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Search Results: 1 - 10 of 251 matches for " electrospinning "
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Electrospun nanofiber-based drug delivery systems  [PDF]
Deng-Guang Yu, Li-Min Zhu, Kenneth White, Chris Branford-White
Health (Health) , 2009, DOI: 10.4236/health.2009.12012
Abstract: Electrospinning is a very simple and versatile process by which polymer nanofibers with di-ameters ranging from a few nanometers to sev-eral micrometers can be produced using an electrostatically driven jet of polymer solution or polymer melt. Significant progress has been made in this process throughout the past few years and electrospinning has advanced its ap-plications in many fields, including pharmaceu-tics. Electrospun nanofibers show great prom-ise for developing many types of novel drug delivery systems (DDS) due to their special characteristics and the simple but useful and effective top-down fabricating process. The current state of electrospun nanofiber-based DDS is focused on drug-loaded nanofiber preparation from pharmaceutical and biode-gradable polymers and different types of DDS. However, there are more opportunities to be exploited from the electrospinning process and the corresponding drug-loaded nanofibers for drug delivery. Additionally, some other related challenges and the possible resolutions are outlined in this review.
Nanopores Structure in Electrospun Bacterial Cellulose  [PDF]
Ligia Maria Manzine Costa, Gabriel Molina de Olyveira, Pierre Basmaji, Lauro Xavier Filho
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.31012
Abstract: Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavours, especially for medical devices, lately, bacterial cellulose mats are used in the treatment of skin conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as a support for cell proliferation, its pores allow gas exchange between the organism and the environment. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization and cell support. In this work, we obtain first electrospun bacterial cellulose mats after chemical treatment and without conductive additives. With DMA/LiClmechanism dissolution, modified bacterial cellulose was easily electrospun in chloroform/acetone solvents in comparison with BC unmodified. FTIR peaks results are consistent with proposed interactions between cellulose and DMA/LiCl solvent system.
Morphological, Vibrational and Thermal Properties of Confined Graphene Nanosheets in an Individual Polymeric Nanochannel by Electrospinning  [PDF]
Mohammed Khenfouch, Mimouna Ba?toul, Hassane Aarab, Malek Maaza
Graphene (Graphene) , 2012, DOI: 10.4236/graphene.2012.12002
Abstract: Graphene is a single layer of carbon atoms arranged in a two dimension hexagonal lattice. It appeared very quickly that this exceptional material had truly outstanding electronic, mechanical, thermal and optical properties. The main goal of this work is the confinement of graphene nanosheets in an individual polymeric nanofiber and the study of their vibrational and thermal properties in one dimension. After their preparation, graphene sheets were mixed with Polyethylene oxide (PEO) solution to be electrospinned. The synthesized nanofibers were systematically investigated by Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy measurements and their morphology and structure were characterized by atomic force microscopy (AFM), optical microscope and Scanning Electron Microscope (SEM) and finally thermogravimetric analysis (TGA) to check G/PEO mass ratio and interactions to prove the capability of PEO to be a good envelope for the confinement and the alignment of graphene nanosheets in a one dimensional system.
Electrospinning of Gelatin Functionalized with Silver Na-noparticles for Nanofiber Fabrication  [PDF]
Marwa A. Oraby, Ahmed I. Waley, Ahmed I. El-Dewany, Ebtesam A. Saad, Bothaina M. Abd El-Hady
Modeling and Numerical Simulation of Material Science (MNSMS) , 2013, DOI: 10.4236/mnsms.2013.34013

The present paper deals with gelatin nanofibres functionalized with silver nanoparticles, prepared by electrospinning using solutions of gelatin mixed with silver nitrate (AgNO3). As a common solvent for gelatin and silver nitrate (AgNO3), a mixture of acetic acid and water (70:30 v/v) was selected. In this system, acetic acid was used as a solvent for gelatin, and at the same time reducing agent for silver ions in solution. Silver nanoparticles (nAg) were stabilized through a mechanism that involves an interaction of the oxygen atoms of the carbonyl groups of gelatin. The viscosity and the conductivity of the gelatinous solutions were found to increase with the solution concentration. There is an observed decrease in the viscosity of the nAg containing gelatin solutions with the aging time increasing, whereas the conductiity of the AgNO3—containing gelatin solutions was greater than that of the base gelatin solution. The gelatin nanofibres functionalized with silver nanoparticles were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and antimicrobial test. The results of investigations by TEM and XRD confirmed the presence of silver nanoparticles with diameters in the range of (2

Ketoprofen/ethyl Cellulose Nanofibers Fabricated Using an Epoxy-coated Spinneret  [PDF]
Xiao-Yan Li, Deng-Guang Yu, Cai-Tao Fu, Rui Wang, Xia Wang
Modeling and Numerical Simulation of Material Science (MNSMS) , 2013, DOI: 10.4236/mnsms.2013.34B002

The present study investigates the preparation of sustained release drug-loaded nanofibers using a novel epoxy-coated spinneret. With ethyl cellulose (EC) and ketoprofen (KET) as the filament-forming matrix and the active pharmaceutical ingredient, Drug-loaded composite nanofibers are generated smoothly and continuously with few user interventions. Field-emission scanning electron microscopic observations demonstrated that the composite nanofibers prepared using the epoxy-coated spinneret have better quality than those from a traditional stainless steel spinneret in terms of diameter and its distribution. Both of the composite nanofibers are in essential a molecular solid dispersion of EC and KET based on the hydrogen bonding between them, as verified by XRD and ATR-FTIR results. In vitro dissolution tests show that the nanofibers resulted from the new spinneret provide a finer sustained KET release profile than their counter-parts. Epoxy-coated spinneret is a useful tool to facilitate the electrospinning process through the prevention of clogging for generating high quality nanofibers.

