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Search Results: 1 - 10 of 20247 matches for " embryonic and fetal development "
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Modelo experimental para restri??o do crescimento fetal em ratos: efeito sobre o glicogênio hepático e morfometria intestinal e renal
Bueno, Márcia Pereira;Barini, Ricardo;Gon?alves, Frances Lilian Lanhellas;Veríssimo, Rilde Plutarco;Sbragia, Louren?o;
Revista Brasileira de Ginecologia e Obstetrícia , 2010, DOI: 10.1590/S0100-72032010000400003
Abstract: purpose: to evaluate the effectiveness of the iugr model by uterine artery ligation mimicking placental insufficiency in rats. methods: sprague-dawley rat fetuses were divided into three groups: iugr (intrauterine growth restriction), with fetuses in the right horn of pregnant rats subjected to right uterine artery ligation at 18.5 days of gestation (term = 22 days); c-iugr (control of restriction), with control fetuses in the left horn, and ec (external control), with fetuses of intact rats. animals were harvested by cesarean section at day 21.5 days of gestation. fetuses were weighed and then sacrificed. the intestine, liver, kidney and placenta were weighed and dissected for morphometric and histological analysis. results: the morphometric data showed decreased body weight (bw), liver weight (lw) and intestinal weight (iw) of fetuses with iugr compared to c-iugr and ec (p<0.001). the placental weight (pw), renal weight (rw) and lw/bw, iw/bw, and rw/bw ratios did not change. iugr fetuses had decreased kidney thickness (p<0.001) and decreased thickness of the intestinal mucosa and submucosa (p<0.05). histological evaluation showed reduction of liver glycogen storage in fetuses with iugr compared to c-iugr and ce. conclusions: the model described was efficient and caused symmetric fetal iugr with decreased size of most organs, especially the liver, and changes in glycogen stores.
Análisis Macroscópico y Microscópico del Desarrollo Embrionario y Fetal en el Gato (Felis catus), en Relación con el Desarrollo de la Vesícula Coriónica y de la Placenta
Illanes,Julio; Orellana,Cupertina; Fertilio,Bárbara; Leyton,Victor; Venegas,Felipe;
International Journal of Morphology , 2007, DOI: 10.4067/S0717-95022007000300002
Abstract: the domestic cat (felis catus) presents a gestation that lasts 62 ± 5 days. however, gestational age determination in a more precise way is difficult, as there are no analysis that correlate chorionic vesicle size; placental development; embryonic and fetal development during gestation. in this work 12 gravid uteruses from hybrid cats between 8 and 18 months of age were studied; these were fixed in 10% neutral formaldehyde. for each uterus the chorionic vesicles number was determined. the embryos, fetuses and placenta were removed, measured, weighed and photographed for morphologic analysis. the embryonic and fetal stages of development were determined according to the external characteristics and structures of the embryos or fetuses, from gastrulation to term. at 13 days of gestation a late gastrula was observed; between days 13 and 18, somitic embryos; between days 18 and 28, prefetal embryos; and fetuses from day 28 until birth. the amnion is closed by day 17; differentiation of the facial region occurs between days 16 and 28, while limb development takes place between days 17 and 28. at 15 days of gestation the heart begins to beat and the endocardial tube is observed. septation of the heart occurs between days 17 and 20 and the neural tube is closed by day 17. all parameters studied in the different developmental stages in the cat are significantly correlated (p < 0.0001)
Embriopatía por isotretinoína: Un da?o evitable
Troncoso Sen,Mónica; Rojas H,Carla; Bravo C,Eduardo;
Revista médica de Chile , 2008, DOI: 10.4067/S0034-98872008000600012
Abstract: retinoic acid is a widely used drug in the treatment of cystic acné. it has teratogenic effects that depend on the gestational period in which it is used. we report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. she had a retardation of psychomotor development and a brain mri showed frontal atrophy and a malformation of the posterior fossa. we discuss the mechanisms ofthe teratogenic effeets of retinoic acid
