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Search Results: 1 - 10 of 45 matches for " narcolepsy "
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Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report  [PDF]
Heleen Binnenmars, Herman H. D. Idzerda, Hanno L. Tan, Gerard C. M. Linssen
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.36092
Abstract: Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.
Zolpidem-Induced Narcolepsy, Faint, Seizure or Coma? A Case Report  [PDF]
Abdolhamid Parsa, Amir Mohammadkhan, Mohammad Babaeian
Case Reports in Clinical Medicine (CRCM) , 2017, DOI: 10.4236/crcm.2017.62004
Abstract: Zolpidem, as an imidazopyridine agent, is a widely prescribed drug among practitioners for short-term treatment of insomnia. Nevertheless, there have been a number of cases associated with the adverse effects of the stated drug recently. Many cases of serious complications induced by high dose of zolpidem have been reported. Further to the existing reports of adverse reactions to zolpidem, throughout the current manuscript, another case of zolpidem-induced loss of consciousness is going to be presented. The case had taken 100 mg of zolpidem and afterwards, went into an unknown status of narcolepsy, faint, seizure or transient coma. Overdosing zolpidem and being affected by its central effects, he performed risky actions such as cooking by a gas oven and eating meal while intoxicated. The current case suggests that zolpidem overdose might contribute to loss of consciousness and exhibition of high-risk behaviors.
Las hipersomnias: diagnóstico, clasificación y tratamiento
Erro,M. E.; Zandio,B.;
Anales del Sistema Sanitario de Navarra , 2007, DOI: 10.4321/S1137-66272007000200010
Abstract: hypersomnia or excessive daytime sleepiness is common in neurological practice and may have different etiologies. hypersomnia may be defined as sleepiness at an inappropriate time or in an inappropriate situation. it is important to consider that hypersomnia is at times referred to as tiredness or fatigue. a detailed clinical history is essential to reach an accurate diagnosis. a correct diagnosis is necessary to initiate the appropriate treatment considering the negative social and occupational consequences of hypersomnia. excessive daytime sleepiness syndromes include primary sleep disorders like narcolepsy and hypersomnia secondary to several neurological and psychiatric disorders and also as an adverse effect of numerous drugs.
Report of two narcoleptic patients with remission of hypersomnolence following use of prednisone
Coelho, Fernando Morgadinho Santos;Pradella-Hallinan, Márcia;Alves, Gabriela Rodrigues;Bittencourt, Lia Rita Azeredo;Tufik, Sérgio;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000200028
Abstract: this article focuses on 2 clinical case reports of narcoleptic patients who experienced an absence of excessive sleepiness during treatment of other illnesses with 40 mg daily intake of prednisone.
Narcolepsy in Childhood: Case Report Case Report
?brahim Durukan,Murat Erdem,O?uzhan ?z,Dursun Karaman
N?ropsikiyatri Ar?ivi , 2011,
Abstract: Narcolepsy is a syndrome characterized by abnormality in the regulation of the sleep-wake cycle. It is a chronic disease commonly diagnosed between the ages of 40 and 60. However, the first symptoms often appear in childhood and/or adolescence. It is accepted that pediatric cases of narcolepsy generally remain unrecognized and undiagnosed. Clinical heterogeneity, especially in childhood, and development of symptoms over time contribute to the delay in diagnosis and treatment. The clinical symptoms and polysomnographic findings of five cases of pediatric narcolepsy are presented in this case report. (Archives of Neuropsychiatry 2011; 48: 158-61)
Narcolepsy and Orexins: An Example of Progress in Sleep Research
Alberto K. De la Herrán-Arita,René Drucker-Colín
Frontiers in Neurology , 2011, DOI: 10.3389/fneur.2011.00026
Abstract: Narcolepsy is a chronic neurodegenerative disease caused by a deficiency of orexin-producing neurons in the lateral hypothalamus. It is clinically characterized by excessive daytime sleepiness and by intrusions into wakefulness of physiological aspects of rapid eye movement sleep such as cataplexy, sleep paralysis, and hypnagogic hallucinations. The major pathophysiology of narcolepsy has been recently described on the bases of the discovery of the neuropeptides named orexins (hypocretins) in 1998; considerable evidence, summarized below, demonstrates that narcolepsy is the result of alterations in the genes involved in the pathology of the orexin ligand or its receptor. Deficient orexin transmission is sufficient to produce narcolepsy, as we describe here, animal models with dysregulated orexin signaling exhibit a narcolepsy-like phenotype. Remarkably, these narcoleptic models have different alterations of the orexinergic circuit, this diversity provide us with the means for making comparison, and have a better understanding of orexin-cell physiology. It is of particular interest that the most remarkable findings regarding this sleep disorder were fortuitous and due to keen observations. Sleep is a highly intricate and regulated state, and narcolepsy is a disorder that still remains as one of the unsolved mysteries in science. Nevertheless, advances and development of technology in neuroscience will provide us with the necessary tools to unravel the narcolepsy puzzle in the near future. Through an evaluation of the scientific literature we traced an updated picture of narcolepsy and orexins in order to provide insight into the means by which neurobiological knowledge is constructed.
