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Search Results: 1 - 10 of 494 matches for " steroids "
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The effect of low dose steroid (Physiologic dose) and Chloroquine in the treatment of rheumatoid arthritis
Gharibdoost F,Hekmat S,Jalali F
Tehran University Medical Journal , 1999,
Abstract: Introduction: The regulation of neuroendocrine axis is one of the most important goals in the treatment of Rheumatoid Arthritis. Disease modifying drugs such as chloroquine with low dose steroid is the first choice in clinical practice by some physicians. This combination therapy is evaluated by this study. Methods: This survey is a prospective study on furty patients. Variables for determining the activity index of disease were joint tenderness, joint swelling, morning stiffness and erythrocytes sedimentation rate in two years follow up. Results: Decrementation of disease activity index was statistically significant before and after treatment, joint tenderness (X2=7.205, P=0.007), morning stiffness (X2=19.253, P=0.00001), joint swelling (X2=14.107, P=0.0001), ESR (T=2.428, P=0.02). Conclusion: The combination of chloroquine with low dose steroid is beneficial in the treatment of Rheumatoid arthritis
Steroids from the Whole Plants of Leucaena Leucocephala  [PDF]
Chung-Yi Chen, Yau-Der Wang
American Journal of Analytical Chemistry (AJAC) , 2010, DOI: 10.4236/ajac.2010.11004
Abstract: Four steroids, 5α,8α-epidioxy-(24ξ)-ergosta-6,22-dien-3β-ol (1), β-sitosterol (2), β-sitostenone (3), and stigmastenone (4), along with 10 known compounds were isolated from the whole plants of Leucaena leucocephala (Leguminosae). 1, Lupeol (5), 1,3-dipalmitoyl-2-oleoylglycerol (6), methylparabene (8) and isovanillic acid (9) were found for the first time from the species. The structure of these compounds were characterized and identified by spectra analyses.
Sex Steroids and Breast Cancer: An Overview  [PDF]
Zeina Nahleh, Juan E. Arenas, Arafat Tfayli
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.44097

Sex steroids, also known as sex hormones are synthesized naturally by the gonads (ovaries or testes). The two main classes of sex steroids, androgens and estrogens, are crucial hormones for the proper development and function of the body; they regulate sexual differentiation, the secondary sex characteristics, and sexual habits. They are also well known to influence many common cancers, especially hormonally driven cancers such as breast and prostate cancer. In this report, we review the association of sex steroids with cancer and the potential use of endocrine manipulation in cancer therapy as well as the limitations and challenges faced in this field.

