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Search Results: 1 - 10 of 3613 matches for " rotavirus infections "
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A rotavirose e a vacina oral de rotavírus humano no cenário brasileiro: revis?o integrativa da literatura
Salvador,Pétala Tuani Candido de Oliveira; Almeida,Taciana Jacinto de; Alves,Kisna Yasmin Andrade; Dantas,Cilene Nunes;
Ciência & Saúde Coletiva , 2011, DOI: 10.1590/S1413-81232011000200020
Abstract: due to the epidemiological relevance of rotavirus disease on the worldwide panorama as an important cause of morbid-mortality in the infantile public and to the still incipient production of studies concerning the problematic in the nationwide scenario, not to mention the unique necessity of encouraging the promotion of care and education as inseparable factors in the health spaces, it was delimited as study object of the present article the rotavirus disease in the brazilian scenario, emphasizing the vaccination as preventive measure against this ill. thus it is aimed to analyze the publications about rotavirus disease in our country's contexture, stressing the vaccination against the rotavirus (vorh) as the strategy mentioned. it is a bibliographic research performed on the bdenf, lilacs, scielo and medline databases, in february 2010. during the study the following thematic pillars were discussed: rotavirus characteristics; the rotavirus disease as a public health issue; and the vaccination against rotavirus as primordial action of health care. the study evidenced the epidemiological importance of rotavirus disease in the worldwide scenario and the relevance of vaccination as preventive measure against such problematics.
Monitoring the circulation of rotavirus among children after the introduction of the RotarixTM vaccine in Goiania, Brazil
Borges, Ana Maria Tavares;Souza, Menira Dias e;Fiaccadori, Fabíola Souza;Cardoso, Divina das Dores de Paula;
Memórias do Instituto Oswaldo Cruz , 2011, DOI: 10.1590/S0074-02762011000400018
Abstract: the epidemiological features of rotavirus a (rva) infection differ between children from developing and developed countries which could result in differences in vaccine efficacy around the world. to evaluate the impact of rotarixtm on rva prevalence, we monitored rva genotypes circulating in goiania by monitoring virus in faecal samples from children that had or had not been previously vaccinated. from february-november of 2008, 220 faecal samples were collected from children in seven day-care centres. rva detection was performed by two methodologies and the results were confirmed by polyacrylamide gel electrophoresis. from the 220 samples, eight were rva-positive (3.6%) and five were from children that had received either one or two doses of the vaccine. all positive samples were collected from children with diarrhoea during august and september. genotyping of the rva characterised five of the viral samples as genotype g2p[4] and one as g8p[4], suggesting that g2p[4] was the predominant circulating genotype in goiania during the study. the fact that vaccinated children were also infected by rva suggests that the vaccine does not fully protect against infection by the g2[p4] rva genotype.
Comportamiento clínico y costos de la gastroenteritis por rotavirus en lactantes: Adquisición comunitaria versus nosocomial
Delpiano M.,Luis; Riquelme R,Joel; Casado F.,M. Cristina; álvarez H.,Ximena;
Revista chilena de infectología , 2006, DOI: 10.4067/S0716-10182006000100003
Abstract: this is a prospective 12 month (july 2003-june 2004) cohort study in one large tertiary hospital of santiago, chile aimed to describe clinic features and calculate the direct costs of hospitalization associated to community-acquired (n = 78) and nosocomially-acquired (n = 52) rotavirus infection. a gastroenteritis severity score after rennels 1996, (0 to 17 points) was applied and costs where calculated based on those assigned by the chilean national funds for health (fonasa). severe gastroenteritis manifested by a score > 14 occurred in 26.9% and 9.6% of community and nosocomially-acquired cases respectively (p < 0.015). the former had lower bicarbonate levels (p < 0.001), and required more volume expansion compared to the latter (p < 0.023). the average cost was us 277 per case for community acquired rotavirus and us 268 for nosocomial infection. in this hospital the cost of nosocomial rotavirus infection was ~ us$ 13,900 for a 12 month period. these results should stimulate the implementation of active prevention and control programs
Gastroenteritis Aguda en Ni?os Hospitalizados (2005-2010): Análisis Epidemiológico, Microbiológico y Clínico
Castillo Serrano,Ana; Plaza Almeida,Josefa; García González,Verónica; García Mialdea,Olga; Gutiérrez Junquera,Carolina; Sainz de Baranda Camino,Caridad;
Revista Clínica de Medicina de Familia , 2011, DOI: 10.4321/S1699-695X2011000200005
Abstract: objective: the main objective is to analyse the clinical, epidemiological and microbiological characteristics of patients hospitalised with acute gastroenteritis (ag) in the university of albecete hospital complex. the secondary objective is to determine the prevalence in the vaccinated population after the introduction of the rotavirus vaccine at the end of 2006 and if there is any change in the epidemiological pattern. design: patients aged under 5 years admitted to the albacete university hospital complex between october 2004 and april 2010 were studied. main measurements: demographic, epidemiological and clinical data were collected for all patients admitted for gastroenteritis. results: children hospitalised for ag represent 7.8-15.0% of the total annual hospitalisations of children under the age 5 years. the mean age of the children was 14 months. the aetiology was viral in 65% of patients. the rotavirus was the most commonly isolated virus, g9 and g1 being the predominant serotypes. after the introduction of the vaccine a 79% decrease in hospitalisations secondary to a rotavirus infection was reported. conclusions: there is a decreasing trend in the number of hospitalisations due to ag in children under 5 years. the ag is predominantly of viral aetiology mainly retrovirus. usefulness of the severity score as a predictor of aetiology. significant reduction in the number of admittances secondary to rotavirus after the introduction of the vaccine in 2006. in our study it was imposible to determine if vaccination is the only determining factor. high percentage of patients without microbiological diagnosis with the detection tests routinely used in our health area.
