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Search Results: 1 - 10 of 12139 matches for " drug-induced "
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Carbimazole Drug-Induced Hepatitis during Treatment of Graves’ Disease: About Four Cases at Dakar Teaching Hospital  [PDF]
Abdoulaye Leye, Michel Assane Ndour, Nafy Ndiaye Sarr, Ngoné Diaba Diack, Yakham Mohamed Leye, Dominique Emmanuel Faye
Open Journal of Internal Medicine (OJIM) , 2017, DOI: 10.4236/ojim.2017.74010
Abstract: Introduction: Mostly reported common side effects of carbimazole are cutaneous allergies and severe agranulocytosis. However, hepatotoxicity is rarely described. Thus, we report four observations of carbimazole drug-induced hepatitis during the treatment of Graves’ disease, which imputability is likely and probably an immuno-allergic mechanism. Observations: They were four women whose average age was 43 years, with extreme ages of 32 and 54. Patients were monitored and treated with carbimazole in doses contained between 40 mg and 60 mg per day. Clinical manifestations of liver injury were mainly dominated by cholestatic jaundice, found in 100% of our patients. A painful sensitivity of the right hypochondrium was concomitant with jaundice for two patients. The jaundice time to onset after the beginning of treatment with carbimazole varies between 1 month and 6 months. They all had acute hepatitis. The biological assays used to determine the type of liver injury showed, in all cases, a mixed, cholestatic and cytolytic hepatitis. Therapeutically, in all patients, carbimazole was stopped as soon as the suspicion of its incrimination in the occurrence of liver damage was set up. They all had a substitution of carbimazole with benzylthiouracil. Evolution was favorable for all patients, after therapeutic substitution. It was marked by disappearance of jaundice and normalization of the liver biological parameters within a maximum delay of two months after stopping carbimazole use. Conclusion: Treatment with synthetic antithyroid drugs, particularly carbimazole that is most widely used in our regions, requires clinical and biological monitoring. This surveillance, which is often difficult in Africa because of the limited economic resources, can lead to the occurrence of side effects such as potentially serious drug-induced hepatitis, but which has been favorable in our observations.
A strategy to improve the detection of drug-induced hepatotoxicity
Ruiz Montero,A.; Durán Quintana,J. A.; Jiménez Sáenz,M.; Abadín Delgado,J. A.;
Revista Espa?ola de Enfermedades Digestivas , 2005, DOI: 10.4321/S1130-01082005000300003
Abstract: aims: to report a new strategy for the detection of hepatotoxic adverse drug reactions (adrs) in hospitalized patients improving the results obtained with other methods. design: the model is based on the identification of a single alert signal in various target clinical departments over a 12-month period. each patient was later interviewed following a set protocol. the main results analyzed were the drugs suspected of adr; causal relationship between suspected drugs and adrs; adr severity, and incidence of hepatotoxic adr/100,000 inhabitants. subjects: population served by a university-affiliated urban teaching hospital (519,381 inhabitants). results: the overall ratio of confirmed/suspected adrs was high (35/80). the most commonly reported drug was amoxicillin-clavulanic acid (4 cases). with regard to causality, 2 suspected cases were classified as definite and 14 as probable. the distribution according to the severity of hepatotoxicity was 6 severe and 29 mild cases. the incidence of hepatotoxic adrs/100,000 inhabitants as revealed by our method was much higher versus voluntary report (6.74 and 1.79, respectively). conclusions: our method has proven effective for improving the detection of hepatotoxic adrs, and may be extended to other types of adverse reactions.
