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Search Results: 1 - 10 of 25 matches for " flavanone. "
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Phytochemical Study of Glycosmis Mauritiana  [PDF]
Javed Intekhab, Mohammad Aslam, Hira Khalid
American Journal of Plant Sciences (AJPS) , 2011, DOI: 10.4236/ajps.2011.25078
Abstract: Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1- Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteolin-4'-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyra- nosyl-(1→6)}-β-D-glycopyranoside]. The isolated compounds were characterized by UV, IR and N. M. R (1H, 13C) studies.
Synthesis and study of cholosubstituted 4-aroyl pyrazolines and isoxazolines and their effects on inorganic ions in blood serum in albino rats
AMOL D. BHOYAR,GANESH N. VANKHADE,PRITHVISIGH R. RAJPUT
Nusantara Bioscience , 2011,
Abstract: Bhoyar AD, Vankhade GN, Rajput PR. 2011. Synthesis and study of cholosubstituted 4-aroyl pyrazolines and isoxazolines and their effects on inorganic ions in blood serum in albino rats. Nusantara Bioscience 3: 118-123. Condensation of 2-substitutied 3,5-dichloroacetophenones (2a-b) obtained from the condensation of 2-hydroxy 3,5-dichloro-acetophenone (1) and benzoyl chloride were dissolved in NaOH, on treatment under Baker-Venkatraman transformation in presence of KOH with pyridine gives 1-(2-hydroxy-3,5-dichlorophenyl)-3-substituted-1,3-propanediones (3a-b). Then converted into 3-aroyl-6,8-dichloroflavanones (4a-d) by using different aromatic aldehyde in ethanol containing little piperidine. The condensation of (4a-d) and phenylhydrazinehydrochloride, piperidine in DMF gives 3-(2-hydroxy3,5-dichlorophenyl)-4-substitution-1-phenyl- 2pyrazolines (5a-d) and condensation of (4a-d) and hydroxylamine-hydrochloride gives 3-(2-hydroxy-3,5-dichlorophenyl)-4-aroyl-5-substituted isoxazolines (6a-d). The above compounds are screened for their activities and have been found to exhibit significant effects on inorganic ions in blood serum in albino rats.
Two New Phenolic Glycosides from Viscum articulatum
Yang Li,Yan-Li Zhao,Ning Huang,Yong-Tang Zheng,Yong-Ping Yang,Xiao-Li Li
Molecules , 2008, DOI: 10.3390/molecules13102500
Abstract: Two new phenolic glycosides, 1-O-benzyl-[5-O-benzoyl-β-D-apiofuranosyl (1→2)]-β-D-glucopyranoside (1), and 4`-hydroxy-7,3`-dimethoxyflavan-5-O- β-D-gluco-pyranoside (2), together with nine known flavanones 3 - 11, have been isolated from the dried whole plants of Viscum articulatum.Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Compound 9 showed weak anti-HIV-1 activity.
Three new compounds from Piper montealegreanum Yuncker (Piperaceae)
Alves, Harley da S.;Souza, Maria de F. V. de;Chaves, Maria C. de O.;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000800026
Abstract: three new compounds: two flavonoids [(s)-8-formyl-3',5-dihydroxy-7-methoxy-6methylflavanone (1) and 3'-formyl-3,4',6'-trihydroxy-2'-methoxy-5'-methylchalcone (2)] and one phenylpropanoid [ethyl 3,4-methylenedioxy-5-methoxy-7,8-dihydrocinnamate (3)] were isolated from dried branches of piper montealegreanum. their structures were established by uv, ir, ms, 1d and 2d (1h and 13c) nmr spectroscopic techniques, besides interpretation of spectral data (1h and 13c nmr) of methylated derivatives of 1 and 2 compounds.
A COMPARATIVE STUDY OF BACTERIOSTATIC ACTIVITY OF SYNTHETIC HYDROXYLATED FLAVONOIDS
Olivella, Mónica S.;Zarelli, Valeria E.P.;Pappano, Nora B.;Debattista, Nora B.;
Brazilian Journal of Microbiology , 2001, DOI: 10.1590/S1517-83822001000300013
Abstract: among other properties, flavonoids present a notable bacteriostatic activity. in this paper, minimal inhibitory concentrations (mics) of 5,7,4'-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2',4',4- trihydroxychalcone (isoliquitirigenin) against staphylococcus aureus atcc 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. specific growth rates and mics were determined by a turbidimetric kinetic method. the observed sequence micflavanone (inactive) >mic7-hidroxyflavanone (197.6 μgml-1)>mic5,7,4'-trihydroxyflavanone (120 μgml-1) showed that the introduction of an electron donating group (-oh) causes an increase in bioactivity. on the other hand, the comparisons mic5,7,4'-trihydroxyflavanone (120 μgml-1) >>> mic2',4',4-trihydroxychalcone (29 μgml-1) and mic5,7-dihydroxyflavone (105 μgml-1) >>> mic2',4'-dihydroxychalcone (28.8 μgml-1) indicated that the chalcone structure is the most favourable for bacteriostatic activity within the flavonoid family.
