently reported, but knowledge about the effects of cognitive and neuropsychiatric symptoms on daily activities in various dementia subtypes is conflicting. In this study, we investigated the influence of cognitive and neuropsychiatric symptoms on daily activities in mild cognitive impairment (MCI), Alzheimer Disease (AD) and Vascular Dementia (VD) patients. Method: Eighteen MCI, 40 AD, 17 VD patients and 23 healthy volunteers, making a total of 98 persons, were admitted to the study. All patients were evaluated with cognitive, neuropsychiatric and functionality scales found in the Dokuz Eylül dementia database registry, and patients were diagnosed according to DSM-IV and international study group criteria. Results: All groups were matched according to sex and education. We showed NPI (neuropsychiatric inventory for all frequency, severity, caregiver distress scores) and cognitive decline (MMSE scores) as being more prominent among AD; it has a significantly negative effect on Blessed functionality scale and instrumental daily living scale, and results were correlated with each other in all three groups. Discussion: Our results suggest that patients who have complaints of forgetfulness should be given a cognitive evaluation in addition to neuropsychiatric and functional scales determination. (Archives of Neuropsychiatry 2008; 45: 14-8)
Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment
Sudo, Felipe Kenji;Alves, Gilberto Sousa;Alves, Carlos Eduardo de Oliveira;Lanna, Maria Elisa;Ericeira-Valente, Letice;Moreira, Denise Madeira;Engelhardt, Eliasz;Laks, Jerson;
Arquivos de Neuro-Psiquiatria , 2010, DOI: 10.1590/S0004-282X2010000200005
Abstract: objective: cerebrovascular disease (cvd) is associated with cognitive deficits. this cross-sectional study examines differences among healthy elderly controls and patients with vascular mild cognitive impairment (vamci) and vascular dementia (vad) in performances on camcog subscales. method: elderly individuals (n=61) were divided into 3 groups, according to cognitive and neuroimaging status: 16 controls, 20 vamci and 25 vad. vamci and vad individuals scored over 4 points on the hachinski ischemic scale. results: significant differences in total camcog scores were observed across the three groups (p<0.001). vad subjects performed worse than those with vamci in most camcog subscales (p<0.001). all subscales showed differences between controls and vad (p<0.001). performance on abstract thinking showed difference between vamci and controls (p<0.001). conclusion: camcog discriminated controls from vamci and vad. assessment of abstract thinking may be useful as a screening item for diagnosis of vamci.
Perfil cognoscitivo de adultos mayores de 60 a os con y sin deterioro cognoscitivo
Josefina Montes-Rojas,Lidia Gutiérrez-Gutiérrez,Juan Felipe Silva-Pereira,Guillermo Garcia-Ramos
Revista Chilena de Neuropsicologia , 2012, DOI: 10.5839/rcnp.2012.0703.05
Abstract: Introduction: During aging cognitive function processes may decrease and fluctuate. This makes the task of distinguishing between normal aging and pathological deterioration clinically difficult. Variables such as age, academic level and social demographics combine to impede an objective analysis. The goal of the study was to characterize the neuropsychological profile of Mexican senior citizens who expressed a subjec- tive complaint regarding memory. Method: A sample of 536 people over the age of 60 was studied. Each had reported memory issues between 2006 and 2010 at the Salvador Zubiran National Institute of Medical Science and Nutrition. For interdisciplinary consensus the sample was divided into: Normal Aging (NA), Slight Cognitive Deterioration (SCD), Alzheimer Disease (AL), Vascular Dementia (VA) and Mixed De- mentia (MD). Z points were used to calculate ANOVA with repeated measurements. Results: The population yielded statistical differences stemming from neuropsychological evaluations. 29% of the sample were classified NA with no current objective alterations in cognitive func- tions. The largest group, 46%, were classified as SCD, manifesting some alterations in memory and attention. AL was found in 12% with severe alterations in memory, executive functions and language. A similar cognitive profile was shared with the 6% of the group with MD, with only difference in the severity of cognitive alterations. Those with a VA profile manifested affected functions for attention, visual construction, calculation and motor coordination.