Critical Evaluation for Alternative Causes of Drug Induced and Herbal Induced (DILI/HILI) Hepatotoxicity  [PDF]
Vasilios Frankos, Raushanah Najeeullah, Joel Morgan
Health (Health) , 2016, DOI: 10.4236/health.2016.89084
Abstract: The objective of this review is to highlight the continued exclusion of discussion in the literature regarding alternative causes and proper causality assessment of cases of hepatotoxicity when use of dietary supplements is reported. Though independent experts are working diligently to advance the discussion related to alternative causes of hepatotoxicity resulting in idiosyncratic drug-induced liver injury/herb-induced liver injury (DILI/HILI), the literature continues to recite the same cases, such as those presented here, to reiterate potentially biased positions and ignore current, standardized and valid evaluations utilizing the Roussel Uclaf Causality Assessment Method (RUCAM). Several historical cases purporting hepatotoxicity induced by use of dietary supplements are presented in this review to demonstrate how such cases may be improperly assessed due to bias, inconsistent use of causality assessment methods, as well as use of causality assessment methods deemed obsolete. This in essence, delays any true progress in establishing sound criteria to determine and address the actual cause(s) of DILI/HILI.
Care strategies for patients with severe drug-induced hepatitis  [PDF]
Tingting Zhang, Yuan Liu, Qingqing Xu, Yaping Han, Jun Li
Health (Health) , 2011, DOI: 10.4236/health.2011.34040
Abstract: Objective: The aim of this study is to analyse the clinical characteristics of 32 patients with severe drug-induced hepatitis, reinforce the practice of unique nursing and holistic nursing, improve the therapeutic effect, reduce the patients’ mortality, and increase their quality of life. Methods: We give patients individualized dietary guidance, medication nursing, and psychological care according to the characteristics of severe hepatitis and its complications, using com- prehensive medical treatment and combined signs of Traditional Chinese Medicine. Results: Overall, 22 (68.8%) out of 32 cases were improved, 8 (25.0%) cases died, and 2 (6.2%) cases were discharged of free will. In addition, the average hospital stay was 28.75 days. Conclusion: This study indicates that dietary guidance for the patients with severe drug-induced hepatitis varies with the individual. The result embodies the concept of Traditional Chinese Medicine that different treatment for the same disease and different diet for the same disease. Special nursing enriches the connotation of holistic nursing. Both of them are vital for improving the survival rate and promoting rehabilitation of patients with severe drug-induced hepatitis.
Non genetic risk factors of long-QT syndrome  [PDF]
Ewa Moric-Janiszewska, Grzegorz Hibner
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.21007
Abstract: The purpose of the present study is to provide guidelines regarding risk factors that may worsen the Long-QT Syndrome (LQTS), based on available literature. This review evaluates the current knowledge on these risk factors of acquired LQTS, with an emphasis on non genetic risk factors, including environmental factors. PubMed was searched for literature in English from 1999 to 2011 on the molecular and clinical studies of Long-QT syndrome. We agree, with recent investigations described in the literature, that variety of factors, inherited or environmental, can influence expression of ion channel proteins with impact on repolarization.
Enfermedad hepática tóxica inducida por drogas: Revisión sistemática estructurada
Sierra A,Fernando; Torres P,Diana del P;
Revista Colombiana de Gastroenterologia , 2005,
Abstract: the authors have followed a concise and structured review of drug-induced toxic hepatic disease and they proposed some guidelines for understanding and managing patients and adverse hepatic reaction to drugs, based on scientific evidence having the greatest credibility, validity, trustworthiness and pertinence.
Acute generalized exanthematous pustulosis (AGEP). Case report
Belda Junior, Walter;Ferolla, Ana Carolina Junqueira;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2005, DOI: 10.1590/S0036-46652005000300011
Abstract: acute generalized exanthematous pustulosis (agep) is a drug-induced dermatosis characterized by an acute episode of sterile pustules over erythematous-edematous skin. it is accompanied by an episode of fever, which regresses a few days after discontinuation of the drug that caused the condition or as a result of corticosteroid treatment. the main triggering drugs are antibiotics, mainly beta-lactam ones. other medications, such as antifungal agents, non steroid anti-inflammatory drugs, analgesics, antiarrhythmic, anticonvulsant and antidepressant drugs, may also be responsible. histologically, it is characterized by the existence of vasculitis, associated with non-follicular subcorneal pustules. a case of a caucasian female outpatient unit of dermatology with agep, who presented with generalized pustulosis lesions after the use of cephalosporin for urinary infection is related. the diagnosis was confirmed by the clinical and pathological correlations, the resolution of the dermatosis after discontinuation of the drug and use of systemic corticosteroid treatment, and the recurrence of the disorder after the introduction of a similar drug. the importance of the recognition of this drug-induced dermatosis is given by its main differential clinical and histological diagnoses: generalized pustular psoriasis and subcorneal pustulosis.
