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Search Results: 1 - 10 of 126 matches for " microalbuminuria "
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Microalbuminuria in pediatric patients with hypertension  [PDF]
Nata?a Mar?un Varda
Health (Health) , 2013, DOI: 10.4236/health.2013.54A006
Abstract:

Microalbuminuria in adults has been found to be an early indicator of both renal and systemic vascular disease, as well as significant cardiovascular risk predictor and therapeutic marker. Its role in essential hypertension in adults has also been well established. As diseases like hypertension and obesity have their roots in childhood and are already present in children, influencing the morbidity in adulthood, the role of microalbuminuria has been extensively investigated in children as well. Most investigations have been performed in diabetic children, confirming its clinical significance. There is also enough evidence to suggest that microalbuminuria in obese children should be taken as seriously as in children with diabetes. In children with hypertension rare studies also indicate that its presence identifies hypertensive children with higher risk, although the exact role has to be confirmed in prospective and larger studies. The mechanisms of microalbuminuria onset could be the result of renal damage secondary to hypertension or underlying renal and systemic endothelial dysfunction. Evidence from small intervention studies in children with microalbuminuria also suggests that early intervention with antihypertensive drugs is likely to be beneficial, pointing out the role of microalbuminuria as a therapeutic marker in children too. In addition, we have to stress the importance of follow-up of children with microalbuminuria, confirmation of its persistence and identification of progression. However, longitudinal prospective studies in children, investigating its future cardiovascular risk, are still lacking.

Prevalence of Microalbuminury and Associated Risk Factors in a Population of Diabetics Followed at the Marc Sankale Center of Dakar  [PDF]
Sow Djiby, Diédhiou Demba, Ndour Michel Assane, Diallo Ibrahima Mané, Diouf Mahecor, Ka-Cissé Marie, Sarr Anna, Ndour Mbaye Maimouna
Open Journal of Internal Medicine (OJIM) , 2018, DOI: 10.4236/ojim.2018.81004
Abstract: Introduction: To describe the epidemiologic profile, clinical and paraclinical of diabetics presenting microalbuminuria at Marc Sankale center. Patients and methods: We have done cross-sectional and retrospective study in a descriptive and analytic view or way. It happened within 6 months. Diabetic patients who performed the nycthemeral urinary albumin dose and mentioned in the file were included. The last study is considered as a positive one from 30 to 299mg/24h: Microalbuminuria. The creatinine has been noted and the clearing of the creatinine is calculated through the formula of Cockcroft and Gault. The statistical analysis of data has been done thanks to software such as excel 2013 and SPSS VER 18.0. Results: 221 patients have been noted with 70% women and 30% men. The age varied between 30 years and 85 years with an average of 56, 62 against 9.97 years. Sixty three (63) patients have microalbuminuria (29%); creatinine has been regularized to 25 patients with 14.8% of cases. Among the microalbuminuria patients having completed the creatinine, 32 patients (42.7%) and 16 (21.3%) are respectively in a state of chronical renal failure, light and moderated. Conclusion: The microalbuminuria is frequent to diabetics. But in our series a starting renal insufficiency could precede that microalbuminuria.
Prevalence of microalbuminuria in type 2 diabetes patients in Tirana, a preliminary multicenter study  [PDF]
Nevi Pasko, Florian Toti, Ervin Zekollari, Arjana Strakosha, Viola Kacori, Nestor Thereska
Journal of Diabetes Mellitus (JDM) , 2013, DOI: 10.4236/jdm.2013.33022
Abstract:

Background: Microalbuminuria is often the first sign of renal involvement predicting overt nephropathy. For this reason, monitoring microalbuminuria and other risk factors associated with this condition is important to take measures to prevent or postpone overt nephropathy. This study aimed to investigate the prevalence of microalbuminuria in type 2 diabetes patients attending three diabetes centers in Tirana city. Patients and Methods: Two hundred and twenty patients with type 2 diabetes attending diabetes centers in Tirana were recruited in this crosssectional study. Medical records were used to collect data on duration of diabetes, waist circumference, history of hypertension, smoking. Blood samples were drawn after 12 h overnight fasting to measure glycosylated hemoglobin (HbA1c), serum cholesterol, triglyceride and creatinine. Microalbuminuria was assessed using dipstick kits in early morning urine samples. Results: The prevalence of normoalbuminuria was 58.3%, microalbuminuria 38.6% and macroalbuminuria 3.1%. Systolic and diastolic blood pressure (p < 0.01), HbA1c(p < 0.01) and fasting plasma glucose (p < 0.001) were significantly higher in microalbuminuric than in normoalbuminuric subjects. Multiple logistic regression analysis using microalbuminuria as the dependent variable in males shows that independent risk factors for diabetes patients with microalbuminuria were duration of diabetes, systolic blood pressure and waist circumference. We found that the OR for microalbuminuria became statistically significantly increased only at 16 years after the diagnosis of type 2 diabetes. At this time, 43.7% of patients had microalbuminuria. Conclusions: We found a high proportion of type 2 diabetes patients with microalbuminuria which raises