Mortalidad por enfermedad diarreica en menores, antes y después de la introducción de la vacuna contra el rotavirus
Esparza-Aguilar,Marcelino; Bautista-Márquez,Aurora; González-Andrade,María del Carmen; Richardson-López-Collada,Vesta Louise;
Salud Pública de México , 2009, DOI: 10.1590/S0036-36342009000400004
Abstract: objective: to analyze the mortality due to acute diarrhea in children younger than five years old, before and after the introduction of rotavirus vaccine in mexico. material and methods: number of deaths and mortality rates due to acute diarrhea were compared by children's age and states' vaccine status using annual percentage differences before (2000-2005) and after (2006-2007) the introduction of the hrv. results: from 2000-2007, deaths due to acute diarrhea in children under five years of age dropped 42%. in those states that received the hrv early in 2006, diarrhea mortality decreased between 2006-2007 15.8% in children younger than one year old and 22.7% in children 1-4 years old. discussion: the observed reduction in mortality due to acute diarrhea in children under five years of age after 2005 can be, in part, attributed to the hrv.
An evaluation of the relationship between rotavirus diarrhea and bacterial infection and acute hepatitis in children
Anna Kacerka,Kamila Wójcik,Jan Kuydowicz,Barbara Cielecka
Polish Gastroenterology , 2009,
Abstract: introduction: Rotaviruses are the most important cause of acute diarrhea in children requiring admission to the hospital. In the authors? practice, various complications accompanying rotavirus-induced diarrhea are observed, such as respiratory inflammation, co-infection with pathogenic bacteria, and liver damage. Aim of the study: The clinical course of rotavirus infection in children was analyzed. Material and methods: The study group was composed of 245 consecutive children with the gastrointestinal tract infection hospitalized at the Department of Infectious Diseases and Hepatology, Medical University of Lodz. The clinical course and complications of rotavirus infection were studied. Results: Rotavirus infection was confirmed in 93/245 (38%) patients with gastrointestinal tract infection. Pathogenic intestinal bacteria coexisted in 29 cases with rotaviral infection. Coexistence of rotavirus diarrhea and infections of the respiratory system was observed in 24% of the patients. Overall, 27 patients (28%) had acute hepatitis caused by rotaviruses. Conclusion: The presented study confirms that the coexistence of rotavirus-induced diarrhea and gastrointestinal, urinary, and respiratory tract bacterial infection is a frequent event. The coexisting acute hepatitis observed in this study group could be a manifestation of rotavirus infection.
Comportamiento clínico y costos de la gastroenteritis por rotavirus en lactantes: Adquisición comunitaria versus nosocomial Clinical features and costs of rotavirus gastroenteritis in infants: community versus nosocomialy acquired infection
Luis Delpiano M.,Joel Riquelme R,M. Cristina Casado F.,Ximena álvarez H.