Enfermedad hepática tóxica inducida por drogas: Revisión sistemática estructurada
Fernando Sierra A,Diana del P Torres P
Revista Colombiana de Gastroenterologia , 2005,
Abstract: Basado en una exhaustiva, sistemática y estructurada revisión de la enfermedad hepática tóxica inducida por drogas, se plantean algunas pautas de entendimiento y manejo del paciente con reacción adversa a drogas, fundamentando las mismas en los artículos de mayor confiabilidad, validez, y pertinencia. The authors have followed a concise and structured review of drug-induced toxic hepatic disease and they proposed some guidelines for understanding and managing patients and adverse hepatic reaction to drugs, based on scientific evidence having the greatest credibility, validity, trustworthiness and pertinence.
Doxycycline-induced esophagitis: Report of two cases and review of the literature
Muhammed Sa??kara,Ya?ar Nazl?gül,Güler K?z?lca,Oktay Bulur
Dicle Medical Journal , 2010,
Abstract: Although it is not so frequent in medical literature, drug-induced esophageal injury is important, because of its possible complications. Here, we reported two patients with ulcerative esophagitis secondary to doxycycline use. Both patients applied to outpatient clinic with retrosternal pain, odynofagia and dysphagia. Symptoms had been developed after three days of doxicycline treatment in the first patient, and after two days in the second patient. Upper gastrointestinal endoscopy revealed ulcers in patient 1 at the upper 1/3 segment of esophagus and in patient 2 at the middle 1/3 segment of esophagus. Based on the endoscopic findings, the patients were diagnosed as drug-induced esophageal injury resulting from doxycycline treatments. Doxycycline treatments were stopped and lansoprazole and sucralfate was started.
Difficult road to diagnosing dementia with Lewy bodies (DLB). Case report [Trudna droga do rozpoznania ot pienia z cia ami Lewy’ego. Opis przypadku]
Sokó?-Szaw?owska, Marlena,Poleszczyk, Anna
Psychiatria Polska , 2013,
Abstract: Aim. The main aim of the study was to present the case of a patient with neurological, depressive and psychotic symptoms, most probably connected with progressing dementia with Lewy bodies (DLB). Method. The systematic symptom analysis based on the clinical examination and medical documentation. Results. During the first hospitalisation, the presented patient was diagnosed with acute and transient psychotic disorders (F23). After being discharged from the ward, the patient experienced recurrence of previous symptoms with a short period of time. The two following diagnoses after hospital treatment were established as a depressive episode with psychotic symptoms. During the fourth hospitalisation, the patient was diagnosed with organic delusional (schizophrenia-like) disorder (F06.2). After six years, thorough analysis of clinical history as well as the course of existing disorder made it possible to diagnose the patient as having dementia with Lewy bodies-DLB (F02.8). Since that time, the patient has been taking rivastigmine, which has turned out to be a successful treatment. It has been 6 months since the patient left the hospital and still remains in remission. Social functioning of the woman is similar to the period before the first episode. Conclusions. The presented case demonstrates, that DLB symptomatology is a difficult problem in everyday psychiatric practice. A differential diagnosis of psychopathological and neurological symptoms covers many disorders, which together, with the clinical picture variation may delay effective treatment.
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