Comparison between different methods of urine collection for estimation of albumin-creatinine ratio in patients with type-2 diabetes mellitus  [PDF]
Subinay Datta, Mrinal Pal
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.34043
Abstract: In patients with diabetes mellitus, urinary albumin-creatinine-ratio (ACR) predicts progressive kidney disease. In order to determine the better urine sample for detecting ACR, we estimated ACR in three modes of urine sample. Two hundred patients of uncontrolled diabetes mellitus with proteinuria irrespective of age and sex were studied for urinary ACR in all the three types of samples over a period of 2 years. The statistical analysis showed that first morning ACR (r = 0.999, p > 0.001) of the subjects was more significantly correlated with their 24 hour urine sample ACR than spot urine (r = 0.995, p < 0.001). We conclude that early morning specimens should be used instead of spot and 24 hour sample.
Urine albumin excretion: Characterization of normal variability in healthy children  [PDF]
John Robert Brandt, Craig Stephen Wong, Aaron Jacobs, Amy Otten Staples
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.32012
Abstract:

Objective: Elevated urine albumin to creatinine ratio (ACR) of >30 mg/gm is a widely agreed upon indicator of pathologic albuminuria in children. However, the most reliable specimen to measure ACR in children remains undefined. We assess the range and limits of upright and supine total albumin and ACR in healthy children. Methods: Healthy children age 6 - 18 years completed 24-hour and split upright and supine urine collections. Upright, supine and 24-hour protein, albumin and creatinine were measured. Primary outcomes are range and variation in urine albumin by diurnal status, age, gender, BMI percentile and Tanner stage. Results: In healthy children, with mean age 12.9 year (sd 3.2), upright ACR was 2-fold greater than supine (13.9 vs 6.8 mg/gm, p = 0.02). The range of ACR was much greater in the upright (2 - 323 mg/gm) compared to the supine (1.7 - 76 mg/gm) samples. The average total 24-hour urine albumin was 8.4 mg (sd 9.8) and the mean ACR was 8.9 mg/gm (sd 11.7). The 24-hour albumin increased with age and Tanner stage, but this relationship was not significant after adjusting for BSA or urine creatinine. A supine or upright ACR of >30 mg/gm was found in 5.4% of each group. However, in all subjects with an elevated ACR on an individual upright or supine sample, a second 1st am ACR sample was normal. Conclusions: In healthy children there is a marked diurnal variability in ACR with a higher value from a daytime sample compared to 1st morning specimen. Screening for pathologic albuminuria should always use a first morning urine specimen.

Microalbuminuria and Kidney Disease Risk in HIV Patients Taking Combined Antiretroviral Therapy  [PDF]
Huylmer Lucena Chaves, Mayanna Pinho Batista, Adriana de Menezes Gomes, Amanda Antunes Costa, André Tigre Lima, Vinícius Diniz Arcelino do Ceará, Pedro Rubens Araújo Carvalho, Linna Albuquerque Sampaio, Fabrício de Maicy Bezerra, Melissa Soares Medeiros
World Journal of AIDS (WJA) , 2014, DOI: 10.4236/wja.2014.42029
Abstract:

Objectives: This study proposes to evaluate risk factors for kidney disease in HIV patients treated chronically and correlate with microalbuminuria measurements. Methods: Review charts and analyses of microalbuminuria in subgroup of HIV patients treated at Ceara/Brazil. Results: 149 patients, 69.1% male, mean 38.5 years old, infection mean 86.8 months. Mean Creatinine Clearance 110.2%, Creatinine 0.97, Urea 27.76 mg/dl, CD4+ 600.37 cels/mm3 and detectable viral load 530.59 copies with 61.7% undetectable. Mean Dosages of microalbuminuria/24h 147, 46 ± 820, 45 (N = 48) and microalbuminuria (mg/dl) 32.05 ± 85.25 (N = 43). Kidney Diseases Classification analyses evidenced 6.4% patients in stages ≥3 and 6.2% presented altered Microalbuminuria/24h. Patients using Tenofovir (TDF) 27.27% had Stage 2 and protease inhibitors (PI) had 4.1% in Stage 3. Proteinuria was observed in 5% stage ≥3. Association PI/TDF had 4.1% in Stage 3. No statistical difference between CD4 > or < 350 cels/mm3 and microalbuminuria/24h > 300 mg (p = 0.69); detectable/undetectable viral load and microalbuminuria/24h (p = 0.63) or stage ≥3 (p = 0.17); relation to Diabetes or arterial hypertension and microalbuminuria 24 h (p = 0.5 and p = 0.21); relation stage ≥3 and microalbuminuria/24h (p = 0.33); relation HIV diagnoses >/< 60 months and stage ≥3 (p = 0.51); or microalbuminuria/24h and TDF (p = 0.4), PI (p = 1), TDF/PI (p = 0.69), Atazanavir (p = 0.4) or Lopinavir/r (p = 1) regimens. There was statistical significance comparing age > or < 50 years and stage ≥3 (p = 0.001) without difference with age > or < 50 years and microalbuminuria/24h (p = 0.55) or microalbuminuria mg/d (p = 0.32). Relating comorbidities risk (Diabetes Mellitus plus Systemic Arterial Hypertension) to Kidney Diseases, it was found that 55.5% patients in Stage 3 or above with comorbidities compared with 15% with comorbidities in lower stages (P = 0.005).

