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Search Results: 1 - 10 of 11974 matches for " granulocytic colony stimulating factor. "
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Neutropenias congénitas
Nú?ez Quintana,Aramís; Nordet Carrera,Ileana; Menéndez Veitía,Andrea; González Otero,Alejandro;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: neutrophils play a vital role in the protection of the organism against bacterial and mycotic infections. chronic severe neutropenia is defined as an absolute number of neutrophils under 500xmm3 that persist months or years. the causes of this condition are multiple. they may be congenital and exist since birth, or acquired and appear at any moment of life. the severe congenital neutropenias may appear isolatedly or they may be associated with complex genetic syndromes. among the first, clinical neutropenia and kostmann’s syndrome are of great interest due to the recent discovery of a mutation common to both affecting the neutrophil elastase gene (ela2). the use of the granulocytic colony stimulating factor has improved the prognosis of these entities
Obtención y procesamiento de progenitores hematopoyéticos de sangre periférica para terapia celular en enfermedades angiológicas Obtaining and processing of peripheral blood hematopoietic progenitor cells for cell therapy of angiological diseases
Ana Iris González Iglesias,Mariela Forrellat Barrios,Tania González Suárez,Odalis Salgado Arozena
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2011,
Abstract: Se evaluó la seguridad y efectividad de un método manual de recolección de células progenitoras hematopoyéticas de sangre periférica movilizadas con factores estimuladores de colonias granulocíticas (FEC-G) de producción nacional (Leukocim y Hebervital). Se estudiaron 250 pacientes seleccionados para terapia celular en el Servicio de Angiología del Hospital General Docente "Enrique Cabrera". La obtención y separación de las células mononucleares autólogas de sangre periférica (CMN-SP) se realizó mediante el método dise ado en el Instituto de Hematología e Inmunología. Para valorar la eficacia del método se analizaron en el concentrado obtenido las variables: contenido de células nucleadas, de células mononucleadas y de células CD 34+. Además, se determinó la viabilidad celular y la contaminación microbiológica. Se comprobó la eficiencia y seguridad del método de recolección y procesamiento para la obtención de un concentrado con un contenido de células mononucleares adecuado, sin complicaciones de importancia clínica. Se demostró la eficacia de los factores estimuladores de colonias granulocíticas empleados. Los efectos adversos de la movilización resultaron ligeros e independientes del factor estimulador utilizado. The safety and effectiveness of a manual collection method of peripheral blood hematopoietic progenitor cells mobilized by the Cuban-made granulocytic colony-stimulating factors (Leukocim and Hebervital) were evaluated. Two hundred patients, who had been selected for the cell therapy at the Angiology Service of "Enrique Cabrera" General Teaching Hospital, were studied. The method designed by the Institute of Hematology and Immunology served to obtain and separate autologous mononuclear cells from the peripheral blood. For the purpose of assessing the efficacy of this method, the variables contents of nucleate cells, of mononucleate cells and of CD 34+ cells were analyzed in the final concentrate. Additionally, the cell viability and the microbiological pollution were determined. The efficiency and safety of the collecting and processing method for obtaining one concentrate with adequate content of mononuclear cells and no significant clinical complications was confirmed. The efficacy of the Cuban granulocytic colony-stimulating factors was proved. The adverse effects of the mobilization were mild and unrelated to the used stimulating factor.