A COMPARATIVE STUDY OF BACTERIOSTATIC ACTIVITY OF SYNTHETIC HYDROXYLATED FLAVONOIDS
Olivella Mónica S.,Zarelli Valeria E.P.,Pappano Nora B.,Debattista Nora B.
Brazilian Journal of Microbiology , 2001,
Abstract: Among other properties, flavonoids present a notable bacteriostatic activity. In this paper, minimal inhibitory concentrations (MICs) of 5,7,4'-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2',4',4- trihydroxychalcone (isoliquitirigenin) against Staphylococcus aureus ATCC 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. Specific growth rates and MICs were determined by a turbidimetric kinetic method. The observed sequence MICflavanone (inactive) >MIC7-hidroxyflavanone (197.6 μgml-1)>MIC5,7,4'-trihydroxyflavanone (120 μgml-1) showed that the introduction of an electron donating group (-OH) causes an increase in bioactivity. On the other hand, the comparisons MIC5,7,4'-trihydroxyflavanone (120 μgml-1) >>> MIC2',4',4-trihydroxychalcone (29 μgml-1) and MIC5,7-dihydroxyflavone (105 μgml-1) >>> MIC2',4'-dihydroxychalcone (28.8 μgml-1) indicated that the chalcone structure is the most favourable for bacteriostatic activity within the flavonoid family.
Isolation and Structure Elucidation of a Flavanone, a Flavanone Glycoside and Vomifoliol from Echiochilon Fruticosum Growing in Tunisia
S. Hammami,H. Ben Jannet,A. Bergaoui,L. Ciavatta,G. Cimino,Z. Mighri
Molecules , 2004, DOI: 10.3390/90700602
Abstract: A flavanone and a flavanone glycoside, together with vomifoliol, have been isolated for the first time from the aerial parts of the plant Echiochilon fruticosum and identified. Their structures were established on the basis of spectroscopic measurements, mainly 2D NMR using COSY, HMQC and HMBC experiments.
Antiradical and Cytoprotective Activities of Several C-Geranyl-substituted Flavanones from Paulownia tomentosa Fruit
Ale? Zima,Jan Ho?ek,Jakub Treml,Jan Muselík,Pavel Suchy,Gabriela Pra?anová,Ana Lopes,Milan ?emli?ka
Molecules , 2010, DOI: 10.3390/molecules15096035
Abstract: Antiradical and cytoprotective activities of several flavanones isolated from Paulownia tomentosa (Thunb.) Steud. (Scrophulariaceae) have been evaluated using different in vitro and in vivo methods. The capacity of flavanones to scavenge radicals was measured in vitro by means of DPPH and ABTS assays, the inhibition of hydroxyl radicals produced in Fenton reactions, FRAP, scavenging superoxide radicals using enzymatic and nonenzymatic assays and the inhibition of peroxynitrite-induced nitration of tyrosine. The in vivo testing involved measuring the cytoprotective effect of chosen flavanones against alloxan-induced diabetes in mice. The activity of tested compounds was expressed either as a Trolox? equivalent or was compared with rutin or morine as known antioxidant compounds. The highest activity in most tests was observed for diplacone and 3′-O-methyl-5′-hydroxydiplacone, and the structure vs. the antioxidant activity relationship of geranyl or prenyl-substituted flavonoids with different substitutions at the B and C ring was discussed.
Pterocarpans and a novel flavanone from harpalyce brasiliana roots
Araújo, Renata M. de;Lima, Mary Anne S.;Silveira, Edilberto R.;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000500019
Abstract: the novel (-)-7,8,3',4'-trihydroxy-8-(3'',7''-dimethyl-octa-2'',6''-dienoyl)-flavanone was isolated from the etoh extract from the roots of harpalyce brasiliana (leguminosae) together with the known pterocarpans (-)-2-geranyl-3-hydroxy-8,9-methylenedioxypterocarpan, harpalicin, medicarpin, maackiain and cabenegrins a-i and a-ii. the isolated metabolites were characterized on the basis of spectroscopic data, mainly 1d and 2d nmr.
CONSTITUENTS FROM FERONIA LIMONIA
J. Intekhab,M. Aslam
Analele Universitatii Bucuresti : Chimie , 2009,
Abstract: The root and stem bark of Feronia limonia yielded 5, 7-dihydroxy-3', 4'-dimethoxy -6, 8-di (3-methylbut-2-enyl) flavanone along with several known compounds viz., stigmasterol, friedelin, β-sitosterol-3-O-β-D-glucopyranoside, bergapten, xanthotoxin, scopoletin, isoimperatorin, osthol and 6, 7-dimethoxycoumarin. These compounds were characterized on the basis of U.V, IR, N.M.R (1H, 13C) and mass spectral studies.
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