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Recurrent Giant Phyllodes Tumour of the Breast Pathological Considerations and Management Approach for Recurrence and Metastasis  [PDF]
Norman Oneil Machado
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.34043
Abstract: Phyllodes tumours are rare and account for 0.4% of all breast tumours. The majority of them tend to be less than 5 cms in size with giant tumours larger than 10 cms being about 20% of these cases. They display a broad range of clinical and pathological behavior and are regarded as falling within the spectrum of fibroepithelial neoplasms. Surgery has been the primary modality of treatment. However the extent of resection and the role of adjuvant radiotherapy and chemotherapy are still controversial. The risk of recurrence is (4.7% - 30%) for benign phyllodes tumour and (30% - 65%) for borderline and malignant phyllodes tumour. A case of giant phyllodes tumour measuring 36 × 30 cm and weighing 6.8 kg is presented, which had recurred following a previous resection 5 years back. The literature is reviewed with regards to pathology, the role of investigations, nature of resection and the risk factors for recurrence and metastasis
Infantile Hemangiopericytoma: Two Cases Report and Literature Review  [PDF]
Gamal Al-Saied, Amin Abokifa, Mohamed Al-Saeed, Mohamed Abdul Aziz, Tharwat Hussain, Medhat Ibrahim, Moemen Hafez, Dalal Nemenqani, Naglaa Fawzy, Mohamed Shahin
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.27083
Abstract: Hemangiopericytoma is a rare vascular tumour of infants. Although generally considered to be benign, local recurrence and metastases can occur. Herein, we report on two full term girls, delivered with lumbosacral swelling and left thigh swelling respectively. Complete surgical excision with safety margins was performed for each lesion. Histologic examination of both lesions showed picture of infantile hemangiopericytoma. There is no evidence of local recurrence or distant metastasis during last 20 and 17 months for 1st case and 2nd case respectively. In conclusion; most infantile hemangiopericytoma follow a benign course. Rarely these tumours behave aggressively with local infiltration, recurrences and even distant metastases. Careful follow up is therefore essential.
Granular Cell Tumour of Larynx— A Case Report  [PDF]
D. S. Deenadayal, B. Naveen Kumar, Nabeelah Naeem, Vyshanavi Bommakanti
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2016, DOI: 10.4236/ijohns.2016.54026
Abstract: Granular cell tumors, also called Abrikossoff tumors, are benign, slowly growing neoplasms. They may occur anywhere in the body, but head and neck accounts to 45% - 65% of these cases. The most common site is the tongue. Larynx is relatively an uncommon location for these tumours, accounting for approximately three to 10 per cent of the reported cases. Laryngeal granular cell tumour is extremely rare accounting for only 19 reported cases under the age of 17 years. As many as 10% of patients experience multifocal synchronous or metachronous tumors. We present a rare case report of granular cell tumour of the larynx.
Aggressive Angiomyxoma: An Unusual Female Pelvic Tumour. Report of Three Cases and Review of the Literature  [PDF]
Juan Antonio Martín-Cartes, Manuel Bustos-Jiménez, María Jesús Tamayo-López, María del Carmen Palacios-González, Virginia Gómez-Cabeza de Vaca, Antonio Mu?oz Ortega
Surgical Science (SS) , 2010, DOI: 10.4236/ss.2010.12008
Abstract: Aggressive angiomyxoma was first described in 1983 by Steeper and Rosai, and fewer than 150 cases have been reported in the world medical literature. It is a soft-tissue tumour of the pelvis and perineum. The recurrence rate is high, and often extensive resections are performed with considerable morbidity. These tumours are benign, locally infiltrative mesenchymal neoplasms with a predilection for the female pelvis and perineum and they usually tend to recur. Furthermore, these tumours often reach too large dimensions before becoming clinically symptomatic; their incidence is higher in women of the reproductive age group; however a few cases of its occurrence outside the pelvis have also been reported. In this study, we reported three cases with aggressive pelvic angiomyxoma treated with surgical methods and used an approach that described by Kraske in order to get access to lower rectal cancers. Accurate preoperative diagnosis should alert the surgeon to the need for wide excision, which is essential for prevention of local recurrence.