Porous Electrospun Nanofiber from Biomass-Based Polyester Blends of Polylactic Acid and Polybutylene Succinate  [PDF]
Manisara Phiriyawirut, Kanokwan Sarapat, Sutasinee Sirima, Anrasee Prasertchol
Open Journal of Polymer Chemistry (OJPChem) , 2019, DOI: 10.4236/ojpchem.2019.91001
Abstract: We studied the electrospinning process of the blend of polylactic acid (PLA) and polybutylene succinate (PBS). The blend PLA/PBS ratio 95/5, 90/10, 85/15 and 80/20 wt% were prepared by dissolved in mixture of solvent between dichloromethane (DCM) and N, N-dimethylformamide (DMF) at ratio 3/1. The suitable condition for electrospun of the blend was 17% wt concentration, 16 kV and 18 cm projection distance. The round fiber with pore on the surface was observed. Increasing content of PBS in the blend impact to the diameter of fibril decreased from 1350, 1290, 1210 and 1170 nm, respectively; while the pore on the surface changes from circle to oval shape. Regarding the thermal properties, blending of PBS increases the glass transition temperature (Tg) of PLA without affect to the melting temperature (Tm) of the electrospun nanofibers. The best tensile properties of PLA/PBS nanofibers were achieved at blend ratio of 95/5, and Young’s modulus is increased comparing to those of the pure electrospun fibers.
Superthin combined PVA-graphene film
Kong Hai-Yan,He Ji-Huan
Thermal Science , 2012, DOI: 10.2298/tsci1205560k
Abstract: Superthin polyvinil alcohol graphene sheet of several nanometers in thickness is obtained by the electrospinning. Polyvinil alcohol (10 wt.%) solution with the additive of ash (0.5 wt.%) is used for this purpose
Mathematical Models of Bead-Spring Jets during Electrospinning for Fabrication of Nanofibers
Thananchai DASRI
Walailak Journal of Science and Technology , 2012, DOI: 10.2004/vol10iss1pp
Abstract: Electrospinning is a popular technique to produce structures in the form of nanofibers. These nanofibers can be used for many applications such as filtration composites, insulator and energy storage. The technique is based on the electrostatic force that acts on the polymeric solution. However, during the electrospinning process the liquid jet shows unstable behavior. This problem causes the random formation of nanofibers. This article focuses on the mathematical models to describe the dynamics behavior of the fluid jet in the electrospinning process. There are a lot of different parameters in the model. Variation in these parameters results in a change in jet behaviors. This brief review is a summary of the authors’ recent work. The Reneker’s model and Wu’s model are used to describe the dynamics behavior of the jet used in electrospinning.
Ammonia Sensing Behaviors of TiO2-PANI/PA6 Composite Nanofibers
Qingqing Wang,Xianjun Dong,Zengyuan Pang,Yuanzhi Du,Xin Xia,Qufu Wei,Fenglin Huang
Sensors , 2012, DOI: 10.3390/s121217046
Abstract: Titanium dioxide-polyaniline/polyamide 6 (TiO2-PANI/PA6) composite nanofibers were prepared by in situ polymerization of aniline in the presence of PA6 nanofibers and a sputtering-deposition process with a high purity titanium sputtering target. TiO2-PANI/PA6 composite nanofibers and PANI/PA6 composite nanofibers were fabricated for ammonia gas sensing. The ammonia sensing behaviors of the sensors were examined at room temperature. All the results indicated that the ammonia sensing property of TiO2-PANI/PA6 composite nanofibers was superior to that of PANI/PA6 composite nanofibers. TiO2-PANI/PA6 composite nanofibers had good selectivity to ammonia. It was also found that the content of TiO2 had a great influence on both the morphology and the sensing property of TiO2-PANI/PA6 composite nanofibers.
Cytotoxicity tests for nanostructured chitosan/PEO membranes using the agar diffusion method
Vulcani, Valcinir Aloisio Scalla;Bizarria, Maria Trindade Marques;d?ávila, Marcos Akira;Mei, Lucia Helena Innocentini;Bernal, Cláudia;Perussi, Janice Rodrigues;
Materials Research , 2012, DOI: 10.1590/S1516-14392012005000013
Abstract: electrospinning is used to produce fibers in the nanometer range by stretching a polymeric jet using electric fields of high magnitude. chitosan is an abundant natural polymer that can be used to obtain biocompatible nanostructured membranes. the objectives of this work were to obtain nanostructured membranes based on blends of chitosan and polyoxyethylene (peo), and evaluate their thermal and morphological properties, as well as their in vitro biocompatibility by agar diffusion cytotoxicity tests for three different cell lines. a nanostructured fibrous membrane with fiber diameters in the order of 200 nm was obtained, which presented a rough surface and thickness ranging from one to two millimeters. the results of the cytotoxicity tests evidenced that the chitosan/peo membranes are non-toxic to the cells studied in this work. further, the electrospinning technique was effective in obtaining nanostructured chitosan/peo membranes, which showed biocompatibility according to in vitro preliminary tests using the cell lines.
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