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Influence of Salt Concentration on Histamine Formation in Fermented Tuna Viscera (Dayok)  [PDF]
Jesebel R. Besas, Erlinda I. Dizon
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.32029
Abstract: The formation of histamine in fermented tuna (Thunnus albacares) viscera (dayok) at different salt concentrations (10%, 17.5% and 25%) for 7 days at ambient temperature was investigated. Effect on chemical and microbiological changes on tuna viscera were monitored. Results demonstrated that the levels of pH, lactic acid, amino nitrogen and total volatile base nitrogen (TVB-N) increased as time of dayok fermentation progressed. The total plate count and lactic acid bacteria count decreased with increasing salt concentration. Histamine levels decreased during fermentation as salt concentration increased. Histamine levels above FDA standard limit of 50 ppm are formed at low salt concentration (10%) with a total plate count of 107 cfu/g. Results revealed that application of salt concentration greater than 17% can minimize the formation of histamine.
Association between Urinary Neurotransmitter Status and Scoliosis Progression: A Case-Controlled Series  [PDF]
Mark W. Morningstar, Clayton J. Stitzel, Brian Dovorany, Aatif Siddiqui
Open Journal of Clinical Diagnostics (OJCD) , 2018, DOI: 10.4236/ojcd.2018.83003
Abstract: Previous investigations into the relationship between neurotransmitter abnormalities and idiopathic scoliosis have been mixed. The purpose of the present study was to evaluate the differences in a urinary neurotransmitter profile across three different groups. These groups included a progressive scoliosis group, a non-progressive scoliosis group, and a non-scoliotic control group. When evaluating urinary neurotransmitter levels across all groups, statistically significant differences were observed between all three groups for multiple neurotransmitters. The differences seemed to increase as the scoliosis increased in Cobb angle measurement. Further studies should seek to distinguish a potential cause or effect relationship between these neurotransmitter abnormalities and idiopathic scoliosis onset and/or progression.
Histamine modulates microglia function
Raquel Ferreira, Tiago Santos, Joana Gon?alves, Gra?a Baltazar, Lino Ferreira, Fabienne Agasse, Liliana Bernardino
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-90
Abstract: Firstly, we detected the expression of all known histamine receptor subtypes (H1R, H2R, H3R and H4R), using a murine microglial cell line and primary microglia cell cultures from rat cortex, by real-time PCR analysis, immunocytochemistry and Western blotting. Then, we evaluated the role of histamine in microglial cell motility by performing scratch wound assays. Results were further confirmed using murine cortex explants. Finally, interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels were evaluated by ELISA measurements to determine the role of histamine on the release of these inflammatory mediators.After 12 h of treatment, 100 μM histamine and 10 μg/ml histamine-loaded poly (lactic-co-glycolic acid) microparticles significantly stimulated microglia motility via H4R activation. In addition, migration involves α5β1 integrins, and p38 and Akt signaling pathways. Migration of microglial cells was also enhanced in the presence of lipopolysaccharide (LPS, 100 ng/ml), used as a positive control. Importantly, histamine inhibited LPS-stimulated migration via H4R activation. Histamine or H4R agonist also inhibited LPS-induced IL-1β release in both N9 microglia cell line and hippocampal organotypic slice cultures.To our knowledge, we are the first to show a dual role of histamine in the modulation of microglial inflammatory responses. Altogether, our data suggest that histamine per se triggers microglia motility, whereas histamine impedes LPS-induced microglia migration and IL-1β release. This last datum assigns a new putative anti-inflammatory role for histamine, acting via H4R to restrain exacerbated microglial responses under inflammatory challenge, which could have strong repercussions in the treatment of CNS disorders accompanied by microglia-derived inflammation.