A Rare Cause of Melaena-Duodenal Gangliocytic Paraganglioma  [PDF]
Carmencita Esquivel, Suresh Navadgi, Greg Otto, Rebecca Thomas
Surgical Science (SS) , 2012, DOI: 10.4236/ss.2012.34045
Abstract: Gangliocytic paraganglioma (GP), a rare tumour that arises most frequently from the periampullary area, is considered to be a benign neoplasm with a potential for lymphatic spread. Distant metastases are rare [1]. We report a case of a 51 year old female who presented with abdominal pain, anaemia and melaena. Endoscopy, push enteroscopy and biopsy revealed a periampullary neuroendocrine tumour. Immunohistochemistry of the pancreatic duodenectomy specimen demonstrated a duodenal gangliocytic paraganglioma with no lymph node metastases. We review the literature on this rare tumour and the current treatment protocol.
Advanced Papillary Carcinoma of the Breast Presenting as an Ulcerated Anterior Chest Wall Tumour: Case Report  [PDF]
U. Abubakar, J. N. Legbo, S. M. Sahabi, C. Opara, I. R. Jamalu, N. Musa, S. Aliyu
Advances in Breast Cancer Research (ABCR) , 2014, DOI: 10.4236/abcr.2014.31001

BACKGROUND: Papillary carcinoma of the breast is a rare malignant tumour accounting for 1% - 2% of all breast cancers in women. Papillary carcinomas of the chest wall are always secondary to thyroid, thymus and ovaries. Other variants of breast cancer metastasizing to the chest wall have been reported. CASE: We report a 67-year-old woman presented to us with an ulcerated anterior chest wall mass of 1-year duration, bilateral axillary, supraclavicular and cervical swellings of 8-month duration. There was a history of breast lump which was noticed 5 years prior to presentation, no history of breast malignancy in the past and no family history of breast cancer. Examination revealed an ulcerated, nodular mass over the sternal angle which measured 14 cm × 12 cm

Comparison between Metastatic Spinal Tumour of Unknown Primary Tumour with a Known Primary  [PDF]
Wissam Jassim Sagban, S.M.S. Ridha, Zaki Noah Hasan
World Journal of Neuroscience (WJNS) , 2016, DOI: 10.4236/wjns.2016.61002
Abstract: Patients presented with spinal metastases from unknown primary tumours are rare. In this research we evaluated all patients with metastatic spinal tumour of unknown primary tumour, all patients were evaluated pre-operatively and comparison was done to those patients who had known primary tumour the study aimed to compare the group with known primary and the group with the unknown primary regarding the: mean age, gender, duration of symptoms, complication rate, region of the spine affected by metastasis, presence or absence of other skeletal or visceral metastasis, histological cell type and neurological outcome. Method: A retrospective study was performed on 40 patients presented to Neuroscience hospital in Baghdad from January 2010 till January 2014; all patients with metastatic spinal tumour were included in our study. We reviewed all patients’ records including age, sex, primary tumour, duration of their symptoms, neurological out come and complications. Results: Out of the 40 patient who presented with spinal tumours that underwent surgery duo to metastatic spinal tumour, five patients presented with spinal compression duo to metastatic tumour of unknown primary tumour (12.5%). The mean age was 64 years, 4 male and one female. For those with a known primary tumour mean age was 61 year, 22 male 13 female. Duration of symptoms prior to surgery was the same 180 days for those with unknown primary and 190 day for those with known primary tumours. They also had similar neurological outcome (80%) remain the same or improved post operatively for those with unknown primary and (85.7%) for those with a known primary tumour, and a similar complication rate for unknown primary was 25% versus 28% for known. The primary site of metastatic spinal tumour of unknown primary was confirmed after histopathology all shown adenocarcinoma four from the lung (80%) and one from colorectal. While the most common known carcinoma site were the lung 18 patient (51.4%), colorectal 8 (22.8%), breast 7 (20%), and renal 2 (5.71%). All patient who complain from secondary spinal metastasis with unknown primary tumour didn’t show any other skeletal or visceral metastasis, while those with a known primary tumour 6 patient out of 35 (17.1%) shown involvement of other site, the indication of surgery was to remove cord compression and restore neurological deficit. The most common site for metastasis was the dorsal spine for those of an unknown primary tumour 4 out of 5 patients (80%), and for those of a known primary tumour it was the lumbar area 28 out of 35 patient (80%). In conclusion