Embriopatía por isotretinoína: Un da o evitable Isotretinoin embryophaty: Report of one case
Mónica Troncoso Sen,Carla Rojas H,Eduardo Bravo C
Revista médica de Chile , 2008,
Abstract: Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid
Symphysis-fundal height curve in the diagnosis of fetal growth deviations
Freire,Djacyr Magna Cabral; Cecatti,Jose Guilherme; Paiva,Cláudio Sergio Medeiros;
Revista de Saúde Pública , 2010, DOI: 10.1590/S0034-89102010005000044
Abstract: objective: to validate a new symphysis-fundal curve for screening fetal growth deviations and to compare its performance with the standard curve adopted by the brazilian ministry of health. methods: observational study including a total of 753 low-risk pregnant women with gestational age above 27 weeks between march to october 2006 in the city of jo?o pessoa, northeastern brazil. symphisys-fundal was measured using a standard technique recommended by the brazilian ministry of health. estimated fetal weight assessed through ultrasound using the brazilian fetal weight chart for gestational age was the gold standard. a subsample of 122 women with neonatal weight measurements was taken up to seven days after estimated fetal weight measurements and symphisys-fundal classification was compared with lubchenco growth reference curve as gold standard. sensitivity, specificity, positive and negative predictive values were calculated. the mcnemar χ2 test was used for comparing sensitivity of both symphisys-fundal curves studied. results: the sensitivity of the new curve for detecting small for gestational age fetuses was 51.6% while that of the brazilian ministry of health reference curve was significantly lower (12.5%). in the subsample using neonatal weight as gold standard, the sensitivity of the new reference curve was 85.7% while that of the brazilian ministry of health was 42.9% for detecting small for gestational age. conclusions: the diagnostic performance of the new curve for detecting small for gestational age fetuses was significantly higher than that of the brazilian ministry of health reference curve.
Análisis Macroscópico y Microscópico del Desarrollo Embrionario y Fetal en el Gato (Felis catus), en Relación con el Desarrollo de la Vesícula Coriónica y de la Placenta Macroscopic and Microscopic Analysis of the Embryonic and Fetal Growth in the Cat (Felis catus), in Relation to Chorionic Vesicle and Placental Development
Julio Illanes,Cupertina Orellana,Bárbara Fertilio,Victor Leyton
International Journal of Morphology , 2007,
Abstract: La gata doméstica (Felis catus) presenta una gestación que dura, en promedio 62 + 5 días. Sin embargo, establecer la edad gestacional en forma más o menos precisa resulta difícil, ya que no existe un análisis que correlacione el tama o de la vesícula coriónica; desarrollo de la placenta; desarrollo embrionario y Fetal durante la gestación. En este trabajo se utilizaron 12 úteros grávidos, provenientes de gatas mestizas entre 8 y 18 meses de edad, éstos fueron fijados en formol neutro al 10%. Para cada útero se determinó el número de vesículas coriónicas, de cada una se removieron el embrión, feto y la placenta, los que fueron medidos, tarados y fotografiados para su análisis morfológico. Las etapas del desarrollo embrionario y Fetal fueron establecidas conforme a las características y estructuras externas de los embriones y fetos, desde el inicio hasta el término de la gestación. A los 13 días de gestación se observó una gástrula tardía. Embriones somíticos, entre los 13 y 18 días. Embriones prefetales, entre los 18 y 28 días, y fetos desde el día 28 hasta el nacimiento. El amnios se cierra a los 17 días; la formación de la cara y cuello ocurre entre los 16 y 28 días, y de los miembros, entre los 17 y 28 días de gestación. A los 15 días de gestación comienza el latido cardiaco, momento en que se observa el tubo endocárdico. El tabicamiento del corazón se produce entre los 17 y 20 días. El tubo neural está cerrado a los 17 días de gestación. Todos los parámetros estudiados en los diferentes estadios del desarrollo en el gato están