Revista chilena de infectología , 2006,
Abstract: Este estudio observacional prospectivo describe elementos clínicos y costos directos de lactantes hospitalizados (julio 2003 a junio 2004), con diarrea confirmada por rotavirus de adquisición comunitaria (G-1, n = 78) y otros de adquisición nosocomial (G-2, n = 52). Se les aplicó una escala de gravedad de gastroenteritis, según Rennels 1996, de 0 a 17 puntos y asignó costos directos según arancel FONASA. Un 26,9 % de pacientes del G-1 tuvo puntaje > a 14 v/s 9,6 % del G-2 (p < 0,015). Así también los lactantes del G-1 presentaron menor nivel de bicarbonato plasmático (p < 0,001) y mayor frecuencia de shock o requerimiento de expansión de volumen (p < 0,023). El costo promedio total fue de $143.805 (US 277) para un caso de rotavirosis adquirida en la comunidad y $139.423 (US 268) para la de origen nosocomial. Hubo un gasto de $ 7.250.010 (US 13.900) en esta infección nosocomial, lo que amerita la implementación de un programa activo de prevención y control This is a prospective 12 month (July 2003-June 2004) cohort study in one large tertiary hospital of Santiago, Chile aimed to describe clinic features and calculate the direct costs of hospitalization associated to community-acquired (n = 78) and nosocomially-acquired (n = 52) rotavirus infection. A gastroenteritis severity score after Rennels 1996, (0 to 17 points) was applied and costs where calculated based on those assigned by the Chilean National Funds for Health (FONASA). Severe gastroenteritis manifested by a score > 14 occurred in 26.9% and 9.6% of community and nosocomially-acquired cases respectively (p < 0.015). The former had lower bicarbonate levels (p < 0.001), and required more volume expansion compared to the latter (p < 0.023). The average cost was US 277 per case for community acquired rotavirus and US 268 for nosocomial infection. In this hospital the cost of nosocomial rotavirus infection was ~ US$ 13,900 for a 12 month period. These results should stimulate the implementation of active prevention and control programs
Frequency and Demographic Study of Rotavirus Acute Gastroenteritis in Hospitalized Children of Borazjan City during 2008-2009
M Kargar,A Najafi,K Zandi,A Barazesh
Journal of Shahid Sadoughi University of Medical Sciences , 2011,
Abstract: Introduction: Rotaviruses are one of the most important causes of severe viral gastroenteritis and death among children, worldwide. The aim of this study was to determine the prevalence of Rotavirus gastroenteritis in hospitalized children of Borazjan. Methods: This cross sectional – descriptive study was done on 375 stool samples of children younger than 7 years old hospitalized in 17 Shahrivar hospitals of Borazjan due to severe diarrhea. Group A Rotaviruses were identified by Enzyme Immunoassay(EIA) test. Data was analyzed by SPSS software. Results: Of the total, 91(24.27%) rotavirus infections were detected. The highest incidence was observed in children aged 12-17 months(6.93%). Diarrhea(91.21%), vomiting(64.83%), moderate dehydration (57.14%), abdominal pain (56.04%) and fever (53.84%) were the most frequent clinical symptoms. There was a significant relationship between the virus and seasons(P=0). The highest prevalence was in autumn (54.94%) while the least was in summer(2.20%). Conclusion: Because of the high frequency of rotavirus infection, surveillance and expanded program of immunization is necessary, especially in children less than 2 years old.
Rotavirus: Enfermedad emergente de transmisión digestiva
María de los Angeles González Fernández,Roxana Hidalgo Rodríguez,Lis Silva Blay
Revista Cubana de Pediatr?-a , 2003,
Abstract: Las enfermedades diarreicas agudas (EDA), constituyen una de las principales causas de morbilidad y mortalidad infantil al nivel mundial. En los últimos a os han sido descubiertos algunos virus asociados con la producción de manifestaciones diarreicas, y esto se corrobora con la presencia de partículas virales observadas al microscopio electrónico en heces fecales de pacientes con episodios de diarreas. Entre los agentes virales asociados con enfermedad diarreicas, son los rotavirus los de mayor importancia médica, por lo que la detección, la identificación, los estudios de inmunización, así como la obtención de una vacuna para la prevención de este agente infeccioso, resultan de gran valor epidemiológico, puesto que la gastroenteritis viral es causa de deshidratación en casi aproximadamente 500 000 ni os anualmente, tanto en países desarrollados como en subdesarrollados, y resulta en costos médicos directos de $ 264 millones y $ 1 billón de costos totales para la sociedad. Acute diarrheal diseases (ADD) are one of the main causes of infant morbidity and mortality at the world level. Some viruses associated with the production of diarrheal manifestations have been discovered in the last years. It is corroborated with the presence of viral particles observed on the electronic microscope in stools from patients with episodes of diarrhea. Among the viral agents associated with diarrheal diseases, the rotaviruses are the most important from the medical point of view. Therefore, the detection, identification, immunization studies, as well as the obtention of a vaccine for the prevention of these infectious agents are of great epidemiological value, since viral gastroenteritis causes dehydration in approximately 500 000 children annually, both in developed and underdeveloped countries, which result in direct medical costs of $264 million and $ 1 billion of total costs for society.
Molecular characterization of G and P-types bovine rotavirus strains from Goiás, Brazil: high frequency of mixed P-type infections
Caruzo, Thabata Alessandra Ramos;Brito, Willia Marta Elsner Diederichsen de;Munford, Veridiana;Rácz, Maria Lúcia;
Memórias do Instituto Oswaldo Cruz , 2010, DOI: 10.1590/S0074-02762010000800014
Abstract: in this study, 331 samples from calves less than one month old from a dairy herd in the district of piracanjuba, state of goiás, brazil were tested for rotavirus. thirty-three samples (9.9%) tested positive for rotavirus. out of those, 31 were submitted to g and p characterization by reverse transcription followed by semi-nested polymerase chain reaction. two samples were characterized as g6p[1], three as g10p[11] and five as g6p[11]. the majority of the samples (51.6%) displayed multiple p genotypes (p-genotype mixtures), including typical human genotypes p[4] and p[6m], suggesting the occurrence of co-infections and genetic reassortment. also, the detection of human genotypes in bovine samples may be considered evidence of the zoonotic potential of rotaviruses. to our knowledge, this is the first report of such a high frequency of p genotype mixtures in bovine rotavirus samples. it also increases data on g and p rotavirus genotypes circulating in dairy herds in brazil and can help in the development of more efficient immunization approaches, thereby controlling infection and reducing economical losses.
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