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Search Results: 1 - 10 of 32839 matches for " jianyou guo "
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Vanadium-Enriched Cordyceps sinensis, a Contemporary Treatment Approach to Both Diabetes and Depression in Rats
Jianyou Guo,ChangYu Li,Jie Wang,Yongmei Liu,Jiahui Zhang
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/neq058
Abstract: This article studies a contemporary treatment approach toward both diabetes and depression management by vanadium-enriched Cordyceps sinensis (VECS). Streptozotocin-induced hyperglycemic rats were used in the study. After the rats were administered with VECS, a significant reduction in blood glucose levels was seen (P < .05) and the levels of serum insulin increased significantly (P < .05). At the same time, the study revealed a significant decrease in immobility with a corresponding increase in the swimming and climbing behavior in hyperglycemic rats following VECS treatment. The results described herein demonstrate that VECS is a contemporary treatment approach that advocates an aggressive stance toward both diabetes and depression management.
Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
Zhenquan Liu, Pengtao Li, Dan Zhao, Huiling Tang, Jianyou Guo
Behavioral and Brain Functions , 2010, DOI: 10.1186/1744-9081-6-61
Abstract: The right middle cerebral artery occlusion model was used in the study. The effects of Cordyceps sinensis (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+K+ATPase activity and glutathione S transferase activity in a rat model were studied respectively.Cordyceps sinensis extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of Cordyceps sinensis extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.These experimental results suggest that complement Cordyceps sinensis extract is protective after cerebral ischemia in specific way. The administration of Cordyceps sinensis extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.Ischemic hypoxic brain injury often causes irreversible brain damage. The cascade of events leading to neuronal injury and death in ischemia includes the release of cytokines and free radicals, and induction of inflammation, apoptosis, and excitotoxicity [1]. Reperfusion of ischemic areas could exacerbate ischemic brain damage through the generation of reactive oxygen species. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. Recently, from the point of view of "self-medication" or "preventive medicine," several dietary supplements are used in the prevention of life-style related diseases including cerebral
Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study
Chun-chao Han, Hong Wei, Jianyou Guo
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-100
Abstract: EIU was induced in rats via a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS inoculation, fermented and non-fermented extracts of S. flavescens (FSE and NFSE, respectively) were administered orally, and the aqueous humor was collected from both eyes 24 hours later. The anti-inflammatory effects of FSE and NFSE were examined in terms of regulation of nuclear factor kappa B (NF-κB) activation and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), intercellular cell adhesion molecule (ICAM)-1, and cyclooxygenase-2 (COX-2). The regulation of maleic dialdehyde (MDA) levels and polymorphonuclear cell (PMN) infiltration by FSE and NFSE were also examined.Treatment with FSE significantly inhibited LPS-induced increases in IL-1β and TNF-α production and the expression of iNOS, ICAM-1 and COX-2. Moreover, FSE suppressed LPS-induced NF-κB activation, and reduced both MDA levels and infiltration by PMN.These results indicate that solid state fermentation may enhance the anti-inflammatory effects of S. flavescens.Inflammation plays an important role in a wide variety of chronic human diseases including cardiovascular diseases and cancer. Although various chemical regimens have been used to treat inflammation, efficacy can be unsatisfactory and may encounter the problem of drug resistance. To improve treatments based on anti-inflammatory chemicals, novel therapeutic strategies may be developed from medical plants used in Chinese Traditional Medicine. Of the huge array of candidates available, we chose to investigate Sophora flavescens (Leguminosae) because of its potential health promoting properties; it is anti-inflammatory, an anti-asthmatic, an anthelmintic, and a free radical scavenger, and it has antimicrobial activities and improves mental health [1-5].The roots of S. flavescens (Leguminosae) have been traditionally used in East Asian countries as an herbal medicine and food ingredient
The effects of corn silk on glycaemic metabolism
Jianyou Guo, Tongjun Liu, Linna Han, Yongmei Liu
Nutrition & Metabolism , 2009, DOI: 10.1186/1743-7075-6-47
Abstract: Alloxan and adrenalin induced hyperglycemic mice were used in the study. The effects of corn silk on blood glucose, glycohemoglobin (HbA1c), insulin secretion, damaged pancreatic β-cells, hepatic glycogen and gluconeogenesis in hyperglycemic mice were studied respectively.After the mice were orally administered with corn silk extract, the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, respectively), while the level of insulin secretionn was markedly elevated in alloxa-induced hyperglycemic mice (p < 0.05). The alloxan-damaged pancreatic β-cells of the mice were partly recovered gradually after the mice were administered with corn silk extract 15 days later. Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. However, ascension of blood glucose induced by adrenalin and gluconeogenesis induced by L-alanine were not inhibited by corn silk extract treatment (p > 0.05). Although corn silk extract increased the level of hepatic glycogen in the alloxan-induced hyperglycemic mice, there was no significant difference between them and that of the control group(p > 0.05).Corn silk extract markedly reduced hyperglycemia in alloxan-induced diabetic mice. The action of corn silk extract on glycaemic metabolism is not via increasing glycogen and inhibiting gluconeogenesis but through increasing insulin level as well as recovering the injured β-cells. The results suggest that corn silk extract may be used as a hypoglycemic food or medicine for hyperglycemic people in terms of this modern pharmacological study.Corn silk (ZeamaysL.) refers to the stigmas from the female flowers of maize. Fresh corn silk resembles soft silk threads 10-20 cm long that are either light green or yellow-brown in color. Corn silk contains proteins, vitamins, carbohydrates, Ca, K, Mg and Na salts, fixed and volatile oils, steroids such as sitosterol and stigmasterol, alkaloids, saponins, tannins, and fl
Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
Weifeng Ji,Haiying Huang,Ji Chao,Wuchao Lu,Jianyou Guo
Evidence-Based Complementary and Alternative Medicine , 2014, DOI: 10.1155/2014/679259
Abstract: Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80?mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-α and IL-1β level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy. 1. Introduction Diabetic neuropathy is the most common of secondary complications associated with diabetes mellitus and is characterized by the slowing of nerve conduction velocity, elevated pain, sensory loss, and nerve fiber degeneration. Diabetes induced neuropathic pain is recognized as one of the most difficult types of pain to treat with conventional analgesics. Current treatment of peripheral diabetic neuropathy (PDN) involves the use of tricyclic antidepressant, selective serotonin reuptake inhibitors [1], anticonvulsants, opioids and antioxidant protein kinase C inhibitors, COX-2 inhibitors [2], nonsteroidal anti-inflammatory drugs as mild analgesics, and so on. However, these therapies provide relief only to a fraction of patients and their side effect profiles limit their use [3, 4]. Thus, there is a need for new therapeutic interventions targeting primary mechanisms resulting in nerve damage in PDN. Recently, from the point of view of “self-medication” or “preventive medicine,” several dietary supplements are used in the prevention of lifestyle related diseases including diabetes. Mushrooms and primarily basidiomycetous fungi are valuable foods that are low in calories and high in minerals, essential amino acids, vitamins, and fibers [5]. Some of them produce substances with potential medical effect and are called medicinal mushrooms [6]. The basidiomycete Agaricus brasiliensis (AbS) is native to Brazil and is widely grown in Japan because of its medicinal properties. It is widely used for nonprescript, medicinal purposes, both as an edible mushroom and in the form of extracts. AbS has traditionally been used for the
Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus
Jun Ren, Jin-Li Shi, chunchao han, Zhen-Quan Liu, jianyou guo
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-52
Abstract: The effects of TFC on cytokines levels, total antioxidant activity, antinociceptive effects in vivo, LD50 and tactile hyperalgesia were analyzed respectively.TFC treatment decreased the levels of cytokines and total antioxidant status (TAOS) and inhibited the acetic acid-induced abdominal constrictions in mice. In addition, TFC reduced CFA-induced tactile hyperalgesia in a dose-dependent manner and the LD50 of TFC was determined to be 400?mg/kg. However, TFC did not significantly inhibit the reaction time to thermal stimuli in the hot-plate test.TFC showed anti-inflammatory, antioxidant, peripheral antinociceptive and antihyperalgesic activity in various models of inflammatory pain. The data suggest that TFC may be a viable treatment option for inflammatory pain.