Coelho, Fernando Morgadinho Santos;Elias, Rosilene Motta;Pradella-Hallinan, Márcia;Bittencourt, Lia Rita Azeredo;Tufik, Sérgio;
Revista de Psiquiatria Clínica , 2007, DOI: 10.1590/S0101-60832007000300005
Abstract: background: narcolepsy is a chronic neurological syndrome with prevalence between 0.018% and 0.040% without important ethnic differences. narcolepsy is characterized by excessive daytime sleepiness and cataplexy. the pathophysiology of the illness is not known; even so it possesses genetic marker (allele hla dqb1 *0602) and with abnormalities in the neurotransmission of hypocretin has been described in patients with narcolepsy. objectives: resume news discoveries in narcolepsy and show diagnoses and treatment options. methods: bibliographic review. results and discussion: the diagnoses of narcolepsy must be done with the international classification of sleep disorders criteria. the hypocretin dosage is the best exam to confirm diagnose in narcoleptic patients with typical cataplexy. the treatment is carried through with behavior actions and symptomatic drugs that promote the vigil and control the cataplexy. differential diagnoses as schizophrenia, epilepsy, depression and others sleep disorders need to be eliminated.
Value of Multiple Sleep Latency Test Periods and Clinical Correlation
Ibrahim Oztura,Ahmet Turan Evlice,Baris Baklan
Cukurova Medical Journal , 2013,
Abstract: Aim:Patients with complaints excessive daytime sleepiness were evaluated with Multiple Sleep Latency Test (MSLT) electrophysiological findings and researched narcolepsy symptoms like nightmare, hallucinations, cataplexy in this study. Material and Method: To study 26 patients were admitted retrospectively with complaints of excessive daytime sleepiness at Dokuz Eylul University Faculty of Medicine Sleep Clinic in the dates December 2009- December 2010. Cases of narcolepsy symptoms (hallucinations-nightmare-cataplexy) and MSLT were evaluated together. The onset of REM sleep (SOREM) was counted, than SOREM (+) and SOREM (-) patients sleep latency and narcolepsy symptoms were compared. All data were analyzed with SPSS 20.0. Results: The mean sleep latency assessed sleep latencies, gradually widening towards the end of the first sleep period, and it has been observed to be statistically significant(p:0.007). Conclusion: The mean sleep latency assessed sleep latencies, gradually widening towards the end of the first sleep period, and it has been observed to be statistically significant(p:0.007) and we thinked that it can be decreased of need to sleep during nap periods. [Cukurova Med J 2013; 38(4.000): 712-718]
Narcolepsia: actualización en etiología, manifestaciones clínicas y tratamiento
Pabón,R.M.; García de Gurtubay,I.; Morales,G.; Urriza,J.; Imirizaldu,L.; Ramos-Argüelles,F.;
Anales del Sistema Sanitario de Navarra , 2010, DOI: 10.4321/S1137-66272010000300007
Abstract: narcolepsy is a disease that involves an alteration in the generation and organisation of sleep. the main symptoms are excessive daytime sleepiness and cataplexy, followed by hypnagogic hallucinations, sleep paralysis and disrupted nocturnal sleep. the prevalence of typical narcolepsy oscillates between 25-50: 100.000 in general. recently there has been a peak incidence in patients born in the month of march. according to the new classification, the multiple sleep latency test (mslt) is mandatory for diagnosing narcolepsy without cataplexy, and advisable for diagnosing narcolepsy with cataplexy. until now, the attempt has been made to control each symptom by its own specific treatment. at present, new american and european treatment guidelines propose new drugs that act on all the symptoms. the application of new criteria of diagnosis and treatment has improved the diagnosis, giving better options of treatment.
Quality of life in patients with narcolepsy: a WHOQOL-bref study
Rovere, Heloísa;Rossini, Sueli;Reim?o, Rubens;
Arquivos de Neuro-Psiquiatria , 2008, DOI: 10.1590/S0004-282X2008000200004
Abstract: objective: to evaluate the perception of quality of life (ql) in brazilian patients with narcolepsy. method: 40 adult patients aged between 20 and 72 years (mean=41.55; sd=14.50); (28 f; 12m), with the diagnosis of chronic narcolepsy were followed up at the outpatient clinic (patient group). the control group was composed of 40 adults. the instrument utilized was the world health organization quality of life (whoqol-bref). results: the two groups were homogeneous and no difference was found with regards to age, sex, and demographic characteristics. the perception of ql in physical, psychological and social domains showed lower scores in those patients with narcolepsy than in the control group (p<0.05). concerning physical domain, all the aspects evaluated were significantly impaired, in patient group, including sleep satisfaction (p<0.001); energy for daily activities (p=0.039); capacity to perform activities (p=0.001); and capacity to work (p=0.001). conclusion: the perception of ql showed severe impairment in patients with narcolepsy for physical, psychological and social domains.
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