Comparative biorelease study of fluticasone in combination with antibacterial (Neomycin) and or antifungal (coltrimazol, miconazole) agents by histamine percutaneous reaction method in healthy volunteers
Shahani S,Jerajani H,Sharma K,Cooverji N
Indian Journal of Dermatology, Venereology and Leprology , 1997,
Abstract: Fluticasone propionate is a novel, potent and topically active synthetic corticosteroid preparation with a much reduced potential, in relation to its anti-inflammatory potency, for unwanted systemic side effects. It is indicated for the treatment of eczema, dermatitis etc. The objective of the present study was to evaluate and compare the biorelease of fluticassone with placebo (base formulation); its combination with antifungal (miconazole, clotrimazole) and / or antibacterial agents based on the attenuation of histamine induced wheal and flare reaction and flare intensity (on visual analouge scale) by McNemar test. In the present study, fluticasone alone and in combination with clotrimazole, miconazole and neomycin significantly reduced the wheal and flare response of histamine prick test. The flare intensity response was also significantly inhibited by these treatments. Furthermore, there was no difference in the anti-inflammatory activity of various treatment groups. It may, therefore, be concluded that antibacterial (neomycin) and / or antifungal (miconazole, clotrimazole) agents in combination with steroid (fluticasone) do not alter the pharmacodynamic response of the latter.
In Vivo Histamine Optical Nanosensors
Kevin J. Cash,Heather A. Clark
Sensors , 2012, DOI: 10.3390/s120911922
Abstract: In this communication we discuss the development of ionophore based nanosensors for the detection and monitoring of histamine levels in vivo. This approach is based on the use of an amine-reactive, broad spectrum ionophore which is capable of recognizing and binding to histamine. We pair this ionophore with our already established nanosensor platform, and demonstrate in vitro and in vivo monitoring of histamine levels. This approach enables capturing rapid kinetics of histamine after injection, which are more difficult to measure with standard approaches such as blood sampling, especially on small research models. The coupling together of in vivo nanosensors with ionophores such as nonactin provide a way to generate nanosensors for novel targets without the difficult process of designing and synthesizing novel ionophores.
Efeito da histamina na regenera??o hepática: estudo experimental em ratos
Biondo-Sim?es, Maria de Lourdes Pessole;Greca, Fernando Hintz;Smaniotto, Gustavo Henrique;Techy, Fernando;Soares, Diogo de Paula;Kannenberg, Cassiana;Castro, Cibele Cristina de Lara;Vasconcelos, Cynthia Neves de;
Acta Cirurgica Brasileira , 2000, DOI: 10.1590/S0102-86502000000100002
Abstract: many substances have been used after partial hepatectomy in order to determine how they act on the process of hepatic regeneration. an adequate blood flow seems to be very important in this process. increased plasma histamine levels after hepatectomy in rats have been reported by some investigators. substances that inhibit histidine-decarboxylase and histaminase lead to an elevation in endogenous histamine with sinusoid vasodilation and acceleration of hepatic regeneration. the objective of the present study was to determine the effect of exogenous histamine administered to partially hepatectomized rats. thirty two wistar rats were submitted to approximately 67% hepatectomy. the animals in the experimental group received subcutaneously 0.5 mg/kg/day of histamine and the controls received an equal volume of isotonic saline. determinations were made after 36 hours and after 7 days. liver weight did not differ between groups. the number of mitotic figures in 10 fields was higher in the experimental group after 36 hours (p=0.010). on the seventh day, the number of mitotic figures was similar for both groups. we conclude that the administration of exogenous histamine, perhaps due to the short half-life of the substance, increases the number of mitotic figures at the beginning of the process but has no effect on regeneration after 7 days.