Li Baosheng Dong Guangrong Gao Shangyu Shao Yajun Shen Jianyou,

地理研究 , 1989,
Abstract: 对萨拉乌苏河地区上更新统地层作进一步划分的基础上,本文论述本区晚更新世前期萨拉乌苏组沉积时的古地理环境为暖湿的森林草原。后期城川组主要形成于干冷的荒漠草原—荒漠环境,期间经历了一系列温凉湿润的灌丛草原—疏林草原、森林草原等环境的交替演化过程。
A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
Jun He,Guang Ouyang,Zhixiang Yuan,Rongsheng Tong,Jianyou Shi,Liang Ouyang
Molecules , 2013, DOI: 10.3390/molecules18055142
Abstract: An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione . The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.

WU Faquan,LIU Tong,TANG Xianliang,LIU Jianyou,

岩石力学与工程学报 , 2009,
Abstract: 小湾坝基开挖引起了一系列岩体卸荷变形破坏现象,包括岩体中已有结构面的回弹松动与剪切错动,以及完整岩体的岩爆拱裂、薄板状破裂等新生破裂.开挖中岩体的新生破裂面在空间分布上有如下特点:破裂面产状与开挖面具有较好的一致性;在深度分布上,开挖卸荷破裂面相对集中在开挖面之下4~6 m的深度以上.岩体的卸荷变形破坏导致了岩体完整性的显著降低,但卸荷松动过程的主体部分多在几个月内完结.无论是岩体开挖卸荷还是河流天然切割卸荷都是一个能量释放过程,并且卸荷变形破坏具有显著的空间分布规律,因此采用能量方法研究岩体的卸荷分带是合适的.给出了岩体卸荷分带的应变能方法,小湾水电站的实际应用表明该方法是可行的、有效的.
Enhanced UV Light emission from Silicon nanoparticles induced by Au ion implantation
Akhilesh Singh,Karol G. Grycznski,Bibhu Rout,Jianyou Li,Floyd McDaniel,Arup Neogi,Gayatri Sahu,Durga P. Mahapatra
Physics , 2008,
Abstract: Study of light emitting silicon fabricated by ion implantation.
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