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Search Results: 1 - 2 of 2 matches for " pyrazolopyrimidines "
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Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position
Eljazi I. Al-Afaleq,Samar A. Abubshait
Molecules , 2001, DOI: 10.3390/60700621
Abstract: Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,Nacetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)-pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-( p-tolyl) pyridazin-3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities.
Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives
Saleh A. Bahashwan,Ahmed A. Fayed,Abd El-Galil E. Amr,Eman M. Flefel,Atef Kalmouch
Molecules , 2013, DOI: 10.3390/molecules181215051
Abstract: A new series of fused triazolo- and tetrazolopyrimidine derivatives 2– 14 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD 50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
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