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Search Results: 1 - 10 of 2333 matches for " somatic dysfunction. "
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Osteopathy and physical therapy- a gap bridging between two professions.
Rafael Zegarra-Parodi
Journal of Physical Therapy , 2010,
Abstract: Numerous treatment approaches exist within manual and manipulative therapy for the management of a variety of musculoskeletal and non-musculoskeletal conditions. Most of the techniques such as manipulation, muscle energy techniques, positional release techniques, myofascial release techniques and craniosacral therapy, which are also commonly used in manual therapy. Traditionally osteopathy developed the “art” and "science" of these techniques while most of the research supporting their use in clinical practice is now published by physical therapists. Orthopaedic Manual Physical Therapy encompasses the so-called bridge for the plausible gap between the two professions. While osteopaths work under the somatic dysfunction model and physical therapists under the pain and movement model, the recent International Association for the Study of Pain (IASP) global year against musculoskeletal pain emphasized the “biopsychosocial model.” The biopsychosocial model demands both the professions to work hand-in-hand and to understand mutual responsibilities and roles. Such an inter-professional teamwork would henceforth facilitate better patient recovery and care.
Somatic cell mutations in cerebral tissue of cattle affected by bovine spongiform encephalopathy  [PDF]
Matteo Busconi, Corrado Fogher
Agricultural Sciences (AS) , 2010, DOI: 10.4236/as.2010.11005
Abstract: In animals the prion disease includes sheep and goat scrapie and the bovine spongiform encephalopathy (BSE). While several polymorphisms of the prion (PRNP) gene have been identified in sheep and some of them have been associated with susceptibility to scrapie, few mutations are reported in cattle and no correlation with BSE have been demonstrated. Genetic screening for mutants in the PRNP gene of 21 BSE positive animals by direct sequencing of the amplified gene, using DNA extracted from brain as template, confirmed that only few polymorphisms are present. However DNA molecules cloned and sequenced from the population of fragments considering a total of 90 clones from 9 BSE positive and 70 clones from 7 BSE negative animals, gave a highly significant differences in the frequency of mutations (p = 0.01). The high frequency and type of variants found cannot be explained only with misincorporation error of the Taq polymerase. Interestingly one of the mutations found in the BSE positive animals (F209S) corresponds to a mutant that causes a familiar form of prion disease in humans (F198S). These data can be explained with the presence of somatic mutations modifying the PRNP gene in single brain cells.
Advances in Somatic Embryogenesis Research of Horticultural Plants  [PDF]
Aiqing Ji, Xueqing Geng, Yan Zhang, Guoliang Wu
American Journal of Plant Sciences (AJPS) , 2011, DOI: 10.4236/ajps.2011.26087
Abstract: Advances in horticulture plant biotechnologies provide new opportunities for researchers to study the field of vegetative propagation and genetic engineering. Developments of clonal propagation methods, especially somatic embryogenesis (SE), have numerous potential applications. This paper reviewed progress of research on SE in horticultural plants in last decade; analyzed plant regeneration having both direct and indirect SE from the characteristics of occurrence means, but mainly in an indirect way; and discussed the impact factors of SE, as well as reviewed the research in the practical applications of horticulture plants SE in the practice.
Temporal epigenetic modifications differentially regulate ES cell-like colony formation and maturation  [PDF]
Jong S. Rim, Karen L. Strickler, Christian W. Barnes, Lettie L. Harkins, Jaroslaw Staszkiewicz, Jeffrey M. Gimble, Gregory H. Leno, Kenneth J. Eilertsen
Stem Cell Discovery (SCD) , 2012, DOI: 10.4236/scd.2012.22008
Abstract: Human somatic cells can be directly reprogrammed to induced pluripotent stem (iPS) cells by forced expression of the transcription factors Oct4, Sox2, and either Klf4 and cMyc or Nanog and Lin28, using virus-based systems. However, low reprogramming efficiency and the potential for deleterious virus-induced genomic modification limit the clinical potential of this technology. Recent reports indicate, however, that the generation of iPS cells can be enhanced by the addition of synthetic small molecules, including epigenetic modulators. In this report, we demonstrate that the epigenetic modifiers Valproic Acid (VPA) and 5-azacytidine activate the reciprocal transcriptional regulation of endogenous pluripotency transcription factor genes in human dermal fibroblasts and that VPA alone can directly activate endogenous Oct4 in the absence of transgenes. Moreover, using human adipose cells, we demonstrate that histone deacetylase inhibition, prior to reprogramming factor transfection, increases embryonic stem (ES) cell-like colony formation ~2 - 3 fold. In addition, DNA methyltransferase (DNMT) inhibition during human ES cell culture promotes maturation of reprogrammed somatic cells, increasing the yield ~4 fold. These data provide proof of principle that reprogramming efficiency can be improved by inhibiting specific repressive epigenetic regulatory components at the levels of ES cell-like colony formation and maturation. In addition, these studies raise the interesting possibility that a more efficient small molecule-based reprogramming system may provide a superior alternative to current virus-based approaches.
