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Search Results: 1 - 10 of 34654 matches for " lung cancer risk "
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Polymorphisms of GSTs in Lung Adenocarcinoma Patients Followed in the Context of a Biobank  [PDF]
Fotis Vlastos, Georgios Hillas, Nektarios Anagnostopoulos, Jean Michel Vignaud, Nadine Martinet, Nikolaos G. Koulouris
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A004

Background: Lung Adenocarcinoma (ADC) has been recently associated with distinct molecular changes, leading to the development of molecular-based targeted therapy. The Nancy’s Centre of Biological Resources (“Centre des Ressources Biologiques”, CRB) is an ISO 9001-2000 certified biobank with biological material and follow-up data from lung cancer patients, which collected during the last 20 years. Objective: To estimate and compare the frequency of Glutathionne S-Transferase (GST) polymorphisms in a French population of ADC patients. Methods: A retrospective study was conducted by the CRB between 1988 and 2007: 296 consecutive patients operated upon for ADC and 447 healthy subjects were evaluated. Genomic DNA was obtained from peripheral blood samples collected in EDTA tubes. The DNA was extracted using proteinase K digestion and phenol: chloroform purification. The GST polymorphisms were studied with duplex SYBR Green q PCR using specific primers and results being read on melt curves. Results: Two GST classes were monitored during this research. The Mu class GST (GSTM) and the Theta class GST (GSTT) members. We studied the incidence of each genotype, as well as the GSTMT (combined Mu and Theta class) and null genotype in ADC and control patients. ADC patients had a higher incidence of

Epidemiology of lung cancer
Bahader Yasser,Jazieh Abdul-Rahman
Annals of Thoracic Medicine , 2008,
Abstract: Lung cancer ranks first in the world in incidence and mortality. Multiple risk factors have been identified and the majority of lung cancer cases are preventable. This manuscript presents a summary of the epidemiology of lung cancer and the risk factors.
Polymorphism of Cell Cycle Regulating Genes Bcl-2 (-938C>A), Bax (-248G>A) and p27 (-326T>G) and the Risk of Lung Cancer
Irina A. Kuznetsova,Kristina I. Yankovich,Natalia V. Kozlova,Sergey S. Rakitin, PhD
International Journal of BioMedicine , 2012,
Abstract: The development of lung cancer is a complex and multistep process in which the functioning of many genes and the regulating mechanisms of the cell cycle, growth, cell differentiation, apoptosis, signals transduction from the cell surface to the nucleus, and DNA repair is structurally and functionally disrupted. Currently, specific attention has been paid to studies on the allelic polymorphism of oncogenes and oncosuppressors, which are the cell cycle regulators. We evaluated the frequency distribution of the alleles and genotypes of three polymorphisms: Bcl-2 (-938C>A), Bax (-248G>A), and p27 (-326T>G). Genomic DNA was obtained from 93 patients with lung cancer and 230 healthy controls. DNA samples were genotyped on the polymorphism of three genes. The study was performed using the PCR/RFLP analysis. The frequency of the minor genotypes of Bcl-2 (-938C>A) and Bax (-248G>A) polymorphisms in lung cancer patients was higher than that observed in the control group of healthy individuals. It was noted that risking relevance to the origin and development of lung cancer has a carrier functionally defective variants of cell cycle-regulated genes Bcl-2 (-938C>A) and Bax (-248G>A). The results of our study can be utilized to identify the groups at high risk of developing lung cancer, in order to further the discovery of preventive actions.
Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
Li Huan,Yang Lixin,Zhao Xueying,Wang Jiucun
BMC Medical Genetics , 2012, DOI: 10.1186/1471-2350-13-118
Abstract: Background Lung cancer is a complex polygenic disease. Although recent genome-wide association (GWA) studies have identified multiple susceptibility loci for lung cancer, most of these variants have not been validated in a Chinese population. In this study, we investigated whether a genetic risk score combining multiple. Methods Five single-nucleotide polymorphisms (SNPs) identified in previous GWA or large cohort studies were genotyped in 5068 Chinese case–control subjects. The genetic risk score (GRS) based on these SNPs was estimated by two approaches: a simple risk alleles count (cGRS) and a weighted (wGRS) method. The area under the receiver operating characteristic (ROC) curve (AUC) in combination with the bootstrap resampling method was used to assess the predictive performance of the genetic risk score for lung cancer. Results Four independent SNPs (rs2736100, rs402710, rs4488809 and rs4083914), were found to be associated with a risk of lung cancer. The wGRS based on these four SNPs was a better predictor than cGRS. Using a liability threshold model, we estimated that these four SNPs accounted for only 4.02% of genetic variance in lung cancer. Smoking history contributed significantly to lung cancer (P < 0.001) risk [AUC = 0.619 (0.603-0.634)], and incorporated with wGRS gave an AUC value of 0.639 (0.621-0.652) after adjustment for over-fitting. This model shows promise for assessing lung cancer risk in a Chinese population. Conclusion Our results indicate that although genetic variants related to lung cancer only added moderate discriminatory accuracy, it still improved the predictive ability of the assessment model in Chinese population.
Stratified Cox Regression Analysis of Survival under CIMAvax®EGF Vaccine  [PDF]
Carmen Viada Gonzalez, Jean-Fran?ois Dupuy, Martha Fors López, Patricia Lorenzo Luaces, Camilo Rodríguez Rodríguez, Gisela González Marinello, Elia Neninger Vinagera, Beatriz García Verdecia, Bárbara Wilkinson Brito, Liana Martínez Pérez, Mayelin Troche de la Concepción, Tania Crombet-Ramos
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48A002

Background: The Center of Molecular Immunology (CIM) is a center in Cuba devoted to the research, development and manufacturing of biotechnological products. CIMAvax?EGF is a vaccine for the treatment of non-small cell lung cancer patients (NSCL). Purpose: The aim of this work is to evaluate the effects of some potential prognostic factors on the overall survival of patients treated with CIMAvax?EGF vaccine, based on data collected in a phase II and a phase III clinical trials. Methods: The stratified Cox regression model is used to evaluate the effects of these prognostic factors, based on separate analysis for each trial, and on the combined data from both trials. Results: Patients with Performance status 0 or 1, with IV stage of tumor and male under 60 years obtain more benefit in terms of overall survival if they receive CIMAvax?EGF. Conclusions: Vaccinated group has a better performance if patients have a performance status 0 or 1, stage IV and age under 60 years. These prognostic factors influence overall survival in a positive way for those patients that received CIMAvax?EGF.

Compara??o entre os volumes pulmonares irradiados com técnica bidimensional e tridimensional conformada na radioterapia de pacientes com tumores de pulm?o localmente avan?ados
Carvalho, Heloisa de Andrade;Sales, Camila Pessoa de;Stuart, Silvia Radwanski;Gil, Erlon;Nunes, André Costa Navega;Ferauche, Debora Cartelle;
Radiologia Brasileira , 2009, DOI: 10.1590/S0100-39842009000500009
Abstract: objective: to compare and quantify irradiated lung volumes using two-dimensional (2d) and three-dimensional (3d) conformal planning for radiotherapy in the treatment of lung cancer. materials and methods: 2d and 3d conformal radiotherapy plannings were performed for 27 patients with lung cancer. prescribed doses ranged from 45 to 66 gy. the analysis covered the doses to planning target volume (ptv), gross tumor volume (gtv) and lungs (lung volume receiving 20 gy or 30 gy - v20 and v30, respectively, and mean dose). the doses to adjacent organs at risk (spinal cord, esophagus and heart) were maintained below the tolerance limits. results: gtv ranged from 10.5 to 1,290.0 cm3 (mean, 189.65 cm3). on average, a total of 59.33 fields were utilized in the 2d planning and 75.65 fields in the 3d planning. lung volumes were significantly preserved (p < 0.05) with the 3d conformal planning in all the evaluated cases, with about 15% decrease in the irradiated lung volumes. lungs without tumor were most benefited from this technique. conclusion: 3d radiotherapy allowed a better sparing of the lungs, both in cases of early and advanced tumors. 3d radiotherapy should be used in the treatment of patients with lung cancer, even in cases of large tumors.