Neutropenias congénitas Congenital neutropenias
Aramís Nú?ez Quintana,Ileana Nordet Carrera,Andrea Menéndez Veitía,Alejandro González Otero
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: Los neutrófilos desempe an un papel vital en la protección del organismo frente a infecciones bacterianas y micóticas. La neutropenia crónica severa, se define como un número absoluto de neutrófilos menor de 500xmm3 que persiste meses o a os. Las causas de esta condición son múltiples; pueden ser congénitas y existir desde el nacimiento, o adquiridas y aparecer en cualquier momento de la vida. Las neutropenias congénitas severas se pueden presentar de forma aislada o estar asociadas con síndromes genéticos complejos. Dentro de las primeras, la neutropenia cíclica y el síndrome de Kostmann han cobrado gran interés por el descubrimiento reciente de una mutación común a ambas que afecta al gen de la elastasa del neutrófilo (ELA2). El uso del factor estimulante de colonias granulocíticas ha mejorado el pronóstico de estas entidades Neutrophils play a vital role in the protection of the organism against bacterial and mycotic infections. Chronic severe neutropenia is defined as an absolute number of neutrophils under 500xmm3 that persist months or years. The causes of this condition are multiple. They may be congenital and exist since birth, or acquired and appear at any moment of life. The severe congenital neutropenias may appear isolatedly or they may be associated with complex genetic syndromes. Among the first, clinical neutropenia and Kostmann’s syndrome are of great interest due to the recent discovery of a mutation common to both affecting the neutrophil elastase gene (ELA2). The use of the granulocytic colony stimulating factor has improved the prognosis of these entities
Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the biological behaviours of bone marrow mesenchymal stem cells  [PDF]
Feng-Ping Tang, Xing-Huo Wu, Xi-Lin Yu, Shu-Hua Yang, Wei-Hua Xu, Jin Li
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.23033
Abstract: Aim: The effects of granulocyte colony- stimu-lating factor (G-CSF) and stem cell factor (SCF) on the proliferation and osteogenic differentia-tion capacity of bone marrow mesenchymal stem cells (MSCs) were studied in the experi-ment. Methods: Bone marrow MSCs were col-lected from rabbits successfully, and treated with various concentrations of G-CSF, SCF or a combination of the two. Flow cytometric ana-lyse, MTT test, CFU-F assay, and alkaline phosphatase (ALP) activity measurement were employed. Results: The results of flow cytome-try showed that immunophenotype of the cells were CD29+/CD45-, CD105+/ CD34–, CD90+/ HLADR–. MSCs were shown to constitutively express low levels of c-kit which could be en-hanced by SCF. G-CSF and SCF had an obvious facilitative effect on the proliferation of MSCs in a dose-dependent fashion. In addition, G-CSF and SCF would be effective in reversibly pre-venting their differentiation, as showed by the decrease of ALP activity, leading to self-renewal rather than differentiative cell divisions. The effects of G-CSF were superior to SCF. And cells in the group treated with combination of G-CSF and SCF showed more powerful effects than the groups treated with G-CS, SCF, or none of the two. Conclusion: On the whole, these studies demonstrated that MSCs responsed to G-CSF, SCF, and to G-CSF plus SCF in a manner that suppressed differentiation, and promotes proliferation and self-renewal, and support the view that these factors could act synergistically.
The Improvement of Myocardial Function by Granulocyte Colony Stimulating Factor Following Acute Anterior Myocardial Infarction: A Double Blind Placebo Controlled Study
J Kojuri,A Moaref,P Dehghani
Iranian Cardiovascular Research Journal , 2011,
Abstract: Background: In patients with acute myocardial infarction (AMI),reperfusion of the occluded infarct-related artery significantly improves acuteand late clinical outcome. There is increasing evidence that transplantation ofautologous stem cells improves cardiac function after AMI. For propagation ofperipheral blood stem cells, application of granulocyte–colony stimulatingfactor (G-CSF) has been shown to be feasible, effective, and safe.Methods: Ten patients in the treatment group and 10 patients in thecontrol group were enrolled in this prospective, randomized controlled anddouble blind study. Two weeks after myocardial infarction that was followed bysuccessful recanalization and stent implantation, the patients of the treatmentgroup received 10 μg/kg body weight per day (divided BID) G-CSF subcutaneouslyfor a maximum duration of 5.0 days. In both groups, ejection fraction wasevaluated with echocardiography and cardiac perfusion scans 10 days and 6 monthsafter myocardial infarction. The Tei index was measured by echocardiography.Results: No severe side effects of G-CSF treatment were observed. Therewas no significant improvement of left ventricular ejection fraction when theG-CSF treated group was compared to the control group (P=0.821 for cardiac scanand P=0.705 for echocardiography). Changes in Tei index was not significant inthe treatment group(P=0.815); however, it was significantly deteriorated in the control group(P=0.005).Conclusion: In patients with acute anterior myocardial infarction,treatment with G-CSF, is feasible and safe and seems to be effective inimproving global cardiac function without affecting the ejection fraction underclinical conditions.
Agranulocytosis induced by metamizole and its management with granulocyte growth factor
?eleketi? Du?ica,Trpkovi? Andreja,Cvetkovi? Zorica
Vojnosanitetski Pregled , 2005, DOI: 10.2298/vsp0501079c
Abstract: Drug-induced agranulocytosis was defined as a severe selective neutropenia caused by an unexpected drug reaction. Metamizole was the most common nonopioid analgesic drug associated with agranulocytosis. It was also associated with combined blood dyscrasias and other severe immunologic disorders. The risk of agranulocytosis by metamizole seemed to be considerably higher than estimated formerly. Modern management with broad-spectrum antibiotics and haematopoietic growth factors reduced the mortality in those patients. Two cases of agranulocytosis caused by metamizole were reported.