Dasatinib-Induced Hepatic Dysfunction  [PDF]
Arumugam Manoharan
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.41003

A 53-year-old man with chronic myeloid leukaemia developed significant hepatic dysfunction when treatment was changed from imatinib (because of drug-induced rash) to dasatinib. Liver function tests returned to normal 77 days after cessation of therapy and have remained normal despite recommencement of dasatinib. Although the pathogenesis for the significant hepatic dysfunction is unclear, this case illustrates the reversibility of this event with dose interruption and that dasatinib can be safely recommenced for ongoing treatment.

Does Male Circumcision Adversely Affect Sexual Sensation, Function, or Satisfaction? Critical Comment on Morris and Krieger (2013)  [PDF]
Gregory J. Boyle
Advances in Sexual Medicine (ASM) , 2015, DOI: 10.4236/asm.2015.52002
Abstract: Morris and Krieger (2013) have argued that male circumcision does not impact adversely on sexual sensation, satisfaction, and/or function. In the present paper, it is argued that such a view is untenable. By selectively citing Morris’ own non-peer-reviewed letters and opinion pieces purporting to show flaws in studies reporting evidence of negative effects of circumcision, and by failing adequately to account for replies to these letters by the authors of the original research (and others), Morris and Krieger give an incomplete and misleading account of the available literature. Consequently, Morris and Krieger reach an implausible conclusion that is inconsistent with what is known about the anatomy and functions of the penile foreskin, and the likely effects of its surgical removal.
Erectile Dysfunction in Hemodialysis in Togo  [PDF]
Kossi Akomola Sabi, Béfa Noto Kadou Kaza, Eyram Yoan Amekoudi, Jacques Vigan, Souleymane Pessinaba, Kafui Avouwadan, Kodjo Tengue, Tchilabalo Matchona Kpatcha, Dazé Apollinaire Gnionsahe
Open Journal of Nephrology (OJNeph) , 2016, DOI: 10.4236/ojneph.2016.64018
Abstract: Objectives: To determine the prevalence and risk factors of erectile dysfunction (ED) in men on hemodialysis in Togo. Methods: Prospective cross-sectional study, descriptive and analytical ranging from December 2015 to February 2016 in the hemodialysis unit of CHU SO, only dialysis center in the country. The evaluation of the ED was made through IIEF-5 questionnaire. Results: 39 men (67.2%) of 58 hemodialysis is a sex ratio M/F of 2.05. The average age was 43.5 years with extremes of 25 and 59 years. The majority of men had a profession in 19 cases (48.7%). The mean duration of dialysis was 30 months with a range of 4 months and 90 months. Initial glomerular nephropathy was in 19 cases (48.7%) and vascular in 14 cases (35.9%). 38 patients were hypertensive (97.4%) and 6 diabetic men (15.4%). The prevalence of ED was 74.3% (29 cases). ED score was less than 10 points in 14 cases (35.9%); 01 case (2.6%) between 11 and 16 points; 06 cases (15.4%) between 17 to 21 points; 08 cases (20.5%) between 22 and 25 points; and 10 cases (25.6%) between 26 and 30 points. Age, profession and duration of dialysis were risk factors associated with ED (P <
Female Sexual Dysfunction in Elfayoum Governorate  [PDF]
Samar El-Tahlawi, Noha Ezzat Mohammad, Asmaa Younes Elsary, Noha Mohamed Yousef, Talal Abdelreheem
Advances in Sexual Medicine (ASM) , 2018, DOI: 10.4236/asm.2018.81001
Abstract: Introduction: female sexual dysfunction (FSD) is a complex and poorly understood condition that affects females of all ages. Female sexual dysfunction has been a cyclic rather than a linear process that emphasizes biologic, psychological, social, hormonal, and environmental factors. Female sexual dysfunction is a high prevalent disorder reaching up to 60% of females with reported higher levels in postmenopausal. Aim of the work: was to estimate prevalence of FSD and its related factors in Elfayoum city. Subject and Method: This study was a cross sectional descriptive study conducted in Elfayoum city included 508 married females (above 21 years old) during the period from September 2016 to March 