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Search Results: 1 - 10 of 19973 matches for " lung cancer "
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Leptomeningeal Carcinomatosis Presenting Early in Non-Small Cell Lung Cancer  [PDF]
Ezra N. Teitelbaum, Susan M. Hasselquist, Imad A. Tabbara, Gregory D. Trachiotis
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.28093
Abstract: Purpose: We present the case of a patient presenting with altered mental status on post-operative day seven after a diagnostic lung biopsy. The diagnosis of carcinomatous letomeningeal metastasis was confirmed. Methods: We discuss meningeal carcinomatosis in lung cancer, and describe challenges to diagnosis, therapy, and prognosis. Results: A review of the literature describing the clinical and oncologic principles of letomeningeal carcinomatosis in lung cancer is performed. Discussion: Leptomeningeal carcinomatosis (LC) occurs in approximately 5% of patients with non-small cell lung cancer and incurs a bleak prognosis. Presenting neurologic symptoms can be varied and diagnosis is confirmed via lumbar puncture and cerebrospinal fluid cytology. Few data exist regarding optimal treatment, although intrathecal chemotherapy has been shown to provide a modest improvement in median survival.
Lung Cancer: Facts, Figures and Reflections on Spending  [PDF]
Usman Ahmad, Michael Ruschel, Frank C. Detterbeck
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.32016
Abstract: The war on cancer was declared 40 years ago. While the potential for reducing deaths is increasing, so are the costs. Finding the right prioritization in our complex world is difficult; we present some interesting facts regarding other wars and aspects of society that are worth reflecting on as we struggle to find the right balance.
Fatal Complications and Early Death after Surgical Treatment of Lung Cancer in 2000 and 2010. A Population Based Study  [PDF]
Hans Rostad
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.41019
Abstract:

In the year 2000 lung cancer was operated in 349 patients in Norway, in 2010 the number was 461. In the first period fatal surgical hemorrhage occurred in eight patients, in four of them peroperatively. Postoperative hemorrhage occurred in four patients in the year 2000 and in two in 2010. Ten patients died intra- or postoperatively in the two periods which is a mortality rate within 30 days after surgery of 4.3% in the first and 1.1% in the second period. Pneumonectomy was performed in 34 patients in 2000 and eight in 2010, respectively. Altogether 19 patients died within six months after surgery without having experienced surgical complications. Pneumonectomy should not be performed in elderly and debilitated persons.

Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer  [PDF]
Yanan Liu, Yinghui Huang
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.410B042
Abstract:

Object: To explore the therapeutic effects and therapeutic mechanisms of Conditional Replication Adenovirus(CRAd) in combination with cisplatin on lung cancer cells. Methods: Using MTS / PMS assay, in vitro cell inhibition assay was performed to detect the cell viability of two lung cancer cell lines, NCI-H292 and NCI-H661. PCR was employed to detect the Coxsackie receptor(CAR) expression of cancer cells. The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model. Results: The CRAd with cisplatin is superior to the use of cisplatin or CRAd viruse alone on the suppression of lung cancer cell growth. The mechanism of inhibition is associated with the increased CAR expression. Conclusion: The application of CRAd in combination with cisplatin could play a better therapeutic effect on lung cancer cell growth inhibition.

Conditional Replication Adenovirus Sensitizes A549 Cancer Cell to Cisplatin  [PDF]
Yanan Liu, Yinghui Huang
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.410B043
Abstract:

Objective: The aim of the study was to improve the therapeutic effect for lung cancer using a synergetic strategy of adenovirus-based gene therapy combined with chemotherapy. Methods: A conditional replication adenovirus(CRAd) was employed to treat the A549 lung cancer cells and cisplatin-resisted A549(A549-DDP) cells. In vitro MTS / PMS assay were used to evaluate the cell viability. PCR were used to detect expression of Coxsackie receptor (CAR) and Multidrug resistance(MDR) gene. The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model. Results: The CRAd sensitizes A549 cancer cells to cisplatin. The mechanism of enhanced cell growth inhibition is associated with the increased CAR and MDR expression. Conclusion: Our approach is better than the conventional gene therapy and chemotherapy strategy.

Non Small-Cell Lung Cancer Metastatic to the Mitral Valve: Case Report and Review of the Literature  [PDF]
Daniel J. Axelson, Natalie P. Kreitzer, Gregory J. Fermann
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.37094
Abstract:

In 2008, 1.6 million new cases of lung cancer were diagnosed worldwide, representing 13% of all cancer cases for the year, and in 2010, 19% of cancer deaths were attributed to lung cancer. Though lung cancer frequently metastasizes to the adrenal glands, bone, brain, liver, and other lung, it infrequently metastasizes to the heart. Here, we report a case of lung cancer metastatic to the mitral valve.