The Effectiveness of Cognitive Rehabilitation on Improving the Selective Attention in Patients with Mild Cognitive Impairment  [PDF]
Arezoo Shomali Oskoei, Vahid Nejati, Bita Ajilchi
Journal of Behavioral and Brain Science (JBBS) , 2013, DOI: 10.4236/jbbs.2013.36049
Abstract: Purpose: The aim of the present study is to evaluate the effectiveness of cognitive rehabilitation on improving selective attention in patients with mild cognitive impairment. Methods: It was a quasi-experimental study with pre-test and post-test. The population in this study was all individuals referred to a neurology clinic in Tehran in 2012. The group was comprised of 40 patients with mild cognitive impairment who were evaluated with early detection and assessment by a medical psychologist (MMSE score lower than 25 and Wechsler memory test) and were selected by available sampling. They were also older than 55 years and had a minimum education at degree level, together with a lack of neurological and psychiatric comorbidities and impaired sensory and motor retardation, according to their nursing history and medical records. They were randomly divided into experimental and control groups (20 patients in each group). The experimental group was given 12 sessions (two hours each section) of cognitive rehabilitation with Neurocognitive Joyful Attentive Training Intervention (NEJATI). The control group, as expected with this group, did not receive any trial period. The selective attention of both groups was evaluated, before and after receiving intervention, by a Strop computer programme. Data were analysed using the covariance statistical test, MANCOVA. Results: The results show an increase in selective attention scores in the experimental group compared with the control group. Therefore, we can conclude that cognitive rehabilitation leads to improvement in the performance of selective attention (F = 4/97; sig < 0/05). Conclusion: Cognitive rehabilitation can impact on improving selective focus in people with mild cognitive impairment.
The Impact of Cognitive Reserve on the Neuropsychological Functioning of Hispanic Patients with Minor Neurocognitive Disorder  [PDF]
Jorge A. Herrera Pino, Nora Dieguez, Jose Armas
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.410A004

The purpose of this study was to explore the impact of cognitive reserve, on the neuropsychological status of a sample of otherwise healthy Hispanic patients, who complained of memory difficulties, and thus were suspected to present minor neurocognitive disorder. To this effect, 100 consecutive cases referred for neuropsychological evaluation by their primary care physicians comprised the initial sample. Two groups of 32 patients were formed on the basis of their scores in the Cognitive Reserve Questionnaire (CRQ) that was administered to all participants. The results obtained by both groups in an eclectic battery of neuropsychological instruments were compared. The results indicated that the CRQ High Score group had significantly better performance than the CRQ Low Score group in the tests administered, except those tapped into memory processes. This was interpreted, to be related to the fact that all of these patients fell into the category of mild cognitive impairment of the amnestic type, as neither group performed well in these specific instruments. The findings of this study were interpreted to lend support to the notion that better cognitive reserve was associated with better cognitive status in the later years of life.

Prevalence of Mild Cognitive Impairment in Individuals Aged over 65 in a Rural Area in North Greece  [PDF]
Magda Tsolaki, Tania Kakoudaki, Anthoula Tsolaki, Eleni Verykouki, Vassiliki Pattakou
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.31002
Abstract: There are no data available on the prevalence of Mild Cognitive Impairment (MCI) in Greece, and the existing information about dementia shows important variations depending on the geographical setting as well as the methodology employed. The aim of this study was to determine the prevalence of MCI in individuals aged over 65 in a rural area in the north part of Greece. From 1428 residents, 678 were finally examined, with a mean age of 73.35 years. Assessments, including neuropsychological testing, neurological examination and medical history, were used to assign a diagnosis of normal cognition, mild cognitive impairment (MCI), with or without depression, depression or dementia according to suitable criteria. A questionnaire was also used to obtain social and demographic data. The 26.3% were classified as Mild Cognitive Impaired without depression, the 8.8% as Mild Cognitive Impaired due to depression, 5.9% had sole depression, the 2.4% were diagnosed with dementia and 56.6% had normal mental status. The observed prevalence for MCI with and without depression implies a total of 35.1% of all people aged over 65 with MCI in the study area. Mild cognitive impairment is more prevalent in Greece than dementia, and its subtypes vary in prevalence.
Longitudinal Follow-Up of a Population with MCI: Predictive Value of the MIS Test with Delayed Recall for Progression to Dementia  [PDF]
Labos Edith, Cavagna Marina, Camera Luis, Boietti Bruno, Schapira Marcelo
Advances in Alzheimer's Disease (AAD) , 2018, DOI: 10.4236/aad.2018.74012
Background: Early detection of dementia is currently of great interest and of crucial importance for the implementation of preventive measures and treatment of the disease. Impairment in verbal episodic memory, and in particular in a delayed recall phase, is considered one of the early markers of progression from mild cognitive impairment (MCI) to dementia. Therefore, having cognitive screening instruments with predictive value for progression is of utmost importance. Objective: The purpose of this work is to show the predictive value, sensitivity and specificity of the Memory Impairment Screen with delayed recall (MIS-DR) to predict conversion to dementia in patients with MCI. Methods: In retrospective study 502 patients over 60 years old, evaluated in the Older Adult Functional Evaluation Unit of our hospital for cognitive complaint, were diagnosed with MCI. They were followed up to assess conversion to dementia. Results: During follow up, 144 participants developed dementia (28.6%, 95% CI 24.76 - 32.85) and the average time of progression to dementia were 23 months (SD 13.2). The cut-off point was established below 6 for MIS-DR and it showed a sensitivity of 76% (95% CI 68.77 - 77.84) and a specificity of 56% (95% CI 50.44 - 61.58), with a positive predictive value of 41% (95% CI 34.78 - 47.6) and a negative predictive value of 85% (95% CI 80.53 -
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