significativamente correlacionados (p < 0.0001) The domestic cat (Felis catus) presents a gestation that lasts 62 ± 5 days. However, gestational age determination in a more precise way is difficult, as there are no analysis that correlate chorionic vesicle size; placental development; embryonic and Fetal development during gestation. In this work 12 gravid uteruses from hybrid cats between 8 and 18 months of age were studied; these were fixed in 10% neutral formaldehyde. For each uterus the chorionic vesicles number was determined. The embryos, fetuses and placenta were removed, measured, weighed and photographed for morphologic analysis. The embryonic and Fetal stages of development were determined according to the external characteristics and structures of the embryos or fetuses, from gastrulation to term. At 13 days of gestation a late gastrula was observed; between days 13 and 18, somitic embryos; between days 18 and 28, prefetal embryos; and fetuses from day 28 until birth. The amnion is closed by day 17; differentiation o
The Fate of Motherhood, Fetuses and Neonates in Drug Addicted Pregnant Women
J Sharifian,M Jahanian,F Tavassoli,S Tavassoli
Journal of Shahid Sadoughi University of Medical Sciences , 2011,
Abstract: Introduction: Drug addiction causes many complications for mother and fetus. Preterm labor, spontaneous abortion, intrauterine fetal growth retardation, prenatal mortality, placental abruption, preeclampsia, PROM, cesarean delivery and congenital anomalies among the newborns of addicted mothers are increased. The purpose of this study was to evaluate the final of maternal, fetal and neonatal of drugs addicted pregnant women. Methods: The study is a Cross-Sectional study was done on 236 pregnant women 19-40 years old addicted to drugs and 236 pregnant women non-addicted that referred for delivery to maternity hospitals of Imam Reza(as) and Imam Sajjad(as) during 2008-2010. Measuring instruments were: observing and checklist includes various sections were related on the aims. Data Analysis was done using SPSS. After ensuring that these values followed the normal distribution, chi-square test and Fisher exact test to compare qualitative variables of two groups and for quantitative variables T test was used. Confidence coefficient of 95% was considered. Results: The results showed complication such as placental abruption, preterm labor, preeclampsia, hypertension, PROM, cesarean, hepatitis B, meconium in the amniotic fluid, intrauterine fetal growth retardation, anomalies in infant, low Apgar score in the first and fifth minutes, fetal death, hypoglycemia, neonatal convulsions, breathing problems, RDS, need to neonatal resuscitation, admission in NICU, neonatal death in the first three days of birth, weight loss, low circumference head size among infants were born of mothers addicted compared with the control group had shown significant increase. Conclusion: Opium addiction causes serious complications for mother, fetus and newborn.
Ontogenesis of Gonadotropin-Releasing Hormone Neurons: A Model for Hypothalamic Neuroendocrine Cell Development
Erica L. Stevenson,Kristina M. Corella,Wilson C. J. Chung
Frontiers in Endocrinology , 2013, DOI: 10.3389/fendo.2013.00089
Abstract: The vertebrate hypothalamo–pituitary–gonadal axis is the anatomical framework responsible for reproductive competence and species propagation. Essential to the coordinated actions of this three-tiered biological system is the fact that the regulatory inputs ultimately converge on the gonadotropin-releasing hormone (GnRH) neuronal system, which in rodents primarily resides in the preoptic/hypothalamic region. In this short review we will focus on: (1) the general embryonic temporal and spatial development of the rodent GnRH neuronal system, (2) the origin(s) of GnRH neurons, and (3) which transcription – and growth factors have been found to be critical for GnRH neuronal ontogenesis and cellular fate-specification. Moreover, we ask the question whether the molecular and cellular mechanisms involved in GnRH neuronal development may also play a role in the development of other hypophyseal secreting neuroendocrine cells in the hypothalamus.