2017. Results: The prevalence of FSD among studied group was 61.2% versus 38.8% had normal sexual function, desire dysfunction was 42.3%, arousal dysfunction was 39.2%, lubrication dysfunction was 25%, orgasm dysfunction was 58.5%, satisfaction dysfunction was 58.1% and pain was 43.3%. There was statistically significant negative correlation between Female Sexual Function Index (FSFI) score and each of female and husband age, duration of marriage, and number of children. Low mean of FSFI score was found among females with irregular menstrual cycle, using contraceptive, not pregnant, mutilated and females who’s their husband had erectile or ejaculation disorders. Conclusion and recommendation: High prevalence of FSD among females in Elfayoum governorate. Many factors are found to affect FSD as FGM, each of female and husband age, duration of marriage, and number of children.
Subjective symptoms related to depression and suicidal risk in a Japanese community: a cross-sectional study  [PDF]
Shigeki Takemura, Kouichi Yoshimasu, Jin Fukumoto, Hiroichi Yamamoto, Kazuhisa Miyashita
Open Journal of Psychiatry (OJPsych) , 2011, DOI: 10.4236/ojpsych.2011.12007
Abstract: BACKGROUND: This cross-sectional study aimed to assess the association between self-reported somatic and mental symptoms and the presence of major depressive disorder (MDD) and suicidal risk among community dwellers in Japan. METHODS: From two locations in Japan, we recruited 734 community dwellers who underwent an annual health screening. Basic symptoms of MDD, dysthymia, and the presence of associated suicidal risk were determined using a brief structured diagnostic psychiatric interview, Mini International Neuropsychiatric Interview (MINI). Information regarding self-reported somatic and mental symptoms was obtained from a self-administered questionnaire used in the annual health check-up. Suicidal risk was evaluated on the basis of six relevant questions asked in MINI. Logistic regression model was used to calculate age- and gender-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for MDD. Further adjustment for basic symptoms of MDD was performed to calculate ORs and CIs for suicidal risk. RESULTS: A myriad of somatic symptoms, including headache, heavy headedness, eye strain, and shoulder stiffness [adjusted OR (95% CI), 11.4 (1.22 - 107) at location 1; 5.17 (1.23 - 21.7) at location 2], were associated with the presence of MDD. Dysmenorrhea [6.07 (1.14 - 32.3) at location 1] and dysesthesia, arthralgia, and swelling in the extremities [2.72 (1.14 - 6.47) at location 2] were significantly associated with an increase in suicidal risk, independent of the presence of basic symptoms of MDD. CONCLUSION: Several somatic symptoms, especially pain-related ones, may serve as possible signs of depression and suicidal risk among community dwellers.
Asymmetric Somatic Plant Hybridization: Status and Applications  [PDF]
Lakshmanan Prabhu Shankar, Eeckhaut Tom, Deryckere Dieter, Van Bockstaele Erik, Van Huylenbroeck Johan
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.48A001

To create asymmetric somatic hybrids, the genome of the so-called donor protoplast is fragmented prior to protoplast fusion. As a result, only a limited amount of the donor genome is transferred to the fusion product. This technique can circumvent some commonly observed problems related to symmetric fusion and offers a practical breeding tool for asexual hybridization. Genomes are typically fragmented by irradiation, microprotoplast production or application of metabolic inhibitors such as iodoacetamide. Irradiation and microprotoplast production fragment the nuclear genome, whereas iodoacetamide inactivates the cytoplasmic genome. It can therefore be used to introduce cytoplasmic male sterility, an important practical application. For hybrid verification and genome characterization, molecular markers and cytogenetic techniques are applied. This review highlights and discusses progress made during the last decade in spermatophytes asymmetric protoplast fusion.

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