Púrpura de Schonlein-Henoch asociado a varicela: Caso clínico
Cerda L,Jaime; Fuentes P,Paulina; Potin S,Marcela;
Revista chilena de pediatría , 2004, DOI: 10.4067/S0370-41062004000200008
Abstract: in order to discuss the role of varicella zoster virus (vzv) infection as a potential trigger of henloch-schonlein purpura (hsp) we present the case of a 4 year old boy with hsp and varicella. the clinical course was complicated by severe abdominal pain, requiring systemic steroids. on the 5th day of evolution, a vesicular exanthem appeared (vzv confirmed by direct immunoflouescence). intravenous acyclovir was used empirically considering the risk of using high dose steroids in the presence of vzv. both pathologies resolved uneventfully
Corticosteróides tópicos no tratamento da fimose primária em idade pediátrica: revis?o baseada na evidência
Pires,Paulo; Teixeira,Hermínia; Lopes,Irene; Santos,José Agostinho;
Revista Portuguesa de Clínica Geral , 2011,
Abstract: goals: phimosis is defined as the presence of a non-retractable foreskin by a narrow preputial ring. it can be classified as primary or secondary. primary phimosis is present in 96% of newborns, and tends to resolve spontaneously in the first 3 years of life. after this age treatment may be considered. circumcision is the classic treatment, but is associated with morbidity and costs. recently, several authors have reported the use of topical steroids as an alternative treatment for phimosis with good results. the aim of this review is to evaluate the available evidence on the efficacy and safety of topical steroids in the treatment of primary phimosis in children aged 3 to 18 years. data sources: medline, evidence-based medicine web sites, the index of portuguese medical journals and references of selected articles. review methods: practice guidelines, systematic reviews, meta-analyses and randomized controlled trials (rct) were searched using the keywords phimosis and steroids. the strength of recommendation taxonomy (sort) of the american family physician was used to classify the articles. results: forty four articles were found and four met the inclusion criteria for this review. one guideline proposes treatment with a topical steroid, 0,05% to 0,1%, twice a day for 20 to 30 days (sor a). three randomized controlled trials found that the use of topical steroids in the treatment of primary phimosis is effective, with a resolution rate of 65,8% to 90% and no reported adverse effects (evidence level 1). conclusions: the available evidence suggests that the use of topical steroids for the treatment of primary phimosis in pediatric patients is effective and without adverse effects (sor a). the application of the drug requires retraction of the foreskin, which must be repeated for maintaining hygiene. topical steroids are safe and effective for the treatment of phimosis and can be recommended by the family physician.
Role of Steroids in COPD
Vishnu Sharma
Online Journal of Health & Allied Sciences , 2002,
Abstract: There has been a lot of debate regarding the role of steroids in the management of Chronic Obstructive Pulmonary Disease. Now with a better understanding of the pathophysiology of COPD, the role of steroids in the management of COPD has become clearer.
Blood lipids may have influence on the emotional well-being in young men  [PDF]
Edyta Kramek, Sylwia Jastrzebska, Renata Walczak-Jedrzejowska, Katarzyna Marchlewska, Elzbieta Oszukowska, Anna Guminska, Krzysztof Kula, Jolanta Slowikowska-Hilczer
Health (Health) , 2010, DOI: 10.4236/health.2010.25066
Abstract: Anamnestic data on general health and medical conditions were achieved from 136 men (20-49 yrs). Beck Depression Inventory II (BDI-II) questionnaire was used to assess depressive symptomatology. Body weight, height, waist and hip circumference, arterial blood pressure were mea- sured. Serum levels of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglicerydes (TG), glucose, SHBG, total testosterone, DHEA-S and estradiol were determined. Calculated were body mass index (BMI), waist to hip ratio (WHR) and free testosterone index (FTI). In men aged 40-49 general health significantly got worse, BMI, WHR, blood pressure increased and mean serum levels of FTI, DHEA-S, estradiol decreased in comparison to younger men. Only in 40-49 age band BDI-II scoring was negatively related with FTI, however, in the whole group there were no significant correlations. Nevertheless, some symptoms of depression were negatively related with LDL-C or HDL-C and positively with TG. Similar relations were found among young men, but not in the middle-aged. Conclusions: Only blood lipids may have influence on emotional well-being in young healthy men. The decreased testosterone level becomes probably the main risk factor for the lower mood in middle-aged men. Atherosclerosis risk factors and general health worsen with the advancing age, but they have no significant effect on psychological situation.
Osteonecrosis: The perils of steroids. A review of the literature and case report  [PDF]
Ben J. Brooker, Prue P. A. Keith
Case Reports in Clinical Medicine (CRCM) , 2012, DOI: 10.4236/crcm.2012.12008
Abstract: Non-traumatic osteonecrosis is a cause of joint pain and deformity, not uncommonly caused by corticosteroid use. Despite this, corticosteroid induced osteonecrosis is poorly represented in the literature. We performed a detailed review of corticosteroid induced osteonecrosis, including aetiology, prevention, screening, clinical presentation, investigations, staging systems and treatment. We present this in the context of a patient at our institution who developed bilateral hip, shoulder and knee osteonecrosis following high dose corticosteroid therapy for dermatomyositis.
Adrenal insufficiency and bowel obstruction: An overlooked association  [PDF]
Ryan A. Kunjal, Ria R. Ramadoo, Surujpal Teelucksingh, Vijay Naraynsingh
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22029

Bowel obstruction is a documented but rare presentation of adrenal insufficiency (AI). We report a case of acute AI manifesting as intestinal pseudo-obstruction (IPO) in a patient with underlying iatrogenic adrenal suppression. An 83 years old female was admitted for partial small bowel obstruction that failed to resolve with conservative management. She then underwent exploratory laparotomy where no mechanical obstruction was found and the small bowel was manually decompressed. Postoperatively she developed acute swelling of her right ankle which was similar to mono-articular attacks in the past. This was diagnosed clinically as gout. Her obstruction failed to settle and a second laparotomy was done which yielded the same as the first. Given her past account of arthritic pain, direct questioning of steroid use unearthed a history of multiple intra-articular corticosteroid injections for analgesia. She also described several short courses of high dose oral steroids for respiratory tract infections, including a recent course which was abruptly stopped two days prior to presentation. Clinical suspicion of AI was supported by biochemical testing of stress cortisol levels and change in the serum cortisol in response to 250 μg of synthetic adrenocorticotropic hormone. Moreover, her improvement following a therapeutic trial of steroid replacement was dramatic and strongly supports this diagnosis. It is therefore worthwhile to consider a diagnosis of AI in cases of bowel obstruction in patients with comorbidities that predispose to steroid use and especially in settings where steroid abuse is prevalent.

Role of Intratympanic Steroids in the Management of Meniere’s Disease—A Review of 151 Cases  [PDF]
D. S. Deenadayal, D. Vidyasagar, Vyshanavi Bommakanti, Karuna Goel, Nabeelah Naeem
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2016, DOI: 10.4236/ijohns.2016.52018
Abstract: Objective: To assess the outcomes of hearing and vertigo in patients with Meniere’s disease who were treated with intratympanic methylprednisolone. Study Design: Retrospective study. Setting: Tertiary referral hospital. Methods: In our study with 151 patients [191 ears] were diagnosed as Menieres as per 1995 AAO-HNS guidelines. As an office based procedure these patients were treated with intratympanic methyl prednisolone. Results: There was a 98.6% improvement in the vertigo control rate, a 73.82% improvement in hearing and 29.31% had a definitive improvement in tinnitus. Conclusion: We conclude from our study that intratympanic steroid injection significantly controls vertigo, tinnitus and improves hearing in Meniere’s disease with minimal complications. Hence, it can be tried as a first line treatment for patients with Meniere’s disease.
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