Chemotherapy-Induced Tumour Lysis Syndrome in Gastric Adenocarcinoma with Diffuse Liver Metastases: A Case Report  [PDF]
Nurhan Onal Kalkan, Ay?e Oter Almal?, Azer Gokmen, Erkan Dogan
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.91003
Abstract: Tumour Lysis Syndrome (TLS) is an important oncological emergency case which is often found together with haematological malignities and, much less often, with solid tumours. While TLS seen in solid tumour cases usually develops following a cytotoxic chemotherapy and its prognosis is poor. We present the case of a 60-year-old man with gastric adenocarcinoma with diffuse liver metastases (image shows diffuse liver metastatic lesions) and high serum LDH levels, who developed TLS after systemic chemotherapy. With urgent and proper supportive treatment (intravenous intensive hydration, sodium bicarbonate, diuretic, calcium gluconate, allopurinol and haemodialysis), an impressive recovery from TLS was achieved in the patient with an advanced stage gastric cancer. The purpose of this report is to emphasize that although the present case was a rare, high physician attention is required because significant morbidity or mortality may occur when the syndrome is not duly considered during the pre-cytotoxic evaluation of the patient, when preventive measures are not taken, or if the appropriate treatment is not applied immediately once the syndrome appears, especially in patients who have high tumour burden solid cancer.
Sources of Variability in the Use of Standardized Perfusion Value for HCC Studies  [PDF]
Michela D’Antò, Mario Cesarelli, Francesco Fiore, Maria Romano, Paolo Bifulco
Open Journal of Medical Imaging (OJMI) , 2012, DOI: 10.4236/ojmi.2012.22006
Abstract: Hepatocellular carcinoma (HCC) is one of the world’s most common malignant tumours. As known, liver tumour tissue is characterised by an increased blood supply related to neoangionesis which causes an increased arterial vascularisation. CT Perfusion Imaging is an important, non invasive, technique for qualitative assessment of tissue perfusion after contrast agent administration. Nevertheless, being able to reliably quantifying angiogenesis is increasingly important to both the evaluation of the disease progression and monitoring of the therapeutic response of HCC. With this in mind, we believe that could be helpful to employ Standardised Perfusion Value (SPV), which has the potential to be a useful non-invasive marker of HCC angiogenesis. However, before using SPV in clinical practice, we need to verify its reliability. There are different causes of variability in applying the SPV index, e.g., the technical specifications of the CT system employed and the image processing system. In this paper the authors will analyse the variability of the BFa estimates and the variability due to the calibration procedure of the CT system, this with the objective of verifying how these factors affects SPV values. In our case, perfusion MDCT images of seventeen HCC patients were analysed. A software application, based on maximum slope method, was developed to compute BFa and SPV values. Four radiologists were involved in images processing evaluating variability related to ROI selection; each radiologist repeated the ROI drawing four times on the same image set. We computed the k calibration factor in order to evaluate SPV variability due to calibration protocol of CT systems. Results show that calibration factor variance, due to the position in the gantry, is less than BFa variability. So, we conclude that, when daily calibration is preferred, a simplified protocol, which neglects the dependence of K factor from the position, may be utilised; at least until the intrinsic variability of perfusion parameter computation operator-dependent will be reduced.
Primary Chondrosarcoma of the Mammary Gland of a Spayed American Akita Bitch: A Case Report  [PDF]
Frank Herbert Comhaire, Inge Matteeusen, Hilde De Cock
Open Journal of Veterinary Medicine (OJVM) , 2012, DOI: 10.4236/ojvm.2012.22014
Abstract: An eleven-year-old spayed American Akita bitch rapidly developed a mammary tumour which was surgically removed. The histological examination revealed the tumour to be a sarcoma that presented positive immunohistochemical staining against vimentin and protein S 100. There was no staining against pan-actin. Based on the histological aspect and the pattern of immunohistochemical staining the diagnosis of primary extraskeletal chondrosarcoma of the mammary gland was considered most probable. Two months later the patient was euthanized with recurrent local tumour and metastases in the lungs.
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