Microalbuminuria en adolescentes obesos Microalbuminuria present in obese adolescents
Regino Pi?eiro Lamas,Karina Callejas de la Pe?a,Larisa Pacheco Torres,María Caridad Duarte
Revista Cubana de Pediatr?-a , 2009,
Abstract: INTRODUCCIóN. La alta prevalencia de obesidad en los adolescentes incrementa el riesgo de da o renal a esta edad. El objetivo de este estudio fue conocer la presencia de microalbuminuria en los adolescentes obesos y su relación con algunas variantes clínicas y bioquímicas que pueden ser factores de riesgo de da o renal. MéTODOS. Se estudiaron 57 adolescentes obesos, de uno y otro sexo, con edades entre 10 y 15 a os. Se realizaron estudios de microalbuminuria en dos ocasiones, glucemia, insulina, colesterol total y triglicéridos en ayunas. RESULTADOS. La microalbuminuria fue positiva en más de la mitad de los obesos estudiados, lo cual indicó la existencia de un da o glomerular. Se observó representatividad de la microalbuminuria positiva en edades de 13 a 15 a os, sin distinción por sexo. El tiempo de evolución y la gravedad de la obesidad no tuvieron influencia en la microalbuminuria. A pesar que 11 de los 18 pacientes con hipertensión arterial tuvieron microalbuminuria positiva (61,1 %), no se encontró relación significativa con la microalbuminuria. La dislipidemia e insulinorresistencia influyeron significativamente en la microalbuminuria. CONCLUSIONES. La presencia de microalbuminuria se observó en más de la mitad de los pacientes con síndrome metabólico, lo que sugiere que esta es un componente importante en dicho síndrome. Se recomienda realizar el estudio de la microalbuminuria a todos los adolescentes obesos. INTRODUCTION: The high prevalence of obesity in adolescents increases the renal damage at this age. The aim of present paper was to know the presence of microalbuminuria in obese adolescents and its relation with some clinical and biochemical variants that may be risk factors of renal damage. METHODS: We studied 57 obese adolescents of both sexes aged between 10 and 15. We made two microalbuminuria studies, as well as glycemia, insulin, total cholesterol, and fast triglycerides. RESULTS: Microalbuminuria was positive in more than half of study obese adolescents explaining presence of a glomerular damage. There was a representativeness of positive microalbuminuria in ages from 13 to 15 years alike the sex. Course time and obesity severity have not influence on microalbuminuria. In spite of that 11 of 18 patients presenting arterial hypertension had also microalbuminuria (61, 1%), there was not a significant relation with microalbuminuria. Dyslipemia and insulin-resistance influenced significantly in microalbuminuria. CONCLUSIONS: Presence of microalbuminuria was observed in more than half of patients presenting metabolic syndrome, suggesting
Microalbuminuria en pacientes adultos ambulatorios sin control nefrológico y con factores de riesgo de enfermedad renal crónica en Servicios de Nefrología de Perú
Nefrología (Madrid) , 2012,
Abstract: chronic kidney disease (ckd) is a public health issue and is considered a common and harmful, but treatable disease. early diagnosis can prevent the possibility of severe vascular damage and its complications, facilitating prompt and aggressive therapeutic measures. objective: to determine the frequency of microalbuminuria (mau) in outpatients with known risk factors and to analyse whether a patient model exists in which screening is more efficient. methods: ours was an observational, cross-sectional study involving 2968 patients from 23 nephrology centres in peru. inclusion criteria were: male and female outpatients aged ≥18 years with previous diagnosis of hypertension (aht), diabetes mellitus (dm) and/or obesity. we obtained values for body mass index (bmi), waist hip ratio (whr), blood pressure, and microalbuminuria by dipstick. we then tested for the association of these variables with mau using odds ratios (or). results: the mean age of our patients was 52.76±14.24 years, 68.41% were women, and 57.48% of the patients came from the capital. dm was diagnosed in 508 patients (19.29%), 1368 (51.93%) had hypertension, and 758 (28.78%) were obese. the frequency of mau was 53.45%, and 8.96% of patients had mau>100 mg/l. there was a highly significant correlation with dm (or: 11.62; 95% ci: 8.55-15.78) and aht (or: 1.48; 95% ci: 1.24-1.76), while being from the capital (or: 0.75; 95% ci: 0.64-0.89) and female sex (or: 0.72; 95% ci: 10.60-0.86) acted as protective factors. conclusions: the frequency of microalbuminuria in the population studied was 53.45%. there was a highly significant correlation with diabetes and a hypertension found during evaluation, while being from the capital and female sex acted as protective factors.
Modificación de los parámetros metabólicos y microalbuminuria en pacientes con diabetes tipo 2 tratados con acarbosa
González Sarmiento,E.; Ergueta Martín,P.; Fernández Martínez,I.; Hinojosa Mena-Bernal,M.C.; Zurro Mu?oz,I.; Zurro Hernández,J.;
Anales de Medicina Interna , 2001, DOI: 10.4321/S0212-71992001000500002
Abstract: objective: to determinate the influence of the acarbosa and microalbuminuria on metabolic parameters in patients diabetics type 2. research desing and methods: we are studied 92 patients with diabetes type 2, treated with acarbose alone or with insuline or oral antidiabetics we are determinated the values of hba1c, total cholesterol, hdl, ldl, triglycerides and microalbuminuria, before and after or the treatment with acarbose. results: the patients presented globally a statistically significant improvement in the levels of hb a1 c, triglycerides and microalbuminuria. in the group treatise with 300 mg/day of acarbose it was observed a significant decrease of the values of hb a1c and triglycerides independently of the associated treatment. in the group treated with 150 mg/day the improvement only it was statistically significant for the levels of hb a1c. conclusions: the treatment with acarbose produces an improvement in the levels of hb a1c independently of the administered dose and of the triglycerides in patients treated wth 300 mg/day without relation to associated treatments therefore, he acarbose win be considered an effective medication to improve the metabolic contral to prevent the cardiovascular risk in those patients
Comparison of methods for urinary albumin determination in patients with type 1 diabetes
Khawali, C.;Andriolo, A.;Ferreira, S.R.G.;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002000300008
Abstract: we tested the correlation of the albumin-to-creatinine ratio (a/c) in an early-morning urine sample, measured with a commercial kit (dca 2000?), with the conventional immunoturbidimetric determination in the laboratory and with overnight albumin excretion rate (reference method). fifty-five type 1 diabetic adolescents had their first-morning urine collected on the 1st and 8th day of the period. urinary albumin and creatinine were determined immediately using the dca 2000? kit. samples were also stored for laboratory analysis. to evaluate the correlation between early-morning urinary a/c ratio and overnight albumin excretion rate, 16 subjects had a timed overnight urine collection. a/c ratios determined with the dca 2000? kit and by the laboratory method were 13.1 ± 20.5 and 20.4 ± 46.3 mg/g, respectively. a/c results by both methods proved to be strongly correlated (r = 0.98, p<0.001). dca 2000?-determined a/c showed 50% sensitivity and 100% specificity when compared to the reference method. spot urinary a/c of the subset of 16 subjects significantly correlated with their overnight albumin excretion rate (r = 0.98, p<0.001). intraindividual variation ranged from 17 to 32% and from 9 to 63% for a/c and overnight albumin excretion rate, respectively. in conclusion, an early-morning specimen should be used instead of timed overnight urine and the a/c ratio is an accurate, reliable and easily determined parameter for the screening of diabetic nephropathy. immediate measurement of the a/c ratio is feasible using the dca 2000? kit. intraindividual variability indicates the need for repeated determinations to confirm microalbuminuria and the diagnosis of incipient diabetic nephropathy.
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