Ginecomastia induzida por anti-histamínicos no tratamento da urticária cr?nica
Ue, Ana Paula Fusel de;Ikino, Juliana Kida;Furlani, Wellington Jesus;Souza, Patrícia Karla de;Rotta, Osmar;
Anais Brasileiros de Dermatologia , 2007, DOI: 10.1590/S0365-05962007000300007
Abstract: antihistaminic drugs are very commonly used in dermatological practice, and are the first-line therapy to chronic urticaria. the commonest side effects are related to the central nervous system. gynecomastia, in turn, may be due to a myriad of disorders, including the use of medication. the case of h1 antihistaminic-induced gynecomastia in a patient undergoing chronic urticaria treatment is reported. radiological and laboratorial investigations discarded other possible causes for the gynecomastia, which disappeared after removal of the medication. antihistaminic-related side effects, including gynecomastia, are discussed.
Análisis proximal y determinación de histamina en atún enlatado en aceite y al natural
Izquierdo,Pedro; García,Aleida; Rivas,Deisy; García,Aiza; Allara,María; González,Peggy;
Revista Científica , 2007,
Abstract: canned tuna is one of the most consumed products in the country because of its easy acquisition, preparation and excellent nutritional properties. the objective of this research was to determine proximate composition and histamine presence in three commercial brands of canned tuna preserved in water and oil, expended in maracaibo city, zulia state, venezuela. 30 cans of each brand were collected, 15 in oil and 15 in water. sampling was performed five times, in 15 days intervals. sample acquisition was made at supermarkets. in moisture, protein and ashes determination were used official methods of analysis reported by association of official analytical chemist (aoac), and for fat analysis bligh and dyer methodology was used. histamine presence was measured by means of high performance liquid chromatography (hplc).differences in proximate composition depending on commercial brand and presentation. moisture values for tuna canned in water were found between 71.98-75.59%, protein between 21.26-25.22%, fat 1.62-2.66% and ashes 1.48-1.57%. values for tuna canned in oil were 66.43-67.12% for humidity, 23.44-25.84% for protein, 6.45-8.68% for fat and 1.11-1.46% for ash content. all analyzed canned tuna samples presented histamine, in some cases histamine concentrations were close to limit established by food and drug administration (fda) of 50 ppm, because of this constant monitoring in canned tuna produced in venezuela is suggested.
Histamine Contents of Some Commercial Vegetable Pickles
K. Ekici,H. Coskun
Pakistan Journal of Nutrition , 2004,
Abstract: Histamine contents of some pickles were aimed to determine in this survey, and 50 samples of vegetable pickles (of 28 as mixed, 6 as hot pepper and 7 as cucumber pickles) were collected from market in Van city. Histamine determination was done by fluorometric method. It was found that the levels of histamine for all pickles were changed between 16.54 and 74.91 mg kg-1 (average 30.73 mg kg-1). The maximum value (74.91 mg kg-1) was obtained from a sample of hot pepper pickles. All values are below the level of 1000 mg kg-1, which is the minimal level for clinical symptoms of toxicity.
The central effect of biological Amines on immunosuppressive effect of restraint stress in rat
Zeraati F,Ghafghazi T,Adib M,Rezaei A
Acta Medica Iranica , 2000,
Abstract: The effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. In rat immunized with sheep red blood cells ( SRBCs). Restraint stress (RS) prevented the booster-induced rise in anti-SRBC antibody titre and cell immunity response. Intracerebroventicular (I.C>V) injection of histamine (150 μg/rat) induced a similar effect with RS. Pretreatment with chlorpheniramine (50 μg/rat) reduced the inhibitory effect of Ras on immune function. Also histamine could inhibit the effect of RS on immune function. Also histamine could inhibitory the effect of chlorpheniramine when injected simultaneously. Pretreatment with ranidine (10 μg/rat) had not a significant effect. Serotonin (3 μg/rat) and dopamine (0.2 μg/rat) could reverse the effects of chlorpheniromine when injected with chlorpheniramine (P<0.05). Epinephrine (0.2 μg/rat) had not a significant effect. The results indicate that histamine mediates the immunosuppression of restraint stress by influencing the histamine H1 receptor in the brain and this effects of histamine may be modulated by serotoninergic and dopaminergic system.
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