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Search Results: 1 - 10 of 8753 matches for " gluten free diet "
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Safety Food in Celiac Disease Patients: A Systematic Review  [PDF]
Mariarita Dessì, Annalisa Noce, Sara Vergovich, Gianluca Noce, Nicola Di Daniele
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.47A008
Abstract: The prevalence of Celiac Disease (CD), an autoimmune enteropathy, characterized by chronic inflammation of the intestinal mucosa, atrophy of intestinal villi and several clinical manifestations has increased in recent years. Epidemiological studies have shown that CD is very common and affects about one in 250 people. The mechanism of the intestinal immune-mediated response is not completely clear, but involves an HLA-DQ2 or HLA-DQ8 restricted T-cell immune reaction in the lamina propria as well as an immune reaction in the intestinal epithelium. Subjects affected by CD cannot tolerate gluten protein, a mixture of storage proteins contained in several cereals (wheat, rye, barley and derivatives). Gluten free-diet remains the cornerstone treatment for celiac patients. Therefore the absence of gluten in natural and processed foods represents a key aspect of food safety of the gluten-free diet. In this review, we evaluate the main studies about the safety food in CD patients.
Coeliac Disease: Gluten Free Diet and… What Else?  [PDF]
Marina Taus, Elsa Veronica Mignini, Daniele Fumelli, Debora Busni, Giulia Nicolai, Carla Carletti, Albano Nicolai
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.611035
Abstract: Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, bloating, pain, flatulence and constipation may sometimes be misleading. Once diagnosed of CD, patients must adhere to Gluten Free Diet, which consists in the lifelong avoidance of gluten containing foods and of those naturally gluten free but at risk of contamination. This dietary approach is considered the only therapy in order to avoid symptoms exacerbation and to reduce the digestive mucosa inflammation, which has been related to higher risks of lymphoproliferative malignancy and other immunological disorders. However, being on a Gluten Free Diet is not as resolving as it may seem since it has several criticalities. First of all, excluding gluten means limiting food variety so that coeliac patients may have unbalanced intake of several nutrients and develop clinical or subclinical deficiencies. This can be due to scarce attention to qualitative and quantitative composition of diets and poor information about gluten-containing foods, which only patient-tailored dietetic protocol and long-term follow-up can achieve. Secondly, Gluten Free Diet may not result in complete remission of mucosal damage or in resolution of symptoms. Unintentional contamination of gluten or poor adherence to diet are the main culprits of the incomplete mucosal healing but other triggers may be involved. Recent research has focused on the role of FODMAPs in changing gut microbiota and on the improvement of Irritable Bowel Syndrome (IBS) symptoms after their dietary avoidance or reduction. Since CD and IBS may share many clinical presentations, further studies are needed to evaluate if a subgroup of CD patients whose symptoms are not improved by Gluten Free Diet could benefit from a new therapeutic approach consisting in both gluten/wheat and FODMAPs avoidance.
Adherencia e impacto de la dieta sin gluten en ni?os con enfermedad celíaca
BRAVO M,FRANCISCA; MU?OZ F,MARíA PAZ;
Revista chilena de pediatría , 2011, DOI: 10.4067/S0370-41062011000300003
Abstract: the treatment of celiac disease (cd) is a strict and permanent gluten-free diet (gfd). factors exist that influence adherence: motivation, information, costs, correct labeling and food availability. objectives: describe adherence and impact of gfd in children with cd. patients and methods: prospective descriptive study, through application of a 28 question survey to children 12-18 y.o. with the disorder, and parents of children 3-18 with the disease. results: median age: 10.5 years, 1.8 years at diagnosis. 62.5% women. adherence to treatment was seen in 42,5% of patients according to parents, 15% according to children > 12 yrs. vs 35% parents of children > 12 y.o. 80% of children state feeling no different on a diet, 70% find the diet hard to follow. 55% have difficulty following the diet, among them, 42,8% are not sure what they can eat, 51.5% state it creates financial distress in the family. about 55% believe it affects family life due to the following: 55% food limitation, 50% food preparation, 75% affect eating out, 35% affect traveling. 50% of parents have fed children a forbidden food, mainly at home (44%). information regarding gfd is obtained at the hospital (85%). there is 32.5% adherence to cd foundations. conclusions: gfd impacts children's lifestyle with difficulty in adherence and management.