The Role of C-Reactive Protein, Granulocyte Colony Stimulating Factor and Total Antioxidant Capacity in Diagnosis of Acute Appendicitis  [PDF]
Bar?? Sevinç, Ahmet Oku?, Serden Ay, Nergis Aksoy, Recep Demirgül
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.73023
Abstract: Background and Aim: Despite the fact that acute appendicitis is the most common surgical emergency all around the world, its diagnosis is still based on clinical evaluation and accuracy of the diagnosis depending on experience. The aim of this study is to evaluate the role of inflammatory markers in diagnosis of acute appendicitis. Material and Method: The study includes 77 cases with histopathologically proven acute appendicitis and 17 control cases. Blood samples were obtained from all cases and C-reactive protein (CRP), Granulocyte Colony Stimulating Factor (G-CSF) and Total Antioxidant Capacity (TAC) were measured. Findings: In cases with acute appendicitis, CRP and G-CSF levels were found to be related to acute appendicitis; however, TAC was not affected by the disease process. Moreover, CRP and G-CSF levels were correlated with the disease severity. Conclusion: Both CRP and G-CSF can be used in diagnosis of acute appendicitis. Furthermore, increased CRP level can be a marker to show advanced cases. However, G-CSF is not an effective marker to show disease severity.
Obtención y procesamiento de progenitores hematopoyéticos de sangre periférica para terapia celular en enfermedades angiológicas
González Iglesias,Ana Iris; Forrellat Barrios,Mariela; González Suárez,Tania; Salgado Arozena,Odalis; Fernández Delgado,Norma D; Hernández Ramírez,Porfirio; Matamoros Martínez de Pinillos,María de los A; Lam Díaz,Rosa M; Socarrás Ferrer,Berta B; Hernández Rego,Yakima;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2011,
Abstract: the safety and effectiveness of a manual collection method of peripheral blood hematopoietic progenitor cells mobilized by the cuban-made granulocytic colony-stimulating factors (leukocim and hebervital) were evaluated. two hundred patients, who had been selected for the cell therapy at the angiology service of "enrique cabrera" general teaching hospital, were studied. the method designed by the institute of hematology and immunology served to obtain and separate autologous mononuclear cells from the peripheral blood. for the purpose of assessing the efficacy of this method, the variables contents of nucleate cells, of mononucleate cells and of cd 34+ cells were analyzed in the final concentrate. additionally, the cell viability and the microbiological pollution were determined. the efficiency and safety of the collecting and processing method for obtaining one concentrate with adequate content of mononuclear cells and no significant clinical complications was confirmed. the efficacy of the cuban granulocytic colony-stimulating factors was proved. the adverse effects of the mobilization were mild and unrelated to the used stimulating factor.
On bio-diversity, complexity of M-CSF and its receptor
Kefu Wu
Chinese Science Bulletin , 2000, DOI: 10.1007/BF02886307
Abstract: With the development of science, the methods and the views of scientific research changed from analyses to syntheses. Recently, more attention has been paid to bio-diversity and complexity. According to the study on M-CSF and its receptor for years, the author suggests that, the multi-level of bio-diversity also appears at the bio-macromolecular level. Probability of bio-diversity is one of the bases for bio-complexity. Cellular sociology and topobiology are important aspects in bio-complexity, and should be developed. If taking Chinese traditional medicine together with the advantage from Reductionism, joining the study on complexity, Chinese scientist would make a chair in the international scientific society.
Expression of granulocyte colony-stimulating factor and its receptor in childhood neuroblastoma
Xin WU,Da-wei HE,Yong-bo ZHANG,Wen-fei HE
Medical Journal of Chinese People's Liberation Army , 2012,
Abstract: Objective  To study the expression of granulocyte colony-stimulating factor (G-CSF) and its receptor (G-CSFR) in neuroblastoma of children. Methods  Twenty-five specimens of neuroblastoma were collected in our department during 2009.1–2011.6. G-CSF and G-CSFR were determined by immunohistochemistry. The correlation between expressions of G-CSF and G-CSFR and age, gender and clinical stage were analyzed. Results  The expression of G-CSF and G-CSFR in neuroblastoma specimens was 68%, 72% respectively. Both G-CSF and G-CSFR were positive in 12(48%)specimens, and both G-CSF and G-CSFR were negative in 2 cases (8%). But according to test of concordance, the positive expression of G-CSF and G-CSFR had no concordance in neuroblastoma specimens (Kappa=-0.0456,P=0.8187). There were 5 cases (20%) showed positive-GCSF but negative-G-CSFR, 6 cases(24%) with negative expression of G-CSF but positive-G-CSFR. No statistical correlation was found between the expression of G-CSF or G-CSFR and gender, age and clinical stage (P>0.05). Conclusions  G-CSF and G-CSFR are highly expressed in children neuroblastoma, regardless of age, gender and clinical stage. For the G-CSFR-positive patients, we recommend the use of G-CSF, and its effect on tumor should be carefully observed.
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