本地胎儿双顶径估算孕龄应用于孕中期产前筛查的意义
窦琳琳(),杨国绘,莫伟明
- , 2017, DOI: 10.3785/j.issn.1008-9292.2017.02.09
Abstract: 建立基于杭州市萧山区孕妇的胎儿双顶径孕龄估算公式,并分析其运用于产前筛查的效果。 选取2012年1月至2015年4月在浙江萧山医院接受产前筛查的3500名孕妇为研究对象,孕龄控制在15周~19周+6。应用超声检查对3500名胎儿的双顶径进行测量,形成基于本地胎儿双顶径的孕龄拟合方程(本地公式)。应用此公式对2014年5月至2015年5月1759名月经不规则或者末次月经不详的孕妇进行产前筛查风险计算,并与LifeCycle 4.0软件内置公式所得的结果进行比较。 应用本地公式以后,唐氏综合征、18三体综合征和神经管畸形的总阳性率从6.96%降至5.85%(P < 0.05)。其中,应用本地公式获得的唐氏综合征的筛查阳性率低于内置公式(P < 0.05),神经管畸形的筛查阳性率高于内置公式(P < 0.05),而两者18三体综合征的筛查阳性率差异无统计学意义(P>0.05)。内置公式与本地公式所得的游离β-人绒毛膜促性腺激素MoM中位数和甲胎蛋白MoM中位数比较差异有统计学意义(均P < 0.05),其中本地公式所得的MoM中位数更接近1。所有确诊孕妇应用孕龄本地公式和内置公式筛查具有相同的疾病检出率。 基于本地区人群的胎儿双顶径估算孕龄可以降低产前筛查的假阳性率,使产前筛查的结果更加准确。
Abstract: Objective To establish a fetal biparietal diameter (BPD)-gestational age formula based on the data of pregnant women from Xiaoshan District of Hangzhou, and to evaluate its application in prenatal screening. Methods Data of 3500 pregnant women with gestational age between 15 weeks and 19 weeks+6 receiving prenatal screening in Xiaoshan Hospital during May 2014 and May 2015 were collected. BPDs were used to establish a localized BPD-gestational age formula. The localized formula was used to evaluate the prenatal screening risks in 1759 pregnant women with irregular menstrual cycles or uncertain last menstrual period (LMP) in Xiaoshan District, and the results were compared with those calculated using formula in LifeCycle 4.0. Results With localized formula, the total positive rate of Down syndrome, trisomy 18 syndrome and deformity of neural tube was decreased from 6.96% to 5.85% (P < 0.05), in which the positive rate of Down syndrome decreased (P < 0.05), that of deformity of neural tube increased (P < 0.05), and that of trisomy 18 syndrome remained the same (P>0.05). The median MoMs of free-hCG β and α-fetoprotein calculated using localized formula were significantly different from those calculated using the formula in LifeCycle 4.0 (all P < 0.05), and the former ones were more closer to 1. For women of fetus diagnosed with the above diseases, the positive rate calculated using localized formula was almost the same as that calculated using the formula in LifeCycle 4.0. Conclusion BPD-gestational age formula should be localized based on the statistical analysis of the local population, which will help to reduce the false positive rate, and make the results more accurate and reliable in prenatal screening. Key words: Embryonic and fetal development Neural tube defects Ultrasonography, prenatal Gestational age Down syndrome Syndrome Mass screening
Expression Patterns of CAPN1 and CAPN8b Genes during Embryogenesis in Xenopus laevis  [PDF]
Lucie Abrouk-Vérot, Claire Brun, Jean-Marie Exbrayat
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.24024
Abstract:

Calpains are a superfamily of Ca2+-dependent cysteine proteases, implicated in various cellular processes and thus probably necessary in all the stages of cell life. The first extended report of quantification of total RNAs within the developmental stages of Xenopus laevis was described in this study. Decreases of total RNAs were positively associated with waves of apoptotic cell death (onset of gastrulation, and morphogenesis). Using qPCR, the temporal expression pattern of CAPN1 and CPAN8b (XCL-2) were characterized during the Xenopus laevis embryogenesis. Transcripts of the CAPN1 and CAPN8 genes were detectable from gastrula stage and their levels oscillated throughout development. The expression of the CAPN1 (mu/I) gene was observed in earliest stage, indicating a maternal origin, while expression of the CAPN8b gene was detectable after midblastula transition. The levels of the two transcripts then started to rise again obviously as a result of zygotic expression (stage 11). The CAPN1 gene expression was particularly expressed at tailbud stage, while the CAPN8 transcripts were found at gastrula, neurula and tailbud stages. This is the first report of quantification of mRNAs CAPN8b and CAPN1 (mu/I) within the developmental stages of Xenopus laevis by qPCR.

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