Associated or Concomitant Diseases Influence Significantly the Health-Sickness Concept in Celiacs  [PDF]
Eduardo Cueto Rúa, Maria Teresita Gonzalez Villar, Ricardo Wright, Claudia Losada Gómez, Karol Martínez, María Arregui, Luciana Guzmán, Cecilia Zubiri, Viviana Bernedo, Anabella Zosi, Lorena Menéndez, Lucas Ruiz, Leopoldo Mancinelli, María Urrutia, Ricardo Drut
Open Journal of Epidemiology (OJEpi) , 2017, DOI: 10.4236/ojepi.2017.72013
Abstract: It is well-known that feeling to be a healthy or sick person most probably results from the mind than from the body. We all know healthy people who feel sick and vice versa. We were interested in the health and sickness feeling of celiac people, their autorating of these feelings and its conditioning factors as well as their expectations. In this paper we present the results of an inquiry to evaluate these situations. We performed a descriptive, transversal and prospective study for 2 years to groups of celiacs and their families. They received a closed inquiry to be completed before the beginning of the talk. The inquiry included personal data and the co-existence of associated or concomitant (AoC) diseases. Most of the sample’s patients felt to be a healthy person (86.8%). Mothers see their children as healthy and the auto rated criteria is significantly better than the adult celiac person (“t”= -6.024 (p = 0.000)). AoC diseases influenced negatively in the feeling of being healthy and strongly decreased the autorating. Longer time passed on treatment reflects an increase feeling of health and of the autorating. In people with AoC diseases and who feel sick, the increased time of treatment did not show significant differences. People with “gluten sensitivity” felt sicker and auto rated themselves with a lower number than celiacs. Many pediatric gastroenterologists notice that the newly agreed definition of celiac disease, referring it as “autoimmune, chronic, incurable, and multisystemic”, results in a very negative character of the condition which might compromise the future labour of this people as well as their admittance to different health insurance systems.
Cross-Reaction between Gliadin and Different Food and Tissue Antigens  [PDF]
Aristo Vojdani, Igal Tarash
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.41005
Abstract:

A subgroup of coeliac disease patients continues to experience symptoms even on a gluten-free diet (GFD). We attempted to determine whether these symptoms could be due to either cross-contamination with gluten-containing foods or cross-reactivity between α-gliadin and non-gluten foods consumed on a GFD. We measured the reactivity of affinity-purified polyclonal and monoclonal α-gliadin 33-mer peptide antibodies against gliadin and additional food antigens commonly consumed by patients on a GFD using ELISA and dot-blot. We also examined the immune reactivity of these antibodies with various tissue antigens. We observed significant immune reactivity when these antibodies were applied to cow’s milk, milk chocolate, milk butyrophilin, whey protein, casein, yeast, oats, corn, millet, instant coffee and rice. To investigate whether there was cross-reactivity between α-gliadin antibody and different tissue antigens, we measured the degree to which this antibody bound to these antigens. The most significant binding occurred with asialoganglioside, hepatocyte, glutamic acid decarboxylase 65, adrenal 21-hydroxylase, and various neural antigens. The specificity of anti-α-gliadin binding to different food and tissue antigens was demonstrated by absorption and inhibition studies. We also observed significant cross-reactivity between α-gliadin 33-mer and various food antigens, but some of these reactions were associated with the contamination of non-gluten foods with traces of gluten. The consumption of cross-reactive foods as well as gluten-contaminated foods may be responsible for the continuing symptoms presented by a subgroup of patients with coeliac disease. The lack of response of some CD patients may also be due to antibody cross-reactivity with non-gliadin foods. These should then be treated as gluten-like peptides and should also be excluded from the diet when the GFD seems to fail.

Celiac disease as potential obstacle to childbearing  [PDF]
Mónika Kovács, Mária Szenes, Tihamér Horváth, Gy?rgy Vajda, Beáta Gasztonyi, Gy?rgy Bártfai
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.42014
Abstract:

AIM: The authors have aimed at confirming or excluding gluten sensitivity in infertile couples. PATIENTS AND METHODS: Between 2004 and 2010, at our outpatient clinics of immunology, both partners of 223 couples, who had striven for having a child unsuccessfully, underwent history taking, physical examination, laboratory and immuno-serologic tests including anti-tissue-transglutaminase antibody (antitTG), as well as deep duodenal biopsy in antibody-carrying patients. RESULTS: Antibodies against tissue transglutaminase were positive in 6/223 female patients of whom the diagnosis of celiac disease was histologically confirmed in 3/223 cases (1.34%). Of the male patients 2/223 (0.9%) have proven to be carriers of the antibody; histology was pathognomonic in both of them. Curiously, one of the male patients with celiac disease has been the partner of a woman who also had celiac disease diagnosed by the authors. In the followup period, a female patient and the female member of the couple with celiac disease gave birth to healthy newborns after spontaneous conception, as the result of a strictly kept gluten-free diet, as well as occasional treatments of acetylsalicylate for antiphos-pholipid syndrome or levothyroxine for latent hypothyroidism due to autoimmune thyroiditis. CONCLUSION: The results underline that it is worth performing a screening for celiac disease in both partners of couples assessed due to the lack of success in having a child, as infertility can be ceased by an appropriate diet.

Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile
Espino,Alberto; Castillo L,Cecilia; Guiraldes,Ernesto; Santibá?ez,Helga; Miquel,Juan Francisco;
Revista médica de Chile , 2011, DOI: 10.4067/S0034-98872011000700003
Abstract: background: celiac disease (cd) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. its prevalence in europe and the usa is 0.5 to 1%. aim: to analyze epidemiological aspects and degree of compliance with gluten-free diet (gfd) among chilean individuals with cd. material and methods: subjects with confirmed or suspected cd were invited to answer an online survey published on the web at www.fundacionconvivir.cl. the answers were reinforced with a telephone interview. results: the survey was answered by 1212 subjects (79% females). median age at diagnosis was 25.8 years (range 1 to 84 years), with a bimodal curve with two peaks at less than 3 years and at 20 to 40 years of age. the diagnosis was made only by serologic markers in 9%, only by intestinal biopsy in 17.5%, and by a combination of both methods in 70%o. conditions associated with cd were reported by 30%> of subjects and 20%> had relatives with cd. the gfd was strictly adhered to by 70%>, occasionally by 27%> and never by 3%>. seventy five percent of subjects with a strict adherence to gfd had a favorable clinical response compared with 42%> of those with incomplete or lack of adherence (odds ratio 4.0, 95%> confidence intervals 2.8-5.7p < 0.01). conclusions: in 30% of respondents, the diagnosis of cd was not confirmed according to international guidelines that require serology and duodenal biopsy. one third of subjects recognized a poor compliance with gfd. those with a strict adherence to it had a more favorable clinical course. however, 25%> did not experience a clinical improvement despite a strict gfd, a finding which requires further study.
Celiac disease: Alternatives to a gluten free diet
Fabiana Zingone,Pietro Capone,Carolina Ciacci
World Journal of Gastrointestinal Pharmacology and Therapeutics , 2010,
Abstract: Celiac disease is a chronic inflammatory disorder of the small intestine caused by the ingestion of gluten or related rye and barley proteins. At present, the only available treatment is a strict gluten-exclusion diet. However, recent understanding of the molecular basis for this disorder has improved and enabled the identification of targets for new therapies. This article aims to critically summarize these recent studies.
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile A national online survey applied to patients with celiac disease in Chile
Alberto Espino,Cecilia Castillo L,Ernesto Guiraldes,Helga Santibá?ez
Revista médica de Chile , 2011,
Abstract: Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. Aim: To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean individuals with CD. Material and Methods: Subjects with confirmed or suspected CD were invited to answer an online survey published on the web at www.fundacionconvivir.cl. The answers were reinforced with a telephone interview. Results: The survey was answered by 1212 subjects (79% females). Median age at diagnosis was 25.8 years (range 1 to 84 years), with a bimodal curve with two peaks at less than 3 years and at 20 to 40 years of age. The diagnosis was made only by serologic markers in 9%, only by intestinal biopsy in 17.5%, and by a combination of both methods in 70%o. Conditions associated with CD were reported by 30%> of subjects and 20%> had relatives with CD. The GFD was strictly adhered to by 70%>, occasionally by 27%> and never by 3%>. Seventy five percent of subjects with a strict adherence to GFD had a favorable clinical response compared with 42%> of those with incomplete or lack of adherence (odds ratio 4.0, 95%> confidence intervals 2.8-5.7p < 0.01). Conclusions: In 30% of respondents, the diagnosis of CD was not confirmed according to international guidelines that require serology and duodenal biopsy. One third of subjects recognized a poor compliance with GFD. Those with a strict adherence to it had a more favorable clinical course. However, 25%> did not experience a clinical improvement despite a strict GFD, a finding which requires further study.
Celiac Disease and Overweight in Children: An Update
Antonella Diamanti,Teresa Capriati,Maria Sole Basso,Fabio Panetta,Vincenzo Maria Di Ciommo Laurora,Francesca Bellucci,Fernanda Cristofori,Ruggiero Francavilla
Nutrients , 2014, DOI: 10.3390/nu6010207
Abstract: The clinical presentation of celiac disease in children is very variable and differs with age. The prevalence of atypical presentations of celiac disease has increased over the past 2 decades. Several studies in adults and children with celiac disease indicate that obesity/overweight at disease onset is not unusual. In addition, there is a trend towards the development of overweight/obesity in celiac patients who strictly comply with a gluten-free diet. However, the pathogenesis and clinical implications of the coexistence of classic malabsorption (e.g., celiac disease) and overweight/obesity remain unclear. This review investigated the causes and main clinical factors associated with overweight/obesity at the diagnosis of celiac disease and clarified whether gluten withdrawal affects the current trends of the nutritional status of celiac disease patients.
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