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Search Results: 1 - 10 of 65 matches for " lignans "
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Phytochemical Composition of Tridax procumbens Linn Leaves: Potential as a Functional Food  [PDF]
Catherine C. Ikewuchi, Jude C. Ikewuchi, Mercy O. Ifeanacho
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.611103
Abstract: The leaves of Tridax procumbens were screened for the presence of bioactive molecules. They had high flavonoids, alkaloids, hydroxycinnamates, tannins and phytosterols, moderate benzoic acid derivatives and lignans, and low carotenoids contents. Thirty nine known alkaloids (mainly akuammidine, 68.756%), twenty three known flavonoids (mainly 17.593% kaempferol and 12.538% (-)-epicatechin), five known carotenoids (mainly lutein, 62.608%), four known benzoic acid derivatives (mainly ferulic acid, 46.091%), two phytosterols (mainly stigmasterol, 80.853%) and six known lignans (mainly galgravin, 77.326%) were detected. Also detected were caffeic acid and tannic acid. The medicinal properties of the flavonoids, phytosterols, alkaloids, tannins, hydroxicinnamates, carotenoids, benzoic acid derivatives and lignans that were present in the leaves were discussed herein and proposed to be explored for their potential medicinal values. The great number of potentially active nutrients and their multifunctional properties make Tridax procumbens a perfect candidate for the production of health-promoting food and food supplements.
Guzmán V,Juan D; Cuca S,Luis E;
Revista Colombiana de Química , 2008,
Abstract: from the ethanolic extract of the bark of the colombian endangered tree dugan- diodendron argyrotrichum (magnoliaceae) was isolated an oil in which major compounds were sesquiterpenes. two sesquiterpenoids torreyol and parthenolide and the aporphine alkaloid n-acetylanonaine were isolated by column chromatography (cg-em) and characterized by 1h and 13c nuclear magnetic resonance (nmr) spectroscopy. the isolated substances were subjected to brine shrimp lethality bioassay. the most toxic compounds were sesquiterpene oil (lc50 = 4,49 mg/ml) and dibenzylbutane lignans (1) (lc50 ~ 50 mg/ml).
Alkaloids, Coumarins and Lignans from Haplophyllum Species
Ayhan Ulubelen,Mehmet ?ztürk
Records of Natural Products , 2008,
Abstract: Although there are a number of Haplophyllum species in the world, H. acutifolium (DC.) G. Don, H. buxbaumii (Poiret) G.Don, H. buxbaumii (Poiret) G.Don, subsp. Buxbaumii, H. cappadocium Spach, H. glabrinum, H. hispanicum Sprach, H. myrtifolium Boiss., H. patavinum (L.) G. D. ON. fil., H. perforatum (M.B.) Vved., H. ptilostylum Spach, H. suaveolens (DC.) G.Don, H. telephioides Boiss., H. thesioides (Fisch ex DC.) G. Don, H. tuberculatum (Forssk.) A.Juss. and H. vulcanicum Boiss. & Heldr. were most studied and a lot of compounds isolated. Only alkaloids, coumarins and lignans of these species are mentioned in this article. In addition some volatile components of H. tuberculatum were also given
New Lignans from the Leaves and Stems of Kadsura philippinensis
Yu-Chi Lin,Yuan-Bin Cheng,Chia-Ching Liaw,I-Wen Lo,Yao-Haur Kuo,Michael Y. Chiang,Chang-Hung Chou,Ya-Ching Shen
Molecules , 2013, DOI: 10.3390/molecules18066573
Abstract: Three novel C19 homolignans, taiwankadsurins D ( 1), E ( 2) and F ( 4), and two new C18 lignans kadsuphilins N ( 3) and O ( 5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1– 5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
Lignans from The Nepalese Sandal Wood Osyris wightiana Wall ex Wight
Sajan L Shyaula,Mangala D Manandhar,Min Choudhary
Journal of Nepal Chemical Society , 2011, DOI: 10.3126/jncs.v28i0.8037
Abstract: The crude ethanolic extract of the Nepalese sandal wood, Osyris wightiana Wall ex Wight, was investigated for phytochemical constituents by chromatographic and spectroscopic techniques. The lignans were the first time reported from the genus Osyris. The lignans, (±) lyoniresinol (1), (±) syringaresinol (2) 5,5’-dimethoxylariciresinol (3), and 5-methoxylariciresinol (4) were isolated from dichloromethane fraction. The structures of compounds were identified by using mass and NMR spectroscopic techniques. DOI: http://dx.doi.org/10.3126/jncs.v28i0.8037 Journal of Nepal Chemical Society Vol.28, 2011 Page 24-28 Uploaded date: March 6, 2013
Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen-Receptor-Positive Breast Cancer Cells  [PDF]
Marlen Szewczyk, Nicole Strater, André Schlichting, Volker Briese, Dagmar-Ulrike Richter
Advances in Biological Chemistry (ABC) , 2014, DOI: 10.4236/abc.2014.42013
Abstract: Flax contains large amounts of hormone-like compounds, especially lignans. These socalled phytoestrogens are thought to inhibit the cell growth of hormone-sensitive cancers. Hence, we analysed the influence of flax root extracts at various stages of maturity on the proliferation and cytotoxicity in oestrogen-receptor-positive breast cancer cells (MCF7) in vitro. Flax root extracts were prepared by using lignan extraction. The extracted compounds were analysed by Pyrolysis-Field Ionisation Mass Spectrometry. Various extract concentrations were applied to the cells to test for proliferation (BrdU test) and cytotoxicity (LDH test). A significantly higher inhibition of cell proliferation was observed with an extract made from 9-week-old flax roots in comparison with that of 3- and 6-week-old roots. Older roots contained more lignans and other phenolic substances than younger roots. The maturity grade of plants or their various parts is thus important for the production and concentration of secondary metabolites and leads to different biological effects on breast cancer cell growth.
Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne
Jieru Guo,Jinwen Zhang,Penghua Shu,Lingmei Kong,Xincai Hao,Yongbo Xue,Zengwei Luo,Yan Li,Gao Li,Guangmin Yao,Yonghui Zhang
Molecules , 2012, DOI: 10.3390/molecules17066424
Abstract: Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P2 (2), P3 (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (?)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro.
Isolation of lignans glycosides from Alibertia sessilis (Vell.) K. Schum. (Rubiaceae) by preparative high-performance liquid chromatography
Silva, V. C. da;Silva, G. H.;Bolzani, V. da S.;Lopes, M. N.;
Eclética Química , 2006, DOI: 10.1590/S0100-46702006000400008
Abstract: enantiomeric aglycone lignans contained in a mixture were separated from a fraction of the extract of the stems of alibertia sessilis (vell.) k. schum. (rubiaceae) by preparative high-performance liquid chromatography. an efficient and fast separation can be achieved with methanol-water (30:70, v/v). their structures were identified as (+)-lyoniresinol 3a-o-b-glucopyranoside and (-)-lyoniresinol 3a-o-b-glucopyranoside, being reported for the first time in rubiaceae.
Rubilar,M; Gutiérrez,C; Verdugo,M; Shene,C; Sineiro,J;
Journal of soil science and plant nutrition , 2010, DOI: 10.4067/S0718-95162010000100010
Abstract: scientific evidence supports flaxseed consumption; however, a large sector of the population is still unaware of the benefits associated to its consumption and its possible applications as functional food ingredient in foodstuffs. flaxseed is mainly known by its high alpha-linolenic acid content, but it is also a lignan source, soluble fibre and protein, compounds which are biologically active in the prevention of some non-transmissible chronic diseases. southern chile has comparative advantages for the cultivation of this crop. together with its full processing, this crop could strengthen regional industry. the purpose of the present review is to highlight the nutritional properties of flaxseed.
Lignanas de Strychnos guianensis (Aublet) Mart.
Pinheiro, Maria Lúcia B.;Rocha, Arnaldo F. Imbiriba da;Fernandes, Marco A. do N.;Monte, Francisco José Queiroz;Villar, José Daniel Figueroa;Cruz, Elizabete Rangel;
Química Nova , 2004, DOI: 10.1590/S0100-40422004000200003
Abstract: the present communication reports the isolation and identification of three lignans from metanolic root extracts of strychnos guianensis (aublet) mart.: olivil (1), cycloolivil (2) and the unknown derivative cycloolivil carbonate (3). from hexane extracts was identified a long chain fatty acid mixture and the triterpene lupeol. the analyses were based on chromatographic and spectroscopy techniques (ir, ms, gc/ms, 1h-nmr and 13c-nmr, 1d (bb, dept 135) and 2d (1h, 1 h-cosy, 1h, 13c-cosy, 1h, 13c-cosy-lr, hmqc, hmbc and noesy) and comparison with literature data.
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