Risk factors of traditional Chinese medical syndromes in moderate and advanced lung cancer patients with concurrent fungal pneumonia
HU Kai-Wen
Zhong Xi Yi Jie He Xue Bao , 2004,
Abstract: Objective: To analyze the relationship between traditional Chinese medical syndromes and fungal pneumonia for moderate and advanced lung cancer patients. Methods: We retrospected 115 moderate and advanced lung cancer patients with different syndromes in traditional Chinese medicine (qi deficiency, yin deficiency, blood deficiency, yang deficiency, blood stasis, phlegm dampness, phlegm heat, damp heat, cold dampness, qi stagnation, heat toxin), who had the concurrent fungal pneumonia, and used regression analysis method to analyze the data. Results: When the patients had the phlegm heat syndrome, they got a significantly higher risk of having fungal pneumonia (P<0.05); and when they had the heat toxin syndrome, they also had a high risk of having fungal pneumonia (P<0.05). Conclusion: The phlegm heat and heat toxin syndromes are the risk factors for moderate and advanced lung cancer patients having concurrent fungal pneumonia.
Journal of Engineering Studies and Research , 2012,
Abstract: The objective of this study is to determine a multivariate model able to perform the identification of the tumor stage and of the histopathological type for lung cancer patients, based on predictive environmental and behavioral factors. The database was built by using clinical and personal information about 106 patients with stage III or IV lung cancer and a mean age of 58 years, who were subjected to radiotherapy at the Radiotherapy Department of "Sf. Ap. Andrei" Emergency Clinical Hospital between January and December 2010. The following factors were taken into consideration: work conditions, smoking habits and duration of the exposure to risk factors. Most of the patients (43.33%) have worked in metallurgy for a mean of 27.54 years and 86.67% have smoked for a mean period of 26.92 years. The duration of smoking and the habit of smoking itself were identified by multiple linear regression as the most important predictive factors for tumor stage and for the histopathological type, respectively. Artificial intelligence techniques were used and the results have indicated that tobacco use and the environmental factors related to the work place (e.g. metallurgical industry) are the best predictive risk factors for the incidence of lung cancer.
Canadian Lung Cancer Relative Risk from Radon Exposure for Short Periods in Childhood Compared to a Lifetime
Jing Chen
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10051916
Abstract: Long-term exposure to elevated indoor radon concentrations has been determined to be the second leading cause of lung cancer in adults after tobacco smoking. With the establishment of a National Radon Program in Canada in 2007 thousands of homes across the country have been tested for radon. Although the vast majority of people are exposed to low or moderate radon concentrations; from time to time; there are homes found with very high concentrations of radon. Among those living in homes with very high radon concentrations, it is typically parents of young children that demonstrate a great deal of concern. They want to know the equivalent risk in terms of the lifetime relative risk of developing lung cancer when a child has lived in a home with high radon for a few years. An answer to this question of risk equivalency is proposed in this paper. The results demonstrate clearly that the higher the radon concentration; the sooner remedial measures should be undertaken; as recommended by Health Canada in the Canadian radon guideline.
Risk Factors for Chemotherapy-Induced Leukopenia in Patients with Lung Cancer  [PDF]
Hongyan Jin, Xiaoya Chen, Wei He, Qian Liu, Zexiong Wei, Jinjun Li
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.73023
Abstract: Objective: This analysis was conducted to clarify risk factors for chemotherapy-induced leukopenia (CIL) in lung cancer. Methods: A retrospective study was conducted on data from 358 patients with lung cancer who received chemotherapy. Results: Among 358 cases of lung cancer who received chemotherapy, a total of 240 patients experienced CIL, rate was 67%. The demographic data including gender (P = 0.795), age (P = 0.134), presence of selected chronic comorbidities (P = 0.23) were not significantly different in the two groups. The weight loss rate, PS score, sub-normal pre-WBC level, sub-normal pre-PLT level, and the cycle of chemotherapy were significantly different between the groups (P < 0.05). Multivariate analysis revealed that the weight loss rate ≥5% (OR = 0.503), sub-normal pre-WBC level (OR = 11.807), the cycle of chemotherapy ≥3 (OR = 3.100) were main risk factors for CIL in lung cancer. Conclusion: Before treatment, weight loss rate is 5% or higher, chemotherapy has a cycle of 3 or more and sub-normal WBC level is independent risk factor of lung cancer after chemotherapy-induced leucopenia.
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