Diagnostic and Prognostic Value of Serum Tissue Polypeptide Antigen in Advanced Lung Cancer  [PDF]
Ahmed El Bastawisy, Mahmoud El Azzouny, Gamal Mohamed, Ahmed Awad Allah, Eman Behiry
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.53030
Abstract:

Lung cancer is a lethal malignancy, however, no serum marker is routinely recommended till now. Prospectively two groups of patients included: Group I: Patients with advanced lung cancer. Group II: patients with benign lung disease as control. Serum Tissue Polypeptide Antigen (TPA) levels were measured by ELISA technique before the first line chemotherapy. The TPA cutoff taken was 1800 pg./ml. End points were comparison of high TPA in cases and controls and correlation between high TPA and disease progression (PD), progression free survival (PFS) and overall survival (OS). 30 patients with advanced lung cancer (16 non-small and 14 small cell lung cancer) and 15 patients with benign lung disease were included and followed up during the period from October 2008 to October 2011 with median follow-up of 1.5 years. High TPA was found in 50% of lung cancer cases compared to 26% in controls (p = 0.014).

A Study on Lung Cancer in Jianghan Plain  [PDF]
Kun Zhang, Man Li, Yanhua Zhang, Xiaochun Peng
Health (Health) , 2014, DOI: 10.4236/health.2014.612164
Abstract: This study was to investigate the epidemiology of lung cancer in Jianghan Plain, providing scientific basis for prevention and treatment of lung cancer. Pathology and clinical data of 1290 patients diagnosed lung cancer from the largest hospital in Jianghan Plain were collected and analyzed. Results found that the lung cancer incidence increased gradually from the age of 40 and at the peak during 61 to 70 years old; the male to female ratio was 2.45:1; Smoking patients were 841 cases, accounting for 65.2% of all cases. Smoke index > 400 was 771 cases accounting for 91.7 percent of smokers and smoking index < 400 was 70 cases accounting for 8.3% of smoking patients. 93.6% of the patients were to start smoking at a young age. The rate of patient pathological cytology diagnosed by fiberoptic bronchoscopy was 31.8%, which showed that it was an important diagnostic method for lung cancer. The main reason for smoking is to break up the monotony and although many patients know nicotine, carbon monoxide is the main smoking harmful substances and smoking may cause lung cancer; not many people can take the initiative to quit smoking. It also showed that squamous cell carcinoma was the main type in smoking patients, while adeno-carcinoma in non-smoking patients. The comprehensive epidemiological analysis suggested that smoking is an important factor in causing lung cancer, smoking cessation education and regular medical examinations to strengthen the prevention of lung cancer have a positive meaning to their family members.
The Outcome of the Chemotherapy and Oncothermia for Far Advanced Adenocarcinoma of the Lung: Case Reports of Four Patients  [PDF]
Doo Yun Lee, Joon Seok Park, Hae Chul Jung, Eun Seol Byun, Seok Jin Haam, Sung Soo Lee
Advances in Lung Cancer (ALC) , 2015, DOI: 10.4236/alc.2015.41001
Abstract:

Lung cancer is one of the most aggressive and lethal form of cancers. Patients with far advanced lung cancer are treated by chemotherapy with or without radiotherapy. However, median survival of these patients is less than 6 months. To increase survival and quality of life for these patients, various forms of complementary treatments have been tried in clinical practices, and oncothermia is supposed to be one of the promising candidates. From May 2008 to November 2013, 4 patients with far advanced lung adenocarcinoma (stages IIIB and IV) were treated with oncothermia in addition to conventional chemotherapy at Gangnam Severance Hospital and Bundang CHA Hospital. All these patients have survived for more than 2 years.

The Correlation of Lung Function Indexes and Survival Time of Patients with Advanced Lung Cancer  [PDF]
Wenjing Xu, Zhenghua Jiang, Dongyun Huang, Muyun Zhu, Qian Huang, Hui Ge, Juan Liu, Yan Qin
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41029
Abstract:

Background: To those patients with advanced lung cancer, the ultimate objective is to improve the quality of life, and lung function is an important factor affecting quality of life. We detect lung function of patients with lung cancer and study the correlation between lung function and the patients’ survival time, to provide reference for evaluation of disease progression and prognosis. Methods: Lung function was detected on 59 cases of lung cancer and 63 normal controls. The relationship between lung function indexes and survival time was analyzed. Results: There was significant difference in ventilation function and diffusing capacity between lung cancer group and control group. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV) were positively correlated to survival time in patients with advanced lung cancer (r = 0.28522064, 0.28053851, 0.28289252, 0.26908133, 0.26335034, 0.28409036, P < 0.05), residual volume/total lung capacity was negatively correlated to survival time (r = ?0.30760097, P < 0.05). Conclusions: The lung function decrease in the patients with lung cancer. Vital capacity (VC), Forced expiratory volume in one second (FEV1), Forced vital capacity (FVC), peak expiratory flow (PEF), peak expiratory flow% (PEF%), Maximal ventilatory volume (MVV), and residual volume/total lung capacity are correlated to survival time in patients with advanced lung cancer. The lung function indexes are important marker of prognosis of patients with lung

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